-
1
-
-
13444269246
-
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer
-
DOI 10.1038/nm1173
-
Dinulescu DM, Ince TA, Quade BJ, et al. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med 2005;11:63-70. (Pubitemid 40215839)
-
(2005)
Nature Medicine
, vol.11
, Issue.1
, pp. 63-70
-
-
Dinulescu, D.M.1
Ince, T.A.2
Quade, B.J.3
Shafer, S.A.4
Crowley, D.5
Jacks, T.6
-
2
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-49.
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
3
-
-
62449153727
-
Ovarian cancer: Pathology, biology, and disease models
-
Rosen DG, Yang G, Liu G, et al. Ovarian cancer: pathology, biology, and disease models. Front Biosci 2009;14:2089-102.
-
(2009)
Front Biosci
, vol.14
, pp. 2089-2102
-
-
Rosen, D.G.1
Yang, G.2
Liu, G.3
-
4
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
DOI 10.1101/gad.938601
-
Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001;15:3059-87. (Pubitemid 33115673)
-
(2001)
Genes and Development
, vol.15
, Issue.23
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
5
-
-
79960876070
-
Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth
-
Kawabata N, Ijiri K, Ishidou Y, et al. Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth. Int J Oncol 2011;39:899-906.
-
(2011)
Int J Oncol
, vol.39
, pp. 899-906
-
-
Kawabata, N.1
Ijiri, K.2
Ishidou, Y.3
-
6
-
-
84862646026
-
Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem
-
Grammel D, Warmuth-Metz M, von Bueren AO, et al. Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem. Acta Neuropathol 2012;123:601-14.
-
(2012)
Acta Neuropathol
, vol.123
, pp. 601-614
-
-
Grammel, D.1
Warmuth-Metz, M.2
Von Bueren, A.O.3
-
7
-
-
84855804948
-
Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells
-
Wang X, Venugopal C, Manoranjan B, et al. Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells. Oncogene 2012;31:187-99.
-
(2012)
Oncogene
, vol.31
, pp. 187-199
-
-
Wang, X.1
Venugopal, C.2
Manoranjan, B.3
-
8
-
-
79955821961
-
Role of GLI2 in the growth of human osteosarcoma
-
Nagao H, Ijiri K, Hirotsu M, et al. Role of GLI2 in the growth of human osteosarcoma. J Pathol 2011;224:169-79.
-
(2011)
J Pathol
, vol.224
, pp. 169-179
-
-
Nagao, H.1
Ijiri, K.2
Hirotsu, M.3
-
9
-
-
84875695304
-
The hedgehog pathway conditions the bone microenvironment for osteolytic metastasis of breast cancer
-
Das S, Samant RS, Shevde LA. The hedgehog pathway conditions the bone microenvironment for osteolytic metastasis of breast cancer. Int J Breast Cancer 2012;2012:298623.
-
(2012)
Int J Breast Cancer
, vol.2012
, pp. 298623
-
-
Das, S.1
Samant, R.S.2
Shevde, L.A.3
-
10
-
-
84856058700
-
The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer
-
Mazumdar T, DeVecchio J, Agyeman A, et al. The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. Oncotarget 2011;2:638-45.
-
(2011)
Oncotarget
, vol.2
, pp. 638-645
-
-
Mazumdar, T.1
DeVecchio, J.2
Agyeman, A.3
-
11
-
-
78651391800
-
Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model
-
Chang HH, Chen BY, Wu CY, et al. Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model. J Biomed Sci 2011;18:6.
-
(2011)
J Biomed Sci
, vol.18
, pp. 6
-
-
Chang, H.H.1
Chen, B.Y.2
Wu, C.Y.3
-
12
-
-
84858142098
-
Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells
-
Eberl M, Klingler S, Mangelberger D, et al. Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Mol Med 2012;4:218-33.
