-
1
-
-
78651423627
-
Experimental approaches for the treatment of malignant gliomas
-
doi 10.1016/j.pharmthera.2010.04.015
-
Arko L, Katsyv I, Park GE, Luan WP, Park JK, (2010) Experimental approaches for the treatment of malignant gliomas. Pharmacol Therapeutics 128: 1-36. doi:10.1016/j.pharmthera.2010.04.015. PubMed: 20546782.
-
(2010)
Pharmacol Therapeutics
, vol.128
, pp. 1-36
-
-
Arko, L.1
Katsyv, I.2
Park, G.E.3
Luan, W.P.4
Park, J.K.5
-
2
-
-
84862827742
-
Key concepts in glioblastoma therapy
-
doi 10.1136/jnnp-2011-300709
-
Bartek JJ, Ng K, Bartek J, Fischer W, Carter B, et al. (2012) Key concepts in glioblastoma therapy. J Neurol Neurosurg, Psychiatry 83: 753-760. doi:10.1136/jnnp-2011-300709. PubMed: 22396442.
-
(2012)
J Neurol Neurosurg, Psychiatry
, vol.83
, pp. 753-760
-
-
Bartek, J.J.1
Ng, K.2
Bartek, J.3
Fischer, W.4
Carter, B.5
-
3
-
-
0030993717
-
Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials
-
doi 10.1016/S0305-7372(97)90019-0
-
Newlands ES, Stevens MFG, Wedge SR, Wheelhouse RT, Brock C, (1997) Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials. Cancer Treat Rev 23: 35-61. doi:10.1016/S0305-7372(97)90019-0. PubMed: 9189180.
-
(1997)
Cancer Treat Rev
, vol.23
, pp. 35-61
-
-
Newlands, E.S.1
Stevens, M.F.G.2
Wedge, S.R.3
Wheelhouse, R.T.4
Brock, C.5
-
4
-
-
0031426782
-
Pharmacokinetics of 3-methyl-(triazen-1-yl)imidazole-4-carboximide following administration of temozolomide to patients with advanced cancer
-
PubMed: 9815639
-
Reid JM, Stevens DC, Rubin J, Ames MM, (1997) Pharmacokinetics of 3-methyl-(triazen-1-yl)imidazole-4-carboximide following administration of temozolomide to patients with advanced cancer. Clin Cancer Res 3: 2392-2398. PubMed: 9815639.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 2392-2398
-
-
Reid, J.M.1
Stevens, D.C.2
Rubin, J.3
Ames, M.M.4
-
5
-
-
1942469956
-
MGMT: it's role in cancer aetiology and cancer therapeutics
-
doi 10.1038/nrc1319
-
Gerson SL, (2004) MGMT: it's role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4: 296-307. doi:10.1038/nrc1319. PubMed: 15057289.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 296-307
-
-
Gerson, S.L.1
-
6
-
-
77949883876
-
The pathobiology of glioma tumors
-
doi 10.1146/annurev-pathol-121808-102109
-
Gladson CL, Prayson RA, Liu WM, (2010) The pathobiology of glioma tumors. Annu. Rev Pathol Mech Dis 5: 33-50. doi:10.1146/annurev-pathol-121808-102109.
-
(2010)
Annu. Rev Pathol Mech Dis
, vol.5
, pp. 33-50
-
-
Gladson, C.L.1
Prayson, R.A.2
Liu, W.M.3
-
7
-
-
0038055835
-
Variability and regulation of O6-alkylguanine-DNA alkyltransferase
-
doi 10.1093/carcin/bgg005
-
Margison GP, Povey AC, Kaina B, Koref M, (2003) Variability and regulation of O6-alkylguanine-DNA alkyltransferase. Carcinogenesis 24: 625-635. doi:10.1093/carcin/bgg005. PubMed: 12727789.
-
(2003)
Carcinogenesis
, vol.24
, pp. 625-635
-
-
Margison, G.P.1
Povey, A.C.2
Kaina, B.3
Koref, M.4
-
8
-
-
71949083197
-
Role of MGMT in Tumor Development, Progression, Diagnosis, Treatment and Prognosis
-
PubMed: 19846906
-
Sharma S, Salehi F, Scheithauer BW, Rotondo F, Syro LV, et al. (2009) Role of MGMT in Tumor Development, Progression, Diagnosis, Treatment and Prognosis. Anticancer Res 29: 3759-3768. PubMed: 19846906.
