메뉴 건너뛰기




Volumn 5, Issue , 2010, Pages 33-50

The pathobiology of glioma tumors

Author keywords

Astrocytoma; Genetic alterations; Glioblastoma; Signaling pathway alterations

Indexed keywords

131I 81C6; 2 METHOXYESTRADIOL; ANTINEOPLASTIC AGENT; ARF PROTEIN; CEDIRANIB; CILENGITIDE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DASATINIB; DELETED IN MALIGNANT BRAIN TUMOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FOCAL ADHESION KINASE; GEFITINIB; IMATINIB; MAB 425; MGCD 265; N ACETYLPROLYLHISTIDYLSERYLCYSTEINYLASPARAGINE AMIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PRINOMASTAT; PROTEIN; PROTEIN MDM2; SORAFENIB; SURAMIN; UNCLASSIFIED DRUG; VANDETANIB; VATALANIB; XL 184; XL 765;

EID: 77949883876     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev-pathol-121808-102109     Document Type: Review
Times cited : (199)

References (138)
  • 1
    • 33645732219 scopus 로고    scopus 로고
    • Molecular pathology of malignant gliomas
    • Louis DN. 2006. Molecular pathology of malignant gliomas. Annu. Rev. Pathol. Mech. Dis. 1:97-117
    • (2006) Annu. Rev. Pathol. Mech. Dis. , vol.1 , pp. 97-117
    • Louis, D.N.1
  • 2
    • 67649259009 scopus 로고    scopus 로고
    • The expanding impact of molecular biology on the diagnosis and treatment of gliomas
    • Mason WP, Cairncross JG. 2008. The expanding impact of molecular biology on the diagnosis and treatment of gliomas. Neurology 71:365-373
    • (2008) Neurology , vol.71 , pp. 365-373
    • Mason, W.P.1    Cairncross, J.G.2
  • 3
    • 3142737393 scopus 로고    scopus 로고
    • Genetic and signaling pathway alterations in glioblastoma: Relevance to novel targeted therapies
    • Rao RD, Uhm JH, Krishnan S, James CD. 2003. Genetic and signaling pathway alterations in glioblastoma: relevance to novel targeted therapies. Front. Biosci. 8:e270-80
    • (2003) Front. Biosci. , vol.8
    • Rao, R.D.1    Uhm, J.H.2    Krishnan, S.3    James, C.D.4
  • 4
    • 54949120568 scopus 로고    scopus 로고
    • Designer therapies for glioblastoma multiforme
    • Sathornsumetee S, Rich JN. 2008. Designer therapies for glioblastoma multiforme. Ann. N.Y. Acad. Sci. 1142:108-132
    • (2008) Ann. N.Y. Acad. Sci. , vol.1142 , pp. 108-132
    • Sathornsumetee, S.1    Rich, J.N.2
  • 5
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S. 2008. Malignant gliomas in adults. N. Engl. J. Med. 359:492-507
    • (2008) N. Engl. J. Med. , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 6
    • 0031806897 scopus 로고    scopus 로고
    • Magnetic field exposure and neurodegenerative disease mortality among electric utility workers
    • Savitz DA, Checkoway H, Loomis DP. 1998. Magnetic field exposure and neurodegenerative disease mortality among electric utility workers. Epidemiology 9:398-404
    • (1998) Epidemiology , vol.9 , pp. 398-404
    • Savitz, D.A.1    Checkoway, H.2    Loomis, D.P.3
  • 7
    • 39149136486 scopus 로고    scopus 로고
    • Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma
    • Mitchell DA, Xie W, Schmittling R, Learn C, Friedman A, et al. 2008. Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. Neuro-Oncology 10:10-18
    • (2008) Neuro-Oncology , vol.10 , pp. 10-18
    • Mitchell, D.A.1    Xie, W.2    Schmittling, R.3    Learn, C.4    Friedman, A.5
  • 8
    • 0027944927 scopus 로고
    • Brain tumors in children
    • Pollack IF. 1994. Brain tumors in children. N. Engl. J. Med. 331:1500-1507
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1500-1507
    • Pollack, I.F.1
  • 9
    • 20344407807 scopus 로고    scopus 로고
    • Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    • Ohgaki H, Kleihues P. 2005. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J. Neuropathol. Exp. Neurol. 64:479-489
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 479-489
    • Ohgaki, H.1    Kleihues, P.2
  • 10
    • 0035425048 scopus 로고    scopus 로고
    • PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    • Dai C, Celestino JC, Okada Y, Louis DN Fuller GN, Holland EC. 2001. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev. 15:1913-1925
    • (2001) Genes Dev , vol.15 , pp. 1913-1925
    • Dai, C.1    Celestino, J.C.2    Okada, Y.3    Louis, D.N.4    Fuller, G.N.5    Holland, E.C.6
  • 14
    • 31644442040 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) and glial tumorigenesis
    • Shih AH, Holland EC. 2006. Platelet-derived growth factor (PDGF) and glial tumorigenesis. Cancer Lett. 232:139-147
    • (2006) Cancer Lett , vol.232 , pp. 139-147
    • Shih, A.H.1    Holland, E.C.2
  • 16
    • 33745796420 scopus 로고    scopus 로고
    • Molecular genetics of oligodendrogliomas: A model for improved clinical management in the field of neurooncology
    • Nutt CL. 2005. Molecular genetics of oligodendrogliomas: a model for improved clinical management in the field of neurooncology. Neurosurg. Focus 19:E2
    • (2005) Neurosurg. Focus. , vol.19
    • Nutt, C.L.1
  • 18
    • 34547432233 scopus 로고    scopus 로고
    • Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma
    • Wiencke JK, Zheng S, Jelluma N, Tihan T, Vandenberg S, et al. 2007. Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro-Oncology 9:271-279
    • (2007) Neuro-Oncology , vol.9 , pp. 271-279
    • Wiencke, J.K.1    Zheng, S.2    Jelluma, N.3    Tihan, T.4    Vandenberg, S.5
  • 19
    • 0033621190 scopus 로고    scopus 로고
    • Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors
    • Shoshan Y, Nishiyama A, Chang A, Mork S, Barnett GH, et al. 1999. Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors. Proc. Natl. Acad. Sci. USA 96:10361-10366
