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Volumn 29, Issue 10, 2009, Pages 3759-3768

Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis

Author keywords

Alkylating agents; Cancer; Glioma; O6 methylguanine (O 6 MG); O6 methylguanine DNA methyltransferase (MGMT); Polymorphism; Promoter methylation; Review; Temozolomide (TMZ)

Indexed keywords

ALKYLATING AGENT; CARMUSTINE; CISPLATIN; DACARBAZINE; LOMEGUATRIB; LOMUSTINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROCARBAZINE; TEMOZOLOMIDE;

EID: 71949083197     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (142)

References (80)
  • 1
    • 1942469956 scopus 로고    scopus 로고
    • MGMT: Its role in cancer aetiology and cancer therapeutics
    • Gerson SL: MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4: 296-307, 2004. (Pubitemid 38525285)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.4 , pp. 296-307
    • Gerson, S.L.1
  • 2
    • 33745686030 scopus 로고    scopus 로고
    • 6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy
    • 6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy. Curr Opin Pharmacol 6: 355-363, 2006.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 355-363
    • Sabharwal, A.1    Middleton, M.R.2
  • 3
    • 34447314728 scopus 로고    scopus 로고
    • MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents
    • DOI 10.1016/j.dnarep.2007.03.008, PII S1568786407001243
    • Kaina B, Christmann M, Naumann S and Roos WP: MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst) 6: 1079-1099, 2007. (Pubitemid 47058389)
    • (2007) DNA Repair , vol.6 , Issue.8 , pp. 1079-1099
    • Kaina, B.1    Christmann, M.2    Naumann, S.3    Roos, W.P.4
  • 4
    • 31544464704 scopus 로고    scopus 로고
    • Targeted modulation of MGMT: Clinical implications
    • DOI 10.1158/1078-0432.CCR-05-2543
    • Liu L and Gerson SL: Targeted modulation of MGMT: clinical implications. Clin Cancer Res 12: 328-331, 2006. (Pubitemid 43166117)
    • (2006) Clinical Cancer Research , vol.12 , Issue.2 , pp. 328-331
    • Liu, L.1    Gerson, S.L.2
  • 5
    • 27744495771 scopus 로고    scopus 로고
    • Epigenetic silencing of the MGMT gene in cancer
    • DOI 10.1139/o05-140
    • Soejima H, Zhao W and Mukai T: Epigenetic silencing of the MGMT gene in cancer. Biochem Cell Biol 83: 429-437, 2005. (Pubitemid 41626761)
    • (2005) Biochemistry and Cell Biology , vol.83 , Issue.4 , pp. 429-437
    • Soejima, H.1    Zhao, W.2    Mukai, T.3
  • 8
    • 0030611736 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase expression
    • 6-methylguanine-DNA methyltransferase expression. Pharmacol Ther 74: 285-297, 1997.
    • (1997) Pharmacol Ther , vol.74 , pp. 285-297
    • Pieper, R.O.1
  • 9
    • 34447342529 scopus 로고    scopus 로고
    • Genetic association and functional studies of major polymorphic variants of MGMT
    • DOI 10.1016/j.dnarep.2007.03.023, PII S1568786407001309
    • Bugni JM, Han J, Tsai MS, Hunter DJ and Samson LD: Genetic association and functional studies of major polymorphic variants of MGMT. DNA Repair (Amst) 6: 1116-1126, 2007. (Pubitemid 47058395)
    • (2007) DNA Repair , vol.6 , Issue.8 , pp. 1116-1126
    • Bugni, J.M.1    Han, J.2    Tsai, M.-S.3    Hunter, D.J.4    Samson, L.D.5
  • 10
    • 44449147948 scopus 로고    scopus 로고
    • Role of mismatch repair and MGMT in response to anticancer therapies
    • DOI 10.2174/187152008784220276
    • Casorelli I, Russo MT and Bignami M: Role of mismatch repair and MGMT in response to anticancer therapies. Anticancer Agents Med Chem 8: 368-380, 2008. (Pubitemid 351761422)
    • (2008) Anti-Cancer Agents in Medicinal Chemistry , vol.8 , Issue.4 , pp. 368-380
    • Casorelli, I.1    Russo, M.T.2    Bignami, M.3
  • 12
    • 34548786267 scopus 로고    scopus 로고
    • Case Report: Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocytoma
    • Fujimaki T, Ishii H, Matsuno A, Arai H and Nakagomi T: Case Report: Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocytoma. World J Surg Oncol 5: 89-93, 2007.
