Dietary components in the development of leptin resistance

Advances in Nutrition

Volumn 4, Issue 2, 2013, Pages 164-175

  Vasselli, Joseph R ^a   Scarpace, Philip J ^b   Harris, Ruth B S ^c   Banks, William A ^d  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LEPTIN;

ADIPOSE TISSUE; ANIMAL; BLOOD; BRAIN; CALORIC INTAKE; DIET; FAT INTAKE; HUMAN; METABOLIC DISORDER; METABOLISM; OBESITY; REVIEW; SUGAR INTAKE; WEIGHT GAIN;

ADIPOSE TISSUE; ANIMALS; BRAIN; DIET; DIETARY FATS; DIETARY SUCROSE; ENERGY INTAKE; GLUCOSE; HUMANS; LEPTIN; METABOLIC DISEASES; OBESITY; WEIGHT GAIN;

EID: 84882970382     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.112.003152     Document Type: Article

References (85)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32.
2. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MS, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-5.
3. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob mRNA in obese and weight reduced subjects. Nat Med. 1995;1:1155-61.
4. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763-70.
5. Myers MG, Heymsfield SB, Haft C, Kahn BB, Laughlin M, Leibel RL, Tschöp MH, Yanovski JA. Challenges and opportunities of defining clinical leptin resistance. Cell Metab. 2012;15:150-6.
6. Munzberg H. Leptin-signaling pathways and leptin resistance. Forum Nutr. 2010;63:123-32.
7. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MK, Considine RV. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 1996;348:159-61.
8. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D, Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and adiposity in humans. Nat Med. 1996;2:589-93.
9. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides. 1996;17:305-11.
10. Banks WA. The blood-brain barrier as a cause of obesity. Curr Pharm Des. 2008;14:1606-14.
11. Myers MG, Cowley MA, Münzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol. 2008;70:537-56.
12. Piper ML, Unger EK, Myers MG, Jr., Xu AW. Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol. 2008;22:751-9.
13. Frederich RC, Hamann A, Anderson S, Löllmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for dietinduced resistance to leptin action. Nat Med. 1995;1:1311-4.
14. El-Haschimi K, Pierroz DD, Hileman SM, Bjørbæk C, Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest. 2000;105:1827-32.
15. Lin S, Thomas TC, Storlien LH, Huang XF. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord. 2000;24:639-46.
16. Lin L, Martin R, Schaffhauser AO, York DA. Acute changes in the response to peripheral leptin with alteration in diet composition. Am J Physiol Regul Integr Comp Physiol. 2001;280:R504-9.
17. Wang J, Obici S, Morgan K, Barzilai N, Feng Z, Rossetti L. Overfeeding rapidly induces leptin and insulin resistance. Diabetes. 2001;50:2786-91.
18. Shapiro A, Mu W, Roncal CA, Cheng KY, Johnson RJ, Scarpace PJ. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high fat feeding. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1370-5.
19. Vasselli JR. Fructose-induced leptin resistance: discovery of an unsuspected form of the phenomenon and its significance. Focus on "Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding." Am J Physiol Regul Integr Comp Physiol. 2008;295:R1365-9.
20. Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, Shafiu M, Segal M, Glassock RJ, Shimada M, et al. Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev. 2009;30:96-116.
21. Catena C, Giacchetti G, Novello M, Colussi G, Cavarape A, Sechi LA. Cellular mechanisms of insulin resistance in rats with fructose-induced hypertension. Am J Hypertens. 2003;16:973-8.
22. Kanarek RB, Orthen-Gambill N. Differential effects of sucrose, fructose and glucose on carbohydrate-induced obesity in rats. J Nutr. 1982;112:1546-54.
23. Mooradian AD, Chehade J, Hurd R, Haas MJ. Monosaccharideenriched diets cause hyperleptinemia without hypophagia. Nutrition. 2000;16:439-41.
24. Shapiro A, Tümer N, Gao Y, Cheng KY, Scarpace PJ. Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content. Br J Nutr. 2011;106:390-7.
25. Shapiro A, Strehler K, Ryder D, Scarpace PJ, Matheny MK, Tümer N. Western-type diet induces oxidative stress and impairs leptin-mediated STAT3 signaling in the hypothalamus, whereas high fructose/low fat or high-fat/sugar free diets do not. The Obesity Society 29th Annual Scientific Meeting; Orlando, FL, October 1-5, 2011. Obesity. 2011;19(S1):S73.
26. Gao S, Kinzig KP, Aja S, Scott KA, Keung W, Kelly S, Strynadka K, Chohnan S, Smith WW, Tamashiro KL, et al. Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci USA. 2007;104:17358-63.
27. Cha SH, Wolfgang M, Tokutake Y, Chohnan S, Lane MD. Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci USA. 2008;105:16871-5.
