-
2
-
-
84868249881
-
q
-
q. Cell Signal 25:255-263.
-
(2013)
Cell Signal
, vol.25
, pp. 255-263
-
-
Adjobo-Hermans, M.J.1
Crosby, K.C.2
Putyrski, M.3
Bhageloe, A.4
Van Weeren, L.5
Schultz, C.6
Goedhart, J.7
Gadella Jr., T.W.8
-
3
-
-
59549094677
-
Regulation of PLCβ1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate
-
Adjobo-Hermans MJ, Goedhart J, and Gadella TW, Jr (2008) Regulation of PLCβ1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate. J Cell Sci 121:3770-3777.
-
(2008)
J Cell Sci
, vol.121
, pp. 3770-3777
-
-
Adjobo-Hermans, M.J.1
Goedhart, J.2
Gadella Jr., T.W.3
-
4
-
-
0037205509
-
Role of the G protein γ subunit in βγ complex modulation of phospholipase Cβ function
-
DOI 10.1074/jbc.M201546200
-
Akgoz M, Azpiazu I, Kalyanaraman V, and Gautam N (2002) Role of the G protein γ subunit in β γ complex modulation of phospholipase Cβ function. J Biol Chem 277:19573-19578. (Pubitemid 34975642)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.22
, pp. 19573-19578
-
-
Akgoz, M.1
Azpiazu, I.2
Kalyanaraman, V.3
Gautam, N.4
-
5
-
-
0032484959
-
The inhibition of cell signaling pathways by antitumor ether lipids
-
DOI 10.1016/S0005-2760(97)00163-X, PII S000527609700163X
-
Arthur G and Bittman R (1998) The inhibition of cell signaling pathways by antitumor ether lipids. Biochim Biophys Acta 1390:85-102. (Pubitemid 28122329)
-
(1998)
Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
, vol.1390
, Issue.1
, pp. 85-102
-
-
Arthur, G.1
Bittman, R.2
-
6
-
-
0035813116
-
Evidence for selective coupling of alpha 1-adrenergic receptors to phospholipase C-β 1 in rat neonatal cardiomyocytes
-
Arthur JF, Matkovich SJ, Mitchell CJ, Biden TJ, and Woodcock EA (2001) Evidence for selective coupling of alpha 1-adrenergic receptors to phospholipase C-β 1 in rat neonatal cardiomyocytes. J Biol Chem 276:37341-37346.
-
(2001)
J Biol Chem
, vol.276
, pp. 37341-37346
-
-
Arthur, J.F.1
Matkovich, S.J.2
Mitchell, C.J.3
Biden, T.J.4
Woodcock, E.A.5
-
7
-
-
0027995232
-
Two forms of phospholipase C-β 1 generated by alternative splicing
-
Bahk YY, Lee YH, Lee TG, Seo J, Ryu SH, and Suh PG (1994) Two forms of phospholipase C-β 1 generated by alternative splicing. J Biol Chem 269:8240-8245.
-
(1994)
J Biol Chem
, vol.269
, pp. 8240-8245
-
-
Bahk, Y.Y.1
Lee, Y.H.2
Lee, T.G.3
Seo, J.4
Ryu, S.H.5
Suh, P.G.6
-
8
-
-
0032484668
-
Localization of two forms of phospholipase C-β1, a and b, in C6Bu-1 cells
-
DOI 10.1016/S0005-2760(97)00128-8, PII S0005276097001288
-
Bahk YY, Song H, Baek SH, Park BY, Kim H, Ryu SH, and Suh PG (1998) Localization of two forms of phospholipase C-β1, a and b, in C6Bu-1 cells. Biochim Biophys Acta 1389:76-80. (Pubitemid 28015062)
-
(1998)
Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
, vol.1389
, Issue.1
, pp. 76-80
-
-
Bahk, Y.Y.1
Song, H.2
Baek, S.H.3
Park, B.Y.4
Kim, H.5
Ryu, S.H.6
Suh, P.-G.7
-
9
-
-
0032189615
-
Cytotoxic etherphospholipid analogues
-
Berkovic D (1998) Cytotoxic etherphospholipid analogues. Gen Pharmacol 31:511-517.
-
(1998)
Gen Pharmacol
, vol.31
, pp. 511-517
-
-
Berkovic, D.1
-
10
-
-
0142215620
-
Cardiac calcium signalling
-
Berridge MJ (2003) Cardiac calcium signalling. Biochem Soc Trans 31:930-933.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 930-933
-
-
Berridge, M.J.1
-
11
-
-
0026694917
-
Phospholipase C-β 1 is a GTPase-activating protein for Gq/11, its physiologic regulator
-
Berstein G, Blank JL, Jhon DY, Exton JH, Rhee SG, and Ross EM (1992) Phospholipase C-β 1 is a GTPase-activating protein for Gq/11, its physiologic regulator. Cell 70:411-418.
-
(1992)
Cell
, vol.70
, pp. 411-418
-
-
Berstein, G.1
Blank, J.L.2
Jhon, D.Y.3
Exton, J.H.4
Rhee, S.G.5
Ross, E.M.6
-
12
-
-
70349205440
-
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-μ opioid receptor-coupling is necessary for morphine induced acute hyperalgesia
-
Bianchi E, Norcini M, Smrcka A, and Ghelardini C (2009) Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-μ opioid receptor-coupling is necessary for morphine induced acute hyperalgesia. J Neurochem 111:171-180.
-
(2009)
J Neurochem
, vol.111
, pp. 171-180
-
-
Bianchi, E.1
Norcini, M.2
Smrcka, A.3
Ghelardini, C.4
-
13
-
-
0029961069
-
1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation
-
1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation. J Biol Chem 271:7999-8007.
-
(1996)
J Biol Chem
, vol.271
, pp. 7999-8007
-
-
Biddlecome, G.H.1
Berstein, G.2
Ross, E.M.3
-
14
-
-
0024574592
-
Inhibition of phospholipase C dependent processes by U-73, 122
-
Bleasdale JE, Bundy GL, Bunting S, Fitzpatrick FA, Huff RM, Sun FF, and Pike JE (1989) Inhibition of phospholipase C dependent processes by U-73, 122. Adv Prostaglandin Thromboxane Leukot Res 19:590-593.
-
(1989)
Adv Prostaglandin Thromboxane Leukot Res
, vol.19
, pp. 590-593
-
-
Bleasdale, J.E.1
Bundy, G.L.2
Bunting, S.3
Fitzpatrick, F.A.4
Huff, R.M.5
Sun, F.F.6
Pike, J.E.7
-
15
-
-
0036938784
-
Disruption of PLC-β1-mediated signal transduction in mutant mice causes age-dependent hippocampal mossy fiber sprouting and neurodegeneration
-
DOI 10.1006/mcne.2002.1199
-
Böhm D, Schwegler H, Kotthaus L, Nayernia K, Rickmann M, Köhler M, Rosenbusch J, Engel W, Flügge G, and Burfeind P (2002) Disruption of PLC-β 1-mediated signal transduction in mutant mice causes age-dependent hippocampal mossy fiber sprouting and neurodegeneration. Mol Cell Neurosci 21:584-601. (Pubitemid 36062716)
-
(2002)
Molecular and Cellular Neuroscience
, vol.21
, Issue.4
, pp. 584-601
-
-
Bohm, D.1
Schwegler, H.2
Kotthaus, L.3
Nayernia, K.4
Rickmann, M.5
Kohler, M.6
Rosenbusch, J.7
Engel, W.8
Flugge, G.9
Burfeind, P.10
-
16
-
-
15444366833
-
Regulatory interactions between the amino terminus of G-protein βγ subunits and the catalytic domain of phospholipase Cβ2
-
DOI 10.1074/jbc.M412514200
-
Bonacci TM, Ghosh M, Malik S, and Smrcka AV (2005) Regulatory interactions between the amino terminus of G-protein βγ subunits and the catalytic domain of phospholipase Cβ2. J Biol Chem 280:10174-10181. (Pubitemid 40395871)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.11
, pp. 10174-10181
-
-
Bonacci, T.M.1
Ghosh, M.2
Malik, S.3
Smrcka, A.V.4
-
17
-
-
33646008247
-
Differential targeting of Gβγ-subunit signaling with small molecules
-
Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, and Smrcka AV (2006) Differential targeting of Gβγ- subunit signaling with small molecules. Science 312:443-446.
-
(2006)
Science
, vol.312
, pp. 443-446
-
-
Bonacci, T.M.1
Mathews, J.L.2
Yuan, C.3
Lehmann, D.M.4
Malik, S.5
Wu, D.6
Font, J.L.7
Bidlack, J.M.8
Smrcka, A.V.9
-
18
-
-
1642388834
-
PKC-α regulates cardiac contractility and propensity toward heart failure
-
DOI 10.1038/nm1000
-
Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, and Liggett SB et al. (2004) PKC-α regulates cardiac contractility and propensity toward heart failure. Nat Med 10:248-254. (Pubitemid 38667614)
-
(2004)
Nature Medicine
, vol.10
, Issue.3
, pp. 248-254
-
-
Braz, J.C.1
Gregory, K.2
Pathak, A.3
Zhao, W.4
Sahin, B.5
Klevitsky, R.6
Kimball, T.F.7
Lorenz, J.N.8
Nairn, A.C.9
Liggett, S.B.10
Bodi, I.11
Wang, S.12
Schwartz, A.13
Lakatta, E.G.14
DePaoli-Roach, A.A.15
Robbins, J.16
Hewett, T.E.17
Bibb, J.A.18
Westfall, M.V.19
Kranias, E.G.20
Molkentin, J.D.21
more..
