-
1
-
-
8444228878
-
An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
-
Adolphe C, Narang M, Ellis T, Wicking C, Kaur P & Wainwright B (2004). An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 131, 5009-5019.
-
(2004)
Development
, vol.131
, pp. 5009-5019
-
-
Adolphe, C.1
Narang, M.2
Ellis, T.3
Wicking, C.4
Kaur, P.5
Wainwright, B.6
-
2
-
-
63949086103
-
Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation
-
Alinger B, Kiesslich T, Datz C, Aberger F, Strasser F, Berr F, Dietze O, Kaserer K & Hauser-Kronberger C (2009). Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation. Virchows Arch 454, 369-379.
-
(2009)
Virchows Arch
, vol.454
, pp. 369-379
-
-
Alinger, B.1
Kiesslich, T.2
Datz, C.3
Aberger, F.4
Strasser, F.5
Berr, F.6
Dietze, O.7
Kaserer, K.8
Hauser-Kronberger, C.9
-
3
-
-
79951850782
-
Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons
-
Beug ST, Parks RJ, McBride HM & Wallace VA (2011). Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons. Mol Cell Neurosci 46, 583-596.
-
(2011)
Mol Cell Neurosci
, vol.46
, pp. 583-596
-
-
Beug, S.T.1
Parks, R.J.2
McBride, H.M.3
Wallace, V.A.4
-
4
-
-
77955293319
-
Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog
-
Buglino JA & Resh MD (2010). Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. PLoS One 5, e11195.
-
(2010)
PLoS One
, vol.5
-
-
Buglino, J.A.1
Resh, M.D.2
-
5
-
-
0028966517
-
Proteolytic processing yields two secreted forms of sonic hedgehog
-
Bumcrot DA, Takada R & McMahon AP (1995). Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol 15, 2294-2303.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2294-2303
-
-
Bumcrot, D.A.1
Takada, R.2
McMahon, A.P.3
-
6
-
-
79961221518
-
Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium
-
Callejo A, Bilioni A, Mollica E, Gorfinkiel N, Andres G, Ibanez C, Torroja C, Doglio L, Sierra J & Guerrero I (2011). Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium. Proc Natl Acad Sci U S A 108, 12591-12598.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 12591-12598
-
-
Callejo, A.1
Bilioni, A.2
Mollica, E.3
Gorfinkiel, N.4
Andres, G.5
Ibanez, C.6
Torroja, C.7
Doglio, L.8
Sierra, J.9
Guerrero, I.10
-
7
-
-
0032506115
-
Characterization of two patched receptors for the vertebrate hedgehog protein family
-
Carpenter D, Stone DM, Brush J, Ryan A, Armanini M, Frantz G, Rosenthal A & de Sauvage FJ (1998). Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A 95, 13630-13634.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 13630-13634
-
-
Carpenter, D.1
Stone, D.M.2
Brush, J.3
Ryan, A.4
Armanini, M.5
Frantz, G.6
Rosenthal, A.7
de Sauvage, F.J.8
-
8
-
-
0037125938
-
Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling
-
Caspary T, Garcia-Garcia MJ, Huangfu D, Eggenschwiler JT, Wyler MR, Rakeman AS, Alcorn HL & Anderson KV (2002). Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling. Curr Biol 12, 1628-1632.
-
(2002)
Curr Biol
, vol.12
, pp. 1628-1632
-
-
Caspary, T.1
Garcia-Garcia, M.J.2
Huangfu, D.3
Eggenschwiler, J.T.4
Wyler, M.R.5
Rakeman, A.S.6
Alcorn, H.L.7
Anderson, K.V.8
-
9
-
-
77955096244
-
Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling
-
Chang H, Li Q, Moraes RC, Lewis MT & Hamel PA (2010). Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling. Int J Biochem Cell Biol 42, 1462-1471.
-
(2010)
Int J Biochem Cell Biol
, vol.42
, pp. 1462-1471
-
-
Chang, H.1
Li, Q.2
Moraes, R.C.3
Lewis, M.T.4
Hamel, P.A.5
-
10
-
-
79952433637
-
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
-
Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA & Salic A (2011). Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol 192, 825-838.