-
(2012)
EMBO Mol Med
, vol.4
, pp. 218-233
-
-
Eberl, M.1
Klingler, S.2
Mangelberger, D.3
-
13
-
-
77954227128
-
The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment
-
Caro I, Low JA. The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment. Clin Cancer Res 2010;16:3335-9.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3335-3339
-
-
Caro, I.1
Low, J.A.2
-
14
-
-
70350534843
-
Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation
-
Katoh Y, Katoh M. Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med 2009;9:873-86.
-
(2009)
Curr Mol Med
, vol.9
, pp. 873-886
-
-
Katoh, Y.1
Katoh, M.2
-
15
-
-
32444449871
-
GLI transcription factors: Mediators of oncogenic Hedgehog signalling
-
DOI 10.1016/j.ejca.2005.08.039, PII S0959804905010592
-
Kasper M, Regl G, Frischauf AM, et al. GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer 2006;42:437-45. (Pubitemid 43227920)
-
(2006)
European Journal of Cancer
, vol.42
, Issue.4
, pp. 437-445
-
-
Kasper, M.1
Regl, G.2
Frischauf, A.-M.3
Aberger, F.4
-
16
-
-
36349002459
-
Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells
-
DOI 10.1158/0008-5472.CAN-07-2015
-
Thiyagarajan S, Bhatia N, Reagan-Shaw S, et al. Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Cancer Res 2007;67:10642-6. (Pubitemid 350145887)
-
(2007)
Cancer Research
, vol.67
, Issue.22
, pp. 10642-10646
-
-
Thiyagarajan, S.1
Bhatia, N.2
Reagan-Shaw, S.3
Cozma, D.4
Thomas-Tikhonenko, A.5
Ahmad, N.6
Spiegelman, V.S.7
-
17
-
-
34547110771
-
Patched1 regulates hedgehog signaling at the primary cilium
-
DOI 10.1126/science.1139740
-
Rohatgi R, Milenkovic L, Scott MP. Patched1 regulates hedgehog signaling at the primary cilium. Science 2007;317:372-6. (Pubitemid 47106377)
-
(2007)
Science
, vol.317
, Issue.5836
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
18
-
-
66749109245
-
Hedgehog signalling in breast cancer
-
Kasper M, Jaks V, Fiaschi M, et al. Hedgehog signalling in breast cancer. Carcinogenesis 2009;30:903-11.
-
(2009)
Carcinogenesis
, vol.30
, pp. 903-911
-
-
Kasper, M.1
Jaks, V.2
Fiaschi, M.3
-
19
-
-
0242581681
-
Hedgehog signalling in the mouse requires intraflagellar transport proteins
-
DOI 10.1038/nature02061
-
Huangfu D, Liu A, Rakeman AS, et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 2003;426:83-7. (Pubitemid 37432545)
-
(2003)
Nature
, vol.426
, Issue.6962
, pp. 83-87
-
-
Huangfu, D.1
Liu, A.2
Rakeman, A.S.3
Murcia, N.S.4
Niswander, L.5
Anderson, K.V.6
-
22
-
-
0033194243
-
Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of GLI-1
-
Kogerman P, Grimm T, Kogerman L, et al. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol 1999;1:312-9. (Pubitemid 129495783)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.5
, pp. 312-319
-
-
Kogerman, P.1
Grimm, T.2
Kogerman, L.3
Krause, D.4
Unden, A.B.5
Sandstedt, B.6
Toftgard, R.7
Zaphiropoulos, P.G.8
-
23
-
-
31744451535
-
Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway
-
DOI 10.1016/j.devcel.2005.12.013, PII S1534580706000050
-
Svärd J, Heby-Henricson K, Persson-Lek M, et al. Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 2006;10:187-97. (Pubitemid 43174952)
-
(2006)
Developmental Cell
, vol.10
, Issue.2
, pp. 187-197
-
-
Svard, J.1
Henricson, K.H.2
Persson-Lek, M.3
Rozell, B.4
Lauth, M.5
Bergstrom, A.6
Ericson, J.7
Toftgard, R.8
Teglund, S.9
-
24
-
-
0347764480
-
All mouse ventral spinal cord patterning by Hedgehog is Gli dependent and involves an activator function of Gli3
-
DOI 10.1016/S1534-5807(03)00394-0, PII S1534580703003940
-
Bai CB, Stephen D, Joyner AL. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell 2004;6:103-15. (Pubitemid 38089209)
-
(2004)
Developmental Cell
, vol.6
, Issue.1
, pp. 103-115
-
-
Bai, C.B.1
Stephen, D.2
Joyner, A.L.3
-
25
-
-
77952898697
-
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
-
Stecca B, Ruiz I Altaba A. Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol 2010;2:84-95.