-
(2009)
Anticancer Res
, vol.29
, pp. 3759-3768
-
-
Sharma, S.1
Salehi, F.2
Scheithauer, B.W.3
Rotondo, F.4
Syro, L.V.5
-
9
-
-
34548721263
-
A single cycle of treatment with temozolomide, alone or combined with O6-methylguanine-DNA methyltransferase and the mismatch repair system
-
PubMed: 16964376
-
Alvino E, Castiglia D, Caporali S, Pepponi R, Caporaso P, et al. (2006) A single cycle of treatment with temozolomide, alone or combined with O6-methylguanine-DNA methyltransferase and the mismatch repair system. Int J Oncol 29: 785-797. PubMed: 16964376.
-
(2006)
Int J Oncol
, vol.29
, pp. 785-797
-
-
Alvino, E.1
Castiglia, D.2
Caporali, S.3
Pepponi, R.4
Caporaso, P.5
-
10
-
-
0034027358
-
Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents
-
doi 10.1016/S1383-5742(00)00016-8
-
Bignami M, O'Driscoll M, Aquilina G, Karran P, (2000) Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents. Mutat Res 462: 71-82. doi:10.1016/S1383-5742(00)00016-8. PubMed: 10767619.
-
(2000)
Mutat Res
, vol.462
, pp. 71-82
-
-
Bignami, M.1
O'Driscoll, M.2
Aquilina, G.3
Karran, P.4
-
11
-
-
33845971555
-
Translesion Synthesis across O6-Alkylguanine DNA Adducts by Recombinant Human DNA Polymerases
-
doi 10.1074/jbc.M608369200
-
Choi J-Y, Chowdhury G, Zang H, Angel KC, Vu CC, et al. (2006) Translesion Synthesis across O6-Alkylguanine DNA Adducts by Recombinant Human DNA Polymerases. J Biol Chem 281: 38244-38256. doi:10.1074/jbc.M608369200. PubMed: 17050527.
-
(2006)
J Biol Chem
, vol.281
, pp. 38244-38256
-
-
Choi, J.-Y.1
Chowdhury, G.2
Zang, H.3
Angel, K.C.4
Vu, C.C.5
-
12
-
-
33646503204
-
ATR kinase activation mediated by MutSα and MutLα in response to cytotoxic O6-methylguanine adducts
-
doi 10.1016/j.molcel.2006.04.023
-
Yoshioka K-I, Yoshioka Y, Hsieh P, (2006) ATR kinase activation mediated by MutSα and MutLα in response to cytotoxic O6-methylguanine adducts. Mol Cell 22: 501-510. doi:10.1016/j.molcel.2006.04.023. PubMed: 16713580.
-
(2006)
Mol Cell
, vol.22
, pp. 501-510
-
-
Yoshioka, K.-I.1
Yoshioka, Y.2
Hsieh, P.3
-
13
-
-
33747341054
-
Mismatch Repair-dependent Iterative Excision at Irreparable O6Methylguanine Lesions in Human Nuclear Extracts
-
doi 10.1074/jbc.M603667200
-
York SJ, Modrich P, (2006) Mismatch Repair-dependent Iterative Excision at Irreparable O6Methylguanine Lesions in Human Nuclear Extracts. J Biol Chem 281: 22674-22683. doi:10.1074/jbc.M603667200. PubMed: 16772289.
-
(2006)
J Biol Chem
, vol.281
, pp. 22674-22683
-
-
York, S.J.1
Modrich, P.2
-
14
-
-
0347364654
-
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
-
doi 10.1073/pnas.2536810100
-
Wang Y, Qin J, (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A 100: 15387-15392. doi:10.1073/pnas.2536810100. PubMed: 14657349.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15387-15392
-
-
Wang, Y.1
Qin, J.2
-
15
-
-
9144227402
-
An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis
-
doi 10.1158/0008-5472.CAN-03-2957
-
Lin DP, Wang Y, Scherer SJ, Clark AB, Yang K, et al. (2004) An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis. Cancer Res 64: 517-522. doi:10.1158/0008-5472.CAN-03-2957. PubMed: 14744764.