-
19
-
-
0028373202
-
Toward the mechanism of phosphoinositide-specific phospholipases C
-
Bruzik KS and Tsai MD (1994) Toward the mechanism of phosphoinositide- specific phospholipases C. Bioorg Med Chem 2:49-72.
-
(1994)
Bioorg Med Chem
, vol.2
, pp. 49-72
-
-
Bruzik, K.S.1
Tsai, M.D.2
-
20
-
-
0033605365
-
Resolution of a signal transfer region from a general binding domain in gβ for stimulation of phospholipase C-β2
-
Buck E, Li J, Chen Y, Weng G, Scarlata S, and Iyengar R (1999) Resolution of a signal transfer region from a general binding domain in gβ for stimulation of phospholipase C-β2. Science 283:1332-1335.
-
(1999)
Science
, vol.283
, pp. 1332-1335
-
-
Buck, E.1
Li, J.2
Chen, Y.3
Weng, G.4
Scarlata, S.5
Iyengar, R.6
-
22
-
-
20544462579
-
G-protein-activated phospholipase C-β, new partners for cell polarity proteins Par3 and Par6
-
DOI 10.1038/sj.onc.1208593
-
Cai Y, Stafford LJ, Bryan BA, Mitchell D, and Liu M (2005) G-protein-activated phospholipase C-β, new partners for cell polarity proteins Par3 and Par6. Oncogene 24:4293-4300. (Pubitemid 40961782)
-
(2005)
Oncogene
, vol.24
, Issue.26
, pp. 4293-4300
-
-
Cai, Y.1
Stafford, L.J.2
Bryan, B.A.3
Mitchell, D.4
Liu, M.5
-
23
-
-
0026676806
-
Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits
-
DOI 10.1038/360684a0
-
Camps M, Carozzi A, Schnabel P, Scheer A, Parker PJ, and Gierschik P (1992) Isozyme-selective stimulation of phospholipase C-β 2 by G protein β γ-subunits. Nature 360:684-686. (Pubitemid 23007685)
-
(1992)
Nature
, vol.360
, Issue.6405
, pp. 684-686
-
-
Camps, M.1
Carozzi, A.2
Schnabel, P.3
Scheer, A.4
Parker, P.J.5
Gierschik, P.6
-
24
-
-
0025103818
-
Guanosine 5'[γ-thio]triphosphate-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate in HL-60 granulocytes. Evidence that the guanine nucleotide acts by relieving phospholipase C from an inhibitory constraint
-
Camps M, Hou CF, Jakobs KH, and Gierschik P (1990) Guanosine 5′-[gamma-thio]triphosphate-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate in HL-60 granulocytes. Evidence that the guanine nucleotide acts by relieving phospholipase C from an inhibitory constraint. Biochem J 271:743-748. (Pubitemid 20384610)
-
(1990)
Biochemical Journal
, vol.271
, Issue.3
, pp. 743-748
-
-
Camps, M.1
Hou, C.2
Jakobs, K.H.3
Gierschik, P.4
-
26
-
-
25844459461
-
RACK1 binds to a signal transfer region of Gβγ and inhibits phospholipase C β2 activation
-
DOI 10.1074/jbc.M505422200
-
Chen S, Lin F, and Hamm HE (2005) RACK1 binds to a signal transfer region of G βγ and inhibits phospholipase C β2 activation. J Biol Chem 280:33445-33452. (Pubitemid 41397143)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.39
, pp. 33445-33452
-
-
Chen, S.1
Lin, F.2
Hamm, H.E.3
-
27
-
-
0033538337
-
Phospholipase C-β1 directly accelerates GTP hydrolysis by Gαq and acceleration is inhibited by Gβ γ subunits
-
Chidiac P and Ross EM (1999) Phospholipase C-β1 directly accelerates GTP hydrolysis by Gαq and acceleration is inhibited by Gβ γ subunits. J Biol Chem 274:19639-19643.
-
(1999)
J Biol Chem
, vol.274
, pp. 19639-19643
-
-
Chidiac, P.1
Ross, E.M.2
-
28
-
-
0027310309
-
1. Catalytic and membrane binding properties
-
Cifuentes ME, Honkanen L, and Rebecchi MJ (1993) Proteolytic fragments of phosphoinositide-specific phospholipase C-δ 1. Catalytic and membrane binding properties. J Biol Chem 268:11586-11593. (Pubitemid 23168104)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.16
, pp. 11586-11593
-
-
Cifuentes, M.E.1
Honkanen, L.2
Rebecchi, M.J.3
-
29
-
-
0033780894
-
Phospholipase C and termination of G-protein-mediated signalling in vivo
-
Cook B, Bar-Yaacov M, Cohen Ben-Ami H, Goldstein RE, Paroush Z, Selinger Z, and Minke B (2000) Phospholipase C and termination of G-protein-mediated signalling in vivo. Nat Cell Biol 2:296-301.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 296-301
-
-
Cook, B.1
Bar-Yaacov, M.2
Cohen Ben-Ami, H.3
Goldstein, R.E.4
Paroush, Z.5
Selinger, Z.6
Minke, B.7
-
31
-
-
0029908035
-
Isoprenylation of the G protein γ subunit is both necessary and sufficient for βγ dimer-mediated stimulation of phospholipase C
-
DOI 10.1021/bi960305j
-
Dietrich A, Brazil D, Jensen ON, Meister M, Schrader M, Moomaw JF, Mann M, Illenberger D, and Gierschik P (1996) Isoprenylation of the G protein γ subunit is both necessary and sufficient for β γ dimer-mediated stimulation of phospholipase C. Biochemistry 35:15174-15182. (Pubitemid 26408848)
-
(1996)
Biochemistry
, vol.35
, Issue.48
, pp. 15174-15182
-
-
Dietrich, A.1
Brazil, D.2
Jensen, O.N.3
Meister, M.4
Schrader, M.5
Moomaw, J.F.6
Mann, M.7
Illenberger, D.8
Gierschik, P.9
-
32
-
-
0028179876
-
Stimulation of phospholipase C-β 2 by recombinant guanine-nucleotide-binding protein β γ dimers produced in a baculovirus/insect cell expression system. Requirement of γ-subunit isoprenylation for stimulation of phospholipase C
-
Dietrich A, Meister M, Brazil D, Camps M, and Gierschik P (1994) Stimulation of phospholipase C-β 2 by recombinant guanine-nucleotide- binding protein β γ dimers produced in a baculovirus/insect cell expression system. Requirement of γ-subunit isoprenylation for stimulation of phospholipase C. Eur J Biochem 219:171-178.
-
(1994)
Eur J Biochem
, vol.219
, pp. 171-178
-
-
Dietrich, A.1
Meister, M.2
Brazil, D.3
Camps, M.4
Gierschik, P.5
-
33
-
-
33646489007
-
The pleckstrin homology domain of phospholipase Cβ transmits enzymatic activation through modulation of the membrane-domain orientation
-
Drin G, Douguet D, and Scarlata S (2006) The pleckstrin homology domain of phospholipase Cβ transmits enzymatic activation through modulation of the membrane-domain orientation. Biochemistry 45:5712-5724.
-
(2006)
Biochemistry
, vol.45
, pp. 5712-5724
-
-
Drin, G.1
Douguet, D.2
Scarlata, S.3
-
34
-
-
0027461517
-
1 for enzyme activity
-
Ellis MV, Carne A, and Katan M (1993) Structural requirements of phosphatidylinositol-specific phospholipase C δ 1 for enzyme activity. Eur J Biochem 213:339-347. (Pubitemid 23106063)
-
(1993)
European Journal of Biochemistry
, vol.213
, Issue.1
, pp. 339-347
-
-
Ellis, M.V.1
Carne, A.2
Katan, M.3
-
35
-
-
0032496273
-
Catalytic domain of phosphoinositide-specific phospholipase C (PLC): Mutational analysis of residues within the active site and hydrophobic ridge of PLCδ1
-
DOI 10.1074/jbc.273.19.11650
-
Ellis MV, James SR, Perisic O, Downes CP, Williams RL, and Katan M (1998) Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcδ1. J Biol Chem 273:11650-11659. (Pubitemid 28272066)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.19
, pp. 11650-11659
-
-
Ellis, M.V.1
James, S.R.2
Perisic, O.3
Downes, C.P.4
Williams, R.L.5
Katan, M.6
-
36
-
-
0029924329
-
Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ
-
DOI 10.1038/380595a0
-
Essen LO, Perisic O, Cheung R, Katan M, and Williams RL (1996) Crystal structure of a mammalian phosphoinositide-specific phospholipase C δ. Nature 380:595-602. (Pubitemid 26119011)
-
(1996)
Nature
, vol.380
, Issue.6575
, pp. 595-602
-
-
Essen, L.-O.1
Perisic, O.2
Cheung, R.3
Katan, M.4
Williams, R.L.5
-
37
-
-
0031016185
-
Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C
-
DOI 10.1021/bi962512p
-
Essen LO, Perisic O, Katan M, Wu Y, Roberts MF, and Williams RL (1997) Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C. Biochemistry 36:1704-1718. (Pubitemid 27086266)
-
(1997)
Biochemistry
, vol.36
, Issue.7
, pp. 1704-1718
-
-
Essen, L.-O.1
Perisic, O.2
Katan, M.3
Yiqin, W.4
Roberts, M.F.5
Williams, R.L.6
-
38
-
-
0034730764
-
A role for nuclear phospholipase Cβ 1 in cell cycle control
-
Faenza I, Matteucci A, Manzoli L, Billi AM, Aluigi M, Peruzzi D, Vitale M, Castorina S, Suh PG, and Cocco L (2000) A role for nuclear phospholipase Cβ 1 in cell cycle control. J Biol Chem 275:30520-30524.
