Alternative splice variants of phospholipase C-β2 are expressed in platelets: Effect on Gαq-dependent activation and localization

Platelets

Volumn 18, Issue 3, 2007, Pages 217-223

  Sun, Liansheng ^a   Mao, Guangfen ^a   Kunapuli, Satya P ^a   Dhanasekaran, Danny N ^a   Rao, A Koneti ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alternative splicing; G q; Phospholipase C 2; Platelets

Indexed keywords

COMPLEMENTARY DNA; GALACTOSIDASE; NUCLEOTIDE; PHOSPHOLIPASE C BETA2;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTE FUNCTION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BLOOD PLATELETS; CELL DIFFERENTIATION; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CYTOPLASM; ENZYME ACTIVATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASE C;

EID: 34248373227     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.1080/09537100601016133     Document Type: Article

References (24)

1. Rhee SG, Choi KD. Regulation of inositol phospholipid-specific phospholipase C isozymes. J Biol Chem 1992;267:12393-12396.
2. Rhee SG, Bae YS. Regulation of phosphoinositide-specific phospholipase C isozymes. J Biol Chem 1997;272:15045-15048.
3. Lee SB, Shin SH, Hepler JR, Gilman AG, Rhee SG. Activation of phospholipase C-β2 mutants by G protein α q and βγ subunits. J Biol Chem 1993;268:25952-25957.
4. Park D, Jhon DY, Lee CW, Ryu SH, Rhee SG. Removal of the carboxyl-terminal region of phospholipase C-β1 by calpain abolishes activation by Gαq. J Biol Chem 1993;268:3710-3714.
5. Wu D, Jiang H, Katz A, Simon MI. Identification of critical regions on phospholipase C-β1 required for activation by G-proteins. J Biol Chem 1993;268:3704-3709.
6. Kim CG, Park D, Rhee SG. The role of carboxyl-terminal basic amino acids in Gαq-dependent activation, particulate association, and nuclear localization of phospholipase C-b1. J Biol Chem 1996;271:21187-21192.
7. Martelli AM, Billi AM, Gilmour RS, Neri LM, Manzoli L, Ognibene A, Cocco L. Phosphoinositide signaling in nuclei of Friend cells: Phospholipase C β down-regulation is related to cell differentiation. Cancer Res 1994;54:2536-2540.
8. Divecha N, Letcher AJ, Banfic HH, Rhee SG, Irvine RF. Changes in the components of a nuclear inositide cycle during differentiation in murine erythroleukaemia cells. Biochem J 1995;312:63-67.
9. Divecha N, Rhee SG, Letcher AJ, Irvine RF. Phosphoinositide signalling enzymes in rat liver nuclei: Phosphoinositidase C isoform β1 is specifically, but not predominantly, located in the nucleus. Biochem J 1993;289:617-620.
10. Martelli AM, Gilmour RS, Bertagnolo V, Neri LM, Manzoli L, Cocco L. Nuclear localization and signalling activity of phosphoinositidase C β in Swiss 3T3 cells. Nature 1992;358:242-245.
11. Bahk YY, Lee YH, Lee TG, Seo J, Ryu SJ, Suh P-G. Two forms of phospholipase C-β1 generated by alternative splicing. J Biol Chem 1993;268:2486-2492.
12. Ferreira PA, Shortridge RD, Pak WL. Distinctive subtypes of bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila. Proc Natl Acad Sci USA 1993;90:6042-6046.
13. Kim MJ, Min DS, Ryu SH, Suh PG. A cytosolic, Gaq- and bg-insensitive splice variant of phospholipase C-β4. J Biol Chem 1998;273:3618-3624.
14. Lee SB, Rhee SG. Molecular cloning, splice variants, expression, and purification of phospholipase C-δ4. J Biol Chem 1996;271:25-31.
15. Nagano K, Fukami K, Minagawa T, Watanabe Y, Ozaki C, Takenawa T. A novel phospholipase C-δ4 (PLC-δ4) splice variant as a negative regulator of PLC. J Biol Chem 1999;274:2872-2879.
16. Shortridge RD, Yoon J, Lending CR, Bloomquist BT, Perdew MH, Pak WL. A Drosophila phospholipase C gene that is expressed in the central nervous system. J Biol Chem 1991;266:12474-12480.
17. Kim S, McKay RR, Miller K, Shortridge RD. Multiple subtypes of phospholipase C are encoded by the norpA gene of Drosophila melanogaster. J Biol Chem 1995;270:14376-14382.
18. Mao GF, Kunapuli SP, Rao AK. Evidence for two alternatively spliced forms of phospholipase C-β2 in haematopoietic cells. Br J Haematol 2000;110:402-408.
19. Park D, Jhon DY, Kriz R, Knopf J, Rhee SG. Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-β2. J Biol Chem 1992;267:16048-16055.
20. Prasad MV, Dermott JM, Heasley LE, Johnson GL, Dhanasekaran N. Activation of Jun kinase/stress-activated protein kinase by GTPase- deficient mutants of Gα12 and Gα 13. J Biol Chem 1995;270:18655-18659.
21. Bertagnolo V, Marchisio M, Capitani S, Neri LM. Intranuclear translocation of phospholipase C β 2 during HL-60 myeloid differentiation. Biochem Biophys Res Commun 1997;235:831-837.
22. Xu A, Suh PG, Marmy-Conus N, Pearson RB, Seok OY, Cocco L, Gilmour RS. Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I. Mol Cell Biol 2001;21:2981-2990.
23. Bahk YY, Song H, Baek SH, Park BY, Kim H, Ryu SH, Suh PG. Localization of two forms of phospholipase C-β1, a and b, in C6Bu-1 cells. Biochim Biophys Acta 1998;1389:76-80.
24. Lee CW, Park DJ, Lee KH, Kim CG, Rhee SG. Purification, molecular cloning, and sequencing of phospholipase C-β4. J Biol Chem 1993;268:21318-21327.