-
(2004)
Cancer Res
, vol.64
, pp. 517-522
-
-
Lin, D.P.1
Wang, Y.2
Scherer, S.J.3
Clark, A.B.4
Yang, K.5
-
16
-
-
5144220638
-
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
-
doi 10.1016/j.ccr.2004.06.024
-
Yang G, Scherer SJ, Shell SS, Yang K, Kim M, et al. (2004) Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility. Cancer Cell 6: 139-150. doi:10.1016/j.ccr.2004.06.024. PubMed: 15324697.
-
(2004)
Cancer Cell
, vol.6
, pp. 139-150
-
-
Yang, G.1
Scherer, S.J.2
Shell, S.S.3
Yang, K.4
Kim, M.5
-
17
-
-
77949329988
-
Interactions of Human Mismatch Repair Proteins MutSa and MutLa with Proteins of the ATR-Chk1 Pathway
-
doi 10.1074/jbc.M109.076109
-
Liu Y, Fang Y, Shao H, Lindsey-Boltz LA, Sancar A, et al. (2010) Interactions of Human Mismatch Repair Proteins MutSa and MutLa with Proteins of the ATR-Chk1 Pathway. J Biol Chem 285: 5974-5982. doi:10.1074/jbc.M109.076109. PubMed: 20029092.
-
(2010)
J Biol Chem
, vol.285
, pp. 5974-5982
-
-
Liu, Y.1
Fang, Y.2
Shao, H.3
Lindsey-Boltz, L.A.4
Sancar, A.5
-
18
-
-
80051948127
-
N-Methyl-N'-nitro-N'-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21-Waf1/Cip1
-
doi 10.1074/jbc.M111.221341
-
Jascur T, Fotedar R, Greene S, Hotchkiss E, Boland CR, (2011) N-Methyl-N'-nitro-N'-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21-Waf1/Cip1. J Biol Chem 286: 29531-29539. doi:10.1074/jbc.M111.221341. PubMed: 21725088.
-
(2011)
J Biol Chem
, vol.286
, pp. 29531-29539
-
-
Jascur, T.1
Fotedar, R.2
Greene, S.3
Hotchkiss, E.4
Boland, C.R.5
-
19
-
-
79953186673
-
hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis
-
doi 10.1074/jbc.M110.210989
-
Pabla N, Ma Z, McIlhatton MA, Fishel R, Dong Z, (2011) hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J Biol Chem 286: 10411-10418. doi:10.1074/jbc.M110.210989. PubMed: 21285353.
-
(2011)
J Biol Chem
, vol.286
, pp. 10411-10418
-
-
Pabla, N.1
Ma, Z.2
McIlhatton, M.A.3
Fishel, R.4
Dong, Z.5
-
20
-
-
69249137054
-
Functions of MutLa, RPA, and HMGB1 in 5'-directed mismatch repair
-
doi 10.1074/jbc.M109.021287
-
Genschel J, Modrich P, (2009) Functions of MutLa, RPA, and HMGB1 in 5'-directed mismatch repair. J Biol Chem 284: 21536-21544. doi:10.1074/jbc.M109.021287. PubMed: 19515846.
-
(2009)
J Biol Chem
, vol.284
, pp. 21536-21544
-
-
Genschel, J.1
Modrich, P.2
-
21
-
-
74549189337
-
New insights into checkpoint kinase 1 in the DNA damage response signaling nework
-
doi 10.1158/1078-0432.CCR-09-1029
-
Dai Y, Grant S, (2010) New insights into checkpoint kinase 1 in the DNA damage response signaling nework. Clin Cancer Res 16: 376-383. doi:10.1158/1078-0432.CCR-09-1029. PubMed: 20068082.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 376-383
-
-
Dai, Y.1
Grant, S.2
-
22
-
-
2442670292
-
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase
-
doi 10.1101/gad.294404
-
Stojic L, Mojas N, Cejka P, di Pietro M, Ferrari S, et al. (2004) Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev 18: 1331-1344. doi:10.1101/gad.294404. PubMed: 15175264.
-
(2004)
Genes Dev
, vol.18
, pp. 1331-1344
-
-
Stojic, L.1
Mojas, N.2
Cejka, P.3
di Pietro, M.4
Ferrari, S.5
-
23
-
-
84874527416
-
Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome
-
Lalezari S, Chou AP, Tran A, Solis OE, Khanlou N, et al. (2013) Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome. Neuro-Oncology.
