N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21 Waf1/Cip1

Journal of Biological Chemistry

Volumn 286, Issue 34, 2011, Pages 29531-29539

  Jascur, Thomas ^a   Fotedar, Rati ^b   Greene, Serena ^a   Hotchkiss, Erin ^a   Boland, C Richard ^a  

^a BAYLOR RESEARCH INSTITUTE   (United States)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE; DNA ALKYLATIONS; DNA DAMAGES; DNA REPAIR; INHIBITOR PROTEINS; MISMATCH REPAIR; NUCLEOTIDE EXCISION REPAIR; PROLIFERATING CELL NUCLEAR ANTIGENS; PROTEASOMES; PROTEIN LEVEL; RAPID DEGRADATION; UBIQUITIN LIGASES;

CELL PROLIFERATION; DNA; IONIZING RADIATION; PROTEINS; REPAIR;

DEGRADATION;

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLINE; METHYLNITRONITROSOGUANIDINE; PROTEASOME; PROTEIN CDT2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DNA ALKYLATION; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CHROMATIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA REPAIR; HELA CELLS; HUMANS; METHYLNITRONITROSOGUANIDINE; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 80051948127     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.221341     Document Type: Article

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