Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors

Journal of Biological Chemistry

Volumn 284, Issue 39, 2009, Pages 26941-26950

  Eggink, Dirk ^a   Langedijk, Johannes P M ^b   Bonvin, Alexandre M J J ^c   Deng, Yiqun ^d   Lu, Min ^d   Berkhout, Ben ^a   Sanders, Rogier W ^a,d  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b Pepscan Systems   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; CHARGED AMINO ACIDS; CLASS I; DRUG RESISTANCE; ELECTROSTATIC ATTRACTIONS; ELECTROSTATIC REPULSION; FUSION INHIBITORS; FUSION PROTEINS; HUMAN IMMUNODEFICIENCY VIRUS-1; MUTATIONAL ANALYSIS; PEPTIDE BINDING; PEPTIDE INHIBITORS; THIRD GENERATION; THREE GENERATIONS; VIRUS ENTRY;

AMINATION; AMINES; AMINO ACIDS; BINDING ENERGY; BINDING SITES; ELECTROSTATICS; ORGANIC ACIDS; PEPTIDES;

ACID RESISTANCE;

ENFUVIRTIDE; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; T 1249; T 2635; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; BIOPHYSICS; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; ELECTRICITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; MOLECULAR INTERACTION; MUTATIONAL ANALYSIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STEREOSPECIFICITY; VIRUS CELL INTERACTION;

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE, TUMOR; CIRCULAR DICHROISM; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STATIC ELECTRICITY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 70350371719     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.004416     Document Type: Article

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