    • (2007) World J Surg Oncol , vol.5 , pp. 89-93
    • Fujimaki, T.1    Ishii, H.2    Matsuno, A.3    Arai, H.4    Nakagomi, T.5
  • 13
    • 38749146312 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase protein expression in patients with recurrent glioblastoma treated with temozolomide
    • DOI 10.1093/jjco/hym132
    • 6-methylguanine-DNA methyltransferase protein expression in patients with recurrent glioblastoma treated with temozolomide. Jpn J Clin Oncol 37: 897-906, 2007. (Pubitemid 351176479)
    • (2007) Japanese Journal of Clinical Oncology , vol.37 , Issue.12 , pp. 897-906
    • Nagane, M.1    Kobayashi, K.2    Ohnishi, A.3    Shimizu, S.4    Shiokawa, Y.5
  • 18
    • 32644467225 scopus 로고    scopus 로고
    • Methylated tumor-specific DNA as a plasma biomarker in patients with glioma
    • DOI 10.1080/07357900500449546, PII V072683716W551V2
    • Weaver KD, Grossman SA and Herman JG: Methylated tumor-specific DNA as a plasma biomarker in patients with glioma. Cancer Invest 24: 35-40, 2006. (Pubitemid 43247271)
    • (2006) Cancer Investigation , vol.24 , Issue.1 , pp. 35-40
    • Weaver, K.D.1    Grossman, S.A.2    Herman, J.G.3
  • 20
    • 36348991428 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase expression in supratentorial diffuse low-grade astrocytoma
    • discussion 608-609
    • 6-methylguanine-DNA methyltransferase expression in supratentorial diffuse low-grade astrocytoma. Surg Neurol 68: 603-608; discussion 608-609, 2007.
    • (2007) Surg Neurol , vol.68 , pp. 603-608
    • Nakasu, S.1    Fukami, T.2    Jito, J.3    Matsuda, M.4
  • 21
    • 33947536116 scopus 로고    scopus 로고
    • A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue
    • DOI 10.1038/labinvest.3700520, PII 3700520
    • Cankovic M, Mikkelsen T, Rosenblum ML and Zarbo RJ: A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue. Lab Invest 87: 392-397, 2007. (Pubitemid 46474563)
    • (2007) Laboratory Investigation , vol.87 , Issue.4 , pp. 392-397
    • Cankovic, M.1    Mikkelsen, T.2    Rosenblum, M.L.3    Zarbo, R.J.4
  • 22
    • 37449009206 scopus 로고    scopus 로고
    • Epigenetic silencing of telomerase and a non-alkylating agent as a novel therapeutic approach for glioma
    • Patel R, Shervington L, Lea R and Shervington A: Epigenetic silencing of telomerase and a non-alkylating agent as a novel therapeutic approach for glioma. Brain Res 1188: 173-181, 2008.
    • (2008) Brain Res , vol.1188 , pp. 173-181
    • Patel, R.1    Shervington, L.2    Lea, R.3    Shervington, A.4
  • 23
    • 34548760880 scopus 로고    scopus 로고
    • MS-MLPA: An attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas
    • DOI 10.1038/labinvest.3700664, PII 3700664
    • Jeuken JW, Cornelissen SJ, Vriezen M, Dekkers MM, Errami A, Sijben A, Boots-Sprenger SH and Wesseling P: MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas. Lab Invest 87: 1055-1065, 2007. (Pubitemid 47429190)
    • (2007) Laboratory Investigation , vol.87 , Issue.10 , pp. 1055-1065
    • Jeuken, J.W.M.1    Cornelissen, S.J.B.2    Vriezen, M.3    Dekkers, M.M.G.4    Errami, A.5    Sijben, A.6    Boots-Sprenger, S.H.E.7    Wesseling, P.8
  • 24
    • 38049161075 scopus 로고    scopus 로고
    • Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide
    • Gilbert MR and Armstrong TS: Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide. Ther Clin Risk Manag 3: 1027-1033, 2007.
