Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier

Diabetes

Volumn 53, Issue 5, 2004, Pages 1253-1260

  Banks, William A ^a,c   Coon, Alan B ^a   Robinson, Sandra M ^a   Moinuddin, Asif ^a   Shultz, Jessica M ^a   Nakaoke, Ryota ^a,b   Morley, John E ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GEMFIBROZIL; INTRALIPID; LEPTIN; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; FATTY ACID ANALYSIS; HYPERTRIGLYCERIDEMIA; IN VITRO STUDY; IN VIVO STUDY; LIPID COMPOSITION; MALE; MILK; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSPORT KINETICS;

ANIMALS; ANTILIPEMIC AGENTS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; DRUG RESISTANCE; FAT EMULSIONS, INTRAVENOUS; GEMFIBROZIL; HYPERTRIGLYCERIDEMIA; LEPTIN; MALE; MICE; MICE, INBRED STRAINS; MILK; TRIGLYCERIDES;

EID: 2342449315     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.5.1253     Document Type: Article

References (48)

1. Zhang Y, Proenca R, Maffel M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
3. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
4. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
5. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295, 1996
6. Pelleymounter MA, Cullen MJ, Healy D, Hecht R, Winters D, McCaleb M: Efficacy of exogenous recombinant murine leptin in lean and obese 10- to 12-mo-old female CD-1 mice. Am J Physiol 275:R950-R959, 1998
7. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, Lubina JA, Patane J, Self B, Hunt P, McCamish M: Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282:1568-1575, 1999
8. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM: Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311, 1996
9. Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El Haschimi K, Banks WA, Flier JS: Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 143:775-783, 2002
10. Banks WA, DiPalma CR, Farrell CL: Impaired transport of leptin across the blood-brain barrier in obesity. Peptides 20:1341-1345, 1999
11. El Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS: Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obestiy. J Clin Invest 105:1827-1832, 2000
12. Yamashita T, Murakami T, Iida M, Kuwajima M, Shima K: Leptin receptor of Zucker fatty rat performs reduced signal transduction. Diabetes 46: 1077-1080, 1997
13. Wilsey J, Zolotukhin S, Prima V, Scarpace PJ: Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity. Am J Physiol 285:R1011-R1020, 2003
14. van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis J: Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 99:385-390, 1997
15. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM: Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci U S A 94:8878-8883, 1997
16. Banks WA, Farrell CL: Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible. Am J Physiology 285:E10-E15, 2003
17. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MD, Considine RV: Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348:159-161, 1996
18. Schwartz MW, Pesldnd E, Raskind M, Boyko EJ, Porte D Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and adiposity in humans. Nat Med 2:589-593, 1996
19. Banks WA: Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations. Current Pharmaceutical Design 9:801-809, 2003
20. Yastin AJ, Akerstrom V: Fasting, but not adrenalectomy, reduces transport of leptin into the brain. Peptides 21:679-682, 2000
21. Kolaczynski JW, Considine RV, Ohannesian J, Marco C, Opentanova I, Nyce MR, Myint M, Caro JF: Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Diabetes 45:1511-1515, 1996
22. Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV Jr. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest 109:1049-1055, 2002
23. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L: Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea pig brain. J Neurochem 51:252-257, 1988
24. Shayo M, McLay RN, Kastin AJ, Banks WA: The putative blood-brain barrier transporter for the β-amyloid binding protein apolipoprotein J is saturated at physiological concentrations. Life Sci 60:L115-L118, 1996
