메뉴 건너뛰기




Volumn 590, Issue 3, 2012, Pages 421-432

Hedgehog signalling in gut development, physiology and cancer

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN;

EID: 84856314865     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.220681     Document Type: Review
Times cited : (62)

References (85)
  • 1
    • 8444228878 scopus 로고    scopus 로고
    • An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
    • Adolphe C, Narang M, Ellis T, Wicking C, Kaur P & Wainwright B (2004). An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 131, 5009-5019.
    • (2004) Development , vol.131 , pp. 5009-5019
    • Adolphe, C.1    Narang, M.2    Ellis, T.3    Wicking, C.4    Kaur, P.5    Wainwright, B.6
  • 3
    • 79951850782 scopus 로고    scopus 로고
    • Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons
    • Beug ST, Parks RJ, McBride HM & Wallace VA (2011). Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons. Mol Cell Neurosci 46, 583-596.
    • (2011) Mol Cell Neurosci , vol.46 , pp. 583-596
    • Beug, S.T.1    Parks, R.J.2    McBride, H.M.3    Wallace, V.A.4
  • 4
    • 77955293319 scopus 로고    scopus 로고
    • Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog
    • Buglino JA & Resh MD (2010). Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. PLoS One 5, e11195.
    • (2010) PLoS One , vol.5
    • Buglino, J.A.1    Resh, M.D.2
  • 5
    • 0028966517 scopus 로고
    • Proteolytic processing yields two secreted forms of sonic hedgehog
    • Bumcrot DA, Takada R & McMahon AP (1995). Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol 15, 2294-2303.
    • (1995) Mol Cell Biol , vol.15 , pp. 2294-2303
    • Bumcrot, D.A.1    Takada, R.2    McMahon, A.P.3
  • 9
    • 77955096244 scopus 로고    scopus 로고
    • Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling
    • Chang H, Li Q, Moraes RC, Lewis MT & Hamel PA (2010). Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling. Int J Biochem Cell Biol 42, 1462-1471.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1462-1471
    • Chang, H.1    Li, Q.2    Moraes, R.C.3    Lewis, M.T.4    Hamel, P.A.5
  • 12
    • 70450257573 scopus 로고    scopus 로고
    • Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation
    • Dennler S, Andre J, Verrecchia F & Mauviel A (2009). Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperation. J Biol Chem 284, 31523-31531.
    • (2009) J Biol Chem , vol.284 , pp. 31523-31531
    • Dennler, S.1    Andre, J.2    Verrecchia, F.3    Mauviel, A.4
  • 13
    • 65549150886 scopus 로고    scopus 로고
    • Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells
    • Dierker T, Dreier R, Petersen A, Bordych C & Grobe K (2009). Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells. J Biol Chem 284, 8013-8022.
    • (2009) J Biol Chem , vol.284 , pp. 8013-8022
    • Dierker, T.1    Dreier, R.2    Petersen, A.3    Bordych, C.4    Grobe, K.5
  • 14
    • 78649307378 scopus 로고    scopus 로고
    • Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion
    • El-Zaatari M, Zavros Y, Tessier A, Waghray M, Lentz S, Gumucio D, Todisco A & Merchant JL (2010). Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology 139, 2061-2071.
    • (2010) Gastroenterology , vol.139 , pp. 2061-2071
    • El-Zaatari, M.1    Zavros, Y.2    Tessier, A.3    Waghray, M.4    Lentz, S.5    Gumucio, D.6    Todisco, A.7    Merchant, J.L.8
  • 16
    • 45149086312 scopus 로고    scopus 로고
    • Primers on molecular pathways GLI: more than just Hedgehog?
    • Fernandez-Zapico ME (2008). Primers on molecular pathways GLI: more than just Hedgehog? Pancreatology 8, 227-229.
    • (2008) Pancreatology , vol.8 , pp. 227-229
    • Fernandez-Zapico, M.E.1
  • 18
    • 0036008549 scopus 로고    scopus 로고
    • Sonic Hedgehog as a mediator of long-range signaling
    • Goetz JA, Suber LM, Zeng X & Robbins DJ (2002). Sonic Hedgehog as a mediator of long-range signaling. Bioessays 24, 157-165.
    • (2002) Bioessays , vol.24 , pp. 157-165
    • Goetz, J.A.1    Suber, L.M.2    Zeng, X.3    Robbins, D.J.4
  • 20
    • 40749144679 scopus 로고    scopus 로고
    • Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
    • Haycraft CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ & Yoder BK (2005). Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1, e53.