-
(2010)
J Mol Cell Biol
, vol.2
, pp. 84-95
-
-
Stecca, B.1
Ruiz, I.2
Altaba, A.3
-
26
-
-
14644401158
-
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
-
DOI 10.1101/gad.325905
-
Stamataki D, Ulloa F, Tsoni SV, et al. A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev 2005;19:626-41. (Pubitemid 40314994)
-
(2005)
Genes and Development
, vol.19
, Issue.5
, pp. 626-641
-
-
Stamataki, D.1
Ulloa, F.2
Tsoni, S.V.3
Mynett, A.4
Briscoe, J.5
-
27
-
-
23844552405
-
Cooperative requirement of the Gli proteins in neurogenesis
-
DOI 10.1242/dev.01905
-
Nguyen V, Chokas AL, Stecca B, et al. Cooperative requirement of the Gli proteins in neurogenesis. Development 2005;132:3267-79. (Pubitemid 41167154)
-
(2005)
Development
, vol.132
, Issue.14
, pp. 3267-3279
-
-
Nguyen, V.1
Chokas, A.L.2
Stecca, B.3
Ruiz I, A.A.4
-
28
-
-
11144327100
-
Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling
-
DOI 10.1016/j.ydbio.2004.10.003, PII S0012160604007183
-
Tyurina OV, Guner B, Popova E, et al. Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Dev Biol 2005;277:537-56. (Pubitemid 40022969)
-
(2005)
Developmental Biology
, vol.277
, Issue.2
, pp. 537-556
-
-
Tyurina, O.V.1
Guner, B.2
Popova, E.3
Feng, J.4
Schier, A.F.5
Kohtz, J.D.6
Karlstrom, R.O.7
-
29
-
-
34250612602
-
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
-
DOI 10.1242/dev.001966
-
Vokes SA, Ji H, McCuine S, et al. Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 2007;134:1977-89. (Pubitemid 46939242)
-
(2007)
Development
, vol.134
, Issue.10
, pp. 1977-1989
-
-
Vokes, S.A.1
Ji, H.2
McCuine, S.3
Tenzen, T.4
Giles, S.5
Zhong, S.6
Longabaugh, W.J.R.7
Davidson, E.H.8
Wong, W.H.9
McMahon, A.P.10
-
30
-
-
53549125545
-
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
-
Vokes SA, Ji H, Wong WH, et al. A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev 2008;22:2651-63.
-
(2008)
Genes Dev
, vol.22
, pp. 2651-2663
-
-
Vokes, S.A.1
Ji, H.2
Wong, W.H.3
-
31
-
-
84859433102
-
BMP and Hedgehog signaling during the development of scleral ossicles
-
Duench K, Franz-Odendaal TA. BMP and Hedgehog signaling during the development of scleral ossicles. Dev Biol 2012;365:251-8.
-
(2012)
Dev Biol
, vol.365
, pp. 251-258
-
-
Duench, K.1
Franz-Odendaal, T.A.2
-
32
-
-
84857119620
-
Sonic hedgehog signaling during adrenal development
-
Laufer E, Kesper D, Vortkamp A, et al. Sonic hedgehog signaling during adrenal development. Mol Cell Endocrinol 2012;351:19-27.
-
(2012)
Mol Cell Endocrinol
, vol.351
, pp. 19-27
-
-
Laufer, E.1
Kesper, D.2
Vortkamp, A.3
-
33
-
-
84856314865
-
Hedgehog signalling in gut development, physiology and cancer
-
Merchant JL. Hedgehog signalling in gut development, physiology and cancer. J Physiol 2012;590:421-32.