-
(2000)
J Biol Chem
, vol.275
, pp. 30520-30524
-
-
Faenza, I.1
Matteucci, A.2
Manzoli, L.3
Billi, A.M.4
Aluigi, M.5
Peruzzi, D.6
Vitale, M.7
Castorina, S.8
Suh, P.G.9
Cocco, L.10
-
39
-
-
14044267590
-
2 activity that are enhanced by Gβγ subunits
-
DOI 10.1021/bi0482607
-
Feng J, Roberts MF, Drin G, and Scarlata S (2005) Dissection of the steps of phospholipase C β 2 activity that are enhanced by G β γ subunits. Biochemistry 44:2577-2584. (Pubitemid 40279561)
-
(2005)
Biochemistry
, vol.44
, Issue.7
, pp. 2577-2584
-
-
Feng, J.1
Roberts, M.F.2
Drin, G.3
Scarlata, S.4
-
40
-
-
0029617615
-
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain
-
DOI 10.1016/0092-8674(95)90219-8
-
Ferguson KM, Lemmon MA, Schlessinger J, and Sigler PB (1995) Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell 83:1037-1046. (Pubitemid 26006545)
-
(1995)
Cell
, vol.83
, Issue.6
, pp. 1037-1046
-
-
Ferguson, K.M.1
Lemmon, M.A.2
Schlessinger, J.3
Sigler, P.B.4
-
41
-
-
70349675048
-
Gq-initiated cardiomyocyte hypertrophy is mediated by phospholipase Cβ1b
-
Filtz TM, Grubb DR, McLeod-Dryden TJ, Luo J, and Woodcock EA (2009) Gq-initiated cardiomyocyte hypertrophy is mediated by phospholipase Cβ1b. FASEB J 23:3564-3570.
-
(2009)
FASEB J
, vol.23
, pp. 3564-3570
-
-
Filtz, T.M.1
Grubb, D.R.2
McLeod-Dryden, T.J.3
Luo, J.4
Woodcock, E.A.5
-
42
-
-
84873115306
-
Nuclear phosphoinositides: Location, regulation and function
-
Fiume R, Keune WJ, Faenza I, Bultsma Y, Ramazzotti G, Jones DR, Martelli AM, Somner L, Follo MY, and Divecha N et al. (2012) Nuclear phosphoinositides: location, regulation and function. Subcell Biochem 59:335-361.
-
(2012)
Subcell Biochem
, vol.59
, pp. 335-361
-
-
Fiume, R.1
Keune, W.J.2
Faenza, I.3
Bultsma, Y.4
Ramazzotti, G.5
Jones, D.R.6
Martelli, A.M.7
Somner, L.8
Follo, M.Y.9
Divecha, N.10
-
43
-
-
0035834674
-
Role of the γ subunit prenyl moiety in G protein β γ complex interaction with phospholipase Cbeta
-
Fogg VC, Azpiazu I, Linder ME, Smrcka A, Scarlata S, and Gautam N (2001) Role of the γ subunit prenyl moiety in G protein β γ complex interaction with phospholipase Cbeta. J Biol Chem 276:41797-41802.
-
(2001)
J Biol Chem
, vol.276
, pp. 41797-41802
-
-
Fogg, V.C.1
Azpiazu, I.2
Linder, M.E.3
Smrcka, A.4
Scarlata, S.5
Gautam, N.6
-
44
-
-
0032557490
-
Molecular basis for interactions of G protein βγ subunits with effectors
-
DOI 10.1126/science.280.5367.1271
-
Ford CE, Skiba NP, Bae H, Daaka Y, Reuveny E, Shekter LR, Rosal R, Weng G, Yang CS, and Iyengar R et al. (1998) Molecular basis for interactions of G protein βγ subunits with effectors. Science 280:1271-1274. (Pubitemid 28269623)
-
(1998)
Science
, vol.280
, Issue.5367
, pp. 1271-1274
-
-
Ford, C.E.1
Skiba, N.P.2
Bae, H.3
Daaka, Y.4
Reuveny, E.5
Shekter, L.R.6
Rosal, R.7
Weng, G.8
Yang, C.-S.9
Iyengar, R.10
Miller, R.J.11
Jan, L.Y.12
Lefkowitz, R.J.13
Hamm, H.E.14
-
45
-
-
69749120682
-
Prediction of protein-protein interfaces on G-protein β subunits reveals a novel phospholipase C β2 binding domain
-
Friedman EJ, Temple BR, Hicks SN, Sondek J, Jones CD, and Jones AM (2009) Prediction of protein-protein interfaces on G-protein β subunits reveals a novel phospholipase C β2 binding domain. J Mol Biol 392:1044-1054.
-
(2009)
J Mol Biol
, vol.392
, pp. 1044-1054
-
-
Friedman, E.J.1
Temple, B.R.2
Hicks, S.N.3
Sondek, J.4
Jones, C.D.5
Jones, A.M.6
-
46
-
-
0028787055
-
The pleckstrin homology domain of phospholipase C-β 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes
-
Garcia P, Gupta R, Shah S, Morris AJ, Rudge SA, Scarlata S, Petrova V, McLaughlin S, and Rebecchi MJ (1995) The pleckstrin homology domain of phospholipase C-β 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes. Biochemistry 34:16228-16234.
-
(1995)
Biochemistry
, vol.34
, pp. 16228-16234
-
-
Garcia, P.1
Gupta, R.2
Shah, S.3
Morris, A.J.4
Rudge, S.A.5
Scarlata, S.6
Petrova, V.7
McLaughlin, S.8
Rebecchi, M.J.9
-
47
-
-
84930210536
-
The phospholipase C isozymes and their regulation
-
Gresset A, Sondek J, and Harden TK (2012) The phospholipase C isozymes and their regulation. Subcell Biochem 58:61-94.
-
(2012)
Subcell Biochem
, vol.58
, pp. 61-94
-
-
Gresset, A.1
Sondek, J.2
Harden, T.K.3
-
48
-
-
79954580597
-
Phospholipase Cβ1b associates with a Shank3 complex at the cardiac sarcolemma
-
Grubb DR, Iliades P, Cooley N, Yu YL, Luo J, Filtz TM, and Woodcock EA (2011) Phospholipase Cβ1b associates with a Shank3 complex at the cardiac sarcolemma. FASEB J 25:1040-1047.
-
(2011)
FASEB J
, vol.25
, pp. 1040-1047
-
-
Grubb, D.R.1
Iliades, P.2
Cooley, N.3
Yu, Y.L.4
Luo, J.5
Filtz, T.M.6
Woodcock, E.A.7
-
49
-
-
84856541265
-
Scaffolding protein Homer 1c mediates hypertrophic responses downstream of Gq in cardiomyocytes
-
Grubb DR, Luo J, Yu YL, and Woodcock EA (2012) Scaffolding protein Homer 1c mediates hypertrophic responses downstream of Gq in cardiomyocytes. FASEB J 26:596-603.
-
(2012)
FASEB J
, vol.26
, pp. 596-603
-
-
Grubb, D.R.1
Luo, J.2
Yu, Y.L.3
Woodcock, E.A.4
-
50
-
-
48749131440
-
The extreme C-terminal region of phospholipase Cβ1 determines subcellular localization and function; the "b" splice variant mediates α1-adrenergic receptor responses in cardiomyocytes
-
Grubb DR, Vasilevski O, Huynh H, and Woodcock EA (2008) The extreme C-terminal region of phospholipase Cβ1 determines subcellular localization and function; the "b" splice variant mediates α1-adrenergic receptor responses in cardiomyocytes. FASEB J 22:2768-2774.
-
(2008)
FASEB J
, vol.22
, pp. 2768-2774
-
-
Grubb, D.R.1
Vasilevski, O.2
Huynh, H.3
Woodcock, E.A.4
-
51
-
-
0042030806
-
The pleckstrin homology domains of phospholipases C-β and -δ confer activation through a common site
-
DOI 10.1074/jbc.M301438200
-
Guo Y, Philip F, and Scarlata S (2003) The Pleckstrin homology domains of phospholipases C-β and -δ confer activation through a common site. J Biol Chem 278:29995-30004. (Pubitemid 36962389)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.32
, pp. 29995-30004
-
-
Guo, Y.1
Philip, F.2
Scarlata, S.3
-
52
-
-
77950473766
-
Differential regulation of phospholipase C-β2 activity and membrane interaction by Galphaq, Gβ1γ2, and Rac2
-
Gutman O, Walliser C, Piechulek T, Gierschik P, and Henis YI (2010) Differential regulation of phospholipase C-β2 activity and membrane interaction by Galphaq, Gβ1γ2, and Rac2. J Biol Chem 285:3905-3915.
-
(2010)
J Biol Chem
, vol.285
, pp. 3905-3915
-
-
Gutman, O.1
Walliser, C.2
Piechulek, T.3
Gierschik, P.4
Henis, Y.I.5
-
53
-
-
80052010597
-
A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits
-
Han DS, Golebiewska U, Stolzenberg S, Scarlata SF, and Weinstein H (2011) A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits. Mol Pharmacol 80:434-445.