-
(2013)
Neuro-Oncology
-
-
Lalezari, S.1
Chou, A.P.2
Tran, A.3
Solis, O.E.4
Khanlou, N.5
-
24
-
-
0029143992
-
Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint
-
PubMed: 7641183
-
Hawn MT, Umar A, Carethers JM, Marra G, Kunkel TA, et al. (1995) Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res 55: 3721-3725. PubMed: 7641183.
-
(1995)
Cancer Res
, vol.55
, pp. 3721-3725
-
-
Hawn, M.T.1
Umar, A.2
Carethers, J.M.3
Marra, G.4
Kunkel, T.A.5
-
25
-
-
0030776227
-
Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6
-
PubMed: 9307278
-
Umar A, Koi M, Risinger JI, Glaab WE, Tindall KR, et al. (1997) Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res 57: 3949-3955. PubMed: 9307278.
-
(1997)
Cancer Res
, vol.57
, pp. 3949-3955
-
-
Umar, A.1
Koi, M.2
Risinger, J.I.3
Glaab, W.E.4
Tindall, K.R.5
-
26
-
-
34247499001
-
Loss of mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment
-
doi 10.1158/1078-0432.CCR-06-2149
-
Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, et al. (2007) Loss of mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Clin Cancer Res 13: 2038-2045. doi:10.1158/1078-0432.CCR-06-2149. PubMed: 17404084.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2038-2045
-
-
Cahill, D.P.1
Levine, K.K.2
Betensky, R.A.3
Codd, P.J.4
Romany, C.A.5
-
27
-
-
33646256145
-
A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy
-
doi 10.1158/0008-5472.CAN-06-0127
-
Hunter C, Smith R, Cahill DP, Stephens P, Stevens C, et al. (2006) A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy. Cancer Res 66: 3987-3991. doi:10.1158/0008-5472.CAN-06-0127. PubMed: 16618716.
-
(2006)
Cancer Res
, vol.66
, pp. 3987-3991
-
-
Hunter, C.1
Smith, R.2
Cahill, D.P.3
Stephens, P.4
Stevens, C.5
-
28
-
-
68049095262
-
MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance
-
doi 10.1158/1078-0432.CCR-08-3012
-
Yip S, Miao J, Cahill DC, Iafrate AJ, Aldape K, et al. (2009) MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance. Clin Cancer Res 15: 4622-4629. doi:10.1158/1078-0432.CCR-08-3012. PubMed: 19584161.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4622-4629
-
-
Yip, S.1
Miao, J.2
Cahill, D.C.3
Iafrate, A.J.4
Aldape, K.5
-
29
-
-
84865396814
-
Assessing cell and organ senescence biomarkers
-
doi 10.1161/CIRCRESAHA.111.247866
-
Bernardes de Jesus B, Blasco MA, (2012) Assessing cell and organ senescence biomarkers. Circ Res 111: 97-109. doi:10.1161/CIRCRESAHA.111.247866. PubMed: 22723221.
-
(2012)
Circ Res
, vol.111
, pp. 97-109
-
-
Bernardes de Jesus, B.1
Blasco, M.A.2
-
30
-
-
79551683487
-
Cellular senescence: putting the paradoxes in perspective
-
doi 10.1016/j.gde.2010.10.005
-
Campisi J, (2011) Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev 21: 107-112. doi:10.1016/j.gde.2010.10.005. PubMed: 21093253.
-
(2011)
Curr Opin Genet Dev
, vol.21
, pp. 107-112
-
-
Campisi, J.1
-
31
-
-
84859372986
-
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
-
doi 10.1038/ncb2466
-
Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, et al. (2012) Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol 14: 355-365. doi:10.1038/ncb2466. PubMed: 22426077.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 355-365
-
-
Fumagalli, M.1
Rossiello, F.2
Clerici, M.3
Barozzi, S.4
Cittaro, D.5
-
32
-
-
84872196694
-
Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells
-
PubMed: 22410783
-
Yasaei H, Gilham E, Pickles JC, Roberts TP, O'Donovan M, et al. (2012) Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells. Oncogene 32: 171-179. PubMed: 22410783.
