Cellular assays for drug discovery in genetic disorders of intracellular trafficking

Annual Review of Genomics and Human Genetics

Volumn 14, Issue , 2013, Pages 159-190

  De Matteis, Maria Antonietta ^a   Vicinanza, Mariella ^a   Venditti, Rossella ^a   Wilson, Cathal ^a  

^a TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

Author keywords

Cell based assays; Genetic diseases; High content screening; Membrane trafficking; Pharmacological approach

Indexed keywords

ADAPTOR PROTEIN; ALPHA GALACTOSIDASE; AMBROXOL; ARIMOCLOMOL; CELASTROL; CLATHRIN; COAT PROTEIN; COAT PROTEIN COMPLEX II; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DYMECLIN; DYSBINDIN; ESCRT PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; HEAT SHOCK PROTEIN 1; HEAT SHOCK PROTEIN 4; LARAZOTIDE; MANNOSE 6 PHOSPHATE; MIGALASTAT; MOLECULAR MOTOR; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL; POLYGLUTAMINE; RAB PROTEIN; SALUBRINAL; SAR1B PROTEIN; SNAP29 PROTEIN; SOMATOMEDIN B RECEPTOR; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; AUTOPHAGOSOME; AUTOPHAGY; BIOGENESIS; CAVEOLA; CELL ASSAY; CYSTIC FIBROSIS; DENT DISEASE; DRUG DEVELOPMENT; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENDOSOME; EXOCYTOSIS; FABRY DISEASE; FRONTOTEMPORAL DEMENTIA; GAUCHER DISEASE; GENETIC DISORDER; HUMAN; HUNTINGTON CHOREA; IMAGE ANALYSIS; INTRACELLULAR MEMBRANE; INTRACELLULAR SPACE; LOWE SYNDROME; LYSOSOME; LYSOSOME STORAGE DISEASE; MACHINE LEARNING; MISSENSE MUTATION; NIEMANN PICK DISEASE; NONHUMAN; PARKINSON DISEASE; PATTERN RECOGNITION; PHAGOSOME; PHENOTYPE; REVIEW; RNA INTERFERENCE; SECRETORY GRANULE;

ANIMALS; DRUG DISCOVERY; GENETIC DISEASES, INBORN; HUMANS; INTRACELLULAR MEMBRANES; PROTEIN TRANSPORT;

EID: 84884298534     PISSN: 15278204     EISSN: 1545293X     Source Type: Book Series    
DOI: 10.1146/annurev-genom-091212-153415     Document Type: Review

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