    • (2005) PLoS Genet , vol.1
    • Haycraft, C.J.1    Banizs, B.2    Aydin-Son, Y.3    Zhang, Q.4    Michaud, E.J.5    Yoder, B.K.6
  • 21
    • 80054022786 scopus 로고    scopus 로고
    • Gli proteins in development and disease
    • Hui CC & Angers S (2011). Gli proteins in development and disease. Annu Rev Cell Dev Biol 27, 513-537.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 513-537
    • Hui, C.C.1    Angers, S.2
  • 23
    • 79551514021 scopus 로고    scopus 로고
    • TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling
    • Johnson RW, Nguyen MP, Padalecki SS, Grubbs BG, Merkel AR, Oyajobi BO, Matrisian LM, Mundy GR & Sterling JA (2011). TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res 71, 822-831.
    • (2011) Cancer Res , vol.71 , pp. 822-831
    • Johnson, R.W.1    Nguyen, M.P.2    Padalecki, S.S.3    Grubbs, B.G.4    Merkel, A.R.5    Oyajobi, B.O.6    Matrisian, L.M.7    Mundy, G.R.8    Sterling, J.A.9
  • 24
    • 0036181085 scopus 로고    scopus 로고
    • Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development
    • Kageyama T (2002). Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development. Cell Mol Life Sci 59, 288-306.
    • (2002) Cell Mol Life Sci , vol.59 , pp. 288-306
    • Kageyama, T.1
  • 25
    • 0026580058 scopus 로고
    • Identifying and counting epithelial cell types in the 'corpus' of the mouse stomach
    • Karam SM & Leblond CP (1992). Identifying and counting epithelial cell types in the 'corpus' of the mouse stomach. Anat Rec 232, 231-246.
    • (1992) Anat Rec , vol.232 , pp. 231-246
    • Karam, S.M.1    Leblond, C.P.2
  • 26
    • 27744445194 scopus 로고    scopus 로고
    • Comparative genomics on Sonic hedgehog orthologs
    • Katoh Y & Katoh M (2005). Comparative genomics on Sonic hedgehog orthologs. Oncol Rep 14, 1087-1090.
    • (2005) Oncol Rep , vol.14 , pp. 1087-1090
    • Katoh, Y.1    Katoh, M.2
  • 27
    • 76049114315 scopus 로고    scopus 로고
    • Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
    • Kim J, Kato M & Beachy PA (2009). Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A 106, 21666-21671.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21666-21671
    • Kim, J.1    Kato, M.2    Beachy, P.A.3
  • 28
    • 0025156778 scopus 로고
    • The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
    • Kinzler KW & Vogelstein B (1990). The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol Cell Biol 10, 634-642.
    • (1990) Mol Cell Biol , vol.10 , pp. 634-642
    • Kinzler, K.W.1    Vogelstein, B.2
  • 30
    • 35848938488 scopus 로고    scopus 로고
    • Non-Canonical Activation of GLI Transcription Factors: Implications for Targeted Anti-Cancer Therapy
    • Lauth M & Toftgard R (2007). Non-Canonical Activation of GLI Transcription Factors: Implications for Targeted Anti-Cancer Therapy. Cell Cycle 6, 2458-2463.
    • (2007) Cell Cycle , vol.6 , pp. 2458-2463
    • Lauth, M.1    Toftgard, R.2
  • 32
    • 0031711075 scopus 로고    scopus 로고
    • Sonic hedgehog is essential to foregut development
    • Litingtung Y, Lei L, Westphal H & Chiang C (1998). Sonic hedgehog is essential to foregut development. Nat Genet 20, 58-61.
    • (1998) Nat Genet , vol.20 , pp. 58-61
    • Litingtung, Y.1    Lei, L.2    Westphal, H.3    Chiang, C.4
  • 34
    • 65549099669 scopus 로고    scopus 로고
    • FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine
    • Madison BB, McKenna LB, Dolson D, Epstein DJ & Kaestner KH (2009). FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. J Biol Chem 284, 5936-5944.
    • (2009) J Biol Chem , vol.284 , pp. 5936-5944
    • Madison, B.B.1    McKenna, L.B.2    Dolson, D.3    Epstein, D.J.4    Kaestner, K.H.5
  • 36
    • 77950624255 scopus 로고    scopus 로고
    • Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors
    • Merchant A, Joseph G, Wang Q, Brennan S & Matsui W (2010a). Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood 115, 2391-2396.