    • (2007) Ther Clin Risk Manag , vol.3 , pp. 1027-1033
    • Gilbert, M.R.1    Armstrong, T.S.2
  • 26
    • 38149046589 scopus 로고    scopus 로고
    • Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: Proposal of a feasible immunohistochemical approach
    • Capper D, Mittelbronn M, Meyermann R and Schittenhelm J: Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach. Acta Neuropathol 115: 249-259, 2008.
    • (2008) Acta Neuropathol , vol.115 , pp. 249-259
    • Capper, D.1    Mittelbronn, M.2    Meyermann, R.3    Schittenhelm, J.4
  • 30
    • 36749008615 scopus 로고    scopus 로고
    • Detailed methylation patterns and protein expression profiles of MGMT in colorectal carcinoma surgical margins
    • DOI 10.1016/j.clinbiochem.2007.09.010, PII S0009912007003578
    • Zhang D, Bai Y, Wang Y, Luo J, Ge Q, Qiao Y, Jia C and Lu Z: Detailed methylation patterns and protein expression profiles of MGMT in colorectal carcinoma surgical margins. Clin Biochem 41: 19-25, 2008. (Pubitemid 350216824)
    • (2008) Clinical Biochemistry , vol.41 , Issue.1-2 , pp. 19-25
    • Zhang, D.1    Bai, Y.2    Wang, Y.3    Luo, J.4    Ge, Q.5    Qiao, Y.6    Jia, C.7    Lu, Z.8
  • 34
    • 0028904619 scopus 로고
    • Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon
    • Zaidi NH, Pretlow TP, O'Riordan MA, Dumenco LL, Allay E and Gerson SL: Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis 16: 451-456, 1995.
    • (1995) Carcinogenesis , vol.16 , pp. 451-456
    • Zaidi, N.H.1    Pretlow, T.P.2    O'Riordan, M.A.3    Dumenco, L.L.4    Allay, E.5    Gerson, S.L.6
  • 35
    • 44449146998 scopus 로고    scopus 로고
    • Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics
    • Deng G, Kakar S, Tanaka H, Matsuzaki K, Miura S, Sleisenger MH and Kim YS: Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics. Eur J Cancer 44: 1290-1301, 2008.
    • (2008) Eur J Cancer , vol.44 , pp. 1290-1301
    • Deng, G.1    Kakar, S.2    Tanaka, H.3    Matsuzaki, K.4    Miura, S.5    Sleisenger, M.H.6    Kim, Y.S.7
  • 36
    • 34447296691 scopus 로고    scopus 로고
    • Live and let die: In vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection
    • Amst
    • Milsom MD and Williams DA: Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection. DNA Repair (Amst) 6: 1210-1221, 2007.
    • (2007) DNA Repair , vol.6 , pp. 1210-1221
    • Milsom, M.D.1    Williams, D.A.2
  • 38
    • 34447327215 scopus 로고    scopus 로고
    • Lung cancer risk and variation in MGMT activity and sequence
    • Amst
    • Povey AC, Margison GP and Santibanez-Koref MF: Lung cancer risk and variation in MGMT activity and sequence. DNA Repair (Amst) 6: 1134-1144, 2007.
    • (2007) DNA Repair , vol.6 , pp. 1134-1144
    • Povey, A.C.1    Margison, G.P.2    Santibanez-Koref, M.F.3
  • 39
    • 20344405446 scopus 로고    scopus 로고
    • DNA methylation disturbances as novel therapeutic target in lung cancer: Preclinical and clinical results
    • DOI 10.1016/j.critrevonc.2005.02.002, PII S1040842805000338
    • Digel W and Lubbert M: DNA methylation disturbances as novel therapeutic target in lung cancer: preclinical and clinical results. Crit Rev Oncol Hematol 55: 1-11, 2005. (Pubitemid 40779471)
    • (2005) Critical Reviews in Oncology/Hematology , vol.55 , Issue.1 , pp. 1-11
    • Digel, W.1    Lubbert, M.2
  • 41
    • 39449085063 scopus 로고    scopus 로고
    • DNA-damage repair; the good, the bad, and the ugly
    • DOI 10.1038/emboj.2008.15, PII EMBOJ200815
    • Hakem R: DNA-damage repair: the good, the bad, and the ugly. EMBO J 27: 589-605, 2008. (Pubitemid 351273123)
