A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits

Molecular Pharmacology

Volumn 80, Issue 3, 2011, Pages 434-445

  Han, Daniel S ^a   Golebiewska, Urszula ^b   Stolzenberg, Sebastian ^a   Scarlata, Suzanne F ^b   Weinstein, Harel ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE C BETA2; PLECKSTRIN;

ARTICLE; CATALYST; FLUORESCENCE ANALYSIS; LIPID BILAYER; LIPID MEMBRANE; MOLECULAR BIOLOGY; MOLECULAR MECHANICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

ENZYME ACTIVATION; FLUORESCENT DYES; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PHOSPHOLIPASE C BETA;

EID: 80052010597     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.073403     Document Type: Article

References (33)

1. Bonacci T.M., Ghosh M., Malik S, and Smrcka A.V. (2005) Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. J Biol Chem 280:10174-10181. (Pubitemid 40395871)
2. Buck E., Li J., Chen Y., Weng G., Scarlata S, and Iyengar R. (1999) Resolution of a signal transfer region from a general binding domain in gbeta for stimulation of phospholipase C-beta2. Science 283:1332-1335.
3. Chen R., Li L, and Weng Z. (2003) ZDOCK: An initial-stage protein-docking algorithm. Proteins 52:80-87. (Pubitemid 36648854)
4. Drin G., Douguet D, and Scarlata S. (2006) The pleckstrin homology domain of phospholipase Cbeta transmits enzymatic activation through modulation of the membrane-domain orientation. Biochemistry 45:5712-5724.
5. Drin G and Scarlata S. (2007) Stimulation of phospholipase C[beta] by membrane interactions, interdomain movement, and G protein binding - How many ways can you activate an enzyme? Cell Signalling 19:1383-1392. (Pubitemid 46818926)
6. Feng J., Roberts M.F., Drin G, and Scarlata S. (2005) Dissection of the steps of phospholipase C beta 2 activity that are enhanced by G beta gamma subunits. Biochemistry 44:2577-2584. (Pubitemid 40279561)
7. Gray J.J., Moughon S., Wang C., Schueler-Furman O., Kuhlman B., Rohl CA, and Baker D. (2003) Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations. J Mol Biol 331:281-299. (Pubitemid 36870793)
8. Guo Y., Golebiewska U., D'Amico S, and Scarlata S. (2010) The small G protein Rac1 activates phospholipase Cδ1 through phospholipase Cβ2. J Biol Chem 285:24999-25008.
9. Harden TK and Sondek J. (2006) Regulation of phospholipase C isoenzymes by ras superfamily GTPases. Annu Rev Pharmacol Toxicol 46:355-379. (Pubitemid 43271194)
10. Hicks S.N., Jezyk M.R., Gershburg S., Seifert J.P., Harden TK, and Sondek J. (2008) General and versatile autoinhibition of PLC isozymes. Mol Cell 31:383-394.
11. Ilkaeva O., Kinch L.N., Paulssen RH, and Ross E.M. (2002) Mutations in the carboxylterminal domain of phospholipase C-beta 1 delineate the dimer interface and a potential Galphaq interaction site. J Biol Chem 277:4294-4300. (Pubitemid 34968694)
12. Jezyk M.R., Snyder J.T., Gershberg S., Worthylake D.K., Harden TK, and Sondek J. (2006) Crystal structure of Rac1 bound to its effector phospholipase C-beta2. Nat Struct Mol Biol 13:1135-1140. (Pubitemid 44885926)
13. z. J Biol Chem 270:1734-1741.
14. Lee C.W., Lee K.H., Lee S.B., Park D, and Rhee S.G. (1994) Regulation of phospholipase C-beta 4 by ribonucleotides and the alpha subunit of Gq. J Biol Chem 269:25335-25338.
15. Li Y., Sternweis P.M., Charnecki S., Smith T.F., Gilman A.G., Neer EJ, and Kozasa T. (1998) Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase. J Biol Chem 273:16265-16272. (Pubitemid 28311403)
