Synergistic activation of phospholipase C-β3 by Gαq and Gβγ describes a simple two-state coincidence detector

Current Biology

Volumn 20, Issue 15, 2010, Pages 1327-1335

  Philip, Finly ^a   Kadamur, Ganesh ^a,b   Silos, Rosa González ^a,c   Woodson, Jimmy ^a   Ross, Elliott M ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

SIGNALING

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; ISOENZYME; LIGAND; PHOSPHOLIPASE C BETA;

ALLOSTERISM; ANIMAL; ARTICLE; CHEMICAL MODEL; ENZYME ACTIVATION; HUMAN; METABOLISM; MOUSE; RAT;

ALLOSTERIC REGULATION; ANIMALS; ENZYME ACTIVATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HUMANS; ISOENZYMES; LIGANDS; MICE; MODELS, CHEMICAL; PHOSPHOLIPASE C BETA; RATS;

EID: 77955508883     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2010.06.013     Document Type: Article

References (45)

1. M. Natarajan, K.-M. Lin, R.C. Hsueh, P.C. Sternweis, and R. Ranganathan A global analysis of cross-talk in a mammalian cellular signalling network Nat. Cell Biol. 8 2006 571 580
2. G. Weber Protein Interactions 1992 Chapman & Hall New York, NY
3. J. Wyman, and S.J. Gill Binding and Linkage. Functional Chemistry of Biological Macromolecules 1990 University Science Books Mill Valley, CA
4. K.E. Prehoda, and W.A. Lim How signaling proteins integrate multiple inputs: A comparison of N-WASP and Cdk2 Curr. Opin. Cell Biol. 14 2002 149 154
5. T. Pawson Dynamic control of signaling by modular adaptor proteins Curr. Opin. Cell Biol. 19 2007 112 116
6. M.J. Winters, R.E. Lamson, H. Nakanishi, A.M. Neiman, and P.M. Pryciak A membrane binding domain in the Ste5 scaffold synergizes with Gβγ binding to control localization and signaling in pheromone response Mol. Cell 20 2005 21 32
7. M. Pu, M.F. Roberts, and A. Gershenson Fluorescence correlation spectroscopy of phosphatidylinositol-specific phospholipase C monitors the interplay of substrate and activator lipid binding Biochemistry 48 2009 6835 6845
8. N.P. Barrera, B. Morales, S. Torres, and M. Villalón Principles: Mechanisms and modeling of synergism in cellular responses Trends Pharmacol. Sci. 26 2005 526 532
9. W.S. Hlavacek, J.R. Faeder, M.L. Blinov, A.S. Perelson, and B. Goldstein The complexity of complexes in signal transduction Biotechnol. Bioeng. 84 2003 783 794
10. T.I.A. Roach, R.A. Rebres, I.D.C. Fraser, D.L. Decamp, K.M. Lin, P.C. Sternweis, M.I. Simon, and W.E. Seaman Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium J. Biol. Chem. 283 2008 17351 17361
11. 1 receptors Neuropharmacology 38 1999 1511 1517
12. 2+ mobilization in a pertussis toxin-sensitive manner in FRTL-5 thyroid cells FEBS Lett. 248 1989 145 149
13. 2+ Biochem. J. 374 2003 281 296
14. C.S. Abrams Intracellular signaling in platelets Curr. Opin. Hematol. 12 2005 401 405
15. J.M. Dickenson, and S.J. Hill Coupling of histamine H1 and adenosine A1 receptors to phospholipase C in DDT1MF-2 cells: Synergistic interactions and regulation by cyclic AMP Biochem. Soc. Trans. 21 1993 1124 1129
16. 2+ signalling pathways Exp. Mol. Med. 31 1999 42 46
17. M.C. Cilluffo, E. Esqueda, and N.A. Farahbakhsh Multiple receptor activation elicits synergistic IP formation in nonpigmented ciliary body epithelial cells Am. J. Physiol. Cell Physiol. 279 2000 C734 C743
18. 2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells. A permissive role for pertussis toxin-sensitive G-proteins Biochem. J. 290 1993 241 247