-
(2011)
J Cell Biol
, vol.192
, pp. 825-838
-
-
Chen, X.1
Tukachinsky, H.2
Huang, C.H.3
Jao, C.4
Chu, Y.R.5
Tang, H.Y.6
Mueller, B.7
Schulman, S.8
Rapoport, T.A.9
Salic, A.10
-
11
-
-
78449240951
-
Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
-
Choi SS, Syn WK, Karaca GF, Omenetti A, Moylan CA, Witek RP, Agboola KM, Jung Y, Michelotti GA & Diehl AM (2010). Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. J Biol Chem 285, 36551-36560.
-
(2010)
J Biol Chem
, vol.285
, pp. 36551-36560
-
-
Choi, S.S.1
Syn, W.K.2
Karaca, G.F.3
Omenetti, A.4
Moylan, C.A.5
Witek, R.P.6
Agboola, K.M.7
Jung, Y.8
Michelotti, G.A.9
Diehl, A.M.10
-
12
-
-
70450257573
-
Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation
-
Dennler S, Andre J, Verrecchia F & Mauviel A (2009). Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation. J Biol Chem 284, 31523-31531.
-
(2009)
J Biol Chem
, vol.284
, pp. 31523-31531
-
-
Dennler, S.1
Andre, J.2
Verrecchia, F.3
Mauviel, A.4
-
13
-
-
65549150886
-
Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells
-
Dierker T, Dreier R, Petersen A, Bordych C & Grobe K (2009). Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells. J Biol Chem 284, 8013-8022.
-
(2009)
J Biol Chem
, vol.284
, pp. 8013-8022
-
-
Dierker, T.1
Dreier, R.2
Petersen, A.3
Bordych, C.4
Grobe, K.5
-
14
-
-
78649307378
-
Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion
-
El-Zaatari M, Zavros Y, Tessier A, Waghray M, Lentz S, Gumucio D, Todisco A & Merchant JL (2010). Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology 139, 2061-2071.
-
(2010)
Gastroenterology
, vol.139
, pp. 2061-2071
-
-
El-Zaatari, M.1
Zavros, Y.2
Tessier, A.3
Waghray, M.4
Lentz, S.5
Gumucio, D.6
Todisco, A.7
Merchant, J.L.8
-
15
-
-
78449258451
-
Requirement of TGFβ signaling for SMO-mediated carcinogenesis
-
Fan Q, He M, Sheng T, Zhang X, Sinha M, Luxon B, Zhao X & Xie J (2010). Requirement of TGFβ signaling for SMO-mediated carcinogenesis. J Biol Chem 285, 36570-36576.
-
(2010)
J Biol Chem
, vol.285
, pp. 36570-36576
-
-
Fan, Q.1
He, M.2
Sheng, T.3
Zhang, X.4
Sinha, M.5
Luxon, B.6
Zhao, X.7
Xie, J.8
-
16
-
-
45149086312
-
Primers on molecular pathways GLI: more than just Hedgehog?
-
Fernandez-Zapico ME (2008). Primers on molecular pathways GLI: more than just Hedgehog? Pancreatology 8, 227-229.
-
(2008)
Pancreatology
, vol.8
, pp. 227-229
-
-
Fernandez-Zapico, M.E.1
-
17
-
-
33745745896
-
Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer
-
Fukaya M, Isohata N, Ohta H, Aoyagi K, Ochiya T, Saeki N, Yanagihara K, Nakanishi Y, Taniguchi H, Sakamoto H, Shimoda T, Nimura Y, Yoshida T & Sasaki H (2006). Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology 131, 14-29.
-
(2006)
Gastroenterology
, vol.131
, pp. 14-29
-
-
Fukaya, M.1
Isohata, N.2
Ohta, H.3
Aoyagi, K.4
Ochiya, T.5
Saeki, N.6
Yanagihara, K.7
Nakanishi, Y.8
Taniguchi, H.9
Sakamoto, H.10
Shimoda, T.11
Nimura, Y.12
Yoshida, T.13
Sasaki, H.14
-
20
-
-
40749144679
-
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
-
Haycraft CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ & Yoder BK (2005). Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1, e53.
-
(2005)
PLoS Genet
, vol.1
-
-
Haycraft, C.J.1
Banizs, B.2
Aydin-Son, Y.3
Zhang, Q.4
Michaud, E.J.5
Yoder, B.K.6
-
21
-
-
80054022786
-
Gli proteins in development and disease
-
Hui CC & Angers S (2011). Gli proteins in development and disease. Annu Rev Cell Dev Biol 27, 513-537.
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 513-537
-
-
Hui, C.C.1
Angers, S.2
-
22
-
-
52149105787
-
Lysosomes in apoptosis
-
Ivanova S, Repnik U, Bojic L, Petelin A, Turk V & Turk B (2008). Lysosomes in apoptosis. Methods Enzymol 442, 183-199.