-
(2012)
J Physiol
, vol.590
, pp. 421-432
-
-
Merchant, J.L.1
-
34
-
-
84856228854
-
Dominant activation of the hedgehog signaling pathway alters development of the female reproductive tract
-
Migone FF, Ren Y, Cowan RG, et al. Dominant activation of the hedgehog signaling pathway alters development of the female reproductive tract. Genesis 2012;50:28-40.
-
(2012)
Genesis
, vol.50
, pp. 28-40
-
-
Migone, F.F.1
Ren, Y.2
Cowan, R.G.3
-
35
-
-
84860186059
-
Pharmacological modulation of the Hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development
-
Nat R, Salti A, Suciu L, et al. Pharmacological modulation of the Hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development. Stem Cells Dev 2012;21:1016-46.
-
(2012)
Stem Cells Dev
, vol.21
, pp. 1016-1046
-
-
Nat, R.1
Salti, A.2
Suciu, L.3
-
36
-
-
84863502126
-
Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice
-
Ren Y, Cowan RG, Migone FF, et al. Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice. Biol Reprod 2012;86:174.
-
(2012)
Biol Reprod
, vol.86
, pp. 174
-
-
Ren, Y.1
Cowan, R.G.2
Migone, F.F.3
-
37
-
-
79960623943
-
Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity
-
Ihrie RA, Shah JK, Harwell CC, et al. Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity. Neuron 2011;71:250-62.
-
(2011)
Neuron
, vol.71
, pp. 250-262
-
-
Ihrie, R.A.1
Shah, J.K.2
Harwell, C.C.3
-
38
-
-
84860214416
-
Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
-
Tang SN, Fu J, Nall D, et al. Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics. Int J Cancer 2012;131:30-40.
-
(2012)
Int J Cancer
, vol.131
, pp. 30-40
-
-
Tang, S.N.1
Fu, J.2
Nall, D.3
-
39
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
Yauch RL, Dijkgraaf GJ, Alicke B, et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 2009;326:572-4.
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
Dijkgraaf, G.J.2
Alicke, B.3
-
40
-
-
19944433687
-
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
-
Reifenberger J, Wolter M, Knobbe CB, et al. Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol 2005;152:43-51.
-
(2005)
Br J Dermatol
, vol.152
, pp. 43-51
-
-
Reifenberger, J.1
Wolter, M.2
Knobbe, C.B.3
-
41
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
Taylor MD, Liu L, Raffel C, et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet 2002;31:306-10.
-
(2002)
Nat Genet
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
Liu, L.2
Raffel, C.3
-
42
-
-
6944238392
-
Loss of heterozygosity at chromosome 9q22-31 is a frequent and early event in ovarian tumors
-
Byrom J, Mudaliar V, Redman CW, et al. Loss of heterozygosity at chromosome 9q22-31 is a frequent and early event in ovarian tumors. Int J Oncol 2004;24:1271-7.
-
(2004)
Int J Oncol
, vol.24
, pp. 1271-1277
-
-
Byrom, J.1
Mudaliar, V.2
Redman, C.W.3
-
43
-
-
77950505872
-
Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh
-
Yamasaki A, Kameda C, Xu R, et al. Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh. Cancer Immunol Immunother 2010;59:675-86.
-
(2010)
Cancer Immunol Immunother
, vol.59
, pp. 675-686
-
-
Yamasaki, A.1
Kameda, C.2
Xu, R.3
-
44
-
-
52149119128
-
A paracrine requirement for hedgehog signalling in cancer
-
Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008;455:406-10.