-
(2011)
Mol Pharmacol
, vol.80
, pp. 434-445
-
-
Han, D.S.1
Golebiewska, U.2
Stolzenberg, S.3
Scarlata, S.F.4
Weinstein, H.5
-
54
-
-
33751229313
-
Phospholipase Cβ 3 Mediates the Scratching Response Activated by the Histamine H1 Receptor on C-Fiber Nociceptive Neurons
-
DOI 10.1016/j.neuron.2006.09.036, PII S0896627306007744
-
Han SK, Mancino V, and Simon MI (2006) Phospholipase Cβ 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons. Neuron 52:691-703. (Pubitemid 44781169)
-
(2006)
Neuron
, vol.52
, Issue.4
, pp. 691-703
-
-
Han, S.-K.1
Mancino, V.2
Simon, M.I.3
-
56
-
-
48349120928
-
General and versatile autoinhibition of PLC isozymes
-
Hicks SN, Jezyk MR, Gershburg S, Seifert JP, Harden TK, and Sondek J (2008) General and versatile autoinhibition of PLC isozymes. Mol Cell 31:383-394.
-
(2008)
Mol Cell
, vol.31
, pp. 383-394
-
-
Hicks, S.N.1
Jezyk, M.R.2
Gershburg, S.3
Seifert, J.P.4
Harden, T.K.5
Sondek, J.6
-
57
-
-
24344475560
-
2+ requirement, and regulation of M current
-
2+ requirement, and regulation of M current. J Gen Physiol 126:243-262.
-
(2005)
J Gen Physiol
, vol.126
, pp. 243-262
-
-
Horowitz, L.F.1
Hirdes, W.2
Suh, B.C.3
Hilgemann, D.W.4
Mackie, K.5
Hille, B.6
-
58
-
-
2142717337
-
In Vivo Activity of a Phospholipase C Inhibitor, 1-(6-((17β -3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in Acute and Chronic Inflammatory Reactions
-
DOI 10.1124/jpet.103.060574
-
Hou C, Kirchner T, Singer M, Matheis M, Argentieri D, and Cavender D (2004) In vivo activity of a phospholipase C inhibitor, 1-(6-((17β-3- methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions. J Pharmacol Exp Ther 309:697-704. (Pubitemid 38542625)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.309
, Issue.2
, pp. 697-704
-
-
Hou, C.1
Kirchner, T.2
Singer, M.3
Matheis, M.4
Argentieri, D.5
Cavender, D.6
-
59
-
-
84874336095
-
Small molecule inhibitors of phospholipase C from a novel high-throughput screen
-
Huang W, Barrett M, Hajicek N, Hicks S, Harden TK, Sondek J, and Zhang Q (2013) Small molecule inhibitors of phospholipase C from a novel high-throughput screen. J Biol Chem 288:5840-5848.
-
(2013)
J Biol Chem
, vol.288
, pp. 5840-5848
-
-
Huang, W.1
Barrett, M.2
Hajicek, N.3
Hicks, S.4
Harden, T.K.5
Sondek, J.6
Zhang, Q.7
-
60
-
-
79955578040
-
A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes
-
Huang W, Hicks SN, Sondek J, and Zhang Q (2011) A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes. ACS Chem Biol 6:223-228.
-
(2011)
ACS Chem Biol
, vol.6
, pp. 223-228
-
-
Huang, W.1
Hicks, S.N.2
Sondek, J.3
Zhang, Q.4
-
62
-
-
0037040173
-
q interaction site
-
DOI 10.1074/jbc.M109612200
-
Ilkaeva O, Kinch LN, Paulssen RH, and Ross EM (2002) Mutations in the carboxylterminal domain of phospholipase C-β 1 delineate the dimer interface and a potential Gαq interaction site. J Biol Chem 277:4294-4300. (Pubitemid 34968694)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.6
, pp. 4294-4300
-
-
Ilkaeva, O.1
Kinch, L.N.2
Paulssen, R.H.3
Ross, E.M.4
-
63
-
-
0030917334
-
2
-
Illenberger D, Schwald F, and Gierschik P (1997) Characterization and purification from bovine neutrophils of a soluble guanine-nucleotide-binding protein that mediates isozyme-specific stimulation of phospholipase C β2. Eur J Biochem 246:71-77. (Pubitemid 27229671)
-
(1997)
European Journal of Biochemistry
, vol.246
, Issue.1
, pp. 71-77
-
-
Illenberger, D.1
Schwald, F.2
Gierschik, P.3
-
64
-
-
0032476733
-
2 by the Rho GTPases Cdc42Hs and Rac1
-
DOI 10.1093/emboj/17.21.6241
-
Illenberger D, Schwald F, Pimmer D, Binder W, Maier G, Dietrich A, and Gierschik P (1998) Stimulation of phospholipase C-β2 by the Rho GTPases Cdc42Hs and Rac1. EMBO J 17:6241-6249. (Pubitemid 28497797)
-
(1998)
EMBO Journal
, vol.17
, Issue.21
, pp. 6241-6249
-
-
Illenberger, D.1
Schwald, F.2
Pimmer, D.3
Binder, W.4
Maier, G.5
Dietrich, A.6
Gierschik, P.7
-
65
-
-
0037474209
-
Specificity and structural requirements of phospholipase C-β stimulation by Rho GTPases versus G protein βγ dimers
-
DOI 10.1074/jbc.M208282200
-
Illenberger D, Walliser C, Nurnberg B, Diaz Lorente M, and Gierschik P (2003a) Specificity and structural requirements of phospholipase C-β stimulation by Rho GTPases versus G protein β γ dimers. J Biol Chem 278:3006-3014. (Pubitemid 36801208)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.5
, pp. 3006-3014
-
-
Illenberger, D.1
Walliser, C.2
Nurnberg, B.3
Lorente, M.D.4
Gierschik, P.5
-
66
-
-
0037424517
-
2 activity and mode of membrane interactions in intact cells
-
DOI 10.1074/jbc.M211971200
-
Illenberger D, Walliser C, Strobel J, Gutman O, Niv H, Gaidzik V, Kloog Y, Gierschik P, and Henis YI (2003b) Rac2 regulation of phospholipase C-β 2 activity and mode of membrane interactions in intact cells. J Biol Chem 278:8645-8652. (Pubitemid 36800620)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.10
, pp. 8645-8652
-
-
Illenberger, D.1
Walliser, C.2
Strobel, J.3
Gutman, O.4
Niv, H.5
Gaidzik, V.6
Kloog, Y.7
Gierschik, P.8
Henis, Y.I.9
-
67
-
-
0031050619
-
Dependence of the activity of phospholipase Cβ on surface pressure and surface composition in phospholipid monolayers and its implications for their regulation
-
DOI 10.1021/bi962108q
-
James SR, Paterson A, Harden TK, Demel RA, and Downes CP (1997) Dependence of the activity of phospholipase C β on surface pressure and surface composition in phospholipid monolayers and its implications for their regulation. Biochemistry 36:848-855. (Pubitemid 27110965)
-
(1997)
Biochemistry
, vol.36
, Issue.4
, pp. 848-855
-
-
James, S.R.1
Paterson, A.2
Harden, T.K.3
Demel, R.A.4
Downes, C.P.5
-
69
-
-
33845367647
-
Crystal structure of Rac1 bound to its effector phospholipase C-β2
-
DOI 10.1038/nsmb1175, PII NSMB1175
-
Jezyk MR, Snyder JT, Gershberg S, Worthylake DK, Harden TK, and Sondek J (2006) Crystal structure of Rac1 bound to its effector phospholipase C-β2. Nat Struct Mol Biol 13:1135-1140. (Pubitemid 44885926)
-
(2006)
Nature Structural and Molecular Biology
, vol.13
, Issue.12
, pp. 1135-1140
-
-
Jezyk, M.R.1
Snyder, J.T.2
Gershberg, S.3
Worthylake, D.K.4
Harden, T.K.5
Sondek, J.6
-
71
-
-
0030878881
-
Roles of phospholipase C β2 in chemoattractant-elicited responses
-
Jiang H, Kuang Y, Wu Y, Xie W, Simon MI, and Wu D (1997) Roles of phospholipase C β2 in chemoattractant-elicited responses. Proc Natl Acad Sci USA 94:7971-7975.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 7971-7975
-
-
Jiang, H.1
Kuang, Y.2
Wu, Y.3
Xie, W.4
Simon, M.I.5
Wu, D.6
-
72
-
-
0029962462
-
Phospholipase C β4 is involved in modulating the visual response in mice
-
DOI 10.1073/pnas.93.25.14598
-
Jiang H, Lyubarsky A, Dodd R, Vardi N, Pugh E, Baylor D, Simon MI, and Wu D (1996) Phospholipase C β 4 is involved in modulating the visual response in mice. Proc Natl Acad Sci USA 93:14598-14601. (Pubitemid 26419013)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.25
, pp. 14598-14601
-
-
Jiang, H.1
Lyubarsky, A.2
Dodd, R.3
Vardi, N.4
Pugh, E.5
Baylor, D.6
Simon, M.I.7
Wu, D.8
-
73
-
-
0028283331
-
Activation of phospholipase C β4 by heterotrimeric GTP-binding proteins
-
Jiang H, Wu D, and Simon MI (1994) Activation of phospholipase C β 4 by heterotrimeric GTP-binding proteins. J Biol Chem 269:7593-7596. (Pubitemid 24217968)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.10
, pp. 7593-7596
-
-
Jiang, H.1
Wu, D.2
Simon, M.I.3
-
75
-
-
0026676807
-
Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C
-
DOI 10.1038/360686a0
-
Katz A, Wu D, and Simon MI (1992) Subunits β γ of heterotrimeric G protein activate β 2 isoform of phospholipase C. Nature 360:686-689. (Pubitemid 23007686)
-
(1992)
Nature
, vol.360
, Issue.6405
, pp. 686-689
-
-
Katz, A.1
Wu, D.2
Simon, M.I.3
-
76
-
-
0029841118
-
The role of carboxyl-terminal basic amino acids in G(q)α-dependent activation, particulate association, and nuclear localization of phospholipase C-β1
-
DOI 10.1074/jbc.271.35.21187
-
Kim CG, Park D, and Rhee SG (1996) The role of carboxyl-terminal basic amino acids in Gqα-dependent activation, particulate association, and nuclear localization of phospholipase C-β1. J Biol Chem 271:21187-21192. (Pubitemid 26292971)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.35
, pp. 21187-21192
-
-
Kim, C.G.1
Park, D.2
Rhee, S.G.3
-
77
-
-
1842373861
-
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
-
DOI 10.1038/38508
-
Kim D, Jun KS, Lee SB, Kang NG, Min DS, Kim YH, Ryu SH, Suh PG, and Shin HS (1997) Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature 389:290-293. (Pubitemid 27406643)
-
(1997)
Nature
, vol.389
, Issue.6648
, pp. 290-293
-
-
Kim, D.1
Jun, K.S.2
Lee, S.B.3
Kang, N.-G.4
Min, D.S.5
Kim, Y.-H.6
Ryu, S.H.7
Suh, P.-G.8
Shin, H.-S.9
-
78
-
-
0032488679
-
A cytosolic, Gα(q)- and βγ-insensitive splice variant of phospholipase C-β4
-
DOI 10.1074/jbc.273.6.3618
-
Kim MJ, Min DS, Ryu SH, and Suh PG (1998) A cytosolic, gαq- and βγ-insensitive splice variant of phospholipase C-β4. J Biol Chem 273:3618-3624. (Pubitemid 28109787)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.6
, pp. 3618-3624
-
-
Kim, M.J.1
Min, D.S.2
Ryu, S.H.3
Suh, P.-G.4
-
79
-
-
79953297067
-
Direct activation of human phospholipase C by its well known inhibitor u73122
-
Klein RR, Bourdon DM, Costales CL, Wagner CD, White WL, Williams JD, Hicks SN, Sondek J, and Thakker DR (2011) Direct activation of human phospholipase C by its well known inhibitor u73122. J Biol Chem 286:12407-12416.