-
(2008)
Methods Enzymol
, vol.442
, pp. 183-199
-
-
Ivanova, S.1
Repnik, U.2
Bojic, L.3
Petelin, A.4
Turk, V.5
Turk, B.6
-
23
-
-
79551514021
-
TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling
-
Johnson RW, Nguyen MP, Padalecki SS, Grubbs BG, Merkel AR, Oyajobi BO, Matrisian LM, Mundy GR & Sterling JA (2011). TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res 71, 822-831.
-
(2011)
Cancer Res
, vol.71
, pp. 822-831
-
-
Johnson, R.W.1
Nguyen, M.P.2
Padalecki, S.S.3
Grubbs, B.G.4
Merkel, A.R.5
Oyajobi, B.O.6
Matrisian, L.M.7
Mundy, G.R.8
Sterling, J.A.9
-
24
-
-
0036181085
-
Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development
-
Kageyama T (2002). Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development. Cell Mol Life Sci 59, 288-306.
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 288-306
-
-
Kageyama, T.1
-
25
-
-
0026580058
-
Identifying and counting epithelial cell types in the 'corpus' of the mouse stomach
-
Karam SM & Leblond CP (1992). Identifying and counting epithelial cell types in the 'corpus' of the mouse stomach. Anat Rec 232, 231-246.
-
(1992)
Anat Rec
, vol.232
, pp. 231-246
-
-
Karam, S.M.1
Leblond, C.P.2
-
26
-
-
27744445194
-
Comparative genomics on Sonic hedgehog orthologs
-
Katoh Y & Katoh M (2005). Comparative genomics on Sonic hedgehog orthologs. Oncol Rep 14, 1087-1090.
-
(2005)
Oncol Rep
, vol.14
, pp. 1087-1090
-
-
Katoh, Y.1
Katoh, M.2
-
27
-
-
76049114315
-
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
-
Kim J, Kato M & Beachy PA (2009). Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A 106, 21666-21671.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 21666-21671
-
-
Kim, J.1
Kato, M.2
Beachy, P.A.3
-
28
-
-
0025156778
-
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
-
Kinzler KW & Vogelstein B (1990). The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol Cell Biol 10, 634-642.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 634-642
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
29
-
-
67650979371
-
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning
-
Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison BB, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz AA, Kottmann AH & Gumucio DL (2009). Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology 137, 618-628.
-
(2009)
Gastroenterology
, vol.137
, pp. 618-628
-
-
Kolterud, A.1
Grosse, A.S.2
Zacharias, W.J.3
Walton, K.D.4
Kretovich, K.E.5
Madison, B.B.6
Waghray, M.7
Ferris, J.E.8
Hu, C.9
Merchant, J.L.10
Dlugosz, A.A.11
Kottmann, A.H.12
Gumucio, D.L.13
-
30
-
-
35848938488
-
Non-Canonical Activation of GLI Transcription Factors: Implications for Targeted Anti-Cancer Therapy
-
Lauth M & Toftgard R (2007). Non-Canonical Activation of GLI Transcription Factors: Implications for Targeted Anti-Cancer Therapy. Cell Cycle 6, 2458-2463.
-
(2007)
Cell Cycle
, vol.6
, pp. 2458-2463
-
-
Lauth, M.1
Toftgard, R.2
-
31
-
-
0028641336
-
Autoproteolysis in hedgehog protein biogenesis
-
Lee JJ, Ekker SC, von Kessler DP, Porter JA, Sun BI & Beachy PA (1994). Autoproteolysis in hedgehog protein biogenesis. Science 266, 1528-1537.
-
(1994)
Science
, vol.266
, pp. 1528-1537
-
-
Lee, J.J.1
Ekker, S.C.2
von Kessler, D.P.3
Porter, J.A.4
Sun, B.I.5
Beachy, P.A.6
-
33
-
-
13944259054
-
Epithelial hedgehog signals pattern the intestinal crypt-villus axis
-
Madison BB, Braunstein K, Kuizon E, Portman K, Qiao XT & Gumucio DL (2005). Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 132, 279-289.
-
(2005)
Development
, vol.132
, pp. 279-289
-
-
Madison, B.B.1
Braunstein, K.2
Kuizon, E.3
Portman, K.4
Qiao, X.T.5
Gumucio, D.L.6
-
34
-
-
65549099669
-
FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine
-
Madison BB, McKenna LB, Dolson D, Epstein DJ & Kaestner KH (2009). FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. J Biol Chem 284, 5936-5944.