-
(2008)
Nature
, vol.455
, pp. 406-410
-
-
Yauch, R.L.1
Gould, S.E.2
Scales, S.J.3
-
45
-
-
63149124772
-
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
-
Tian H, Callahan CA, DuPree KJ, et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A 2009;106:4254-9.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 4254-4259
-
-
Tian, H.1
Callahan, C.A.2
DuPree, K.J.3
-
46
-
-
76349088705
-
National Institutes of Health State-of-the-Science Conference statement: Diagnosis and Management of Ductal Carcinoma In Situ September 22-24, 2009
-
Allegra CJ, Aberle DR, Ganschow P, et al. National Institutes of Health State-of-the-Science Conference statement: Diagnosis and Management of Ductal Carcinoma In Situ September 22-24, 2009. J Natl Cancer Inst 2010;102:161-9.
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 161-169
-
-
Allegra, C.J.1
Aberle, D.R.2
Ganschow, P.3
-
47
-
-
34848901657
-
The Gli code: An information nexus regulating cell fate, stemness and cancer
-
DOI 10.1016/j.tcb.2007.06.007, PII S0962892407001717
-
Ruiz i Altaba A, Mas C, Stecca B. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol 2007;17:438-47. (Pubitemid 47505310)
-
(2007)
Trends in Cell Biology
, vol.17
, Issue.9
, pp. 438-447
-
-
Ruiz I, A.A.1
Mas, C.2
Stecca, B.3
-
48
-
-
77953693899
-
Targeting Hedgehog - A cancer stem cell pathway
-
Merchant AA, Matsui W. Targeting Hedgehog - a cancer stem cell pathway. Clin Cancer Res 2010;16:3130-40.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3130-3140
-
-
Merchant, A.A.1
Matsui, W.2
-
49
-
-
80555145216
-
Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms
-
Singh BN, Fu J, Srivastava RK, et al. Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One 2011;6:e27306.
-
(2011)
PLoS One
, vol.6
-
-
Singh, B.N.1
Fu, J.2
Srivastava, R.K.3
-
50
-
-
73649145223
-
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
-
Varnat F, Duquet A, Malerba M, et al. Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med 2009;1:338-51.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 338-351
-
-
Varnat, F.1
Duquet, A.2
Malerba, M.3
-
51
-
-
35348837163
-
Cyclopamine-mediated Hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
-
DOI 10.1634/stemcells.2007-0166
-
Bar EE, Chaudhry A, Lin A, et al. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 2007;25:2524-33. (Pubitemid 47582744)
-
(2007)
Stem Cells
, vol.25
, Issue.10
, pp. 2524-2533
-
-
Bar, E.E.1
Chaudhry, A.2
Lin, A.3
Fan, X.4
Schreck, K.5
Matsui, W.6
Piccirillo, S.7
Vescovi, A.L.8
DiMeco, F.9
Olivi, A.10
Eberhart, C.G.11
-
52
-
-
64749091867
-
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
Zhao C, Chen A, Jamieson CH, et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009;458:776-9.
-
(2009)
Nature
, vol.458
, pp. 776-779
-
-
Zhao, C.1
Chen, A.2
Jamieson, C.H.3
-
53
-
-
33745728170
-
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
-
Liu S, Dontu G, Mantle ID, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006;66:6063-71.
-
(2006)
Cancer Res
, vol.66
, pp. 6063-6071
-
-
Liu, S.1
Dontu, G.2
Mantle, I.D.3
-
54
-
-
35648995949
-
Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, notch, and bone morphogenic proteins
-
DOI 10.1002/jcb.21509
-
Bailey JM, Singh PK, Hollingsworth MA. Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins. J Cell Biochem 2007;102:829-39. (Pubitemid 350036923)
-
(2007)
Journal of Cellular Biochemistry
, vol.102
, Issue.4
, pp. 829-839
-
-
Bailey, J.M.1
Singh, P.K.2
Hollingsworth, M.A.3
-
55
-
-
79952088432
-
Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer
-
Souzaki M, Kubo M, Kai M, et al. Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer. Cancer Sci 2011;102:373-81.