-
(2012)
Oncogene
, vol.32
, pp. 171-179
-
-
Yasaei, H.1
Gilham, E.2
Pickles, J.C.3
Roberts, T.P.4
O'Donovan, M.5
-
33
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
-
doi 10.1038/nature03918
-
Chen Z, Trotman LC, Shaffer D, Lin H-K, Dotan ZA, et al. (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436: 725-730. doi:10.1038/nature03918. PubMed: 16079851.
-
(2005)
Nature
, vol.436
, pp. 725-730
-
-
Chen, Z.1
Trotman, L.C.2
Shaffer, D.3
Lin, H.-K.4
Dotan, Z.A.5
-
34
-
-
78349257844
-
The essence of senescence
-
PubMed: 21078816
-
Kuilman T, Michaloglou C, Mooi WJ, Peeper DS, (2010) The essence of senescence. Genes Dev 24: 2463-2479. PubMed: 21078816.
-
(2010)
Genes Dev
, vol.24
, pp. 2463-2479
-
-
Kuilman, T.1
Michaloglou, C.2
Mooi, W.J.3
Peeper, D.S.4
-
35
-
-
7044231343
-
The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression
-
doi 10.2152/jmi.51.146
-
Ohtani N, Yamakoshi K, Takahashi A, Hara E, (2004) The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest 51: 146-153. doi:10.2152/jmi.51.146. PubMed: 15460900.
-
(2004)
J Med Invest
, vol.51
, pp. 146-153
-
-
Ohtani, N.1
Yamakoshi, K.2
Takahashi, A.3
Hara, E.4
-
36
-
-
33845977959
-
Mitochondrial Membrane Permeabilization in Cell Death
-
doi 10.1152/physrev.00013.2006
-
Kroemer G, Galluzzi L, Brenner C, (2007) Mitochondrial Membrane Permeabilization in Cell Death. Physiol Rev 87: 99-163. doi:10.1152/physrev.00013.2006. PubMed: 17237344.
-
(2007)
Physiol Rev
, vol.87
, pp. 99-163
-
-
Kroemer, G.1
Galluzzi, L.2
Brenner, C.3
-
37
-
-
79957459076
-
Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation
-
doi 10.1089/ars.2010.3445
-
Sevrioukova IF, (2011) Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation. Antioxid Redox Signal 14: 2545-2578. doi:10.1089/ars.2010.3445. PubMed: 20868295.
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 2545-2578
-
-
Sevrioukova, I.F.1
-
38
-
-
77952909686
-
Resistance to caspase-independent cell death requires persistence of intact mitochondria
-
doi 10.1016/j.devcel.2010.03.014
-
Tait SWG, Parsons MJ, Llambi F, Bouchier-Hayes L, Connell S, et al. (2010) Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell 18: 802-813. doi:10.1016/j.devcel.2010.03.014. PubMed: 20493813.
-
(2010)
Dev Cell
, vol.18
, pp. 802-813
-
-
Tait, S.W.G.1
Parsons, M.J.2
Llambi, F.3
Bouchier-Hayes, L.4
Connell, S.5
-
39
-
-
17844394478
-
Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space
-
doi 10.1038/sj.emboj.7600614
-
Otera H, Ohsakaya S, Nagaura Z-I, Ishihara N, Mihara K, (2005) Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space. EMBO J 24: 1375-1386. doi:10.1038/sj.emboj.7600614. PubMed: 15775970.
-
(2005)
EMBO J
, vol.24
, pp. 1375-1386
-
-
Otera, H.1
Ohsakaya, S.2
Nagaura, Z.-I.3
Ishihara, N.4
Mihara, K.5
-
40
-
-
77952582542
-
Life with or without AIF
-
doi 10.1016/j.tibs.2009.12.008
-
Hangen E, Blomgren K, Bénit P, Kroemer G, Modjtahedi N, (2010) Life with or without AIF. Trends Biochem Sci 35: 278-287. doi:10.1016/j.tibs.2009.12.008. PubMed: 20138767.
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 278-287
-
-
Hangen, E.1
Blomgren, K.2
Bénit, P.3
Kroemer, G.4
Modjtahedi, N.5
-
41
-
-
0042889258
-
CpG methylation-dependent repression of the human 0 6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration
-
doi 10.1093/carcin/bgg086
-
Bhakat KK, Mitra S, (2003) CpG methylation-dependent repression of the human 0 6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration. Carcinogenesis 24: 1337-1345. doi:10.1093/carcin/bgg086. PubMed: 12807730.