    • (2010) Blood , vol.115 , pp. 2391-2396
    • Merchant, A.1    Joseph, G.2    Wang, Q.3    Brennan, S.4    Matsui, W.5
  • 38
    • 77953943126 scopus 로고    scopus 로고
    • Not lost in space: trafficking in the hedgehog signaling pathway
    • Milenkovic L & Scott MP (2010). Not lost in space: trafficking in the hedgehog signaling pathway. Sci Signal 3, pe14.
    • (2010) Sci Signal , vol.3
    • Milenkovic, L.1    Scott, M.P.2
  • 39
    • 0031683165 scopus 로고    scopus 로고
    • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    • Motoyama J, Liu J, Mo R, Ding Q, Post M & Hui CC (1998). Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 20, 54-57.
    • (1998) Nat Genet , vol.20 , pp. 54-57
    • Motoyama, J.1    Liu, J.2    Mo, R.3    Ding, Q.4    Post, M.5    Hui, C.C.6
  • 42
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C & Wieschaus E (1980). Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 45
    • 41549118422 scopus 로고    scopus 로고
    • The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer
    • Omenetti A & Diehl AM (2008). The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol 294, G595-598.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Omenetti, A.1    Diehl, A.M.2
  • 48
    • 0037227766 scopus 로고    scopus 로고
    • The vertebrate primary cilium is a sensory organelle
    • Pazour GJ & Witman GB (2003). The vertebrate primary cilium is a sensory organelle. Curr Opin Cell Biol 15, 105-110.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 105-110
    • Pazour, G.J.1    Witman, G.B.2
  • 53
    • 0029844192 scopus 로고    scopus 로고
    • Cholesterol modification of hedgehog signaling proteins in animal development
    • Porter JA, Young KE & Beachy PA (1996b). Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255-259.
    • (1996) Science , vol.274 , pp. 255-259
    • Porter, J.A.1    Young, K.E.2    Beachy, P.A.3
  • 55
    • 0033916281 scopus 로고    scopus 로고
    • Hedgehog signals regulate multiple aspects of gastrointestinal development
    • Ramalho-Santos M, Melton DA & McMahon AP (2000). Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127, 2763-2772.
    • (2000) Development , vol.127 , pp. 2763-2772
    • Ramalho-Santos, M.1    Melton, D.A.2    McMahon, A.P.3
  • 56
    • 33846489141 scopus 로고    scopus 로고
    • The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1
    • Ramsey VG, Doherty JM, Chen CC, Stappenbeck TS, Konieczny SF & Mills JC (2007). The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development 134, 211-222.
    • (2007) Development , vol.134 , pp. 211-222
    • Ramsey, V.G.1    Doherty, J.M.2    Chen, C.C.3    Stappenbeck, T.S.4    Konieczny, S.F.5    Mills, J.C.6
  • 57
    • 80053413477 scopus 로고    scopus 로고
    • The epigenetic regulation of stem cell factors in hepatic stellate cells
    • Reister S, Kordes C, Sawitza I & Haussinger D (2011). The epigenetic regulation of stem cell factors in hepatic stellate cells. Stem Cells Dev 20, 1687-1699.
    • (2011) Stem Cells Dev , vol.20 , pp. 1687-1699
    • Reister, S.1    Kordes, C.2    Sawitza, I.3    Haussinger, D.4
  • 58
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
    • Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, Beachy PA & Jessell TM (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81, 445-455.
    • (1995) Cell , vol.81 , pp. 445-455
    • Roelink, H.1    Porter, J.A.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5    Beachy, P.A.6    Jessell, T.M.7
  • 59
    • 80054020133 scopus 로고    scopus 로고
    • Morphogen gradients: from generation to interpretation
    • Rogers KW & Schier AF (2011). Morphogen gradients: from generation to interpretation. Annu Rev Cell Dev Biol 27, 377-407.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 377-407
    • Rogers, K.W.1    Schier, A.F.2
  • 60
    • 0029649309 scopus 로고
    • Nobel prizes: fly development work bears prize-winning fruit
    • Roush W (1995). Nobel prizes: fly development work bears prize-winning fruit. Science 270, 380-381.