-
(2011)
Cancer Sci
, vol.102
, pp. 373-381
-
-
Souzaki, M.1
Kubo, M.2
Kai, M.3
-
56
-
-
40949137792
-
Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway
-
DOI 10.1093/carcin/bgm281
-
Yoo YA, Kang MH, Kim JS, et al. Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway. Carcinogenesis 2008;29:480-90. (Pubitemid 351404863)
-
(2008)
Carcinogenesis
, vol.29
, Issue.3
, pp. 480-490
-
-
Yoo, Y.A.1
Kang, M.H.2
Kim, J.S.3
Oh, S.C.4
-
57
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
DOI 10.1038/nature02962
-
Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004;431:707-12. (Pubitemid 39382619)
-
(2004)
Nature
, vol.431
, Issue.7009
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
Dhara, S.4
Gardner, D.5
Maitra, A.6
Isaacs, J.T.7
Berman, D.M.8
Beachy, P.A.9
-
58
-
-
79956219871
-
Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer
-
Onishi H, Kai M, Odate S, et al. Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. Cancer Sci 2011;102:1144-50.
-
(2011)
Cancer Sci
, vol.102
, pp. 1144-1150
-
-
Onishi, H.1
Kai, M.2
Odate, S.3
-
59
-
-
79953788948
-
Targeting the hedgehog pathway: The development of cyclopamine and the development of anti-cancer drugs targeting the hedgehog pathway
-
Gould A, Missailidis S. Targeting the hedgehog pathway: the development of cyclopamine and the development of anti-cancer drugs targeting the hedgehog pathway. Mini Rev Med Chem 2011;11:200-13.
-
(2011)
Mini Rev Med Chem
, vol.11
, pp. 200-213
-
-
Gould, A.1
Missailidis, S.2
-
60
-
-
34249867843
-
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
-
DOI 10.1073/pnas.0609699104
-
Lauth M, Bergström A, Shimokawa T, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A 2007;104:8455-60. (Pubitemid 47175509)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.20
, pp. 8455-8460
-
-
Lauth, M.1
Bergstrom, A.2
Shimokawa, T.3
Toftgard, R.4
-
61
-
-
50649118068
-
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
-
Dierks C, Beigi R, Guo GR, et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 2008;14:238-49.
-
(2008)
Cancer Cell
, vol.14
, pp. 238-249
-
-
Dierks, C.1
Beigi, R.2
Guo, G.R.3
-
62
-
-
84855675635
-
A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists
-
Chenna V, Hu C, Pramanik D, et al. A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists. Mol Cancer Ther 2012;11:165-73.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 165-173
-
-
Chenna, V.1
Hu, C.2
Pramanik, D.3
-
63
-
-
79954611501
-
Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors
-
LoRusso PM, Rudin CM, Reddy JC, et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res 2011;17:2502-11.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2502-2511
-
-
LoRusso, P.M.1
Rudin, C.M.2
Reddy, J.C.3
-
64
-
-
84855661666
-
The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells
-
Tian F, Schrödl K, Kiefl R, et al. The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells. Anticancer Res 2012;32:89-94.
-
(2012)
Anticancer Res
, vol.32
, pp. 89-94
-
-
Tian, F.1
Schrödl, K.2
Kiefl, R.3
-
65
-
-
84856139603
-
Effect of the Hedgehog-inhibitor cyclopamine on mice with osteosarcoma pulmonary metastases
-
Warzecha J, Dinges D, Kaszap B, et al. Effect of the Hedgehog-inhibitor cyclopamine on mice with osteosarcoma pulmonary metastases. Int J Mol Med 2012;29:423-7.
-
(2012)
Int J Mol Med
, vol.29
, pp. 423-427
-
-
Warzecha, J.1
Dinges, D.2
Kaszap, B.3
-
66
-
-
77950647110
-
Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics
-
Peukert S, Miller-Moslin K. Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics. ChemMedChem 2010;5:500-12.
