Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function

Virology

Volumn 401, Issue 2, 2010, Pages 236-247

  Eggink, Dirk ^a   Melchers, Mark ^a   Wuhrer, Manfred ^c   van Montfort, Thijs ^a   Dey, Antu K ^b   Naaijkens, Benno A ^a   David, Kathryn B ^b   Le Douce, Valentin ^a   Deelder, André M ^c   Kang, Kenneth ^d   Olson, William C ^d   Berkhout, Ben ^a   Hokke, Cornelis H ^c   Moore, John P ^b   Sanders, Rogier W ^a,b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d A Subsidiary of Lantheus Holdings   (United States)

Author keywords

DC SIGN; Envelope glycoprotein; Glycosylation; HIV 1; N Acetylglucosaminyltransferase I; Oligomannose

Indexed keywords

GLYCAN; GLYCOPROTEIN; GLYCOPROTEIN GP 140; KIFUNENSINE; LECTIN RECEPTOR; MANNOSE OLIGOSACCHARIDE; MONOCLONAL ANTIBODY 2G12; N ACETYLGLUCOSAMINYLTRANSFERASE; RECOMBINANT PROTEIN; VIRUS ENVELOPE PROTEIN; ALPHA 1,3 MANNOSYL GLYCOPROTEIN BETA 1,2 N ACETYLGLUCOSAMINYLTRANSFERASE I; ALPHA-1,3-MANNOSYL-GLYCOPROTEIN BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE I; POLYSACCHARIDE;

ANTIGEN BINDING; ANTIGENICITY; ARTICLE; CARBOHYDRATE ANALYSIS; CONTROLLED STUDY; GLYCOSYLATION; HUMORAL IMMUNITY; IMMUNOGENICITY; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; VIRUS ATTACHMENT; VIRUS ENTRY; VIRUS ENVELOPE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR GENETICS; PHYSIOLOGY; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA;

CARBOHYDRATE SEQUENCE; CELL LINE; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; N-ACETYLGLUCOSAMINYLTRANSFERASES; POLYSACCHARIDES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 77951988965     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2010.02.019     Document Type: Article

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