-
(2009)
J Biol Chem
, vol.284
, pp. 5936-5944
-
-
Madison, B.B.1
McKenna, L.B.2
Dolson, D.3
Epstein, D.J.4
Kaestner, K.H.5
-
36
-
-
77950624255
-
Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors
-
Merchant A, Joseph G, Wang Q, Brennan S & Matsui W (2010a). Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood 115, 2391-2396.
-
(2010)
Blood
, vol.115
, pp. 2391-2396
-
-
Merchant, A.1
Joseph, G.2
Wang, Q.3
Brennan, S.4
Matsui, W.5
-
38
-
-
77953943126
-
Not lost in space: trafficking in the hedgehog signaling pathway
-
Milenkovic L & Scott MP (2010). Not lost in space: trafficking in the hedgehog signaling pathway. Sci Signal 3, pe14.
-
(2010)
Sci Signal
, vol.3
-
-
Milenkovic, L.1
Scott, M.P.2
-
39
-
-
0031683165
-
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
-
Motoyama J, Liu J, Mo R, Ding Q, Post M & Hui CC (1998). Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 20, 54-57.
-
(1998)
Nat Genet
, vol.20
, pp. 54-57
-
-
Motoyama, J.1
Liu, J.2
Mo, R.3
Ding, Q.4
Post, M.5
Hui, C.C.6
-
40
-
-
78649713510
-
Mature chief cells are cryptic progenitors for metaplasia in the stomach
-
Nam KT, Lee HJ, Sousa JF, Weis VG, O'Neal RL, Finke PE, Romero-Gallo J, Shi G, Mills JC, Peek RM Jr, Konieczny SF & Goldenring JR (2010). Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology 139, 2028-2037.
-
(2010)
Gastroenterology
, vol.139
, pp. 2028-2037
-
-
Nam, K.T.1
Lee, H.J.2
Sousa, J.F.3
Weis, V.G.4
O'Neal, R.L.5
Finke, P.E.6
Romero-Gallo, J.7
Shi, G.8
Mills, J.C.9
Peek Jr, R.M.10
Konieczny, S.F.11
Goldenring, J.R.12
-
41
-
-
38649116307
-
A molecular signature of gastric metaplasia arising in response to acute parietal cell loss
-
Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S & Goldenring JR (2008). A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology 134, 511-522.
-
(2008)
Gastroenterology
, vol.134
, pp. 511-522
-
-
Nozaki, K.1
Ogawa, M.2
Williams, J.A.3
Lafleur, B.J.4
Ng, V.5
Drapkin, R.I.6
Mills, J.C.7
Konieczny, S.F.8
Nomura, S.9
Goldenring, J.R.10
-
42
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
Nusslein-Volhard C & Wieschaus E (1980). Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801.
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
-
43
-
-
79958198050
-
Sonic hedgehog shedding results in functional activation of the solubilized protein
-
Ohlig S, Farshi P, Pickhinke U, van den Boom J, Hoing S, Jakuschev S, Hoffmann D, Dreier R, Scholer HR, Dierker T, Bordych C & Grobe K (2011). Sonic hedgehog shedding results in functional activation of the solubilized protein. Dev Cell 20, 764-774.
-
(2011)
Dev Cell
, vol.20
, pp. 764-774
-
-
Ohlig, S.1
Farshi, P.2
Pickhinke, U.3
van den Boom, J.4
Hoing, S.5
Jakuschev, S.6
Hoffmann, D.7
Dreier, R.8
Scholer, H.R.9
Dierker, T.10
Bordych, C.11
Grobe, K.12
-
45
-
-
41549118422
-
The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer
-
Omenetti A & Diehl AM (2008). The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol 294, G595-598.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.294
-
-
Omenetti, A.1
Diehl, A.M.2
-
46
-
-
4143097168
-
Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia
-
Oniscu A, James RM, Morris RG, Bader S, Malcomson RD & Harrison DJ (2004). Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. J Pathol 203, 909-917.