-
(2010)
ChemMedChem
, vol.5
, pp. 500-512
-
-
Peukert, S.1
Miller-Moslin, K.2
-
67
-
-
0032486433
-
Teratogen-mediated inhibition of target tissue response to Shh signaling
-
DOI 10.1126/science.280.5369.1603
-
Cooper MK, Porter JA, Young KE, et al. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 1998;280:1603-7. (Pubitemid 28277705)
-
(1998)
Science
, vol.280
, Issue.5369
, pp. 1603-1607
-
-
Cooper, M.K.1
Porter, J.A.2
Young, K.E.3
Beachy, P.A.4
-
68
-
-
33748611621
-
Targeting the Hedgehog signaling pathway with small molecules
-
Kiselyov AS. Targeting the hedgehog signaling pathway with small molecules. Anticancer Agents Med Chem 2006;6:445-9. (Pubitemid 44377778)
-
(2006)
Anti-Cancer Agents in Medicinal Chemistry
, vol.6
, Issue.5
, pp. 445-449
-
-
Kiselyov, A.S.1
-
69
-
-
60249088794
-
A small molecule that binds Hedgehog and blocks its signaling in human cells
-
Stanton BZ, Peng LF, Maloof N, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol 2009;5:154-6.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 154-156
-
-
Stanton, B.Z.1
Peng, L.F.2
Maloof, N.3
-
70
-
-
0030111258
-
Sertoli cell signaling by Desert hedgehog regulates the male germline
-
Bitgood MJ, Shen L, McMahon AP. Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol 1996;6:298-304.
-
(1996)
Curr Biol
, vol.6
, pp. 298-304
-
-
Bitgood, M.J.1
Shen, L.2
McMahon, A.P.3
-
71
-
-
0035967181
-
Hedgehog acts as a somatic stem cell factor in the Drosophila ovary
-
DOI 10.1038/35069099
-
Zhang Y, Kalderon D. Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature 2001;410:599-604. (Pubitemid 32267206)
-
(2001)
Nature
, vol.410
, Issue.6828
, pp. 599-604
-
-
Zhang, Y.1
Kalderon, D.2
-
72
-
-
84934441358
-
Study origin of germ cells and formation of new primary follicles in adult human and rat ovaries
-
Bukovsky A, Gupta SK, Virant-Klun I, et al. Study origin of germ cells and formation of new primary follicles in adult human and rat ovaries. Methods Mol Biol 2008;450:233-65.
-
(2008)
Methods Mol Biol
, vol.450
, pp. 233-265
-
-
Bukovsky, A.1
Gupta, S.K.2
Virant-Klun, I.3
-
73
-
-
84861460366
-
Ovarian cancer stem cell markers: Prognostic and therapeutic implications
-
Burgos-Ojeda D, Rueda BR, Buckanovich RJ. Ovarian cancer stem cell markers: prognostic and therapeutic implications. Cancer Lett 2012;322:1-7.
-
(2012)
Cancer Lett
, vol.322
, pp. 1-7
-
-
Burgos-Ojeda, D.1
Rueda, B.R.2
Buckanovich, R.J.3
-
74
-
-
84861344069
-
Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer
-
Cao L, Shao M, Schilder J, et al. Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer. Oncogene 2012;31:2521-34.