-
(2003)
Carcinogenesis
, vol.24
, pp. 1337-1345
-
-
Bhakat, K.K.1
Mitra, S.2
-
42
-
-
79957854823
-
A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells
-
doi 10.1186/1476-4598-10-69
-
Overmeyer JH, Yound A, Bhanot H, Maltese WA, (2011) A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells. Mol Cancer 10: 69. doi:10.1186/1476-4598-10-69. PubMed: 21639944.
-
(2011)
Mol Cancer
, vol.10
, pp. 69
-
-
Overmeyer, J.H.1
Yound, A.2
Bhanot, H.3
Maltese, W.A.4
-
43
-
-
68049142430
-
Prolonged cell cycle response of HeLa cells to low-level alkylation exposure
-
doi 10.1158/0008-5472.CAN-09-0899
-
Schroering AG, Kothandapani A, Patrick SM, Kaliyaperumal S, Sharma VP, et al. (2009) Prolonged cell cycle response of HeLa cells to low-level alkylation exposure. Cancer Res 69: 6307-6314. doi:10.1158/0008-5472.CAN-09-0899. PubMed: 19638578.
-
(2009)
Cancer Res
, vol.69
, pp. 6307-6314
-
-
Schroering, A.G.1
Kothandapani, A.2
Patrick, S.M.3
Kaliyaperumal, S.4
Sharma, V.P.5
-
44
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
doi 10.1073/pnas.92.20.9363
-
Dimri GM, Lee X, Basile G, Acosta M, Scott G, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367. doi:10.1073/pnas.92.20.9363. PubMed: 7568133.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.M.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
-
45
-
-
33845979430
-
The cell cycle and DNA mismatch repair
-
PubMed: 17157834
-
Schroering AG, Edelbrock MA, Richards TJ, Williams KJ, (2007) The cell cycle and DNA mismatch repair. Exp Cell Res 313: 292-304. PubMed: 17157834.
-
(2007)
Exp Cell Res
, vol.313
, pp. 292-304
-
-
Schroering, A.G.1
Edelbrock, M.A.2
Richards, T.J.3
Williams, K.J.4
-
46
-
-
43849107802
-
Rapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatment
-
doi 10.1016/j.dnarep.2008.03.023
-
Schroering AG, Williams KJ, (2008) Rapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatment. DNA Repair 7: 951-969. doi:10.1016/j.dnarep.2008.03.023. PubMed: 18468964.
-
(2008)
DNA Repair
, vol.7
, pp. 951-969
-
-
Schroering, A.G.1
Williams, K.J.2
-
47
-
-
0031419674
-
Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects
-
doi 10.1002/(SICI)1098-2744(199701)18:1
-
Glaab WE, Tindall KR, (1997) Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects. Carcinogenesis 18: 1-8. doi:10.1002/(SICI)1098-2744(199701)18:1. PubMed: 9054582.
-
(1997)
Carcinogenesis
, vol.18
, pp. 1-8
-
-
Glaab, W.E.1
Tindall, K.R.2
-
48
-
-
34648837230
-
Silencing of HPV 18 Oncoproteins With RNA Interference Causes Growth Inhibition of Cervical Cancer Cells
-
doi 10.1177/1933719107311464
-
Lea JS, Sunaga N, Sato M, Kalahasti G, Miller DS, et al. (2007) Silencing of HPV 18 Oncoproteins With RNA Interference Causes Growth Inhibition of Cervical Cancer Cells. Reprod Sci 14: 20-28. doi:10.1177/1933719107311464. PubMed: 17636212.
-
(2007)
Reprod Sci
, vol.14
, pp. 20-28
-
-
Lea, J.S.1
Sunaga, N.2
Sato, M.3
Kalahasti, G.4
Miller, D.S.5
-
49
-
-
0028117269
-
Analysis of the p53 Gene and Its Expression in Human Glioblastoma Cells
-
PubMed: 8306326
-
Van Meir EG, Kikuchi T, Tada M, Li H, Diserens A-C, et al. (1994) Analysis of the p53 Gene and Its Expression in Human Glioblastoma Cells. Cancer Res 54: 649-652. PubMed: 8306326.