-
(2011)
J Biol Chem
, vol.286
, pp. 12407-12416
-
-
Klein, R.R.1
Bourdon, D.M.2
Costales, C.L.3
Wagner, C.D.4
White, W.L.5
Williams, J.D.6
Hicks, S.N.7
Sondek, J.8
Thakker, D.R.9
-
80
-
-
54349085840
-
1-[6-[[(17β)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl] -1H-pyrrole-2,5-dione (U73122) selectively inhibits Kir3 and BK channels in a phospholipase C-independent fashion
-
Klose A, Huth T, and Alzheimer C (2008) 1-[6-[[(17β)-3-methoxyestra- 1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122) selectively inhibits Kir3 and BK channels in a phospholipase C-independent fashion. Mol Pharmacol 74:1203-1214.
-
(2008)
Mol Pharmacol
, vol.74
, pp. 1203-1214
-
-
Klose, A.1
Huth, T.2
Alzheimer, C.3
-
82
-
-
0032515189
-
Phospholipase C cDNAs from sponge and hydra: Antiquity of genes involved in the inositol phospholipid signaling pathway
-
DOI 10.1016/S0014-5793(98)01339-8, PII S0014579398013398
-
Koyanagi M, Ono K, Suga H, Iwabe N, and Miyata T (1998) Phospholipase C cDNAs from sponge and hydra: antiquity of genes involved in the inositol phospholipid signaling pathway. FEBS Lett 439:66-70. (Pubitemid 28537865)
-
(1998)
FEBS Letters
, vol.439
, Issue.1-2
, pp. 66-70
-
-
Koyanagi, M.1
Ono, K.2
Suga, H.3
Iwabe, N.4
Miyata, T.5
-
83
-
-
0029991036
-
2 region that interacts with Gβγ
-
DOI 10.1073/pnas.93.7.2964
-
Kuang Y, Wu Y, Smrcka A, Jiang H, and Wu D (1996) Identification of a phospholipase C β2 region that interacts with Gβ-γ. Proc Natl Acad Sci USA 93:2964-2968. (Pubitemid 26114346)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.7
, pp. 2964-2968
-
-
Kuang, Y.1
Wu, Y.2
Smrcka, A.3
Jiang, H.4
Wu, D.5
-
85
-
-
0027508316
-
Purification, molecular cloning, and sequencing of phospholipase C-β4
-
Lee CW, Park DJ, Lee KH, Kim CG, and Rhee SG (1993a) Purification, molecular cloning, and sequencing of phospholipase C-β 4. J Biol Chem 268:21318-21327. (Pubitemid 23292323)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.28
, pp. 21318-21327
-
-
Lee, C.-W.1
Park, D.J.2
Lee, K.-H.3
Chan, G.K.4
Sue, G.R.5
-
87
-
-
8744219635
-
Pleckstrin homology domains: Not just for phosphoinositides
-
DOI 10.1042/BST0320707
-
Lemmon MA (2004) Pleckstrin homology domains: not just for phosphoinositides. Biochem Soc Trans 32:707-711. (Pubitemid 39524359)
-
(2004)
Biochemical Society Transactions
, vol.32
, Issue.5
, pp. 707-711
-
-
Lemmon, M.A.1
-
88
-
-
0032568664
-
Sites for Gα binding on the G protein β subunit overlap with sites for regulation of phospholipase Cβ and adenyly cyclase
-
DOI 10.1074/jbc.273.26.16265
-
Li Y, Sternweis PM, Charnecki S, Smith TF, Gilman AG, Neer EJ, and Kozasa T (1998) Sites for Galpha binding on the G protein β subunit overlap with sites for regulation of phospholipase Cβ and adenylyl cyclase. J Biol Chem 273:16265-16272. (Pubitemid 28311403)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.26
, pp. 16265-16272
-
-
Li, Y.1
Sternweis, P.M.2
Charneckit, S.3
Smith, T.F.4
Gilman, A.G.5
Neer, E.J.6
Kozasa, T.7
-
89
-
-
0034635221
-
Roles of PLC-β2 and -β3 and PI3kγ in chemoattractant- mediated signal transduction
-
DOI 10.1126/science.287.5455.1046
-
Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, and Wu D (2000) Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science 287:1046-1049. (Pubitemid 30094361)
-
(2000)
Science
, vol.287
, Issue.5455
, pp. 1046-1049
-
-
Li, Z.1
Jiang, H.2
Xie, W.3
Zhang, Z.4
Smrcka, A.V.5
Wu, D.6
-
90
-
-
0037799206
-
Keeping G proteins at bay: A complex between G protein-coupled receptor kinase 2 and Gβγ
-
DOI 10.1126/science.1082348
-
Lodowski DT, Pitcher JA, Capel WD, Lefkowitz RJ, and Tesmer JJ (2003) Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gβγ. Science 300:1256-1262. (Pubitemid 36618232)
-
(2003)
Science
, vol.300
, Issue.5623
, pp. 1256-1262
-
-
Lodowski, D.T.1
Pitcher, J.A.2
Capel, W.D.3
Lefkowitz, R.J.4
Tesmer, J.J.G.5
-
91
-
-
35948968634
-
Structure of Gαq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs
-
Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, and Wieland T et al. (2007) Structure of Gαq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science 318:1923-1927.
-
(2007)
Science
, vol.318
, pp. 1923-1927
-
-
Lutz, S.1
Shankaranarayanan, A.2
Coco, C.3
Ridilla, M.4
Nance, M.R.5
Vettel, C.6
Baltus, D.7
Evelyn, C.R.8
Neubig, R.R.9
Wieland, T.10
-
93
-
-
80052463082
-
q activation
-
q activation. Nat Struct Mol Biol 18:999-1005.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 999-1005
-
-
Lyon, A.M.1
Tesmer, V.M.2
Dhamsania, V.D.3
Thal, D.M.4
Gutierrez, J.5
Chowdhury, S.6
Suddala, K.C.7
Northup, J.K.8
Tesmer, J.J.9
-
95
-
-
0033836429
-
Evidence for two alternatively spliced forms of phospholipase C-β2 in haematopoietic cells
-
DOI 10.1046/j.1365-2141.2000.02201.x
-
Mao GF, Kunapuli SP, and Koneti Rao A (2000) Evidence for two alternatively spliced forms of phospholipase C-β2 in haematopoietic cells. Br J Haematol 110:402-408. (Pubitemid 30646867)
-
(2000)
British Journal of Haematology
, vol.110
, Issue.2
, pp. 402-408
-
-
Guang, F.M.1
Kunapuli, S.P.2
Rao, A.K.3
-
96
-
-
58149400019
-
A novel Gbetagamma-subunit inhibitor selectively modulates μ-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence
-
Mathews JL, Smrcka AV, and Bidlack JM (2008) A novel Gbetagamma-subunit inhibitor selectively modulates μ-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence. J Neurosci 28:12183-12189.
-
(2008)
J Neurosci
, vol.28
, pp. 12183-12189
-
-
Mathews, J.L.1
Smrcka, A.V.2
Bidlack, J.M.3
-
97
-
-
0032506233
-
Transient cardiac expression of constitutively active Gαq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways
-
Mende U, Kagen A, Cohen A, Aramburu J, Schoen FJ, and Neer EJ (1998) Transient cardiac expression of constitutively active Gαq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sci USA 95:13893-13898.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13893-13898
-
-
Mende, U.1
Kagen, A.2
Cohen, A.3
Aramburu, J.4
Schoen, F.J.5
Neer, E.J.6
-
99
-
-
0029860103
-
Opioid μ, δ, and κ receptor-induced activation of phospholipase C- β3 and inhibition of adenylyl cyclase is mediated by G(i2) and G(o) in smooth muscle
-
Murthy KS and Makhlouf GM (1996) Opioid μ, δ, and κ receptor-induced activation of phospholipase C-β 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle. Mol Pharmacol 50:870-877. (Pubitemid 26347707)
-
(1996)
Molecular Pharmacology
, vol.50
, Issue.4
, pp. 870-877
-
-
Murthy, K.S.1
Makhlouf, G.M.2
-
100
-
-
84874888362
-
Structural and functional analysis of the regulator of γ protein signaling 2-gαq complex
-
Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, and Tesmer JJ (2013) Structural and functional analysis of the regulator of γ protein signaling 2-gαq complex. Structure 21:438-448.
