-
1
-
-
84872837247
-
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors
-
Jaspers JE, Kersbergen A, Boon U, Sol W, Deemter L, Zander SA, et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov 2013;3(1):68-81.
-
(2013)
Cancer Discov
, vol.3
, Issue.1
, pp. 68-81
-
-
Jaspers, J.E.1
Kersbergen, A.2
Boon, U.3
Sol, W.4
Deemter, L.5
Zander, S.A.6
-
2
-
-
34547504504
-
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer
-
Rottenberg S, Nygren AO, Pajic M, van Leeuwen FW, van der Heijden I, van de Wetering K, et al. Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci U S A 2007;104:12117-12122.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 12117-12122
-
-
Rottenberg, S.1
Nygren, A.O.2
Pajic, M.3
van Leeuwen, F.W.4
van der Heijden, I.5
van de Wetering, K.6
-
3
-
-
55949092708
-
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
-
Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A 2008; 105: 17079-17084.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17079-17084
-
-
Rottenberg, S.1
Jaspers, J.E.2
Kersbergen, A.3
van der Burg, E.4
Nygren, A.O.5
Zander, S.A.6
-
4
-
-
69249105956
-
Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer
-
Pajic M, Iyer JK, Kersbergen A, van der Burg E, Nygren AO, Jonkers J, et al. Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. Cancer Res 2009;69:6396-6404.
-
(2009)
Cancer Res
, vol.69
, pp. 6396-6404
-
-
Pajic, M.1
Iyer, J.K.2
Kersbergen, A.3
van der Burg, E.4
Nygren, A.O.5
Jonkers, J.6
-
5
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine D A, et al. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 2008;451:1111-1115.
-
(2008)
Nature
, vol.451
, pp. 1111-1115
-
-
Edwards, S.L.1
Brough, R.2
Lord, C.J.3
Natrajan, R.4
Vatcheva, R.5
Levine, D.A.6
-
6
-
-
84860669151
-
Ta rgeting MDR in breast and lung cancer: Discriminating its potential importance from the failure of drug resistance reversal studies
-
Amiri-Kordestani L, Basseville A, Kurdziel K, Fojo AT, Bates SE. Ta rgeting MDR in breast and lung cancer: discriminating its potential importance from the failure of drug resistance reversal studies. Drug Resist Updat 2012;15:50-61.
-
(2012)
Drug Resist Updat
, vol.15
, pp. 50-61
-
-
Amiri-Kordestani, L.1
Basseville, A.2
Kurdziel, K.3
Fojo, A.T.4
Bates, S.E.5
-
7
-
-
84856890066
-
Resistance patterns with tyrosine kinase inhibitors in melanoma: New insights
-
Dummer R, Flaherty KT. Resistance patterns with tyrosine kinase inhibitors in melanoma: new insights. Curr Opin Oncol 2012; 24: 150-154
-
(2012)
Curr Opin Oncol
, vol.24
, pp. 150-154
-
-
Dummer, R.1
Flaherty, K.T.2
-
8
-
-
77955019276
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
-
Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 2010;376:235-244.
-
(2010)
Lancet
, vol.376
, pp. 235-244
-
-
Tutt, A.1
Robson, M.2
Garber, J.E.3
Domchek, S.M.4
Audeh, M.W.5
Weitzel, J.N.6
-
9
-
-
77955039099
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
-
Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell-McGuinn KM, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010;376:245-251.
-
(2010)
Lancet
, vol.376
, pp. 245-251
-
-
Audeh, M.W.1
Carmichael, J.2
Penson, R.T.3
Friedlander, M.4
Powell, B.5
Bell-McGuinn, K.M.6
-
10
-
-
84863236347
-
A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas
-
Kummar S, Ji J, Morgan R, Lenz HJ, Puhalla SL, Belani CP, et al. A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas. Clin Cancer Res 2012;18:1726-1734.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1726-1734
-
-
Kummar, S.1
Ji, J.2
Morgan, R.3
Lenz, H.J.4
Puhalla, S.L.5
Belani, C.P.6
-
11
-
-
77956657460
-
Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer
-
Annunziata CM, O'Shaughnessy J. Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer. Clin Cancer Res 2010; 16: 4517-4526.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4517-4526
-
-
Annunziata, C.M.1
O'Shaughnessy, J.2
-
12
-
-
77953291328
-
53BP1 loss rescues BRCA1 defi ciency and is associated with triple-negative and BRCA-mutated breast cancers
-
Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, et al. 53BP1 loss rescues BRCA1 defi ciency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol 2010;17:688-695.
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 688-695
-
-
Bouwman, P.1
Aly, A.2
Escandell, J.M.3
Pieterse, M.4
Bartkova, J.5
van der Gulden, H.6
-
13
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-defi cient cells by blocking resection of DNA breaks
-
Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, et al. 53BP1 inhibits homologous recombination in Brca1-defi cient cells by blocking resection of DNA breaks. Cell 2010;141:243-254.
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
Callén, E.2
Wong, N.3
Chen, H.T.4
Polato, F.5
Gunn, A.6
-
14
-
-
37349096996
-
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian doublestrand break repair
-
Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, et al. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian doublestrand break repair. Mol Cell 2007;28:1045-1057.
-
(2007)
Mol Cell
, vol.28
, pp. 1045-1057
-
-
Xie, A.1
Hartlerode, A.2
Stucki, M.3
Odate, S.4
Puget, N.5
Kwok, A.6
-
15
-
-
84868221110
-
Trapping of PARP1 and PARP2 by clinical PARP inhibitors
-
Murai J, Huang SY, Das BB, Renaud A, Zhang Y, Doroshow JH, et al. Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Cancer Res 2012;72:5588-5599.
-
(2012)
Cancer Res
, vol.72
, pp. 5588-5599
-
-
Murai, J.1
Huang, S.Y.2
Das, B.B.3
Renaud, A.4
Zhang, Y.5
Doroshow, J.H.6
-
16
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012;487:505-509.
-
(2012)
Nature
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
Fridlyand, J.2
Yan, Y.3
Penuel, E.4
Burton, L.5
Chan, E.6
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