    • (1995) Science , vol.270 , pp. 380-381
    • Roush, W.1
  • 61
    • 77953362373 scopus 로고    scopus 로고
    • Hedgehog signaling and gastrointestinal cancer
    • Saqui-Salces M & Merchant JL (2010). Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta 1803, 786-795.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 786-795
    • Saqui-Salces, M.1    Merchant, J.L.2
  • 62
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki H, Nishizaki Y, Hui C, Nakafuku M & Kondoh H (1999). Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915-3924.
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.3    Nakafuku, M.4    Kondoh, H.5
  • 63
    • 67650289584 scopus 로고    scopus 로고
    • Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
    • Scales SJ & de Sauvage FJ (2009). Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 30, 303-312.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 303-312
    • Scales, S.J.1    de Sauvage, F.J.2
  • 64
    • 33644849523 scopus 로고    scopus 로고
    • Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal
    • Sheng T, Chi S, Zhang X & Xie J (2006). Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal. J Biol Chem 281, 9-12.
    • (2006) J Biol Chem , vol.281 , pp. 9-12
    • Sheng, T.1    Chi, S.2    Zhang, X.3    Xie, J.4
  • 65
    • 0032902081 scopus 로고    scopus 로고
    • The evolution of the hedgehog gene family in chordates: insights from amphioxus hedgehog
    • Shimeld SM (1999). The evolution of the hedgehog gene family in chordates: insights from amphioxus hedgehog. Dev Genes Evol 209, 40-47.
    • (1999) Dev Genes Evol , vol.209 , pp. 40-47
    • Shimeld, S.M.1
  • 66
  • 67
    • 77952898697 scopus 로고    scopus 로고
    • Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
    • Stecca B & Ruiz IAA (2010). Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol 2, 84-95.
    • (2010) J Mol Cell Biol , vol.2 , pp. 84-95
    • Stecca, B.1    Ruiz, I.A.A.2
  • 68
    • 18144388632 scopus 로고    scopus 로고
    • Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells
    • Stepan V, Ramamoorthy S, Nitsche H, Zavros Y, Merchant JL & Todisco A (2005). Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. J Biol Chem 280, 15700-15708.
    • (2005) J Biol Chem , vol.280 , pp. 15700-15708
    • Stepan, V.1    Ramamoorthy, S.2    Nitsche, H.3    Zavros, Y.4    Merchant, J.L.5    Todisco, A.6
  • 70
    • 77649337790 scopus 로고    scopus 로고
    • Hedgehog beyond medulloblastoma and basal cell carcinoma
    • Teglund S & Toftgard R (2010). Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 1805, 181-208.
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 181-208
    • Teglund, S.1    Toftgard, R.2
  • 72
    • 35648977027 scopus 로고    scopus 로고
    • Hedgehog signaling in development and homeostasis of the gastrointestinal tract
    • van den Brink GR (2007). Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol Rev 87, 1343-1375.
    • (2007) Physiol Rev , vol.87 , pp. 1343-1375
    • van den Brink, G.R.1
  • 74
    • 73649087231 scopus 로고    scopus 로고
    • Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling
    • Varnat F, Zacchetti G & Ruiz i Altaba A (2010). Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. Mech Dev 127, 73-81.
    • (2010) Mech Dev , vol.127 , pp. 73-81
    • Varnat, F.1    Zacchetti, G.2    Ruiz i Altaba, A.3
  • 77
    • 33748796068 scopus 로고    scopus 로고
    • How does cholesterol affect the way Hedgehog works?
    • Wendler F, Franch-Marro X & Vincent JP (2006). How does cholesterol affect the way Hedgehog works? Development 133, 3055-3061.
    • (2006) Development , vol.133 , pp. 3055-3061
    • Wendler, F.1    Franch-Marro, X.2    Vincent, J.P.3
  • 79
    • 58149333235 scopus 로고    scopus 로고
    • The primary cilium at the crossroads of mammalian hedgehog signaling
    • Wong SY & Reiter JF (2008). The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol 85, 225-260.
    • (2008) Curr Top Dev Biol , vol.85 , pp. 225-260
    • Wong, S.Y.1    Reiter, J.F.2
  • 85
    • 77953661272 scopus 로고    scopus 로고
    • The human glioma-associated oncogene homolog 1 (GLI1) family of transcription factors in gene regulation and diseases
    • Zhu H & Lo HW (2010). The human glioma-associated oncogene homolog 1 (GLI1) family of transcription factors in gene regulation and diseases. Curr Genomics 11, 238-245.
    • (2010) Curr Genomics , vol.11 , pp. 238-245
    • Zhu, H.1    Lo, H.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.