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Volumn 17, Issue 12, 2011, Pages 1570-1576

Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; CELL COUNT; CELL DIFFERENTIATION; CELL TYPE; DYSAUTONOMIA; EMBRYONIC STEM CELL; GENE MUTATION; GENETIC DISORDER; HUMAN; LONG QT SYNDROME; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; SOMATIC CELL; SPINAL MUSCULAR ATROPHY;

EID: 84856112882     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2504     Document Type: Review
Times cited : (178)

References (38)
  • 2
    • 0030003590 scopus 로고    scopus 로고
    • Animal models of human disease for gene therapy
    • Wilson J.M. Animal models of human disease for gene therapy. J. Clin. Invest. 97, 1138-1141 (1996). (Pubitemid 26085468)
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.5 , pp. 1138-1141
    • Wilson, J.M.1
  • 3
    • 33846677129 scopus 로고    scopus 로고
    • Comparison of treatment effects between animal experiments and clinical trials: Systematic review
    • Perel P. et al. Comparison of treatment effects between animal experiments and clinical trials: Systematic review. Br. Med. J. 334, 197 (2007).
    • (2007) Br. Med. J. , vol.334 , pp. 197
    • Perel, P.1
  • 4
    • 34247263212 scopus 로고    scopus 로고
    • A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: A need for more rigorous testing of neuroprotective agents in animal models of stroke
    • DOI 10.1016/j.expneurol.2007.03.003, PII S0014488607000970
    • Savitz S.I. A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: A need for more rigorous testing of neuroprotective agents in animal models of stroke. Exp. Neurol. 205, 20-25 (2007). (Pubitemid 46621180)
    • (2007) Experimental Neurology , vol.205 , Issue.1 , pp. 20-25
    • Savitz, S.I.1
  • 5
    • 0032491422 scopus 로고    scopus 로고
    • New potential for human embryonic stem cells
    • Gearhart J. New potential for human embryonic stem cells. Science 282, 1061-1062 (1998). (Pubitemid 28516225)
    • (1998) Science , vol.282 , Issue.5391 , pp. 1061-1062
    • Gearhart, J.1
  • 6
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Thomson J.A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998). (Pubitemid 28516247)
    • (1998) Science , vol.282 , Issue.5391 , pp. 1145-1147
    • Thomson, J.A.1
  • 8
    • 69149110895 scopus 로고    scopus 로고
    • Creation of a registry for human embryonic stem cells carrying an inherited defect: Joint collaboration between ESHRE and hESCreg
    • Sermon K.D. et al. Creation of a registry for human embryonic stem cells carrying an inherited defect: Joint collaboration between ESHRE and hESCreg. Hum. Reprod. 24, 1556-1560 (2009).
    • (2009) Hum. Reprod. , vol.24 , pp. 1556-1560
    • Sermon, K.D.1
  • 9
    • 3543030995 scopus 로고    scopus 로고
    • Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells
    • Urbach A., Schuldiner M. & Benvenisty N. Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells. Stem Cells 22, 635-641 (2004). (Pubitemid 39014579)
    • (2004) Stem Cells , vol.22 , Issue.4 , pp. 635-641
    • Urbach, A.1    Schuldiner, M.2    Benvenisty, N.3
  • 10
    • 42649095149 scopus 로고    scopus 로고
    • Genetic Modification of Human Embryonic Stem Cells for Derivation of Target Cells
    • DOI 10.1016/j.stem.2008.04.003, PII S1934590908001744
    • Giudice A. & Trounson A. Genetic modification of human embryonic stem cells for derivation of target cells. Cell Stem Cell 2, 422-433 (2008). (Pubitemid 351598085)
    • (2008) Cell Stem Cell , vol.2 , Issue.5 , pp. 422-433
    • Giudice, A.1    Trounson, A.2
  • 11
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi K. & Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006). (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 12
    • 50149098605 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    • Dimos J.T. et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321, 1218-1221 (2008).
    • (2008) Science , vol.321 , pp. 1218-1221
    • Dimos, J.T.1
  • 13
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient
    • Ebert A.D. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-280 (2009).
    • (2009) Nature , vol.457 , pp. 277-280
    • Ebert, A.D.1
  • 14
    • 70349301819 scopus 로고    scopus 로고
    • Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    • Lee G. et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406 (2009).
    • (2009) Nature , vol.461 , pp. 402-406
    • Lee, G.1
  • 15
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto M.C. et al. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143, 527-539 (2010).
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1
  • 16
    • 79952446402 scopus 로고    scopus 로고
    • Modelling the long QT syndrome with induced pluripotent stem cells
    • Itzhaki I. et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature 471, 225-229 (2011).
    • (2011) Nature , vol.471 , pp. 225-229
    • Itzhaki, I.1
  • 17
    • 79955884485 scopus 로고    scopus 로고
    • Modelling schizophrenia using human induced pluripotent stem cells
    • Brennand K.J. et al. Modelling schizophrenia using human induced pluripotent stem cells. Nature 473, 221-225 (2011).
    • (2011) Nature , vol.473 , pp. 221-225
    • Brennand, K.J.1
  • 18
    • 79954626173 scopus 로고    scopus 로고
    • Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
    • Liu G.H. et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature 472, 221-225 (2011).
    • (2011) Nature , vol.472 , pp. 221-225
    • Liu, G.H.1
  • 19
    • 67650095306 scopus 로고    scopus 로고
    • Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
    • Raya A. et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 460, 53-59 (2009).
    • (2009) Nature , vol.460 , pp. 53-59
    • Raya, A.1
  • 20
    • 79952899995 scopus 로고    scopus 로고
    • Methods for making induced pluripotent stem cells: Reprogramming a la carte