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10361-10366
    • Shoshan, Y.1    Nishiyama, A.2    Chang, A.3    Mork, S.4    Barnett, G.H.5
  • 20
    • 0034039961 scopus 로고    scopus 로고
    • Amplification of the plateletderived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features
    • Smith JS, Wang XY, Qian J, Hosek SM, Scheithauer BW, et al. 2000. Amplification of the plateletderived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features. J. Neuropathol. Exp. Neurol. 59(6):495-503
    • (2000) J. Neuropathol. Exp. Neurol. , vol.59 , Issue.6 , pp. 495-503
    • Smith, J.S.1    Wang, X.Y.2    Qian, J.3    Hosek, S.M.4    Scheithauer, B.W.5
  • 21
    • 33744529640 scopus 로고    scopus 로고
    • Glioma test array for use with formalin-fixed, paraffin-embedded tissue: Array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization
    • Mohapatra G, Betensky RA, Miller ER, Carey B, Gaumont LD, et al. 2006. Glioma test array for use with formalin-fixed, paraffin-embedded tissue: Array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization. J. Mol. Diagn. 8:268-276
    • (2006) J. Mol. Diagn. , vol.8 , pp. 268-276
    • Mohapatra, G.1    Betensky, R.A.2    Miller, E.R.3    Carey, B.4    Gaumont, L.D.5
  • 22
    • 0033566061 scopus 로고    scopus 로고
    • Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype
    • Smith JS, Alderete B, Minn Y, Borell TJ, Perry A, et al. 1999. Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype. Oncogene 18:4144-4152
    • (1999) Oncogene , vol.18 , pp. 4144-4152
    • Smith, J.S.1    Alderete, B.2    Minn, Y.3    Borell, T.J.4    Perry, A.5
  • 23
    • 0032801035 scopus 로고    scopus 로고
    • Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridizati on
    • Bigner SH, Matthews MR, Rasheed BKA,Wiltshire RN, Friedman HS, et al. 1999. Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization. Am. J. Pathol. 155:375-386
    • (1999) Am. J. Pathol. , vol.155 , pp. 375-386
    • Bigner, S.H.1    Matthews, M.R.2    Rasheed, B.K.A.3    Wiltshire, R.N.4    Friedman, H.S.5
  • 24
    • 0035406063 scopus 로고    scopus 로고
    • PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis
    • Sasaki H, Zlatescu MC, Betensky RA, Ino Y, Cairncross JG, Louis DN. 2001. PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. Am. J. Pathol. 159:359-367
    • (2001) Am. J. Pathol. , vol.159 , pp. 359-367
    • Sasaki, H.1    Zlatescu, M.C.2    Betensky, R.A.3    Ino, Y.4    Cairncross, J.G.5    Louis, D.N.6
  • 25
    • 0036645057 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGR) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    • Lokker NA, Sullivan CM, Hollenbach SJ, Israel MA, Giese NA. 2002. Platelet-derived growth factor (PDGR) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res. 62:3729-3735
    • (2002) Cancer Res , vol.62 , pp. 3729-3735
    • Lokker, N.A.1    Sullivan, C.M.2    Hollenbach, S.J.3    Israel, M.A.4    Giese, N.A.5
  • 27
    • 0026793260 scopus 로고
    • Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glialtumors
    • Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, et al. 1992. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res. 52:4550-4553
    • (1992) Cancer Res , vol.52 , pp. 4550-4553
    • Fleming, T.P.1    Saxena, A.2    Clark, W.C.3    Robertson, J.T.4    Oldfield, E.H.5
  • 29
    • 0033045956 scopus 로고    scopus 로고
    • Distinct pattern of PCR-SSCP analysis of p53 mutations in human astrocytomas
    • Thangnipon W, Mizoguchi M, Kukita Y, Inazuka M, Iwaki T, et al. 1999. Distinct pattern of PCR-SSCP analysis of p53 mutations in human astrocytomas. Cancer Lett. 141:195-201
    • (1999) Cancer Lett , vol.141 , pp. 195-201
    • Thangnipon, W.1    Mizoguchi, M.2    Kukita, Y.3    Inazuka, M.4    Iwaki, T.5
  • 31
    • 11444257765 scopus 로고    scopus 로고
    • Genetics of glioblastoma multiforme: Mitogenic signaling and cell cycle pathways converge
    • Soni D, King JA, Kaye AH, Hovens CM. 2005. Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. J. Clin. Neurosci. 12:1-5
    • (2005) J. Clin. Neurosci. , vol.12 , pp. 1-5
    • Soni, D.1    King, J.A.2    Kaye, A.H.3    Hovens, C.M.4
  • 32
    • 34250877865 scopus 로고    scopus 로고
    • Genetic pathways to primary and secondary glioblastoma
    • Ohgaki H, Kleihues P. 2007. Genetic pathways to primary and secondary glioblastoma. Am. J. Pathol. 170:1445-1453
    • (2007) Am. J. Pathol. , vol.170 , pp. 1445-1453
    • Ohgaki, H.1    Kleihues, P.2
  • 33
    • 0030056824 scopus 로고    scopus 로고
    • Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas
    • Tsuzuki T, Tsunoda S, Sakaki T, Konishi N, Hiasa Y, Nakamura M. 1996. Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas. Cancer 78:287-293
    • (1996) Cancer , vol.78 , pp. 287-293
    • Tsuzuki, T.1    Tsunoda, S.2    Sakaki, T.3    Konishi, N.4    Hiasa, Y.5    Nakamura, M.6
  • 34
    • 0028204493 scopus 로고
    • Loci associated with malignant progression in astrocytomas: A candidate on chromosome 19q
    • von Deimling A, Bender B, Jahnke R, Waha A, Kraus J, et al. 1994. Loci associated with malignant progression in astrocytomas: a candidate on chromosome 19q. Cancer Res. 54:1397-1401
    • (1994) Cancer Res , vol.54 , pp. 1397-1401
    • Von Deimling, A.1    Bender, B.2    Jahnke, R.3    Waha, A.4    Kraus, J.5
  • 35
    • 33750038279 scopus 로고    scopus 로고
    • Prognostic stratification of patients with anaplastic gliomas according to genetic profile
    • Dehais C, Laigle-Donadey F, Marie Y, Kujas M, Lejeune J, et al. 2006. Prognostic stratification of patients with anaplastic gliomas according to genetic profile. Cancer 107:1891-1897