-
(1994)
Cancer Res
, vol.54
, pp. 649-652
-
-
Van Meir, E.G.1
Kikuchi, T.2
Tada, M.3
Li, H.4
Diserens, A.-C.5
-
50
-
-
33845317242
-
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
-
doi 10.1073/pnas.0606528103
-
Yu S-W, Andrabi SA, Wang H, Kim NS, Poirier GG, et al. (2006) Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci USA 103: 18314-18319. doi:10.1073/pnas.0606528103. PubMed: 17116881.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 18314-18319
-
-
Yu, S.-W.1
Andrabi, S.A.2
Wang, H.3
Kim, N.S.4
Poirier, G.G.5
-
51
-
-
3042687605
-
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
-
doi 10.1083/jcb.200312031
-
Ekert PG, Read SH, Silke J, Marsden VS, Kaufmann H, et al. (2004) Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J Cell Biol 165: 835-842. doi:10.1083/jcb.200312031. PubMed: 15210730.
-
(2004)
J Cell Biol
, vol.165
, pp. 835-842
-
-
Ekert, P.G.1
Read, S.H.2
Silke, J.3
Marsden, V.S.4
Kaufmann, H.5
-
52
-
-
69249087671
-
Environment-mediated drug resistance: a major contributor to minimal residual disease
-
doi 10.1038/nrc2714
-
Meads MB, Gatenby RA, Dalton WS, (2009) Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer 9: 665-674. doi:10.1038/nrc2714. PubMed: 19693095.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 665-674
-
-
Meads, M.B.1
Gatenby, R.A.2
Dalton, W.S.3
-
53
-
-
33749576589
-
Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line
-
doi 10.1158/1535-7163.MCT-05-0428
-
Auger N, Thillet J, Wanherdrick K, Idbaih A, Legrier M-E, et al. (2006) Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line. Mol Cancer Ther 5: 2182-2192. doi:10.1158/1535-7163.MCT-05-0428. PubMed: 16985051.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2182-2192
-
-
Auger, N.1
Thillet, J.2
Wanherdrick, K.3
Idbaih, A.4
Legrier, M.-E.5
-
54
-
-
84863327274
-
Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cells
-
PubMed: 22564186
-
Happold C, Roth P, Wick W, Schmidt N, Florea A-M, et al. (2012) Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cells. J Neurochem, 122: 444-55. PubMed: 22564186.
-
(2012)
J Neurochem
, vol.122
, pp. 444-455
-
-
Happold, C.1
Roth, P.2
Wick, W.3
Schmidt, N.4
Florea, A.-M.5
-
55
-
-
78049466191
-
Therapeutic Targeting of the DNA Mismatch Repair Pathway
-
doi 10.1158/1078-0432.CCR-10-0821
-
Martin SA, Lord CJ, Ashworth A, (2010) Therapeutic Targeting of the DNA Mismatch Repair Pathway. Clin Cancer Res 16: 5107-5113. doi:10.1158/1078-0432.CCR-10-0821. PubMed: 20823149.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5107-5113
-
-
Martin, S.A.1
Lord, C.J.2
Ashworth, A.3
-
56
-
-
84865085680
-
DNA Damage and Repair in Human Cancer: Molecular Mechanisms and Contribution to Therapy-Related Leukemias
-
doi 10.3390/ijerph9082636
-
Casorelli I, Bossa C, Bignami M, (2012) DNA Damage and Repair in Human Cancer: Molecular Mechanisms and Contribution to Therapy-Related Leukemias. Int J Environ Res Public Health 9: 2636-2657. doi:10.3390/ijerph9082636. PubMed: 23066388.
-
(2012)
Int J Environ Res Public Health
, vol.9
, pp. 2636-2657
-
-
Casorelli, I.1
Bossa, C.2
Bignami, M.3
-
57
-
-
84884211499
-
Therapy-resistant tumor microvascular endothelial cells conribute to treatment failure in glioblastoma multiforme
-
doi 10.1038/onc.2012.172
-
Borovski T, Beke P, van Tellingen O, Rodermond HM, Verhoeff JJ, et al. (2013) Therapy-resistant tumor microvascular endothelial cells conribute to treatment failure in glioblastoma multiforme. Oncogene 32: 1539-1548. doi:10.1038/onc.2012.172. PubMed: 22614016.