19. 2+ release in human embryonic kidney cells J. Pharmacol. Exp. Ther. 307 2003 661 669
20. E. Rozengurt Mitogenic signaling pathways induced by G protein-coupled receptors J. Cell. Physiol. 213 2007 589 602
21. M.J. Rebecchi, and S.N. Pentyala Structure, function, and control of phosphoinositide-specific phospholipase C Physiol. Rev. 80 2000 1291 1335
22. R.C. Carroll, A.D. Morielli, and E.G. Peralta Coincidence detection at the level of phospholipase C activation mediated by the m4 muscarinic acetylcholine receptor Curr. Biol. 5 1995 536 544
23. i-coupled receptors Mol. Pharmacol. 57 2000 700 708
24. 16 and evidence for a synergic interaction between Gβγ and the α subunit of a receptor activated G protein Proc. Natl. Acad. Sci. USA 93 1996 2827 2831
25. q-coupled receptors is mediated by Gβγ exchange Proc. Natl. Acad. Sci. USA 96 1999 10626 10631
26. H. Ogasawara The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection J. Neurosci. 28 2008 4293 4294
27. M. Camps, A. Carozzi, P. Schnabel, A. Scheer, P.J. Parker, and P. Gierschik Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits Nature 360 1992 684 686
28. W. Tang, Y. Tu, S.K. Nayak, J. Woodson, M. Jehl, and E.M. Ross Gβγ inhibits Gα GTPase-activating proteins by inhibition of Gα-GTP binding during stimulation by receptor J. Biol. Chem. 281 2006 4746 4753
29. q J. Biol. Chem. 269 1994 25335 25338
30. D.E. Clapham, and E.J. Neer G protein βγ subunits Annu. Rev. Pharmacol. Toxicol. 37 1997 167 203
31. A.V. Smrcka, and P.C. Sternweis Regulation of purified subtypes of phosphatidylinositol-specific phospholipase Cβ by G protein α and βγ subunits J. Biol. Chem. 268 1993 9667 9674
32. S.N. Hicks, M.R. Jezyk, S. Gershburg, J.P. Seifert, T.K. Harden, and J. Sondek General and versatile autoinhibition of PLC isozymes Mol. Cell 31 2008 383 394
33. A.U. Singer, G.L. Waldo, T.K. Harden, and J. Sondek A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq Nat. Struct. Biol. 9 2002 32 36
34. q-GRK2-Gβγ complex Science 310 2005 1686 1690
35. q and acceleration is inhibited by Gβγ subunits J. Biol. Chem. 274 1999 19639 19643
36. M. Buck, W. Xu, and M.K. Rosen A two-state allosteric model for autoinhibition rationalizes WASP signal integration and targeting J. Mol. Biol. 338 2004 271 285
37. K.E. Prehoda, J.A. Scott, R.D. Mullins, and W.A. Lim Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex Science 290 2000 801 806
38. S.R. Sprang, K.R. Acharya, E.J. Goldsmith, D.I. Stuart, K. Varvill, R.J. Fletterick, N.B. Madsen, and L.N. Johnson Structural changes in glycogen phosphorylase induced by phosphorylation Nature 336 1988 215 221
39. D. Barford, and L.N. Johnson The allosteric transition of glycogen phosphorylase Nature 340 1989 609 616
40. sα with the cytosolic domains of mammalian adenylyl cyclase J. Biol. Chem. 272 1997 22265 22271
41. Y. Nishizuka Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C Science 258 1992 607 614
42. 3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac Cell 108 2002 809 821
43. q and m1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation J. Biol. Chem. 271 1996 7999 8007
44. q Biochem. Pharmacol. 58 1999 39 48
45. S.P.J. Brooks, and K.B. Storey Bound and determined: A computer program for making buffers of defined ion concentrations Anal. Biochem. 201 1992 119 126