    • (2006) Cancer , vol.107 , pp. 1891-1897
    • Dehais, C.1    Laigle-Donadey, F.2    Marie, Y.3    Kujas, M.4    Lejeune, J.5
  • 36
    • 1842536417 scopus 로고    scopus 로고
    • Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from radiation therapy oncology group trials
    • Brat DJ, Seiferheld WF, Perry A, Hammond EH, Murray KJ, et al. 2004. Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from radiation therapy oncology group trials. Neuro-Oncology 6:96-103
    • (2004) Neuro-Oncology , vol.6 , pp. 96-103
    • Brat, D.J.1    Seiferheld, W.F.2    Perry, A.3    Hammond, E.H.4    Murray, K.J.5
  • 37
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP. 1993. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. 53:2736-2739
    • (1993) Cancer Res , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 38
    • 23944509258 scopus 로고    scopus 로고
    • Molecular mechanisms in gliomagenesis
    • Hulleman E, Helin K. 2005. Molecular mechanisms in gliomagenesis. Adv. Cancer Res. 94:1-27
    • (2005) Adv. Cancer Res. , vol.94 , pp. 1-27
    • Hulleman, E.1    Helin, K.2
  • 39
    • 0030806772 scopus 로고    scopus 로고
    • Prognostic factors in malignant glioma: Influence of the overexpression of oncogene and tumor-suppressor gene products on survival
    • Rainov NG, Dobberstein KU, Bahn H, Holzhausen HJ, Lautenschlager C, et al. 1997. Prognostic factors in malignant glioma: influence of the overexpression of oncogene and tumor-suppressor gene products on survival. J. Neurooncol. 35:13-28
    • (1997) J. Neurooncol. , vol.35 , pp. 13-28
    • Rainov, N.G.1    Dobberstein, K.U.2    Bahn, H.3    Holzhausen, H.J.4    Lautenschlager, C.5
  • 40
    • 0030970202 scopus 로고    scopus 로고
    • MDM2 and p53 expression in gliomas: A multivariate survival analysis including proliferation markers and epidermal growth factor receptor
    • Korkolopoulou P, Christodoulou P, Kouzelis K, Hadjiyannakis M, Priftis A, et al. 1997. MDM2 and p53 expression in gliomas: a multivariate survival analysis including proliferation markers and epidermal growth factor receptor. Br. J. Cancer 75:1269-1278
    • (1997) Br. J. Cancer. , vol.75 , pp. 1269-1278
    • Korkolopoulou, P.1    Christodoulou, P.2    Kouzelis, K.3    Hadjiyannakis, M.4    Priftis, A.5
  • 41
    • 0029810125 scopus 로고    scopus 로고
    • Twelve amplified and expressed genes localized in a single domain in glioma
    • Fischer U, Meltzer P, Meese E. 1996. Twelve amplified and expressed genes localized in a single domain in glioma. Hum. Genet. 98:625-628
    • (1996) Hum. Genet. , vol.98 , pp. 625-628
    • Fischer, U.1    Meltzer, P.2    Meese, E.3
  • 42
    • 0032809735 scopus 로고    scopus 로고
    • Common regions of deletion on chromosome 22q12.3-q13.1 and 22q13.2 in human astrocytomas appear related to malignancy grade
    • Ino Y, Silver JS, Blazejewski L, Nishikawa R, Matsutani M, et al. 1999. Common regions of deletion on chromosome 22q12.3-q13.1 and 22q13.2 in human astrocytomas appear related to malignancy grade. J. Neuropathol. Exp. Neurol. 58:881-885
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 881-885
    • Ino, Y.1    Silver, J.S.2    Blazejewski, L.3    Nishikawa, R.4    Matsutani, M.5
  • 43
    • 9244231101 scopus 로고    scopus 로고
    • Recurrent gain of chromosome arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization
    • Schrock E, Blume C, Meffert MC, du Manoir S, Bersch W, et al. 1996. Recurrent gain of chromosome arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization. Genes Chromosomes Cancer 15:199-205
    • (1996) Genes Chromosomes Cancer , vol.15 , pp. 199-205
    • Schrock, E.1    Blume, C.2    Meffert, M.C.3    Manoir, S.4    Bersch, W.5
  • 44
    • 26044467362 scopus 로고    scopus 로고
    • Amplification of genes encoding KIT, PDGFR and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme
    • Joensuu H, Puputti M, Sihto H, Tynninen O, Nupponen NN. 2005. Amplification of genes encoding KIT, PDGFR and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme. J. Pathol. 207:224-231
    • (2005) J. Pathol. , vol.207 , pp. 224-231
    • Joensuu, H.1    Puputti, M.2    Sihto, H.3    Tynninen, O.4    Nupponen, N.N.5
  • 45
    • 0142188691 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
    • Shinojima N, Tada K, Shiraishi S, Kamiryo T, Kochi M, et al. 2003. Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res. 63:6962-6970
    • (2003) Cancer Res , vol.63 , pp. 6962-6970
    • Shinojima, N.1    Tada, K.2    Shiraishi, S.3    Kamiryo, T.4    Kochi, M.5
  • 46
    • 0033968345 scopus 로고    scopus 로고
    • Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas
    • Fujisawa H, Reis RM, Nakamura M, Colella S, Yonekawa Y, et al. 2000. Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas. Lab. Investig. 80:65-72
    • (2000) Lab. Investig , vol.80 , pp. 65-72
    • Fujisawa, H.1    Reis, R.M.2    Nakamura, M.3    Colella, S.4    Yonekawa, Y.5
  • 48
    • 0034998193 scopus 로고    scopus 로고
    • Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization
    • Hui AB-Y, Lo KW, Yin XL, Poon WS, Ng HK. 2001. Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Lab. Investig. 81:717-723
    • (2001) Lab. Investig , vol.81 , pp. 717-723
    • Ab-Y, H.1    Lo, K.W.2    Yin, X.L.3    Poon, W.S.4    Ng, H.K.5
  • 49
    • 0033772866 scopus 로고    scopus 로고
    • Molecular analysis of the PTEN, TP53 andCDKN2Atumor suppressor genes in long-term survivors of glioblastoma multiforme
    • Kraus JA, Glesmann N, Beck M, Krex D, Klockgether T, et al. 2000. Molecular analysis of the PTEN, TP53 andCDKN2Atumor suppressor genes in long-term survivors of glioblastoma multiforme. J. Neurooncol. 48:89-94