16. Lodowski D.T., Pitcher J.A., Capel W.D., Lefkowitz RJ, and Tesmer J.J. (2003) Keeping G proteins at bay: A complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science 300:1256-1262. (Pubitemid 36618232)
17. London N and Schueler-Furman O. (2008) FunHunt: Model selection based on energy landscape characteristics. Biochem Soc Trans 36:1418-1421.
18. Marrink S.J., Risselada H.J., Yefimov S., Tieleman DP, and De Vries A.H. (2007) The MARTINI force field: Coarse grained model for biomolecular simulations. J Phys Chem B 111:7812-7824. (Pubitemid 47169693)
19. Méndez R., Leplae R., Lensink MF, and Wodak S.J. (2005) Assessment of CAPRI predictions in rounds 3-5 shows progress in docking procedures. Proteins 60:150-169. (Pubitemid 40934881)
20. Panchenko M.P., Saxena K., Li Y., Charnecki S., Sternweis P.M., Smith T.F., Gilman A.G., Kozasa T, and Neer E.J. (1998) Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure. J Biol Chem 273:28298-28304. (Pubitemid 28496130)
21. Rebecchi M., Peterson A, and McLaughlin S. (1992) Phosphoinositide- specific phospholipase C-delta 1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate. Biochemistry 31:12742-12747. (Pubitemid 23027052)
22. Rebecchi MJ and Pentyala S.N. (2000) Structure, function, and control of phosphoinositide- specific phospholipase C. Physiol Rev 80:1291-1335.
23. Rebecchi MJ and Scarlata S. (1998) Pleckstrin homology domains: A common fold with diverse functions. Annu Rev Biophys Biomol Struct 27:503-528. (Pubitemid 28286023)
24. Rhee S.G. (2001) Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem 70:281-312.
25. Runnels L.W., Jenco J., Morris A, and Scarlata S. (1996) Membrane binding of phospholipases C-beta 1 and C-beta 2 is independent of phosphatidylinositol 4,5-bisphosphate and the alpha and beta gamma subunits of G proteins. Biochemistry 35:16824-16832.
26. Scarlata S. (2002) Determination of the strength and specificity of membrane-bound protein association using fluorescence spectroscopy. Methods Enzymol 345:306-327.
27. Schneidman-Duhovny D., Inbar Y., Polak V., Shatsky M., Halperin I., Benyamini H., Barzilai A., Dror O., Haspel N., Nussinov R., et al. (2003) Taking geometry to its edge: Fast unbound rigid (and hinge-bent) docking. Proteins 52:107-112. (Pubitemid 36648858)
28. Shan J., Weinstein H, and Mehler E.L. (2010) Probing the structural determinants for the function of intracellular loop 2 in structurally cognate G-protein-coupled receptors. Biochemistry 49:10691-10701.
29. Suh P.G., Park J.I., Manzoli L., Cocco L., Peak J.C., Katan M., Fukami K., Kataoka T., Yun S, and Ryu S.H. (2008) Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB reports 41:415-434.
30. Van der Meer W., Coker G, and Chen S.S.(1994) Resonance Energy Transfer, Theory and Data. VCH Publishers, Inc., New York.
31. Van Der Spoel D., Lindahl E., Hess B., Groenhof G., Mark AE, and Berendsen H.J. (2005) GROMACS: Fast, flexible, and free. J Comput Chem 26:1701-1718. (Pubitemid 43076182)
32. Wang T., Dowal L., El-Maghrabi M.R., Rebecchi M, and Scarlata S. (2000) The pleckstrin homology domain of phospholipase C-beta(2) links the binding of Gbetagamma to activation of the catalytic core. J Biol Chem 275:7466-7469. (Pubitemid 30159640)
33. Wang T., Pentyala S., Rebecchi MJ, and Scarlata S. (1999) Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins. Biochemistry 38:1517-1524.