-
(2013)
Structure
, vol.21
, pp. 438-448
-
-
Nance, M.R.1
Kreutz, B.2
Tesmer, V.M.3
Sterne-Marr, R.4
Kozasa, T.5
Tesmer, J.J.6
-
102
-
-
62749110450
-
Nuclear PLCβ1 is required for 3T3-L1 adipocyte differentiation and regulates expression of the cyclin D3-cdk4 complex
-
O'Carroll SJ, Mitchell MD, Faenza I, Cocco L, and Gilmour RS (2009) Nuclear PLCβ1 is required for 3T3-L1 adipocyte differentiation and regulates expression of the cyclin D3-cdk4 complex. Cell Signal 21:926-935.
-
(2009)
Cell Signal
, vol.21
, pp. 926-935
-
-
O'Carroll, S.J.1
Mitchell, M.D.2
Faenza, I.3
Cocco, L.4
Gilmour, R.S.5
-
103
-
-
2442676625
-
2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-β3 activation
-
DOI 10.1128/MCB.24.11.5069-5079.2004
-
Oh YS, Jo NW, Choi JW, Kim HS, Seo SW, Kang KO, Hwang JI, Heo K, Kim SH, and Kim YH et al. (2004) NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-β3 activation. Mol Cell Biol 24:5069-5079. (Pubitemid 38668068)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.11
, pp. 5069-5079
-
-
Oh, Y.-S.1
Jo, N.W.2
Choi, J.W.3
Kim, H.S.4
Seo, S.-W.5
Kang, K.-O.6
Hwang, J.-I.7
Heo, K.8
Kim, S.-H.9
Kim, Y.-H.10
Kim, I.-H.11
Kim, J.H.12
Banno, Y.13
Ryu, S.H.14
Suh, P.-G.15
-
105
-
-
0032561081
-
2 activation by the G protein βγ subunit map to the sides of the β propeller structure
-
DOI 10.1074/jbc.273.43.28298
-
Panchenko MP, Saxena K, Li Y, Charnecki S, Sternweis PM, Smith TF, Gilman AG, Kozasa T, and Neer EJ (1998) Sites important for PLCβ2 activation by the G protein βγ subunit map to the sides of the β propeller structure. J Biol Chem 273:28298-28304. (Pubitemid 28496130)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.43
, pp. 28298-28304
-
-
Panchenko, M.P.1
Saxena, K.2
Li, Y.3
Charnecki, S.4
Sternweis, P.M.5
Smith, T.F.6
Gilman, A.G.7
Kozasa, T.8
Neer, E.J.9
-
106
-
-
0027537482
-
Removal of the carboxyl-terminal region of phospholipase C-β1 by calpain abolishes activation by Gαq
-
Park D, Jhon DY, Lee CW, Ryu SH, and Rhee SG (1993) Removal of the carboxylterminal region of phospholipase C-β 1 by calpain abolishes activation by G α q. J Biol Chem 268:3710-3714. (Pubitemid 23071018)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.5
, pp. 3710-3714
-
-
Park, D.1
Jhon, D.-Y.2
Lee, C.-W.3
Sung, H.R.4
Sue, G.R.5
-
109
-
-
1442317538
-
BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure
-
DOI 10.1126/science.1092586
-
Peter BJ, Kent HM, Mills IG, Vallis Y, Butler PJ, Evans PR, and McMahon HT (2004) BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science 303:495-499. (Pubitemid 38120842)
-
(2004)
Science
, vol.303
, Issue.5657
, pp. 495-499
-
-
Peter, B.J.1
Kent, H.M.2
Mills, I.G.3
Vallis, Y.4
Butler, P.J.G.5
Evans, P.R.6
McMahon, H.T.7
-
110
-
-
0037201967
-
Multiple roles of pleckstrin homology domains in phospholipase Cβ function
-
DOI 10.1016/S0014-5793(02)03411-7, PII S0014579302034117
-
Philip F, Guo Y, and Scarlata S (2002) Multiple roles of pleckstrin homology domains in phospholipase Cbeta function. FEBS Lett 531:28-32. (Pubitemid 35232780)
-
(2002)
FEBS Letters
, vol.531
, Issue.1
, pp. 28-32
-
-
Philip, F.1
Guo, Y.2
Scarlata, S.3
-
111
-
-
77955508883
-
Synergistic activation of phospholipase C-β3 by Gα(q) and Gβγ describes a simple two-state coincidence detector
-
Philip F, Kadamur G, Silos RG, Woodson J, and Ross EM (2010) Synergistic activation of phospholipase C-β3 by Gα(q) and Gβγ describes a simple two-state coincidence detector. Curr Biol 20:1327-1335.
-
(2010)
Curr Biol
, vol.20
, pp. 1327-1335
-
-
Philip, F.1
Kadamur, G.2
Silos, R.G.3
Woodson, J.4
Ross, E.M.5
-
112
-
-
0028799753
-
Inhibitors of phospholipid intracellular signaling as antiproliferative agents
-
Powis G, Hill SR, Frew TJ, and Sherrill KW (1995) Inhibitors of phospholipid intracellular signaling as antiproliferative agents. Med Res Rev 15:121-138.
-
(1995)
Med Res Rev
, vol.15
, pp. 121-138
-
-
Powis, G.1
Hill, S.R.2
Frew, T.J.3
Sherrill, K.W.4
-
113
-
-
80052194357
-
Let's go bananas: Revisiting the endocytic BAR code
-
Qualmann B, Koch D, and Kessels MM (2011) Let's go bananas: revisiting the endocytic BAR code. EMBO J 30:3501-3515.
-
(2011)
EMBO J
, vol.30
, pp. 3501-3515
-
-
Qualmann, B.1
Koch, D.2
Kessels, M.M.3
-
114
-
-
78651392392
-
q
-
q. J Biol Chem 286:942-951.
-
(2011)
J Biol Chem
, vol.286
, pp. 942-951
-
-
Rebres, R.A.1
Roach, T.I.2
Fraser, I.D.3
Philip, F.4
Moon, C.5
Lin, K.M.6
Liu, J.7
Santat, L.8
Cheadle, L.9
Ross, E.M.10
-
115
-
-
47749085880
-
Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCβ3 to regulate intracellular free calcium
-
Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, and Seaman WE (2008) Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCβ3 to regulate intracellular free calcium. J Biol Chem 283:17351-17361.
-
(2008)
J Biol Chem
, vol.283
, pp. 17351-17361
-
-
Roach, T.I.1
Rebres, R.A.2
Fraser, I.D.3
Decamp, D.L.4
Lin, K.M.5
Sternweis, P.C.6
Simon, M.I.7
Seaman, W.E.8
-
116
-
-
0029661973
-
Phospholipase C β2 association with phospholipid interfaces assessed by fluorescence resonance energy transfer. G protein βγ subunit-mediated translocation is not required for enzyme activation
-
DOI 10.1074/jbc.271.41.25071
-
Romoser V, Ball R, and Smrcka AV (1996) Phospholipase C β2 association with phospholipid interfaces assessed by fluorescence resonance energy transfer. G protein βγ subunit-mediated translocation is not required for enzyme activation. J Biol Chem 271:25071-25078. (Pubitemid 26337864)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.41
, pp. 25071-25078
-
-
Romoser, V.1
Ball, R.2
Smrcka, A.V.3
-
117
-
-
0030478554
-
Membrane binding of phospholipases C-β 1 and C-β 2 is independent of phosphatidylinositol 4,5-bisphosphate and the α and βγ subunits of G proteins
-
Runnels LW, Jenco J, Morris A, and Scarlata S (1996) Membrane binding of phospholipases C-β 1 and C-β 2 is independent of phosphatidylinositol 4,5-bisphosphate and the α and βγ subunits of G proteins. Biochemistry 35:16824-16832.
-
(1996)
Biochemistry
, vol.35
, pp. 16824-16832
-
-
Runnels, L.W.1
Jenco, J.2
Morris, A.3
Scarlata, S.4
-
118
-
-
0033514304
-
Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-β effectors
-
Runnels LW and Scarlata SF (1999) Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-β effectors. Biochemistry 38:1488-1496.
-
(1999)
Biochemistry
, vol.38
, pp. 1488-1496
-
-
Runnels, L.W.1
Scarlata, S.F.2
-
119
-
-
0032549536
-
Identification of a structural element in Phospholipase C β2 that interacts with G protein βγ
-
DOI 10.1074/jbc.273.12.7148
-
Sankaran B, Osterhout J, Wu D, and Smrcka AV (1998) Identification of a structural element in phospholipase C β2 that interacts with G protein βγ subunits. J Biol Chem 273:7148-7154. (Pubitemid 28160388)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.12
, pp. 7148-7154
-
-
Sankaran, B.1
Osterhout, J.2
Wu, D.3
Smrcka, A.V.4
-
120
-
-
0037018925
-
Regulation of the lateral association of phospholipase Cβ2 and G protein subunits by lipid rafts
-
Scarlata S (2002) Regulation of the lateral association of phospholipase Cβ2 and G protein subunits by lipid rafts. Biochemistry 41:7092-7099.