    • (2008) EMBO Journal , vol.27 , Issue.4 , pp. 589-605
    • Hakem, R.1
  • 42
    • 0032100860 scopus 로고    scopus 로고
    • Mammalian base excision repair and DNA polymerase beta
    • DOI 10.1016/S0921-8777(98)00002-0, PII S0921877798000020
    • Wilson SH: Mammalian base excision repair and DNA polymerase beta. Mutat Res 407: 203-215, 1998. (Pubitemid 28275828)
    • (1998) Mutation Research - DNA Repair , vol.407 , Issue.3 , pp. 203-215
    • Wilson, S.H.1
  • 44
    • 4444220781 scopus 로고    scopus 로고
    • Polymorphisms in TDG and MGMT genes - Epidemiological and functional study in lung cancer patients from Poland
    • DOI 10.1046/j.1529-8817.2004.00079.x
    • Krzesniak M, Butkiewicz D, Samojedny A, Chorazy M and Rusin M: Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. Ann Hum Genet 68: 300-312, 2004. (Pubitemid 39162742)
    • (2004) Annals of Human Genetics , vol.68 , Issue.4 , pp. 300-312
    • Krzesniak, M.1    Butkiewicz, D.2    Samojedny, A.3    Chorazy, M.4    Rusin, M.5
  • 45
    • 2342616720 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase-codon 178 genetic polymorphism
    • DOI 10.1016/j.lungcan.2003.12.003, PII S0169500203006299
    • 6-methylguanine- DNA methyltransferase-codon 178 genetic polymorphism. Lung Cancer 44: 281-286, 2004. (Pubitemid 38609435)
    • (2004) Lung Cancer , vol.44 , Issue.3 , pp. 281-286
    • Yang, M.1    Coles, B.F.2    Caporaso, N.E.3    Choi, Y.4    Lang, N.P.5    Kadlubar, F.F.6
  • 50
  • 51
    • 33750450047 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase and endometrial cancer risk
    • DOI 10.1093/carcin/bgl099
    • 6- methylguanine DNA methyltransferase and endometrial cancer risk. Carcinogenesis 27: 2281-2285, 2006. (Pubitemid 44644817)
    • (2006) Carcinogenesis , vol.27 , Issue.11 , pp. 2281-2285
    • Han, J.1    Hankinson, S.E.2    De Vivo, I.3
  • 55
    • 33646366136 scopus 로고    scopus 로고
    • 6-Methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States)
    • DOI 10.1007/s10552-006-0005-y
    • 6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States). Cancer Causes Control 17: 721-731, 2006. (Pubitemid 43668331)
    • (2006) Cancer Causes and Control , vol.17 , Issue.5 , pp. 721-731
    • Tranah, G.J.1    Bugni, J.2    Giovannucci, E.3    Ma, J.4    Fuchs, C.5    Hines, L.6    Samson, L.7    Hunter, D.J.8
  • 56
    • 0345491859 scopus 로고    scopus 로고
    • A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma
    • DOI 10.1179/016164103771954005
    • Inoue R, Isono M, Abe M, Abe T and Kobayashi H: A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma. Neurol Res 25: 875-879, 2003. (Pubitemid 37499726)
    • (2003) Neurological Research , vol.25 , Issue.8 , pp. 875-879
    • Inoue, R.1    Isono, M.2    Abe, M.3    Abe, T.4    Kobayashi, H.5
  • 57
    • 22744445021 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: A case control analysis
    • 6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case control analysis. Cancer Lett 227: 49-57, 2005.
    • (2005) Cancer Lett , vol.227 , pp. 49-57
    • Li, C.1    Liu, J.2    Li, A.3    Qian, L.4    Wang, X.5    Wei, Q.6    Zhou, J.7    Zhang, Z.8
  • 59
    • 34447304855 scopus 로고    scopus 로고
    • 6-Methylguanine-DNA methyltransferase deficiency in developing brain: Implications for brain tumorigenesis
    • Amst
    • 6-Methylguanine- DNA methyltransferase deficiency in developing brain: implications for brain tumorigenesis. DNA Repair (Amst) 6: 1127-1133, 2007.