-
(2013)
Oncogene
, vol.32
, pp. 1539-1548
-
-
Borovski, T.1
Beke, P.2
van Tellingen, O.3
Rodermond, H.M.4
Verhoeff, J.J.5
-
58
-
-
84859727401
-
Human ABCG2: structure, function, and its role in multidrug resistance
-
PubMed: 22509477
-
Mo W, Zhang J-T, (2012) Human ABCG2: structure, function, and its role in multidrug resistance. Int J Biochem Mol Biol 3: 1-27. PubMed: 22509477.
-
(2012)
Int J Biochem Mol Biol
, vol.3
, pp. 1-27
-
-
Mo, W.1
Zhang, J.-T.2
-
59
-
-
0033941733
-
Temozolomide and treatment of malignant glioma
-
doi 10914698
-
Friedman HS, Kerby T, Calvert H, (2000) Temozolomide and treatment of malignant glioma. Clin Cancer Res 6: 2585-2597. PubMed: 10914698.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2585-2597
-
-
Friedman, H.S.1
Kerby, T.2
Calvert, H.3
-
60
-
-
84874832925
-
Molecular Pathways: Targeting PARP in Cancer Treatment
-
doi 10.1158/1078-0432.CCR-12-0163
-
Do K, Chen AP, (2013) Molecular Pathways: Targeting PARP in Cancer Treatment. Clin Cancer Res 19: 977-984. doi:10.1158/1078-0432.CCR-12-0163. PubMed: 23269547.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 977-984
-
-
Do, K.1
Chen, A.P.2
-
61
-
-
84872868283
-
Mechanisms of resistance to PARP inhibitors - three and counting
-
PubMed: 23319766
-
Fojo T, Bates S, (2013) Mechanisms of resistance to PARP inhibitors- three and counting. Cancer Discov, 3: 20-23. PubMed: 23319766.
-
(2013)
Cancer Discov
, vol.3
, pp. 20-23
-
-
Fojo, T.1
Bates, S.2
-
62
-
-
60849125726
-
Effective sensitization by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines
-
doi 10.1158/1535-7163.MCT-08-0854
-
Clarke MJ, Mulligan EA, Grogan PT, Mladek AC, Carlson BL, et al. (2009) Effective sensitization by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines. Mol Cancer Ther 8: 407-414. doi:10.1158/1535-7163.MCT-08-0854. PubMed: 19174557.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 407-414
-
-
Clarke, M.J.1
Mulligan, E.A.2
Grogan, P.T.3
Mladek, A.C.4
Carlson, B.L.5
-
63
-
-
84873054943
-
Predicting Enhanced Cell Killing through PARP Inhibition
-
doi 10.1158/1541-7786.MCR-12-0512
-
Horton JK, Wilson SH, (2013) Predicting Enhanced Cell Killing through PARP Inhibition. Mol Cancer Res 11: 13-18. doi:10.1158/1541-7786.MCR-12-0512. PubMed: 23193155.
-
(2013)
Mol Cancer Res
, vol.11
, pp. 13-18
-
-
Horton, J.K.1
Wilson, S.H.2
-
64
-
-
77950023283
-
PARP inhibition: PARP1 and beyond
-
doi 10.1038/nrc2812
-
Rouleau M, Patel A, Hendzel MJ, Kaufmann SH, Poirier GG, (2010) PARP inhibition: PARP1 and beyond. Nat Rev Cancer 10: 293-301. doi:10.1038/nrc2812. PubMed: 20200537.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 293-301
-
-
Rouleau, M.1
Patel, A.2
Hendzel, M.J.3
Kaufmann, S.H.4
Poirier, G.G.5
-
65
-
-
79953840957
-
Poly(ADP-Ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR Polymerase-1-dependent cell death (parthanatos)
-
PubMed: 21467298
-
Wang Y, Kim NS, Haince J-F, Kang HC, David KK, et al. (2011) Poly(ADP-Ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR Polymerase-1-dependent cell death (parthanatos). Sciencesignaling 4: 1-13. PubMed: 21467298.
-
(2011)
Sciencesignaling
, vol.4
, pp. 1-13
-
-
Wang, Y.1
Kim, N.S.2
Haince, J.-F.3
Kang, H.C.4
David, K.K.5
|