-
(2012)
Oncogene
, vol.31
, pp. 2521-2534
-
-
Cao, L.1
Shao, M.2
Schilder, J.3
-
75
-
-
0035008525
-
Ovarian surface epithelium: Biology, endocrinology, and pathology
-
DOI 10.1210/er.22.2.255
-
Auersperg N, Wong AS, Choi KC, et al. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr Rev 2001;22:255-88. (Pubitemid 32458162)
-
(2001)
Endocrine Reviews
, vol.22
, Issue.2
, pp. 255-288
-
-
Auersperg, N.1
Wong, A.S.T.2
Choi, K.-C.3
Kang, S.K.4
Leung, P.C.K.5
-
76
-
-
35848946387
-
Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: An exception to the norm
-
DOI 10.1002/jcp.21240
-
Ahmed N, Thompson EW, Quinn MA. Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm. J Cell Physiol 2007;213:581-8. (Pubitemid 350058249)
-
(2007)
Journal of Cellular Physiology
, vol.213
, Issue.3
, pp. 581-588
-
-
Ahmed, N.1
Thompson, E.W.2
Quinn, M.A.3
-
77
-
-
38849100342
-
The morphogenic function of E-cadherin-mediated adherens junctions in epithelial ovarian carcinoma formation and progression
-
DOI 10.1111/j.1432-0436.2007.00193.x
-
Wu C, Cipollone J, Maines-Bandiera S, et al. The morphogenic function of E-cadherin-mediated adherens junctions in epithelial ovarian carcinoma formation and progression. Differentiation 2008;76:193-205. (Pubitemid 351197172)
-
(2008)
Differentiation
, vol.76
, Issue.2
, pp. 193-205
-
-
Wu, C.1
Cipollone, J.2
Maines-Bandiera, S.3
Tan, C.4
Karsan, A.5
Auersperg, N.6
Roskelley, C.D.7
-
78
-
-
33947219432
-
Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells
-
DOI 10.1158/0008-5472.CAN-06-2808
-
Symowicz J, Adley BP, Gleason KJ, et al. Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res 2007;67:2030-9. (Pubitemid 46424220)
-
(2007)
Cancer Research
, vol.67
, Issue.5
, pp. 2030-2039
-
-
Symowicz, J.1
Adley, B.P.2
Gleason, K.J.3
Johnson, J.J.4
Ghosh, S.5
Fishman, D.A.6
Hudson, L.G.7
Stack, M.S.8
-
79
-
-
79960849567
-
Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells
-
Ray A, Meng E, Reed E, et al. Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells. Int J Oncol 2011;39:797-804.
-
(2011)
Int J Oncol
, vol.39
, pp. 797-804
-
-
Ray, A.1
Meng, E.2
Reed, E.3
-
80
-
-
33751337806
-
Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis
-
DOI 10.1111/j.1349-7006.2006.00353.x
-
Chen X, Horiuchi A, Kikuchi N, et al. Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis. Cancer Sci 2007;98:68-76. (Pubitemid 44803922)
-
(2007)
Cancer Science
, vol.98
, Issue.1
, pp. 68-76
-
-
Chen, X.1
Horiuchi, A.2
Kikuchi, N.3
Osada, R.4
Yoshida, J.5
Shiozawa, T.6
Konishi, I.7
-
81
-
-
59449104701
-
Role of hedgehog signaling in ovarian cancer
-
Bhattacharya R, Kwon J, Ali B, et al. Role of hedgehog signaling in ovarian cancer. Clin Cancer Res 2008;14:7659-66.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7659-7666
-
-
Bhattacharya, R.1
Kwon, J.2
Ali, B.3
-
82
-
-
58949100355
-
Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
-
Liao X, Siu MK, Au CW, et al. Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 2009;30:131-40.
-
(2009)
Carcinogenesis
, vol.30
, pp. 131-140
-
-
Liao, X.1
Siu, M.K.2
Au, C.W.3
-
83
-
-
71549129295
-
Activation of hedgehog signaling is not a frequent event in ovarian cancers
-
Yang L, He J, Huang S, et al. Activation of hedgehog signaling is not a frequent event in ovarian cancers. Mol Cancer 2009;8:112.
-
(2009)
Mol Cancer
, vol.8
, pp. 112
-
-
Yang, L.1
He, J.2
Huang, S.3
-
84
-
-
83055196860
-
Wnt and hedgehog gene pathway expression in serous ovarian cancer
-
Schmid S, Bieber M, Zhang F, et al. Wnt and hedgehog gene pathway expression in serous ovarian cancer. Int J Gynecol Cancer 2011;21:975-80.
-
(2011)
Int J Gynecol Cancer
, vol.21
, pp. 975-980
-
-
Schmid, S.1
Bieber, M.2
Zhang, F.3
-
85
-
-
82255169379
-
Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model
-
McCann CK, Growdon WB, Kulkarni-Datar K, et al. Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model. PLoS One 2011;6:e28077.
-
(2011)
PLoS One
, vol.6
-
-
McCann, C.K.1
Growdon, W.B.2
Kulkarni-Datar, K.3
|