Transgenic mice overexpressing the rate-limiting enzyme for hexosamine synthesis in skeletal muscle or adipose tissue exhibit total body insulin resistance

Annals of the New York Academy of Sciences

Volumn 967, Issue , 2002, Pages 102-111

  Cooksey, Robert C ^a   McClain, Donald A ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Adipose tissue; Hexosamine(s); Insulin resistance; Transgenic

Indexed keywords

GLUCOSE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; HEXOSAMINE; INSULIN;

ADIPOSE TISSUE; CARBOHYDRATE SYNTHESIS; CONFERENCE PAPER; INSULIN RESISTANCE; METABOLIC REGULATION; MOUSE; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; SKELETAL MUSCLE; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 0036289651     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04268.x     Document Type: Conference Paper

References (43)

1. Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase
2. Human glutamine:fructose-6-phosphate amidotransferase: Characterization of mRNA and chromosomal assignment to 2p13
3. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system: Role of hexosamine biosynthesis in the induction of insulin resistance
4. Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine:fructose-6-phosphate amidotransferase in rat-1 fibroblasts
5. Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles: Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor
6. In vivo glucosamine infusion induces insulin resistance in normoglycemic, but not in hyperglycemic conscious rats
7. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
8. Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle: Implications for glucose toxicity
9. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: Possible relevance to the maladaptive responses to chronic hyperglycaemia
10. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance in multiple insulin sensitive tissues
11. Overexpression of glutamine:fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance
12. Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance
13. Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: Decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione
14. Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance
15. Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: Relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin
16. Hexosamines regulate leptin production in human subcutaneous adipocytes
17. Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production
18. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus
19. Effects of glucosamine infusion on insulin secretion and insulin action in humans
20. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase, but does not alter activation of Akt/protein kinase B in skeletal muscle
21. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle
22. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
23. Hyperglycemia inhibits insulin activation of Akt/protein kinase B, but not phosphatidylinositol 3-kinase in rat skeletal muscle
24. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
25. Thiazolidinediones in the treatment of insulin resistance and type II diabetes
26. The hormone resistin links obesity to diabetes
27. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
28. Hexosamines and insulin resistance
29. Perspective: Hexosamines and nutrient sensing
30. Acute and chronic effects of hyperglycaemia on glucose metabolism: Implications for the development of new therapies
31. The subcellular distribution of terminal N-acetyl-glucosamine moieties: Localization of a novel protein-saccharide linkage, O-linked GlcNAc
32. The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny
33. Functional expression of O-linked GlcNAc transferase: Domain structure and substrate specificity
34. O-GlcNAc and the control of gene expression
35. O-Glycosylation of nuclear and cytosolic proteins: Dynamic interplay between O-GlcNAc and O-phosphate
36. c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas
37. Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells
38. O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions
39. Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility
40. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
41. UDP-N-acetylglucosamine transferase and glutamine:fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues
42. Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells
43. SPINDLY, a tetratricopeptide repeat protein involved in gibberellin signal transduction in Arabidopsis