Direct activation of human phospholipase C by its well known inhibitor U73122

Journal of Biological Chemistry

Volumn 286, Issue 14, 2011, Pages 12407-12416

  Klein, Ryan R ^a,c   Bourdon, David M ^b   Costales, Chester L ^a   Wagner, Craig D ^c   White, Wendy L ^c   Williams, Jon D ^c   Hicks, Stephanie N ^c   Sondek, John ^c   Thakker, Dhiren R ^a  

^a University of North Carolina   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL-FREE; CELLULAR FUNCTION; COVALENT MODIFICATIONS; COVALENT REACTION; DIRECT ACTIVATION; ENZYME ACTIVATION; GLUTATHIONES; L-CYSTEINE; LC/MS/MS; MASS SPECTROMETRIC ANALYSIS; MEMBRANE PHOSPHOLIPIDS; MICELLAR SYSTEMS; PEPTIDE SEQUENCING; PHOSPHOLIPASE C; POLAR HEADGROUPS; REGULATORY PROTEIN; SMALL MOLECULES; TIME-DEPENDENT;

AMINO ACIDS; CATALYSTS; ENZYME ACTIVITY; ENZYMES; PHOSPHOLIPIDS; SUGARS;

ACTIVATION ANALYSIS;

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; PHOSPHOLIPASE C;

ALKYLATION; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE SEQUENCE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ENZYME ACTIVATION; ESTRENES; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINONES; TYPE C PHOSPHOLIPASES;

EID: 79953297067     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.191783     Document Type: Article

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