-
(2004)
J Pathol
, vol.203
, pp. 909-917
-
-
Oniscu, A.1
James, R.M.2
Morris, R.G.3
Bader, S.4
Malcomson, R.D.5
Harrison, D.J.6
-
47
-
-
0034920373
-
Comparative biological responses to human Sonic, Indian, and Desert hedgehog
-
Pathi S, Pagan-Westphal S, Baker DP, Garber EA, Rayhorn P, Bumcrot D, Tabin CJ, Blake Pepinsky R & Williams KP (2001). Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech Dev 106, 107-117.
-
(2001)
Mech Dev
, vol.106
, pp. 107-117
-
-
Pathi, S.1
Pagan-Westphal, S.2
Baker, D.P.3
Garber, E.A.4
Rayhorn, P.5
Bumcrot, D.6
Tabin, C.J.7
Blake Pepinsky, R.8
Williams, K.P.9
-
48
-
-
0037227766
-
The vertebrate primary cilium is a sensory organelle
-
Pazour GJ & Witman GB (2003). The vertebrate primary cilium is a sensory organelle. Curr Opin Cell Biol 15, 105-110.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 105-110
-
-
Pazour, G.J.1
Witman, G.B.2
-
50
-
-
15444359695
-
Identification of a palmitic acid-modified form of human Sonic hedgehog
-
Pepinsky RB, Zeng C, Wen D, Rayhorn P, Baker DP, Williams KP, Bixler SA, Ambrose CM, Garber EA, Miatkowski K, Taylor FR, Wang EA & Galdes A (1998). Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem 273, 14037-14045.
-
(1998)
J Biol Chem
, vol.273
, pp. 14037-14045
-
-
Pepinsky, R.B.1
Zeng, C.2
Wen, D.3
Rayhorn, P.4
Baker, D.P.5
Williams, K.P.6
Bixler, S.A.7
Ambrose, C.M.8
Garber, E.A.9
Miatkowski, K.10
Taylor, F.R.11
Wang, E.A.12
Galdes, A.13
-
51
-
-
15844386540
-
Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
-
Porter JA, Ekker SC, Park WJ, von Kessler DP, Young KE, Chen CH, Ma Y, Woods AS, Cotter RJ, Koonin EV & Beachy PA (1996a). Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell 86, 21-34.
-
(1996)
Cell
, vol.86
, pp. 21-34
-
-
Porter, J.A.1
Ekker, S.C.2
Park, W.J.3
von Kessler, D.P.4
Young, K.E.5
Chen, C.H.6
Ma, Y.7
Woods, A.S.8
Cotter, R.J.9
Koonin, E.V.10
Beachy, P.A.11
-
52
-
-
0028948811
-
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
-
Porter JA, von Kessler DP, Ekker SC, Young KE, Lee JJ, Moses K & Beachy PA (1995). The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374, 363-366.
-
(1995)
Nature
, vol.374
, pp. 363-366
-
-
Porter, J.A.1
von Kessler, D.P.2
Ekker, S.C.3
Young, K.E.4
Lee, J.J.5
Moses, K.6
Beachy, P.A.7
-
53
-
-
0029844192
-
Cholesterol modification of hedgehog signaling proteins in animal development
-
Porter JA, Young KE & Beachy PA (1996b). Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255-259.
-
(1996)
Science
, vol.274
, pp. 255-259
-
-
Porter, J.A.1
Young, K.E.2
Beachy, P.A.3
-
54
-
-
79751501829
-
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
-
Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, Shibata W, Diprete B, Betz KS, Friedman R, Varro A, Tycko B & Wang TC (2011). Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell 19, 257-272.
-
(2011)
Cancer Cell
, vol.19
, pp. 257-272
-
-
Quante, M.1
Tu, S.P.2
Tomita, H.3
Gonda, T.4
Wang, S.S.5
Takashi, S.6
Baik, G.H.7
Shibata, W.8
Diprete, B.9
Betz, K.S.10
Friedman, R.11
Varro, A.12
Tycko, B.13
Wang, T.C.14
-
55
-
-
0033916281
-
Hedgehog signals regulate multiple aspects of gastrointestinal development
-
Ramalho-Santos M, Melton DA & McMahon AP (2000). Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127, 2763-2772.
-
(2000)
Development
, vol.127
, pp. 2763-2772
-
-
Ramalho-Santos, M.1
Melton, D.A.2
McMahon, A.P.3
-
56
-
-
33846489141
-
The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1
-
Ramsey VG, Doherty JM, Chen CC, Stappenbeck TS, Konieczny SF & Mills JC (2007). The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development 134, 211-222.