28. Shapiro A, Strehler K, Ryder D, Tümer N, Scarpace PJ. Fructose-induced leptin resistance involves impaired AMPK but intact STAT3 signaling. Society for the Study of Ingestive Behavior Annual Meeting, Clearwater, FL, July 12-16, 2011. Appetite. 2011;57(S1): S40.
29. Zhang J, Matheny MK, Tümer N, Mitchell MK, Scarpace P. Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent. Am J Physiol Regul Integr Comp Physiol. 2007;292:R868-74.
30. Enriori PJ, Evans AE, Sinnayah P, Jobst EE, Tonelli-Lemos L, Billes SK, Glavas MM, Grayson BE, Perello M, Nillni EA, et al. Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab. 2007;5:181-94.
31. Harris RB, Apolzan JW. Changes in glucose tolerance and leptin responsiveness of rats offered a choice of lard, sucrose and chow. Am J Physiol Regul Integr Comp Physiol. 2012;302:R1327-39.
32. la Fleur SE, van Rozen AJ, Luijendijk MC, Groeneweg F, Adan RA. A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia. Int J Obes (Lond). 2010;34:537-46.
33. Apolzan JW, Harris RB. Differential effects of chow and purified diet on the consumption of sucrose solution and lard and the development of obesity. Physiol Behav. 2012;105:325-31.
34. McClain DA. Hexosamines as mediators of nutrient sensing and regulation in diabetes. J Diabetes Complications. 2002;16:72-80.
35. Srinivasan V, Tatu U, Mohan V, Balasubramanyam M. Molecular convergence of hexosamine biosynthetic pathway and ER stress leading to insulin resistance in l6 skeletal muscle cells. Mol Cell Biochem. 2009;328:217-24.
36. McClain DA, Hazel M, Parker G, Cooksey RC. Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid. Am J Physiol Endocrinol Metab. 2005;288:E973-9.
37. Wells L, Vosseller K, Hart GW. Glycosylation of nucleocytoplasmic proteins: signal transduction and o-glcnac. Science. 2001;291:2376-8.
38. Teo CF, Wollaston-Hayden EE, Wells L. Hexosamine flux, the O-glcnac modification, and the development of insulin resistance in adipocytes. Mol Cell Endocrinol. 2010;318:44-53.
39. Einstein FH, Fishman S, Bauman J, Thompson RF, Huffman DM, Atzmon G, Barzilai N, Muzumdar RH. Enhanced activation of a "nutrientsensing" pathway with age contributes to insulin resistance. FASEB J. 2008;22:3450-7.
40. Ball LE, Berkaw MN, Buse MG. Identification of the major site of Olinked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1. Mol Cell Proteomics. 2006;5:313-23.
41. Kang ES, Han D, Park J, Kwak TK, Oh MA, Lee SA, Choi S, Park ZY, Kim Y, Lee JW. O-glcnac modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Exp Cell Res. 2008;314:2238-48.
42. Klein AL, Berkaw MN, Buse MG, Ball LE. O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple Sh2 domain binding motifs. Mol Cell Proteomics. 2009;8:2733-45.
43. Gewinner C, Hart G, Zachara N, Cole R, Beisenherz-Huss C, Groner B. The coactivator of transcription Creb-binding protein interacts preferentially with the glycosylated form of Stat5. J Biol Chem. 2004;279:3563-72.
44. Cooksey RC, McClain DA. Transgenic mice overexpressing the ratelimiting enzyme for hexosamine synthesis in skeletal muscle or adipose tissue exhibit total body insulin resistance. Ann N YAcad Sci. 2002;967:102-11.
45. Marshall S, Bacote V, Traxinger RR. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system: role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem. 1991;266:4706-12.
46. Issad T, Kuo M. O-glcnac modification of transcription factors, glucose sensing and glucotoxicity. Trends Endocrinol Metab. 2008;19:380-9.
47. Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature. 1998;393:684-8.
48. Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, et al. Stat3 signalling is required for leptin regulation of energy balance but not reproduction. Nature. 2003;421:856-9.
49. BanksWA, Coon AB, Robinson SM, Moinuddin A, Shultz JM, Nakaoke R, Morley JE. Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes. 2004;53:1253-60.
50. Buettner R, Parhofer KG, Woenckhaus M, Wrede CE, Kunz-Schughart LA, Scholmerich J, Bollheimer LC. Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. J Mol Endocrinol. 2006;36:485-501.
51. Vijay-Kumar M, Vanegas SM, Patel N, Aitken JD, Zieglar TR, Ganji V. Fish oil rich diet in comparison to saturated fat rich diet offered protectgion against lipopolysaccharide-induced inflammation and insulin resistance in mice. Nutr Metab. 2011 Mar 9;8(1):16. doi:10.1186/1743-7075-8-16.
52. Vasselli JR, Spilka M. Circulating triglycerides and leptin resistance: a test of the triglyceride hypothesis. The Obesity Society 28th Annual Scientific Meeting; San Diego, CA, October 8-12, 2010. Obesity. 2010;18(S2):S78.
53. Rubin LL, Staddon JM. The cell biology of the blood-brain barrier. Annu Rev Neurosci. 1999;22:11-28.
54. Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis HR Jr. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest. 1997;99:385-90.
55. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA. 1997;94:8878-83.
56. Mantzoros C, Flier JS, Lesem MD, Brewerton TD, Jimerson DC. Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain. J Clin Endocrinol Metab. 1997;82:1845-51.
57. Kastin AJ, Akerstrom V. Fasting, but not adrenalectomy, reduces transport of leptin into the brain. Peptides. 2000;21:679-82.
58. Kastin AJ, Pan W. Dynamic regulation of leptin entry into brain by the blood-brain barrier. Regul Pept. 2000;92:37-43.
59. Kastin AJ, Akerstrom V. Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice. Neuroendocrinology. 2001;73:237-42.
60. Kastin AJ, Akerstrom V, Maness LM. Chronic loss of ovarian function decreases transport of leptin into mouse brain. Neurosci Lett. 2001;310:69-71.
61. Banks WA. Enhanced leptin transport across the blood-brain barrier by alpha1-adrenergic agents. Brain Res. 2001;899:209-17.
62. Hsuchou H, Kastin AJ, Pan W. Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis. J Mol Neurosci. 2012;47:267-77.
63. Pan W, Hsuchou H, Xu C, Wu X, Bouret SG, Kastin AJ. Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice. J Mol Neurosci. 2011;43:478-84.
64. Banks WA, Burney BO, Robinson SM. Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood-brain barrier. Peptides. 2008;29:2061-5.
65. Urayama A, Banks WA. Starvation and triglycerides reverse the obesityinduced impairment of insulin transport at the blood-brain barrier. Endocrinology. 2008;149:3592-7.
66. Heilman KM, Fisher WR. Hyperlipidemic dementia. Arch Neurol. 1974;31:67-8.
67. Mathew NT, Meyer JS, Achari AN, Dodson RF. Hyperlipidemic neuropathy and dementia. Eur Neurol. 1976;14:370-82.
68. Morley JE, Banks WA. Lipids and cognition. J Alzheimers Dis. 2010;20:737-47.
69. Perlmuter LC, Nathan DM, Goldfinger SH, Russo PA, Yates J, Larkin M. Triglyceride levels affect cognitive function in noninsulin-dependent diabetics. J Diabet Complications. 1988;2:210-3.
70. Rogers RL, Meyer JS, McClintic K, Mortel KF. Reducing hypertriglyceridemia in elderly patients with cerebrovascular disease stabilizes or improves cognition and cerebral perfusion. Angiology. 1989;40:260-9.
71. Farr SA, Yamada KA, Butterfield DA, Abdul HM, Xu L, Miller NE, BanksWA. Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology. 2008;149:2628-36.
72. Farr SA, Price TO, Dominguez LJ,Motisi A, Saiano F, NiehoffML,Morley JE, Banks WA, Ercal N, Barbagallo M. Extra virgin olive oil improves learning and memory in SAMP8 mice. J Alzheimers Dis. 2012;28:81-92.
73. Myers MG, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab. 2010;21:643-51.
74. Scarpace PJ, Zhang Y. Leptin resistance: a predisposing factor for dietinduced obesity. Am J Physiol Regul Integr Comp Physiol. 2009;296: R493-500.
75. Flier JS. Clinical review 94: what's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab. 1998;83:1407-13.
76. Leibel RL. Molecular physiology of weight regulation in mice and humans. Int J Obes (Lond). 2008;32(Suppl 7):S98-108.
77. Elinav E, Niv-Spector L, Katz M, Price TO, Ali M, Yacobovitz M, Solomon G, Reicher S, Lynch JL, Halpern Z, et al. Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity. Endocrinology. 2009;150:3083-91.
78. Peters JH, Simasko SM, Ritter RC. Leptin analog antagonizes leptin effects on food intake and body weight but mimics leptin-induced vagal afferent activation. Endocrinology. 2007;148:2878-85.
79. Scarpace PJ, Matheny M, Zhang Y, Cheng K-Y, Tümer N. Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance. J Pharmacol Exp Ther. 2007;320:706-12.
80. Cooling J, Barth J, Blundell J. The high-fat phenotype: is leptin involved in the adaptive response to a high fat (high energy) diet? Int J Obes Relat Metab Disord. 1998;22:1132-5.
81. Chin-Chance C, Polonsky KS, Schoeller DA. Twenty-four-hour leptin levels respond to cumulative short-term energy imbalance and predict subsequent intake. J Clin Endocrinol Metab. 2000;85:2685-91.
82. Bermudez OI, Gao X. Greater consumption of sweetened beverages and added sugars is associated with obesity among US young adults. Ann Nutr Metab. 2010;57:211-8.
83. Malik VS, Hu FB. Sweeteners and risk of obesity and type 2 diabetes: the role of sugar-sweetened beverages. Curr Diab Rep. 2012;12:195-203.
84. Viskaal-van Dongen M, de Graaf C, Siebelink E, Kok FJ. Hidden fat facilitates passive overconsumption. J Nutr. 2009;139:394-9.
85. Lin P-H, Wang Y, Grambow SC, Goggins W, Almirall D. Dietary saturated fat intake is negatively associated with weight maintenance among the PREMIER participants. Obesity (Silver Spring). 2012;20:571-5.