-
(2002)
Biochemistry
, vol.41
, pp. 7092-7099
-
-
Scarlata, S.1
-
121
-
-
0032519443
-
Activation of a phospholipase Cβ2 deletion mutant by limited proteolysis
-
Schnabel P and Camps M (1998) Activation of a phospholipase Cβ2 deletion mutant by limited proteolysis. Biochem J 330:461-468. (Pubitemid 28075775)
-
(1998)
Biochemical Journal
, vol.330
, Issue.1
, pp. 461-468
-
-
Schnabel, P.1
Camps, M.2
-
122
-
-
0027504763
-
2. Identification of regions required for membrane association and stimulation by guanine-nucleotide-binding protein βγ subunits
-
DOI 10.1111/j.1432-1033.1993.tb18343.x
-
Schnabel P, Camps M, Carozzi A, Parker PJ, and Gierschik P (1993) Mutational analysis of phospholipase C-β 2. Identification of regions required for membrane association and stimulation by guanine-nucleotide-binding protein β γ subunits. Eur J Biochem 217:1109-1115. (Pubitemid 23326895)
-
(1993)
European Journal of Biochemistry
, vol.217
, Issue.3
, pp. 1109-1115
-
-
Schnabel, P.1
Camps, M.2
Carozzi, A.3
Parker, P.J.4
Gierschik, P.5
-
123
-
-
0035865394
-
Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors
-
DOI 10.1093/emboj/20.4.767
-
Scott JK, Huang SF, Gangadhar BP, Samoriski GM, Clapp P, Gross RA, Taussig R, and Smrcka AV (2001) Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors. EMBO J 20:767-776. (Pubitemid 32167641)
-
(2001)
EMBO Journal
, vol.20
, Issue.4
, pp. 767-776
-
-
Scott, J.K.1
Huang, S.-F.2
Gangadhar, B.P.3
Samoriski, G.M.4
Clapp, P.5
Gross, R.A.6
Taussig, R.7
Smrcka, A.V.8
-
125
-
-
0042672922
-
Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities
-
DOI 10.1083/jcb.200210109
-
Shin DM, Dehoff M, Luo X, Kang SH, Tu J, Nayak SK, Ross EM, Worley PF, and Muallem S (2003) Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities. J Cell Biol 162:293-303. (Pubitemid 36928842)
-
(2003)
Journal of Cell Biology
, vol.162
, Issue.2
, pp. 293-303
-
-
Shin, D.M.1
Dehoff, M.2
Luo, X.3
Kang, S.H.4
Tu, J.5
Nayak, S.K.6
Ross, E.M.7
Worley, P.E.8
Muallem, S.9
-
126
-
-
0036143898
-
A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq
-
DOI 10.1038/nsb731
-
Singer AU, Waldo GL, Harden TK, and Sondek J (2002) A unique fold of phospholipase C-β mediates dimerization and interaction with G α q. Nat Struct Biol 9:32-36. (Pubitemid 34049176)
-
(2002)
Nature Structural Biology
, vol.9
, Issue.1
, pp. 32-36
-
-
Singer, A.U.1
Waldo, G.L.2
Harden, T.K.3
Sondek, J.4
-
127
-
-
0035931919
-
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A
-
DOI 10.1038/35059138
-
Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, and Sigler PB (2001) Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature 409:1071-1077. (Pubitemid 32204063)
-
(2001)
Nature
, vol.409
, Issue.6823
, pp. 1071-1077
-
-
Slep, K.C.1
Kercher, M.A.2
He, W.3
Cowan, C.W.4
Wensel, T.G.5
Sigler, P.B.6
-
128
-
-
0025793981
-
q
-
Smrcka AV, Hepler JR, Brown KO, and Sternweis PC (1991) Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq. Science 251:804-807. (Pubitemid 21926176)
-
(1991)
Science
, vol.251
, Issue.4995
, pp. 804-807
-
-
Smrcka, A.V.1
Hepler, J.R.2
Brown, K.O.3
Sternweis, P.C.4
-
129
-
-
0027214868
-
Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C β by G protein α and βγ subunits
-
Smrcka AV and Sternweis PC (1993) Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C β by G protein α and β γ subunits. J Biol Chem 268:9667-9674. (Pubitemid 23146026)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.13
, pp. 9667-9674
-
-
Smrcka, A.V.1
Sternweis, P.C.2
-
130
-
-
0038756655
-
2 as an effector site for Rac
-
DOI 10.1074/jbc.M301418200
-
Snyder JT, Singer AU, Wing MR, Harden TK, and Sondek J (2003) The pleckstrin homology domain of phospholipase C-β2 as an effector site for Rac. J Biol Chem 278:21099-21104. (Pubitemid 36806422)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.23
, pp. 21099-21104
-
-
Snyder, J.T.1
Singer, A.U.2
Wing, M.R.3
Harden, T.K.4
Sondek, J.5
-
131
-
-
46249091922
-
Multiple roles of phosphoinositide-specific phospholipase C isozymes
-
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, and Ryu SH (2008) Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep 41:415-434. (Pubitemid 351914885)
-
(2008)
Journal of Biochemistry and Molecular Biology
, vol.41
, Issue.6
, pp. 415-434
-
-
Suh, P.-G.1
Park, J.-I.2
Manzoli, L.3
Cocco, L.4
Peak, J.C.5
Katan, M.6
Fukami, K.7
Kataoka, T.8
Yun, S.9
Sung, H.R.10
-
132
-
-
84864134468
-
GPCR activation of Ras and PI3Kc in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4
-
Suire S, Lécureuil C, Anderson KE, Damoulakis G, Niewczas I, Davidson K, Guillou H, and Pan D, Clark J, Hawkins PT, and Stephens L (2012) GPCR activation of Ras and PI3Kc in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4. EMBO J 31:3118-3129.
-
(2012)
EMBO J
, vol.31
, pp. 3118-3129
-
-
Suire, S.1
Lécureuil, C.2
Anderson, K.E.3
Damoulakis, G.4
Niewczas, I.5
Davidson, K.6
Guillou, H.7
Pan, D.8
Clark, J.9
Hawkins, P.T.10
Stephens, L.11
-
133
-
-
34248373227
-
Alternative splice variants of phospholipase C-β2 are expressed in platelets: Effect on Gαq-dependent activation and localization
-
DOI 10.1080/09537100601016133, PII 778492764
-
Sun L, Mao G, Kunapuli SP, Dhanasekaran DN, and Rao AK (2007) Alternative splice variants of phospholipase C-β2 are expressed in platelets: effect on Gαq-dependent activation and localization. Platelets 18:217-223. (Pubitemid 46744117)
-
(2007)
Platelets
, vol.18
, Issue.3
, pp. 217-223
-
-
Sun, L.1
Mao, G.2
Kunapuli, S.P.3
Dhanasekaran, D.N.4
Rao, A.K.5
-
134
-
-
84878760741
-
WDR26 functions as a scaffolding protein to promote Gβγ- mediated PLCβ2 activation in leukocytes
-
Sun Z, Smrcka AV, and Chen S (2013) WDR26 functions as a scaffolding protein to promote Gβγ-mediated PLCβ2 activation in leukocytes. J Biol Chem. 288:16715-16725
-
(2013)
J Biol Chem
, vol.288
, pp. 16715-16725
-
-
Sun, Z.1
Smrcka, A.V.2
Chen, S.3
-
135
-
-
0030921454
-
Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs
-
DOI 10.1021/bi9702288
-
Tall E, Dormán G, Garcia P, Runnels L, Shah S, Chen J, Profit A, Gu QM, Chaudhary A, and Prestwich GD et al. (1997) Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs. Biochemistry 36:7239-7248. (Pubitemid 27258140)
-
(1997)
Biochemistry
, vol.36
, Issue.23
, pp. 7239-7248
-
-
Tall, E.1
Dorman, G.2
Garcia, P.3
Runnels, L.4
Shah, S.5
Chen, J.6
Profit, A.7
Gu, Q.-M.8
Chaudhary, A.9
Prestwich, G.D.10
Rebecchi, M.J.11
-
136
-
-
83455229876
-
A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis
-
Tang W, Zhang Y, Xu W, Harden TK, Sondek J, Sun L, Li L, and Wu D (2011) A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Dev Cell 21:1038-1050.
-
(2011)
Dev Cell
, vol.21
, pp. 1038-1050
-
-
Tang, W.1
Zhang, Y.2
Xu, W.3
Harden, T.K.4
Sondek, J.5
Sun, L.6
Li, L.7
Wu, D.8
-
137
-
-
1542286680
-
Role of Gαq in smooth muscle cell proliferation
-
DOI 10.1016/j.jvs.2003.10.052
-
Tanski WJ, Roztocil E, Hemady EA, Williams JA, and Davies MG (2004) Role of Gαq in smooth muscle cell proliferation. J Vasc Surg 39:639-644. (Pubitemid 38298637)
-
(2004)
Journal of Vascular Surgery
, vol.39
, Issue.3
, pp. 639-644
-
-
Tanski, W.J.1
Roztocil, E.2
Hemady, E.A.3
Williams, J.A.4
Davies, M.G.5
-
139
-
-
0032584723
-
12, and βγ G protein subunits
-
DOI 10.1074/jbc.273.31.19772
-
Ushio-Fukai M, Griendling KK, Akers M, Lyons PR, and Alexander RW (1998) Temporal dispersion of activation of phospholipase C-β1 and -γ isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, α12, and β γ G protein subunits. J Biol Chem 273:19772-19777. (Pubitemid 28367037)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.31
, pp. 19772-19777
-
-
Ushio-Fukai, M.1
Griendling, K.K.2
Akers, M.3
Lyons, P.R.4
Alexander, R.W.5
-
140
-
-
0038015841
-
Role of Gαq and phospholipase C-β2 in human platelets activation by thrombin receptors PAR1 and PAR4: Studies in human platelets deficient in Gαq and phospholipase C-β2
-
DOI 10.1046/j.1365-2141.2003.04296.x
-
Vaidyula VR and Rao AK (2003) Role of Gαq and phospholipase C-β2 in human platelets activation by thrombin receptors PAR1 and PAR4: studies in human platelets deficient in Gαq and phospholipase C-β2. Br J Haematol 121:491-496. (Pubitemid 36628343)
-
(2003)
British Journal of Haematology
, vol.121
, Issue.3
, pp. 491-496
-
-
Vaidyula, V.R.1
Rao, A.K.2
-
141
-
-
78149410867
-
q signaling complex
-
q signaling complex. Science 330:974-980.