-
(2007)
Development
, vol.134
, pp. 211-222
-
-
Ramsey, V.G.1
Doherty, J.M.2
Chen, C.C.3
Stappenbeck, T.S.4
Konieczny, S.F.5
Mills, J.C.6
-
57
-
-
80053413477
-
The epigenetic regulation of stem cell factors in hepatic stellate cells
-
Reister S, Kordes C, Sawitza I & Haussinger D (2011). The epigenetic regulation of stem cell factors in hepatic stellate cells. Stem Cells Dev 20, 1687-1699.
-
(2011)
Stem Cells Dev
, vol.20
, pp. 1687-1699
-
-
Reister, S.1
Kordes, C.2
Sawitza, I.3
Haussinger, D.4
-
58
-
-
0029004233
-
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
-
Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, Beachy PA & Jessell TM (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81, 445-455.
-
(1995)
Cell
, vol.81
, pp. 445-455
-
-
Roelink, H.1
Porter, J.A.2
Chiang, C.3
Tanabe, Y.4
Chang, D.T.5
Beachy, P.A.6
Jessell, T.M.7
-
59
-
-
80054020133
-
Morphogen gradients: from generation to interpretation
-
Rogers KW & Schier AF (2011). Morphogen gradients: from generation to interpretation. Annu Rev Cell Dev Biol 27, 377-407.
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 377-407
-
-
Rogers, K.W.1
Schier, A.F.2
-
60
-
-
0029649309
-
Nobel prizes: fly development work bears prize-winning fruit
-
Roush W (1995). Nobel prizes: fly development work bears prize-winning fruit. Science 270, 380-381.
-
(1995)
Science
, vol.270
, pp. 380-381
-
-
Roush, W.1
-
61
-
-
77953362373
-
Hedgehog signaling and gastrointestinal cancer
-
Saqui-Salces M & Merchant JL (2010). Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta 1803, 786-795.
-
(2010)
Biochim Biophys Acta
, vol.1803
, pp. 786-795
-
-
Saqui-Salces, M.1
Merchant, J.L.2
-
62
-
-
0032848136
-
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
-
Sasaki H, Nishizaki Y, Hui C, Nakafuku M & Kondoh H (1999). Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915-3924.
-
(1999)
Development
, vol.126
, pp. 3915-3924
-
-
Sasaki, H.1
Nishizaki, Y.2
Hui, C.3
Nakafuku, M.4
Kondoh, H.5
-
63
-
-
67650289584
-
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
-
Scales SJ & de Sauvage FJ (2009). Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 30, 303-312.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 303-312
-
-
Scales, S.J.1
de Sauvage, F.J.2
-
64
-
-
33644849523
-
Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal
-
Sheng T, Chi S, Zhang X & Xie J (2006). Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal. J Biol Chem 281, 9-12.
-
(2006)
J Biol Chem
, vol.281
, pp. 9-12
-
-
Sheng, T.1
Chi, S.2
Zhang, X.3
Xie, J.4
-
65
-
-
0032902081
-
The evolution of the hedgehog gene family in chordates: insights from amphioxus hedgehog
-
Shimeld SM (1999). The evolution of the hedgehog gene family in chordates: insights from amphioxus hedgehog. Dev Genes Evol 209, 40-47.
-
(1999)
Dev Genes Evol
, vol.209
, pp. 40-47
-
-
Shimeld, S.M.1
-
66
-
-
77953962718
-
Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonates
-
Silbereis J, Heintz T, Taylor MM, Ganat Y, Ment LR, Bordey A & Vaccarino F (2010). Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonates. Mol Cell Neurosci 44, 362-373.
-
(2010)
Mol Cell Neurosci
, vol.44
, pp. 362-373
-
-
Silbereis, J.1
Heintz, T.2
Taylor, M.M.3
Ganat, Y.4
Ment, L.R.5
Bordey, A.6
Vaccarino, F.7
-
67
-
-
77952898697
-
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
-
Stecca B & Ruiz IAA (2010). Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol 2, 84-95.
-
(2010)
J Mol Cell Biol
, vol.2
, pp. 84-95
-
-
Stecca, B.1
Ruiz, I.A.A.2
-
68
-
-
18144388632
-
Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells
-
Stepan V, Ramamoorthy S, Nitsche H, Zavros Y, Merchant JL & Todisco A (2005). Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. J Biol Chem 280, 15700-15708.
