A novel Gβγ-subunit inhibitor selectively modulates μ-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence

Journal of Neuroscience

Volumn 28, Issue 47, 2008, Pages 12183-12189

  Mathews, Jennifer L ^a,b   Smrcka, Alan V ^a   Bidlack, Jean M ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b ST JOHN FISHER COLLEGE   (United States)

Author keywords

Antinociception; Dependence; G subunit; Mice; Opioid; Tolerance

Indexed keywords

CYCLOHEXANECARBOXYLIC ACID [2 (4,5,6 TRIHYDROXY 3 OXO 3H XANTHEN 9 YL) (9CL)]; DELTORPHIN; DELTORPHIN 2; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; KAPPA OPIATE RECEPTOR; M 119; MORPHINE; MU OPIATE RECEPTOR; OPIATE ANTAGONIST; PHOSPHOLIPASE C; UNCLASSIFIED DRUG; ANALGESIC AGENT; CYCLIC AMP; CYCLOHEXANE DERIVATIVE; INOSITOL PHOSPHATE; M119 COMPOUND; NALOXONE; PHOSPHOLIPASE C BETA; PLCB3 PROTEIN, MOUSE; XANTHENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG MECHANISM; ENZYME ACTIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL BEHAVIOR; CHEMISTRY; CHO CELL; CRICETULUS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; DRUG POTENTIATION; DRUG TOLERANCE; GENETIC TRANSFECTION; HAMSTER; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; METHODOLOGY; MORPHINE ADDICTION; PAIN ASSESSMENT; PATHOPHYSIOLOGY; PHYSIOLOGY; REACTION TIME; TIME;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; CYCLOHEXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG TOLERANCE; HUMANS; INOSITOL PHOSPHATES; MALE; MICE; MICE, INBRED ICR; MORPHINE; MORPHINE DEPENDENCE; NALOXONE; PAIN MEASUREMENT; PHOSPHOLIPASE C BETA; PROTEIN BINDING; REACTION TIME; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; XANTHENES;

EID: 58149400019     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2326-08.2008     Document Type: Article

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