-
(2010)
Science
, vol.330
, pp. 974-980
-
-
Waldo, G.L.1
Ricks, T.K.2
Hicks, S.N.3
Cheever, M.L.4
Kawano, T.5
Tsuboi, K.6
Wang, X.7
Montell, C.8
Kozasa, T.9
Sondek, J.10
-
142
-
-
0034678048
-
2 links the binding of Gβγ to activation of the catalytic core
-
DOI 10.1074/jbc.275.11.7466
-
Wang T, Dowal L, El-Maghrabi MR, Rebecchi M, and Scarlata S (2000) The pleckstrin homology domain of phospholipase C-β(2) links the binding of gβγ to activation of the catalytic core. J Biol Chem 275:7466-7469. (Pubitemid 30159640)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.11
, pp. 7466-7469
-
-
Wang, T.1
Dowal, L.2
El-Maghrabi, M.R.3
Rebecchi, M.4
Scarlata, S.5
-
143
-
-
0033529292
-
2 with activated Gα(q) subunits: An alternative function for C2-signaling modules
-
DOI 10.1073/pnas.96.14.7843
-
Wang T, Pentyala S, Elliott JT, Dowal L, Gupta E, Rebecchi MJ, and Scarlata S (1999a) Selective interaction of the C2 domains of phospholipase C-β1 and -β2 with activated Gαq subunits: an alternative function for C2-signaling modules. Proc Natl Acad Sci USA 96:7843-7846. (Pubitemid 29328369)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.14
, pp. 7843-7846
-
-
Wang, T.1
Pentyala, S.2
Elliott, J.T.3
Dowal, L.4
Gupta, E.5
Rebecchi, M.J.6
Scarlata, S.7
-
144
-
-
0033514366
-
Differential association of the pleckstrin homology domains of phospholipases C-β 1, C-β 2, and C-δ 1 with lipid bilayers and the β γ subunits of heterotrimeric G proteins
-
Wang T, Pentyala S, Rebecchi MJ, and Scarlata S (1999b) Differential association of the pleckstrin homology domains of phospholipases C-β 1, C-β 2, and C-δ 1 with lipid bilayers and the β γ subunits of heterotrimeric G proteins. Biochemistry 38:1517-1524.
-
(1999)
Biochemistry
, vol.38
, pp. 1517-1524
-
-
Wang, T.1
Pentyala, S.2
Rebecchi, M.J.3
Scarlata, S.4
-
145
-
-
84863506626
-
Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C
-
Wang X, Barrett M, Sondek J, Harden TK, and Zhang Q (2012) Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C. Biochemistry 51:5300-5306.
-
(2012)
Biochemistry
, vol.51
, pp. 5300-5306
-
-
Wang, X.1
Barrett, M.2
Sondek, J.3
Harden, T.K.4
Zhang, Q.5
-
147
-
-
70349819903
-
Selective activation of the "b" splice variant of phospholipase Cβ1 in chronically dilated human and mouse atria
-
Woodcock EA, Grubb DR, Filtz TM, Marasco S, Luo J, McLeod-Dryden TJ, Kaye DM, Sadoshima J, Du XJ, and Wong C et al. (2009a) Selective activation of the "b" splice variant of phospholipase Cβ1 in chronically dilated human and mouse atria. J Mol Cell Cardiol 47:676-683.
-
(2009)
J Mol Cell Cardiol
, vol.47
, pp. 676-683
-
-
Woodcock, E.A.1
Grubb, D.R.2
Filtz, T.M.3
Marasco, S.4
Luo, J.5
McLeod-Dryden, T.J.6
Kaye, D.M.7
Sadoshima, J.8
Du, X.J.9
Wong, C.10
-
148
-
-
77956896618
-
Potential treatment of cardiac hypertrophy and heart failure by inhibiting the sarcolemmal binding of phospholipase Cβ1b
-
Woodcock EA, Grubb DR, and Iliades P (2010) Potential treatment of cardiac hypertrophy and heart failure by inhibiting the sarcolemmal binding of phospholipase Cβ1b. Curr Drug Targets 11:1032-1040.
-
(2010)
Curr Drug Targets
, vol.11
, pp. 1032-1040
-
-
Woodcock, E.A.1
Grubb, D.R.2
Iliades, P.3
-
149
-
-
67449164564
-
Phosphoinositide signalling and cardiac arrhythmias
-
Woodcock EA, Kistler PM, and Ju Y-K (2009b) Phosphoinositide signalling and cardiac arrhythmias. Cardiovasc Res 82:286-295.
-
(2009)
Cardiovasc Res
, vol.82
, pp. 286-295
-
-
Woodcock, E.A.1
Kistler, P.M.2
Ju, Y.-K.3
-
150
-
-
0027465720
-
Identification of critical regions on phospholipase C-β1 required for activation by G-proteins
-
Wu D, Jiang H, Katz A, and Simon MI (1993a) Identification of critical regions on phospholipase C-β 1 required for activation by G-proteins. J Biol Chem 268:3704-3709. (Pubitemid 23071017)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.5
, pp. 3704-3709
-
-
Wu, D.1
Jiang, H.2
Katz, A.3
Simon, M.I.4
-
152
-
-
0030930320
-
Phosphoinositide-specific phospholipase C δ1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: A sequential mechanism and allosteric activation
-
DOI 10.1021/bi971039s
-
Wu Y, Perisic O, Williams RL, Katan M, and Roberts MF (1997) Phosphoinositide-specific phospholipase C δ1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation. Biochemistry 36:11223-11233. (Pubitemid 27398442)
-
(1997)
Biochemistry
, vol.36
, Issue.37
, pp. 11223-11233
-
-
Wu, Y.1
Perisic, O.2
Williams, R.L.3
Katan, M.4
Roberts, M.F.5
-
153
-
-
0032484629
-
Inhibition of phospholipase C blocks opioid receptor-mediated activation of Gi proteins
-
Wu YL, Pei G, and Fan GH (1998) Inhibition of phospholipase C blocks opioid receptor-mediated activation of Gi proteins. Neuroreport 9:99-103. (Pubitemid 28046662)
-
(1998)
NeuroReport
, vol.9
, Issue.1
, pp. 99-103
-
-
Wu, Y.-L.1
Pei, G.2
Fan, G.-H.3
-
154
-
-
67651152910
-
Tumor suppression by phospholipase C-β3 via SHP-1-mediated dephosphorylation of Stat5
-
Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, Kimura A, Kubagawa H, Bertoli LF, and Davis RS et al. (2009) Tumor suppression by phospholipase C-β3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell 16:161-171.
-
(2009)
Cancer Cell
, vol.16
, pp. 161-171
-
-
Xiao, W.1
Hong, H.2
Kawakami, Y.3
Kato, Y.4
Wu, D.5
Yasudo, H.6
Kimura, A.7
Kubagawa, H.8
Bertoli, L.F.9
Davis, R.S.10
-
155
-
-
13044277562
-
Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids
-
DOI 10.1073/pnas.96.18.10385
-
Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, and Wu D (1999) Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids. Proc Natl Acad Sci USA 96:10385-10390. (Pubitemid 29422567)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.18
, pp. 10385-10390
-
-
Xie, W.1
Samoriski, G.M.2
McLaughlin, J.P.3
Romoser, V.A.4
Smrcka, A.5
Hinkle, P.M.6
Bidlack, J.M.7
Gross, R.A.8
Jiang, H.9
Wu, D.10
-
156
-
-
0035951796
-
Reassembly of phospholipase C-β2 from separated domains: Analysis of basal and G protein-stimulated activities
-
Zhang W and Neer EJ (2001) Reassembly of phospholipase C-β2 from separated domains: analysis of basal and G protein-stimulated activities. J Biol Chem 276:2503-2508.
-
(2001)
J Biol Chem
, vol.276
, pp. 2503-2508
-
-
Zhang, W.1
Neer, E.J.2
-
157
-
-
33747603007
-
Phospholipase C-β3 and -β1 form homodimers, but not heterodimers, through catalytic and carboxyl-terminal domains
-
DOI 10.1124/mol.105.021923
-
Zhang Y, Vogel WK, McCullar JS, Greenwood JA, and Filtz TM (2006) Phospholipase C-β3 and -β1 form homodimers, but not heterodimers, through catalytic and carboxyl-terminal domains. Mol Pharmacol 70:860-868. (Pubitemid 44268443)
-
(2006)
Molecular Pharmacology
, vol.70
, Issue.3
, pp. 860-868
-
-
Zhang, Y.1
Vogel, W.K.2
McCullar, J.S.3
Greenwood, J.A.4
Filtz, T.M.5
|