-
(2005)
J Biol Chem
, vol.280
, pp. 15700-15708
-
-
Stepan, V.1
Ramamoorthy, S.2
Nitsche, H.3
Zavros, Y.4
Merchant, J.L.5
Todisco, A.6
-
69
-
-
70349436007
-
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease
-
Syn WK, Jung Y, Omenetti A, Abdelmalek M, Guy CD, Yang L, Wang J, Witek RP, Fearing CM, Pereira TA, Teaberry V, Choi SS, Conde-Vancells J, Karaca GF & Diehl AM (2009). Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology 137, 1478-1488.
-
(2009)
Gastroenterology
, vol.137
, pp. 1478-1488
-
-
Syn, W.K.1
Jung, Y.2
Omenetti, A.3
Abdelmalek, M.4
Guy, C.D.5
Yang, L.6
Wang, J.7
Witek, R.P.8
Fearing, C.M.9
Pereira, T.A.10
Teaberry, V.11
Choi, S.S.12
Conde-Vancells, J.13
Karaca, G.F.14
Diehl, A.M.15
-
70
-
-
77649337790
-
Hedgehog beyond medulloblastoma and basal cell carcinoma
-
Teglund S & Toftgard R (2010). Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 1805, 181-208.
-
(2010)
Biochim Biophys Acta
, vol.1805
, pp. 181-208
-
-
Teglund, S.1
Toftgard, R.2
-
71
-
-
0030929331
-
Post-translational processing and renal expression of mouse Indian hedgehog
-
Valentini RP, Brookhiser WT, Park J, Yang T, Briggs J, Dressler G & Holzman LB (1997). Post-translational processing and renal expression of mouse Indian hedgehog. J Biol Chem 272, 8466-8473.
-
(1997)
J Biol Chem
, vol.272
, pp. 8466-8473
-
-
Valentini, R.P.1
Brookhiser, W.T.2
Park, J.3
Yang, T.4
Briggs, J.5
Dressler, G.6
Holzman, L.B.7
-
72
-
-
35648977027
-
Hedgehog signaling in development and homeostasis of the gastrointestinal tract
-
van den Brink GR (2007). Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol Rev 87, 1343-1375.
-
(2007)
Physiol Rev
, vol.87
, pp. 1343-1375
-
-
van den Brink, G.R.1
-
73
-
-
66149103193
-
Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the hedgehog pathway
-
van Dop WA, Uhmann A, Wijgerde M, Sleddens-Linkels E, Heijmans J, Offerhaus GJ, van den Bergh Weerman MA, Boeckxstaens GE, Hommes DW, Hardwick JC, Hahn H & van den Brink GR (2009). Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the hedgehog pathway. Gastroenterology 136, 2195-2203.
-
(2009)
Gastroenterology
, vol.136
, pp. 2195-2203
-
-
van Dop, W.A.1
Uhmann, A.2
Wijgerde, M.3
Sleddens-Linkels, E.4
Heijmans, J.5
Offerhaus, G.J.6
van den Bergh Weerman, M.A.7
Boeckxstaens, G.E.8
Hommes, D.W.9
Hardwick, J.C.10
Hahn, H.11
van den Brink, G.R.12
-
74
-
-
73649087231
-
Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling
-
Varnat F, Zacchetti G & Ruiz i Altaba A (2010). Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. Mech Dev 127, 73-81.
-
(2010)
Mech Dev
, vol.127
, pp. 73-81
-
-
Varnat, F.1
Zacchetti, G.2
Ruiz i Altaba, A.3
-
75
-
-
0033595706
-
β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G & Citron M (1999). β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
76
-
-
75149191890
-
Interleukin-1β promotes gastric atrophy through suppression of Sonic Hedgehog
-
Waghray M, Zavros Y, Saqui-Salces M, El-Zaatari M, Alamelumangapuram CB, Todisco A, Eaton KA & Merchant JL (2010). Interleukin-1β promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology 138, 562-572.
-
(2010)
Gastroenterology
, vol.138
, pp. 562-572
-
-
Waghray, M.1
Zavros, Y.2
Saqui-Salces, M.3
El-Zaatari, M.4
Alamelumangapuram, C.B.5
Todisco, A.6
Eaton, K.A.7
Merchant, J.L.8
-
77
-
-
33748796068
-
How does cholesterol affect the way Hedgehog works?
-
Wendler F, Franch-Marro X & Vincent JP (2006). How does cholesterol affect the way Hedgehog works? Development 133, 3055-3061.