    • (2007) DNA Repair , vol.6 , pp. 1127-1133
    • Bobola, M.S.1    Blank, A.2    Berger, M.S.3    Silber, J.R.4
  • 61
    • 34147106521 scopus 로고    scopus 로고
    • MGMT expression in oral precancerous and cancerous lesions: Correlation with progression, nodal metastasis and poor prognosis
    • DOI 10.1016/j.oraloncology.2006.05.007, PII S1368837506001382
    • Sawhney M, Rohatgi N, Kaur J, Gupta SD, Deo SV, Shukla NK and Ralhan R: MGMT expression in oral precancerous and cancerous lesions: correlation with progression, nodal metastasis and poor prognosis. Oral Oncol 43: 515-522, 2007. (Pubitemid 46561437)
    • (2007) Oral Oncology , vol.43 , Issue.5 , pp. 515-522
    • Sawhney, M.1    Rohatgi, N.2    Kaur, J.3    Gupta, S.D.4    Deo, S.V.S.5    Shukla, N.K.6    Ralhan, R.7
  • 62
    • 43049151753 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation
    • 6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation. Biochem Pharmacol 75: 2100-2111, 2008.
    • (2008) Biochem Pharmacol , vol.75 , pp. 2100-2111
    • Hermes, M.1    Geisler, H.2    Osswald, H.3    Riehle, R.4    Kloor, D.5
  • 66
    • 33845338456 scopus 로고    scopus 로고
    • Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: Morphological findings
    • DOI 10.1016/j.humpath.2006.07.014, PII S0046817706004886
    • Kovacs K, Horvath E, Syro LV, Uribe H, Penagos LC, Ortiz LD and Fadul CE: Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: Morphological findings. Hum Pathol 38: 185-189, 2007. (Pubitemid 44880216)
    • (2007) Human Pathology , vol.38 , Issue.1 , pp. 185-189
    • Kovacs, K.1    Horvath, E.2    Syro, L.V.3    Uribe, H.4    Penagos, L.C.5    Ortiz, L.D.6    Fadul, C.E.7
  • 68
    • 33748799412 scopus 로고    scopus 로고
    • Antitumour effects of temozolomide in a man with a large, invasive prolactin-producing pituitary neoplasm [4]
    • DOI 10.1111/j.1365-2265.2006.02653.x
    • Syro LV, Uribe H, Penagos LC, Ortiz LD, Fadul CE, Horvath E and Kovacs K: Antitumour effects of temozolomide in a man with a large, invasive prolactin-producing pituitary neoplasm. Clin Endocrinol (Oxf) 65: 552-553, 2006. (Pubitemid 44414285)
    • (2006) Clinical Endocrinology , vol.65 , Issue.4 , pp. 552-553
    • Syro, L.V.1    Uribe, H.2    Penagos, L.C.3    Ortiz, L.D.4    Fadul, C.E.5    Horvath, E.6    Kovacs, K.7
  • 76
    • 62449258056 scopus 로고    scopus 로고
    • Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma: Correlation with MGMT promoter methylation status
    • Brandes AA, Tosoni A, Franceschi E, Sotti G, Frezza G, Amistà P, Morandi L, Spagnolli F and Ermani M: Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma: correlation with MGMT promoter methylation status. J Clin Oncol 27: 1275-1279, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 1275-1279
    • Brandes, A.A.1    Tosoni, A.2    Franceschi, E.3    Sotti, G.4    Frezza, G.5    Amistà, P.6    Morandi, L.7    Spagnolli, F.8    Ermani, M.9
  • 78
    • 0033782928 scopus 로고    scopus 로고
    • Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase
    • Shiraishi A, Sakumi K and Sekiguchi M: Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase. Carcinogenesis 21: 1879-1883, 2000.
    • (2000) Carcinogenesis , vol.21 , pp. 1879-1883
    • Shiraishi, A.1    Sakumi, K.2    Sekiguchi, M.3
  • 79
    • 12744278547 scopus 로고    scopus 로고
    • Preliminary results of a phase I trial using retroviral gene transfer of G156A MGMT to protect hematopoiesis during BG and BCNU therapy of advanced malignancies
    • abstract 1006
    • Reese J, Lingas K, Ksenich P, Sweeney C, Koc O and Gerson S: Preliminary results of a phase I trial using retroviral gene transfer of G156A MGMT to protect hematopoiesis during BG and BCNU therapy of advanced malignancies (abstract 1006). Mol Ther 9: S385-S385, 2004.
    • (2004) Mol Ther , vol.9
    • Reese, J.1    Lingas, K.2    Ksenich, P.3    Sweeney, C.4    Koc, O.5    Gerson, S.6


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