    • (2000) J. Neurooncol , vol.48 , pp. 89-94
    • Kraus, J.A.1    Glesmann, N.2    Beck, M.3    Krex, D.4    Klockgether, T.5
  • 51
    • 0030799909 scopus 로고    scopus 로고
    • Somatic mutations of PTEN in glioblastoma multiforme
    • Wang SI, Puc J, Li J, Bruce JN, Cairns P, et al. 1997. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res. 57:4183-4186
    • (1997) Cancer Res , vol.57 , pp. 4183-4186
    • Wang, S.I.1    Puc, J.2    Li, J.3    Bruce, J.N.4    Cairns, P.5
  • 52
    • 48049097565 scopus 로고    scopus 로고
    • Tyrosine kinase expression in pediatric high grade astrocytoma
    • Liang ML,Ma J, HoM, Solomon L, Bouffet E, et al. 2008. Tyrosine kinase expression in pediatric high grade astrocytoma. J. Neurooncol. 87:247-253
    • (2008) J. Neurooncol , vol.87 , pp. 247-253
    • Liang, M.L.1    Ma, J.2    Ho, M.3    Solomon, L.4    Bouffet, E.5
  • 53
    • 0037099758 scopus 로고    scopus 로고
    • Influence of p53 mutations on prognosis of patients with glioblastoma
    • Shiraishi S, Tada K, Nakamura H, Makino K, Kochi M, et al. 2002. Influence of p53 mutations on prognosis of patients with glioblastoma. Cancer 95:249-257
    • (2002) Cancer , vol.95 , pp. 249-257
    • Shiraishi, S.1    Tada, K.2    Nakamura, H.3    Makino, K.4    Kochi, M.5
  • 54
    • 0030879478 scopus 로고    scopus 로고
    • DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours
    • Mollenhauer J,Wiemann S, Scheurlen W, Korn B, Hayashi Y, et al. 1997. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat. Genet. 17:32-39
    • (1997) Nat. Genet , vol.17 , pp. 32-39
    • Mollenhauer, J.1    Wiemann, S.2    Scheurlen, W.3    Korn, B.4    Hayashi, Y.5
  • 55
    • 0030784940 scopus 로고    scopus 로고
    • MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells
    • Wechsler DS, Shelly CA, Petroff CA, Dang CV. 1997. MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells. Cancer Res. 57:4905-4912
    • (1997) Cancer Res , vol.57 , pp. 4905-4912
    • Wechsler, D.S.1    Shelly, C.A.2    Petroff, C.A.3    Dang, C.V.4
  • 56
    • 0030881477 scopus 로고    scopus 로고
    • Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas
    • Biernat W, Tohma Y, Yonekawa Y, Kleihues P, Ohgaki H. 1997. Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas. Acta Neuropathol. 94:303-309
    • (1997) Acta Neuropathol , vol.94 , pp. 303-309
    • Biernat, W.1    Tohma, Y.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 59
    • 0030874380 scopus 로고    scopus 로고
    • Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene
    • Watts GS, Pieper RO, Costello JF, Peng YM, Dalton WS, Futscher BW. 1997. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol. Cell. Biol. 17:5612-5619
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5612-5619
    • Watts, G.S.1    Pieper, R.O.2    Costello, J.F.3    Peng, Y.M.4    Dalton, W.S.5    Futscher, B.W.6
  • 60
    • 48649086682 scopus 로고    scopus 로고
    • Mechanisms of disease: Temozolomide and glioblastoma-look to the future
    • Mrugala MM, Chamberlain MC. 2008. Mechanisms of disease: temozolomide and glioblastoma-look to the future. Nat. Clin. Pract. Oncol. 5:476-486
    • (2008) Nat. Clin. Pract. Oncol. , vol.5 , pp. 476-486
    • Mrugala, M.M.1    Chamberlain, M.C.2
  • 62
    • 0030823671 scopus 로고    scopus 로고
    • Methylation hot spots in the 5 flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene
    • Qian XC, Brent TP. 1997. Methylation hot spots in the 5 flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene. Cancer Res. 57:3672-3677
    • (1997) Cancer Res , vol.57 , pp. 3672-3677
    • Qian, X.C.1    Brent, T.P.2
  • 63
    • 0032401819 scopus 로고    scopus 로고
    • Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus
    • Uhrbom L, Hesselager G, Nister M, Westermark B. 1998. Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Cancer Res. 58:5275-5279
    • (1998) Cancer Res , vol.58 , pp. 5275-5279
    • Uhrbom, L.1    Hesselager, G.2    Nister, M.3    Westermark, B.4
  • 65
    • 9144251024 scopus 로고    scopus 로고
    • Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
    • Uhrbom L, Nerio E, Holland EC. 2004. Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. Nat. Med. 10:1257-1260
    • (2004) Nat. Med. , vol.10 , pp. 1257-1260
    • Uhrbom, L.1    Nerio, E.2    Holland, E.C.3
  • 66
    • 34547637424 scopus 로고    scopus 로고
    • Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo
    • Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, et al. 2007. Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo. Cancer Res. 67:7335-7342
    • (2007) Cancer Res , vol.67 , pp. 7335-7342
    • Arwert, E.1    Hingtgen, S.2    Figueiredo, J.L.3    Bergquist, H.4    Mahmood, U.5
  • 67
    • 0141994778 scopus 로고    scopus 로고
    • The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged
    • Ding Q, Stewart JE Jr, Olman MA, Klobe MR, Gladson CL. 2003. The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged. J. Biol. Chem. 278:39882-39891
    • (2003) J. Biol. Chem. , vol.278 , pp. 39882-39891
    • Ding, Q.1    Stewart Jr., J.E.2    Olman, M.A.3    Klobe, M.R.4    Gladson, C.L.5
  • 69
    • 0034704174 scopus 로고    scopus 로고
    • Platelet derived growth factor receptor and vascular endothelial growth factor receptor 2 bind to the 3 integrin through its extracellular domain
    • Borges E, Jan Y, Ruoslahti E. 2000. Platelet derived growth factor receptor and vascular endothelial growth factor receptor 2 bind to the 3 integrin through its extracellular domain. J. Biol. Chem. 275:39867-39873
