U73122, an aminosteroid phospholipase C inhibitor, is a potent inhibitor of cardiac phospholipase D by a PIP2-dependent mechanism

Journal of Cardiovascular Pharmacology

Volumn 55, Issue 6, 2010, Pages 555-559

  Burgdorf, Christof ^a   Schäfer, Ulrich ^a   Richardt, Gert ^b   Kurz, Thomas ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b Segeberger Kliniken GmbH   (Germany)

Author keywords

5 bisphosphate; phosphatidylinositol 4; phospholipase C; phospholipase D; rat myocardium; U73122

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; HEART ENZYME; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C INHIBITOR; PHOSPHOLIPASE D; STEROID; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; ESTRANE DERIVATIVE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C; POLYPHOSPHOINOSITIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HEART MUSCLE FIBER MEMBRANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOASSAY; DRUG EFFECTS; DRUG INTERACTION; HEART MUSCLE; MEMBRANE; METABOLISM; WISTAR RAT;

ANIMALS; BIOLOGICAL ASSAY; DRUG INTERACTIONS; ESTRENES; MALE; MEMBRANES; MYOCARDIUM; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE D; PYRROLIDINONES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TYPE C PHOSPHOLIPASES;

EID: 77953749904     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181d8bec5     Document Type: Article

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