    • González F., Boue S. & Izpisua Belmonte J.C. Methods for making induced pluripotent stem cells: Reprogramming a la carte. Nat. Rev. Genet. 12, 231-242 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 231-242
    • González, F.1    Boue, S.2    Izpisua Belmonte, J.C.3
  • 21
    • 55749089875 scopus 로고    scopus 로고
    • Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
    • Aasen T. et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat. Biotechnol. 26, 1276-1284 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , pp. 1276-1284
    • Aasen, T.1
  • 22
    • 67649222358 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    • Chin M.H. et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell 5, 111-123 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 111-123
    • Chin, M.H.1
  • 23
    • 78650752402 scopus 로고    scopus 로고
    • Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
    • Polo J.M. et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat. Biotechnol. 28, 848-855 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 848-855
    • Polo, J.M.1
  • 24
    • 85027958626 scopus 로고    scopus 로고
    • Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
    • Ohi Y. et al. Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat. Cell Biol. 13, 541-549 (2011).
    • (2011) Nat. Cell Biol. , vol.13 , pp. 541-549
    • Ohi, Y.1
  • 25
    • 79959992876 scopus 로고    scopus 로고
    • Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells
    • Bar-Nur O., Russ H.A., Efrat S. & Benvenisty N. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell 9, 17-23 (2011).
    • (2011) Cell Stem Cell , vol.9 , pp. 17-23
    • Bar-Nur, O.1    Russ, H.A.2    Efrat, S.3    Benvenisty, N.4
  • 26
    • 77955449906 scopus 로고    scopus 로고
    • Epigenetic memory in induced pluripotent stem cells
    • Kim K. et al. Epigenetic memory in induced pluripotent stem cells. Nature 467, 285-290 (2010).
    • (2010) Nature , vol.467 , pp. 285-290
    • Kim, K.1
  • 27
    • 77952425747 scopus 로고    scopus 로고
    • Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
    • Stadtfeld M. et al. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature 465, 175-181 (2010).
    • (2010) Nature , vol.465 , pp. 175-181
    • Stadtfeld, M.1
  • 28
    • 56549127713 scopus 로고    scopus 로고
    • Guidelines and techniques for the generation of induced pluripotent stem cells
    • Maherali N. & Hochedlinger K. Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell 3, 595-605 (2008).
    • (2008) Cell Stem Cell , vol.3 , pp. 595-605
    • Maherali, N.1    Hochedlinger, K.2
  • 29
    • 68549128962 scopus 로고    scopus 로고
    • Directed differentiation of pluripotent stem cells: From developmental biology to therapeutic applications
    • Irion S., Nostro M.C., Kattman S.J. & Keller G.M. Directed differentiation of pluripotent stem cells: From developmental biology to therapeutic applications. Cold Spring Harb. Symp. Quant. Biol. 73, 101-110 (2008).
    • (2008) Cold Spring Harb. Symp. Quant. Biol. , vol.73 , pp. 101-110
    • Irion, S.1    Nostro, M.C.2    Kattman, S.J.3    Keller, G.M.4
  • 30
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development
    • DOI 10.1016/j.cell.2008.02.008, PII S009286740800216X
    • Murry C.E. & Keller G. Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development. Cell 132, 661-680 (2008). (Pubitemid 351260059)
    • (2008) Cell , vol.132 , Issue.4 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 31
    • 77957729169 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem-cell models for long-QT syndrome
    • Moretti A. et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N. Engl. J. Med. 363, 1397-1409 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1397-1409
    • Moretti, A.1
  • 32
    • 79952438377 scopus 로고    scopus 로고
    • Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
    • Yazawa M. et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 471, 230-234 (2011).
    • (2011) Nature , vol.471 , pp. 230-234
    • Yazawa, M.1
  • 33
    • 78650995671 scopus 로고    scopus 로고
    • A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects
    • Zhang J. et al. A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell 8, 31-45 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 31-45
    • Zhang, J.1
  • 34
    • 79957866291 scopus 로고    scopus 로고
    • Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs
    • Liu G.H. et al. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell 8, 688-694 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 688-694
    • Liu, G.H.1
  • 35
    • 70450285340 scopus 로고    scopus 로고
    • Technical challenges in using human induced pluripotent stem cells to model disease
    • Saha K. & Jaenisch R. Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 5, 584-595 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 584-595
    • Saha, K.1    Jaenisch, R.2
  • 36
    • 79952898021 scopus 로고    scopus 로고
    • Investigating monogenic and complex diseases with pluripotent stem cells
    • Zhu H., Lensch M.W., Cahan P. & Daley G.Q. Investigating monogenic and complex diseases with pluripotent stem cells. Nat. Rev. Genet. 12, 266-275 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 266-275
    • Zhu, H.1    Lensch, M.W.2    Cahan, P.3    Daley, G.Q.4
  • 37
    • 79952172335 scopus 로고    scopus 로고
    • LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress
    • Nguyen H.N. et al. LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell 8, 267-280 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 267-280
    • Nguyen, H.N.1
  • 38
    • 77949424341 scopus 로고    scopus 로고
    • Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
    • Agarwal S. et al. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 464, 292-296 (2010).
    • (2010) Nature , vol.464 , pp. 292-296
    • Agarwal, S.1


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