25. Abbott NJ, Hughes CCW, Revest PA, Greenwood J: Development and characterization of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier. J Cell Sci 103:23-37, 1992
26. Deli MA, Joo F. Cultured vascular endothelial cells of the brain. Keio J Med 45:183-198, 1996
27. Kis B, Kaiya H, Nishi R, Deli MA, Abraham CS, Yanagita T, Isse T, Gotoh S, Kobayashi H, Wada A, Niwa M, Kangawa K, Greenwood J, Yamashita H, Ueta Y: Cerebral endothelial cells area major source of adrenomedullin. J Neuroendocrinology 14:283-293, 2002
28. Domotor E, Sipos I, Kittel A, Abbott NJ, Adam-Vizi V: Improved growth of cultured brain microvascular endothelial cells on glass coated with a biological matrix. Neurochem Int 33:473-478, 1998
29. Demeuse P, Kerkhofs A, Struys-Ponsar C, Knoops B, Remacle C, van den Bosch de Aguilar P: Compartmentalized coculture of rat brain endothelial cells and astrocytes: a syngenic model to study the blood-brain barrier. J Neurosci Methods 121:21-31, 2002
30. Maresh GA, Maness LM, Zadina JE, Kastin AJ: In vitro demonstration of a saturable transport system for leptin across the blood-brain barrier. Life Sci 69:67-73, 2001
31. Smith QR, Momma S, Aoyagi M, Rapoport SI: Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem 49:1651-1658, 1987
32. Zlokovic BV, Begley DJ, Djuricic BM, Mitrovic DM: Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-α-aminoisobutyric acid. J Neurochem 46:1444-1451, 1986
33. Banks WA, Clever CM, Farrell CL: Partial saturation and regional variation in the blood to brain transport of leptin in normal weight mice. Am J Physiol 278:E1158-E1165, 2000
34. Christie WW: Composition and structure of milk lipids. In Advanced Dairy Chemistry. Volume. 2: Lipids. Fox PF, Ed. Chapman and Hall, 1994, p. 1-36
35. Resto M, O'Connor D, Leef K, Funanage V, Spear M, Locke R: Leptin levels in preterm human breast milk and infant formula. Pediatrics 108:E15, 2001
36. Smith-Kirwin SM, O'Connor DM, De Johnston J, Lancey ED, Hassink SG, Funanage VL: Leptin expression in human mammary epithelial cells and breast milk. J Clin Endocrinol Metab 83:1810-1813, 1998
37. Neville MC, Picciano MF: Regulation of milk lipid secretion and composition. Ann Rev Nutr 17:159-184, 1997
38. Banks WA, Kastin AJ: Modulation of the carrier-mediated transport of the Tyr-MIF-1 across the blood-brain barrier by essential amino acids. J Pharmacol Exp Ther 239:668-672, 1986
39. Banks WA, Kastin AJ, Fasold MB: Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium and albumin. J Pharmacol Exp Ther 244:579-585, 1988
40. Banks WA: Enhanced leptin transport across the blood-brain barrier by al-adrenergic agents. Brain Res 899:209-217, 2001
41. Kastin AJ, Akerstrom V: Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice. Neuroendocrinology 73:237-242, 2001
42. Steinberg GR, Bonen A, Dyck DJ: Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats. Am J Physiol 282:E593-E600, 2002
43. Reidy SP, Weber JM: Accelerated substrate cycling: a new energy-wasting role for leptin in vivo. Am J Physiol 282:E312-E317, 2002
44. Matsuoka N, Ogawa Y, Masuzaki H, Ebihara K, Aizawa-Abe M, Satoh N, Ishikawa E, Fujisawa Y, Kosaki A, Yamada K, Kuzuya H, Nakao K: Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin. Am J Physiol Endocrinol Metab 280:E334-E339, 2001
45. Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, Gorden P, Garg A: Leptin-replacement therapy for lipodystrophy. N Engl J Med 346:570-578, 2002
46. Banks WA, Phillips-Conroy JE, Jolly CJ, Morley JE: Serum leptin levels in wild and captive populations of baboons (Papio): implications for the ancestral role of leptin. J Clin Endocrinol Metab 86:4615-4320, 2001
47. Hansen BC, Saye J, Wennogle LP: The Metabolic Syndrome X: Convergence of Insulin Resistance, Glucose Intolerance, Hypertension, Obesity, and Dyslipidemia: Searching for the Underlying Defects. New York, New York Academy of Sciences, 1999, p. 1-336
48. Banks WA, Altmann J, Sapolsky RM, Phillips-Conroy JE, Morley JE: Serum leptin levels as a marker for a syndrome X-like condition in wild baboons. J Clin Endocrinol Metab 88:1234-1240, 2003