    • (2000) J. Biol. Chem. , vol.275 , pp. 39867-39873
    • Borges, E.1    Jan, Y.2    Ruoslahti, E.3
  • 71
    • 33846004471 scopus 로고    scopus 로고
    • Integrin regulation by vascular endothelial growth factor in human brain microvascular endothelial cells: Role of 61 integrin in angiogenesis
    • Lee TH, Seng S, Li H, Kennel SJ, Avraham HK, Avraham S. 2006. Integrin regulation by vascular endothelial growth factor in human brain microvascular endothelial cells: role of 61 integrin in angiogenesis. J. Biol. Chem. 281:40450-40460
    • (2006) J. Biol. Chem. , vol.281 , pp. 40450-40460
    • Lee, T.H.1    Seng, S.2    Li, H.3    Kennel, S.J.4    Avraham, H.K.5    Avraham, S.6
  • 72
    • 33748068089 scopus 로고    scopus 로고
    • New concepts regarding focal adhesion kinase promotion of cell migration and proliferation
    • Cox BD, Natarajan M, Stettner MR, Gladson CL. 2006. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J. Cell Biochem. 99:35-52
    • (2006) J. Cell Biochem. , vol.99 , pp. 35-52
    • Cox, B.D.1    Natarajan, M.2    Stettner, M.R.3    Gladson, C.L.4
  • 73
    • 21344470873 scopus 로고    scopus 로고
    • Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells
    • Stettner MR, Wang W, Nabors LB, Bharara S, Flynn DC, et al. 2005. Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells. Cancer Res. 65:5535-5543
    • (2005) Cancer Res , vol.65 , pp. 5535-5543
    • Stettner, M.R.1    Wang, W.2    Nabors, L.B.3    Bharara, S.4    Flynn, D.C.5
  • 74
    • 14844327984 scopus 로고    scopus 로고
    • P27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain
    • Ding Q, Grammer JR, Nelson MA, Guan JL, Stewart JE Jr, Gladson CL. 2005. p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. J. Biol. Chem. 280:6802-6815
    • (2005) J. Biol. Chem , vol.280 , pp. 6802-6815
    • Ding, Q.1    Grammer, J.R.2    Nelson, M.A.3    Guan, J.L.4    Stewart Jr., J.E.5    Gladson, C.L.6
  • 75
    • 0033833068 scopus 로고    scopus 로고
    • Pyk2 and FAK differentially regulate progression of the cell cycle
    • Zhao J, Zheng C, Guan J. 2000. Pyk2 and FAK differentially regulate progression of the cell cycle. J. Cell Sci. 113:3063-3072
    • (2000) J. Cell Sci. , vol.113 , pp. 3063-3072
    • Zhao, J.1    Zheng, C.2    Guan, J.3
  • 76
    • 0035661624 scopus 로고    scopus 로고
    • Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression
    • Zhao J, Pestell R, Guan JL. 2001. Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol. Biol. Cell 12:4066-4077
    • (2001) Mol. Biol. Cell. , vol.12 , pp. 4066-4077
    • Zhao, J.1    Pestell, R.2    Guan, J.L.3
  • 77
    • 0038433306 scopus 로고    scopus 로고
    • Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression
    • Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL. 2003. Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol. Cell 11:1503-1515
    • (2003) Mol. Cell. , vol.11 , pp. 1503-1515
    • Zhao, J.1    Bian, Z.C.2    Yee, K.3    Chen, B.P.4    Chien, S.5    Guan, J.L.6
  • 78
    • 0041737535 scopus 로고    scopus 로고
    • Molecular mechanisms of glioma invasiveness: The role of proteases
    • Rao JS. 2003. Molecular mechanisms of glioma invasiveness: the role of proteases. Nat. Rev. Cancer 3:489-501
    • (2003) Nat. Rev. Cancer. , vol.3 , pp. 489-501
    • Rao, J.S.1
  • 80
    • 9144232309 scopus 로고    scopus 로고
    • Molecular mechanisms of glioma cell migration and invasion
    • Demuth T, Berens ME. 2004. Molecular mechanisms of glioma cell migration and invasion. J. Neurooncol. 70:217-228
    • (2004) J. Neurooncol. , vol.70 , pp. 217-228
    • Demuth, T.1    Berens, M.E.2
  • 81
    • 77952929061 scopus 로고    scopus 로고
    • Role and regulation of proteases in human gliomas
    • ed. U Lendeckel, N Hooper, New York: Springer
    • Lakka S, Rao J. 2005. Role and regulation of proteases in human gliomas. In Proteases in the Brain, ed. U Lendeckel, N Hooper, pp. 151-177 New York: Springer
    • (2005) Proteases in the Brain , pp. 151-177
    • Lakka, S.1    Rao, J.2
  • 82
    • 15444355527 scopus 로고    scopus 로고
    • Scatter factor promotes motility of human glioma and neuromicrovascular endothelial cells
    • Lamszus K, Schmidt NO, Jin L, Laterra J, Zagzag D, et al. 1998. Scatter factor promotes motility of human glioma and neuromicrovascular endothelial cells. Int. J. Cancer 75:19-28
    • (1998) Int. J. Cancer. , vol.75 , pp. 19-28
    • Lamszus, K.1    Schmidt, N.O.2    Jin, L.3    Laterra, J.4    Zagzag, D.5
  • 83
    • 57349179996 scopus 로고    scopus 로고
    • Epidermal growth factorinduced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence
    • Kim HD, Guo TW, Wu AP, Wells A, Gertler FB, Lauffenburger DA. 2008. Epidermal growth factorinduced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Mol. Biol. Cell. 19: 4249-4259
    • (2008) Mol. Biol. Cell. , vol.19 , pp. 4249-4259
    • Kim, H.D.1    Guo, T.W.2    Wu, A.P.3    Wells, A.4    Gertler, F.B.5    Lauffenburger, D.A.6
  • 85
    • 33745778950 scopus 로고    scopus 로고
    • Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses
    • Assanah M, Lochhead R, Ogden A, Bruce J, Goldman J, Canoll P. 2006. Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. J. Neurosci. 26:6781-6790
    • (2006) J. Neurosci. , vol.26 , pp. 6781-6790
    • Assanah, M.1    Lochhead, R.2    Ogden, A.3    Bruce, J.4    Goldman, J.5    Canoll, P.6
  • 86
    • 33645022769 scopus 로고    scopus 로고
    • HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells
    • Natarajan M, Stewart JE, Golemis EA, Pugacheva EN, Alexandropoulos K, et al. 2006. HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells. Oncogene 25:1721-1732