-
(2006)
Development
, vol.133
, pp. 3055-3061
-
-
Wendler, F.1
Franch-Marro, X.2
Vincent, J.P.3
-
78
-
-
77649128078
-
Non-consensus GLI binding sites in Hedgehog target gene regulation
-
Winklmayr M, Schmid C, Laner-Plamberger S, Kaser A, Aberger F, Eichberger T & Frischauf AM (2010). Non-consensus GLI binding sites in Hedgehog target gene regulation. BMC Mol Biol 11, 2.
-
(2010)
BMC Mol Biol
, vol.11
, pp. 2
-
-
Winklmayr, M.1
Schmid, C.2
Laner-Plamberger, S.3
Kaser, A.4
Aberger, F.5
Eichberger, T.6
Frischauf, A.M.7
-
79
-
-
58149333235
-
The primary cilium at the crossroads of mammalian hedgehog signaling
-
Wong SY & Reiter JF (2008). The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol 85, 225-260.
-
(2008)
Curr Top Dev Biol
, vol.85
, pp. 225-260
-
-
Wong, S.Y.1
Reiter, J.F.2
-
80
-
-
75149149098
-
Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells
-
Xiao C, Ogle SA, Schumacher MA, Orr-Asman MA, Miller ML, Lertkowit N, Varro A, Hollande F & Zavros Y (2010). Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology 138, 550-561.
-
(2010)
Gastroenterology
, vol.138
, pp. 550-561
-
-
Xiao, C.1
Ogle, S.A.2
Schumacher, M.A.3
Orr-Asman, M.A.4
Miller, M.L.5
Lertkowit, N.6
Varro, A.7
Hollande, F.8
Zavros, Y.9
-
81
-
-
73449090411
-
Sonic hedgehog relates to colorectal carcinogenesis
-
Yoshikawa K, Shimada M, Miyamoto H, Higashijima J, Miyatani T, Nishioka M, Kurita N, Iwata T & Uehara H (2009). Sonic hedgehog relates to colorectal carcinogenesis. J Gastroenterol 44, 1113-1117.
-
(2009)
J Gastroenterol
, vol.44
, pp. 1113-1117
-
-
Yoshikawa, K.1
Shimada, M.2
Miyamoto, H.3
Higashijima, J.4
Miyatani, T.5
Nishioka, M.6
Kurita, N.7
Iwata, T.8
Uehara, H.9
-
82
-
-
77952745877
-
Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria
-
Zacharias WJ, Li X, Madison BB, Kretovich K, Kao JY, Merchant JL & Gumucio DL (2010). Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria. Gastroenterology 138, 2368-2377.
-
(2010)
Gastroenterology
, vol.138
, pp. 2368-2377
-
-
Zacharias, W.J.1
Li, X.2
Madison, B.B.3
Kretovich, K.4
Kao, J.Y.5
Merchant, J.L.6
Gumucio, D.L.7
-
83
-
-
79957591569
-
Hedgehog signaling controls homeostasis of adult intestinal smooth muscle
-
Zacharias WJ, Madison BB, Kretovich KE, Walton KD, Richards N, Udager AM, Li X & Gumucio DL (2011). Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol 355, 152-162.
-
(2011)
Dev Biol
, vol.355
, pp. 152-162
-
-
Zacharias, W.J.1
Madison, B.B.2
Kretovich, K.E.3
Walton, K.D.4
Richards, N.5
Udager, A.M.6
Li, X.7
Gumucio, D.L.8
-
84
-
-
36349013850
-
Reduced pepsin a processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation
-
Zavros Y, Waghray M, Tessier A, Bai L, Todisco A, Gumucio DL, Samuelson LC, Dlugosz A & Merchant JL (2007). Reduced pepsin a processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. J Biol Chem 282, 33265-33274.
-
(2007)
J Biol Chem
, vol.282
, pp. 33265-33274
-
-
Zavros, Y.1
Waghray, M.2
Tessier, A.3
Bai, L.4
Todisco, A.5
Gumucio, D.L.6
Samuelson, L.C.7
Dlugosz, A.8
Merchant, J.L.9
-
85
-
-
77953661272
-
The human glioma-associated oncogene homolog 1 (GLI1) family of transcription factors in gene regulation and diseases
-
Zhu H & Lo HW (2010). The human glioma-associated oncogene homolog 1 (GLI1) family of transcription factors in gene regulation and diseases. Curr Genomics 11, 238-245.
-
(2010)
Curr Genomics
, vol.11
, pp. 238-245
-
-
Zhu, H.1
Lo, H.W.2
|