    • (2006) Oncogene , vol.25 , pp. 1721-1732
    • Natarajan, M.1    Stewart, J.E.2    Golemis, E.A.3    Pugacheva, E.N.4    Alexandropoulos, K.5
  • 87
    • 0037105704 scopus 로고    scopus 로고
    • Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: Differences in integrin signaling during cell adhesion to osteopontin versus vitronectin
    • Ding Q, Stewart J Jr, Prince CW, Chang PL,Trikha M, et al. 2002. Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin versus vitronectin. Cancer Res. 62:5336-5343
    • (2002) Cancer Res , vol.62 , pp. 5336-5343
    • Ding, Q.1    Stewart Jr., J.2    Prince, C.W.3    Chang, P.L.4    Trikha, M.5
  • 89
    • 33748997415 scopus 로고    scopus 로고
    • Ephrin-B3 ligand promotes glioma invasion through activation of Rac1
    • Nakada M, Drake KL, Nakada S, Niska JA, Berens ME. 2006. Ephrin-B3 ligand promotes glioma invasion through activation of Rac1. Cancer Res. 66:8492-8500
    • (2006) Cancer Res , vol.66 , pp. 8492-8500
    • Nakada, M.1    Drake, K.L.2    Nakada, S.3    Niska, J.A.4    Berens, M.E.5
  • 90
    • 2342577589 scopus 로고    scopus 로고
    • The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells
    • Nakada M, Niska JA, Miyamori H, McDonough WS,Wu J, et al. 2004. The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res. 64:3179-3185
    • (2004) Cancer Res , vol.64 , pp. 3179-3185
    • Nakada, M.1    Niska, J.A.2    Miyamori, H.3    McDonough, W.S.4    Wu, J.5
  • 91
    • 0030918130 scopus 로고    scopus 로고
    • Glioma invasion in vitro is mediated by CD44-hyaluronan interactions
    • Radotra B, McCormick D. 1997. Glioma invasion in vitro is mediated by CD44-hyaluronan interactions. J. Pathol. 181:434-438
    • (1997) J. Pathol. , vol.181 , pp. 434-438
    • Radotra, B.1    McCormick, D.2
  • 92
    • 0028858363 scopus 로고
    • Hyaluronic acid/CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro
    • Koochekpour S, Pilkington GJ, Merzak A. 1995. Hyaluronic acid/CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro. Int. J. Cancer 63:450-454
    • (1995) Int. J. Cancer. , vol.63 , pp. 450-454
    • Koochekpour, S.1    Pilkington, G.J.2    Merzak, A.3
  • 93
    • 0028136623 scopus 로고
    • CD44 mediates human glioma cell adhesion and invasion in vitro
    • Merzak A, Koocheckpour S, Pilkington GJ. 1994. CD44 mediates human glioma cell adhesion and invasion in vitro. Cancer Res. 54:3988-3992
    • (1994) Cancer Res , vol.54 , pp. 3988-3992
    • Merzak, A.1    Koocheckpour, S.2    Pilkington, G.J.3
  • 94
    • 0027753101 scopus 로고
    • Characterization of integrin receptors in normal and neoplastic human brain
    • Paulus W, Baur I, Schuppan D, Roggendorf W. 1993. Characterization of integrin receptors in normal and neoplastic human brain. Am. J. Pathol. 143:154-163
    • (1993) Am. J. Pathol. , vol.143 , pp. 154-163
    • Paulus, W.1    Baur, I.2    Schuppan, D.3    Roggendorf, W.4
  • 95
    • 0026334978 scopus 로고
    • Glioblastoma expression of vitronectin and the v3 integrin: Adhesion mechanism for transformed glial cells
    • Gladson CL, Cheresh DA. 1991. Glioblastoma expression of vitronectin and the v3 integrin: adhesion mechanism for transformed glial cells. J. Clin. Investig. 88:1924-1932
    • (1991) J. Clin. Investig. , vol.88 , pp. 1924-1932
    • Gladson, C.L.1    Cheresh, D.A.2
  • 97
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, et al. 2007. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 21:2683-2710
    • (2007) Genes Dev , vol.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3    Mukasa, A.4    Stommel, J.M.5
  • 98
    • 0141612789 scopus 로고    scopus 로고
    • FAK signaling in anaplastic astrocytoma and glioblastoma tumors
    • Natarajan M, Hecker TP, Gladson CL. 2003. FAK signaling in anaplastic astrocytoma and glioblastoma tumors. Cancer J. 9:126-133
    • (2003) Cancer J , vol.9 , pp. 126-133
    • Natarajan, M.1    Hecker, T.P.2    Gladson, C.L.3
  • 99
    • 0034532347 scopus 로고    scopus 로고
    • P125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo
    • Wang D, Grammer JR, Cobbs CS, Stewart JE Jr, Liu Z, et al. 2000. p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo. J. Cell Sci. 113:4221-4230
    • (2000) J. Cell Sci. , vol.113 , pp. 4221-4230
    • Wang, D.1    Grammer, J.R.2    Cobbs, C.S.3    Stewart Jr., J.E.4    Liu, Z.5
  • 100
    • 0037359549 scopus 로고    scopus 로고
    • Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation
    • Lipinski CA, Tran NL, Bay C, Kloss J, McDonough WS, et al. 2003. Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation. Mol. Cancer Res. 1:323-332
    • (2003) Mol. Cancer Res. , vol.1 , pp. 323-332
    • Lipinski, C.A.1    Tran, N.L.2    Bay, C.3    Kloss, J.4    McDonough, W.S.5
  • 101
    • 20344393365 scopus 로고    scopus 로고
    • The tyrosine kinase pyk2 promotes migration and invasion of glioma cells
    • Lipinski CA, Tran NL, Menashi E, Rohl C, Kloss J, et al. 2005. The tyrosine kinase pyk2 promotes migration and invasion of glioma cells. Neoplasia 7:435-445
    • (2005) Neoplasia , vol.7 , pp. 435-445
    • Lipinski, C.A.1    Tran, N.L.2    Menashi, E.3    Rohl, C.4    Kloss, J.5
  • 103
    • 0033556443 scopus 로고    scopus 로고
    • Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: Differential involvement of focal adhesion kinase and p130Cas
    • Tamura M, Gu J, Takino T, Yamada KM. 1999. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res. 59:442-449
    • (1999) Cancer Res , vol.59 , pp. 442-449
    • Tamura, M.1    Gu, J.2    Takino, T.3    Yamada, K.M.4
  • 104
    • 0033606767 scopus 로고    scopus 로고
    • Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
    • Gu J, Tamura M, Pankov R, Danen EH, Takino T, et al. 1999. Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J. Cell Biol. 146:389-403
    • (1999) J. Cell Biol. , vol.146 , pp. 389-403
    • Gu, J.1    Tamura, M.2    Pankov, R.3    Danen, E.H.4    Takino, T.5
  • 105
    • 0033564807 scopus 로고    scopus 로고
    • Malignant astrocytoma cell attachment and migration to various matrix proteins is differentially sensitive to phosphoinositide 3-OH kinase inhibitors
    • Ling J, Liu Z, Wang D, Gladson CL. 1999. Malignant astrocytoma cell attachment and migration to various matrix proteins is differentially sensitive to phosphoinositide 3-OH kinase inhibitors. J. Cell Biochem. 73:533-544
    • (1999) J. Cell Biochem. , vol.73 , pp. 533-544
    • Ling, J.1    Liu, Z.2    Wang, D.3    Gladson, C.L.4
  • 106
    • 44649145104 scopus 로고    scopus 로고
    • BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion
    • Viapiano MS, Hockfield S, Matthews RT. 2008. BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion. J. Neurooncol. 88:261-272
    • (2008) J. Neurooncol. , vol.88 , pp. 261-272
    • Viapiano, M.S.1    Hockfield, S.2    Matthews, R.T.3
  • 107
    • 34547134691 scopus 로고    scopus 로고
    • Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice
    • Gondi CS, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS. 2007. Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice. Clin. Cancer Res. 13:4051-4060
    • (2007) Clin. Cancer Res. , vol.13 , pp. 4051-4060
    • Gondi, C.S.1    Lakka, S.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5    Rao, J.S.6
  • 110
    • 9144231998 scopus 로고    scopus 로고
    • RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
    • Gondi CS, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS. 2004. RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas. Oncogene 23:8486-8496
    • (2004) Oncogene , vol.23 , pp. 8486-8496
    • Gondi, C.S.1    Lakka, S.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5    Rao, J.S.6
  • 111
    • 20444470108 scopus 로고    scopus 로고
    • Specific interference of urokinasetype plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by doublestranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas
    • Lakka SS, Gondi CS, Dinh DH, Olivero WC, Gujrati M, et al. 2005. Specific interference of urokinasetype plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by doublestranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas. J. Biol. Chem. 280:21882-21892
    • (2005) J. Biol. Chem. , vol.280 , pp. 21882-21892
    • Lakka, S.S.1    Gondi, C.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5
  • 112
    • 0035861684 scopus 로고    scopus 로고
    • Down-regulation of integrin alpha vbeta 3 expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes
    • Adachi Y, Lakka SS, Chandrasekar N,Yanamandra N, Gondi CS, et al. 2001. Down-regulation of integrin alpha vbeta 3 expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes. J. Biol. Chem. 276:47171-47177
    • (2001) J. Biol. Chem. , vol.276 , pp. 47171-47177
    • Adachi, Y.1    Lakka, S.S.2    Chandrasekar, N.3    Yanamandra, N.4    Gondi, C.S.5
  • 113
    • 15844420283 scopus 로고    scopus 로고
    • Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin v3
    • Brooks PC, Strombland S, Sanders LC, von Schalscha TL, Aimes RT, et al. 1996. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin v3. Cell 85:683-693
    • (1996) Cell , vol.85 , pp. 683-693
    • Brooks, P.C.1    Strombland, S.2    Sanders, L.C.3    Von Schalscha, T.L.4    Aimes, R.T.5
  • 114
    • 0035947675 scopus 로고    scopus 로고
    • Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion
    • Belkin AM, Akimov SS, Zaritskaya LS, Ratnikov BI, Deryugina EI, StronginAY. 2001. Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion. J. Biol. Chem. 276:18415-18422
    • (2001) J. Biol. Chem. , vol.276 , pp. 18415-18422
    • Belkin, A.M.1    Akimov, S.S.2    Zaritskaya, L.S.3    Ratnikov, B.I.4    Deryugina, E.I.5    Strongin, A.Y.6
  • 115
    • 23644443053 scopus 로고    scopus 로고
    • Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    • Zhu Y, Guignard F, Zhao D, Liu L, Burns DK, et al. 2005. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8:119-130
    • (2005) Cancer Cell , vol.8 , pp. 119-130
    • Zhu, Y.1    Guignard, F.2    Zhao, D.3    Liu, L.4    Burns, D.K.5
  • 116
    • 44849089702 scopus 로고    scopus 로고
    • Pten haploinsufficiency accelerates formation of high-grade astrocytomas
    • Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, et al. 2008. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 68:3286-3294
    • (2008) Cancer Res , vol.68 , pp. 3286-3294
    • Kwon, C.H.1    Zhao, D.2    Chen, J.3    Alcantara, S.4    Li, Y.5
  • 117
    • 57849109837 scopus 로고    scopus 로고
    • Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
    • Alcantara Llaguno S, Chen J, Kwon CH, Jackson EL, Li Y, et al. 2009. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15:45-56
    • (2009) Cancer Cell , vol.15 , pp. 45-56
    • Alcantara Llaguno, S.1    Chen, J.2    Kwon, C.H.3    Jackson, E.L.4    Li, Y.5
  • 118
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    • Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN. 2000. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat. Genet. 25:55-57
    • (2000) Nat. Genet. , vol.25 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5    Fuller, G.N.6
  • 119
    • 27144540888 scopus 로고    scopus 로고
    • RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma
    • SharmaMK,Zehnbauer BA,WatsonMA,GutmannDH.2005.RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma. Neurology 65:1335-1336
    • (2005) Neurology , vol.65 , pp. 1335-1336
    • Sharma, M.K.1    Zehnbauer, B.A.2    Watson, M.A.3    Gutmann, D.H.4
  • 120
    • 0032418416 scopus 로고    scopus 로고
    • A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
    • Holland EC, Hively WP, DePinho RA, Varmus HE. 1998. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 12:3675-3685
    • (1998) Genes Dev , vol.12 , pp. 3675-3685
    • Holland, E.C.1    Hively, W.P.2    De Pinho, R.A.3    Varmus, H.E.4
  • 121
    • 62449252775 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis
    • Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, et al. 2009. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc. Natl. Acad. Sci. USA 106:2712-2716
    • (2009) Proc. Natl. Acad. Sci. USA. , vol.106 , pp. 2712-2716
    • Zhu, H.1    Acquaviva, J.2    Ramachandran, P.3    Boskovitz, A.4    Woolfenden, S.5
  • 122
    • 54549095950 scopus 로고    scopus 로고
    • P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    • Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, et al. 2008. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455:1129-1133
    • (2008) Nature , vol.455 , pp. 1129-1133
    • Zheng, H.1    Ying, H.2    Yan, H.3    Kimmelman, A.C.4    Hiller, D.J.5
  • 123
    • 0035009282 scopus 로고    scopus 로고
    • Animal models of cell cycle dysregulation and the pathogenesis of gliomas
    • Holland EC. 2001. Animal models of cell cycle dysregulation and the pathogenesis of gliomas. J. Neurooncol. 51:265-276
    • (2001) J. Neurooncol. , vol.51 , pp. 265-276
    • Holland, E.C.1
  • 125
    • 0028055043 scopus 로고
    • Histological characteristics and expression of acidic and basic fibroblast growth factor genes in intracerebral xenogeneic transplants of human glioma cells
    • Finkelstein SD, Black P, Nowak TP, Hand CM, Christensen S, Finch PW. 1994. Histological characteristics and expression of acidic and basic fibroblast growth factor genes in intracerebral xenogeneic transplants of human glioma cells. Neurosurgery 34:136-143
    • (1994) Neurosurgery , vol.34 , pp. 136-143
    • Finkelstein, S.D.1    Black, P.2    Nowak, T.P.3    Hand, C.M.4    Christensen, S.5    Finch, P.W.6
  • 126
    • 0031460765 scopus 로고    scopus 로고
    • In vitro and in vivo models for the study of brain tumor invasion
    • Pilkington GJ, Bjerkvig R, De Ridder L, Kaaijk P. 1997. In vitro and in vivo models for the study of brain tumor invasion. Anticancer Res. 17:4107-4109
    • (1997) Anticancer Res , vol.17 , pp. 4107-4109
    • Pilkington, G.J.1    Bjerkvig, R.2    De Ridder, L.3    Kaaijk, P.4
  • 127
    • 0021331818 scopus 로고
    • Intracerebral transplantation of a human glioma line in immunosuppressed rats
    • Saris SC, Bigner SH, Bigner DD. 1984. Intracerebral transplantation of a human glioma line in immunosuppressed rats. J. Neurosurg. 60:582-588
    • (1984) J. Neurosurg. , vol.60 , pp. 582-588
    • Saris, S.C.1    Bigner, S.H.2    Bigner, D.D.3
  • 128
    • 85052669553 scopus 로고    scopus 로고
    • Model systems in neurooncology
    • Tonn JC. 2002. Model systems in neurooncology. Acta Neurochir. Suppl. 83:79-83
    • (2002) Acta Neurochir. Suppl , vol.83 , pp. 79-83
    • Tonn, J.C.1
  • 129
    • 0344420263 scopus 로고    scopus 로고
    • Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR
    • Pandita A, Aldape KD, Zadeh G, Guha A, James CD. 2004. Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR. Genes Chromosomes Cancer 39:29-36
    • (2004) Genes Chromosomes Cancer , vol.39 , pp. 29-36
    • Pandita, A.1    Aldape, K.D.2    Zadeh, G.3    Guha, A.4    James, C.D.5
  • 130
    • 0025686126 scopus 로고
    • Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts
    • Bigner SH, Humphrey PA,Wong AJ,Vogelstein B, Mark J, et al. 1990. Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. Cancer Res. 50:8017-8022
    • (1990) Cancer Res , vol.50 , pp. 8017-8022
    • Bigner, S.H.1    Humphrey, P.A.2    Wong, A.J.3    Vogelstein, B.4    Mark, J.5
  • 131
    • 17844399776 scopus 로고    scopus 로고
    • Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme
    • Giannini C, Sarkaria JN, Saito A, Uhm JH, Galanis E, et al. 2005. Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme. Neuro-Oncology 7:164-176
    • (2005) Neuro-Oncology , vol.7 , pp. 164-176
    • Giannini, C.1    Sarkaria, J.N.2    Saito, A.3    Uhm, J.H.4    Galanis, E.5
  • 132
    • 33845612616 scopus 로고    scopus 로고
    • Cancer: Stem cells and brain tumours
    • Dirks PB. 2006. Cancer: stem cells and brain tumours. Nature 444:687-688
    • (2006) Nature , vol.444 , pp. 687-688
    • Dirks, P.B.1
  • 134
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S,Wu Q, McLendon RE, Hao Y, Shi Q, et al. 2006. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-760
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5
  • 136
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • DOI 10.1038/nrd2115, PII NRD2115
    • Folkman J. 2007. Angiogenesis: an organizing principle for drug discovery? Nat. Rev.Drug Discov. 6:273-286 (Pubitemid 46505878)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 137
    • 40849087625 scopus 로고    scopus 로고
    • Molecular cancer therapy: Can our expectation be MET?
    • Migliore C, Giordano S. 2008. Molecular cancer therapy: can our expectation be MET? Eur. J. Cancer 44:641-651
    • (2008) Eur. J. Cancer. , vol.44 , pp. 641-651
    • Migliore, C.1    Giordano, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.