Molecular convergence of hexosamine biosynthetic pathway and ER stress leading to insulin resistance in L6 skeletal muscle cells

Molecular and Cellular Biochemistry

Volumn 328, Issue 1-2, 2009, Pages 217-224

  Srinivasan, V ^a   Tatu, U ^b   Mohan, V ^a   Balasubramanyam, M ^a  

^a MADRAS DIABETES RESEARCH FOUNDATION   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Diabetes; ER stress; Glucose uptake; HBP; Insulin resistance; JNK; OGT; RNAi; Skeletal muscle; UDP GlcNAc

Indexed keywords

CALNEXIN; CALRETICULIN; CHAPERONE; GLUCOSAMINE; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; GLYCOSYLTRANSFERASE; HEXOSAMINE; INSULIN; O GLYCOSYLTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ANIMAL CELL; ARTICLE; CARBOHYDRATE SYNTHESIS; CELL LEVEL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCOSE TRANSPORT; GLYCOSYLATION; INSULIN RESISTANCE; MUSCLE CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; SKELETAL MUSCLE; UPREGULATION;

ANIMALS; ENDOPLASMIC RETICULUM; GLUCOSE; GLYCOSYLTRANSFERASES; HEXOSAMINES; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; METABOLIC NETWORKS AND PATHWAYS; MICE; MUSCLE, SKELETAL;

EID: 67650252008     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0092-7     Document Type: Article

References (28)

1. Marshall S, Bacote V, Traxinger RR (1991) Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system: Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem 266:4706-4712
2. Herbert L, McClain DA (1996) Overexpression of glutamine: fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance. J Clin Invest 97:1235-1241. doi: 10.1172/JCI118538
3. Buse MG (2006) Hexosamine. Insulin resistance and the complications of diabetes: Current status. Am J Physiol 290:E1-E8
4. Ozcan U, Cao Q, Yilmaz E et al (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461. doi: 10.1126/science.1103160
5. Sundar Rajan S, Srinivasan V, Balasubramanyam M et al (2007) Endoplasmic reticulum (ER) stress & diabetes. Indian J Med Res 125:411-424
6. Werstuck GH, Khan MI, Femia G et al (2006) Glucosamine induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model. Diabetes 55:93-101. doi: 10.2337/diabetes.55.01.06.db05-0633
7. Yki-Järvinen H, Daniels MC, Virkamäki A et al (1996) Increased glutamine: Fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM. Diabetes 45:302-307. doi: 10.2337/ diabetes.45.3.302
8. Wang H, Kouri H, Wollheim CB (2005) ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity. J Cell Sci 118:3905-3915. doi: 10.1242/jcs.02513
9. Daniels MC, Ciaraldi TP, Nikoulina S et al (1996) Glutamine: fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: Relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin. J Clin Invest 97:1235-1241. doi: 10.1172/JCI118538
10. Span PN, Pouwels MJ, Olthaar AJ et al (2001) Assay for hexosamine pathway intermediates (uridine diphosphate-N-acetyl amino sugars) in small samples of human muscle tissue. Clin Chem 47:944-946
11. Clark SF, Moler JC, James DE (2000) Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance. J Biol Chem 275:3819-3826. doi: 10.1074/jbc.275.6.3819
12. DeFronzo RA (1988) The triumvirate: β-cell, muscle, liver. Collusion responsible for NIDDM. Diabetes 37:667-687
13. Baron AD, Brechtel G, Wallace P et al (1988) Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 255:E769-E774
14. Srinivasan V, Sandhya N, Sampathkumar R et al (2007) Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with Type 2 diabetes: Interrelationships with hyperglycemia and oxidative stress. Clin Biochem 40:952-957. doi: 10.1016/j.clinbiochem.2007.05.002
15. Robinson KA, Ball LE, Buse MG (2007) Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 292:E884-E890. doi: 10.1152/ ajpendo.00569.2006
16. Parker GJ, Lund KC, Taylor RP et al (2003) Insulin resistance of glycogen synthase mediated by O-linked N-acetylglucosamine. J Biol Chem 278:10022-10027. doi: 10.1074/jbc.M207787200
17. Arias EB, Kim J, Cartee GD (2004) Prolonged incubation in PUGNAc results in increased protein O-linked glycosylation and insulin resistance in rat skeletal muscle. Diabetes 53:921-930. doi: 10.2337/diabetes.53.4.921
18. Park SY, Ryu J, Lee W (2005) O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes. Exp Mol Med 37:220-229
19. McClain DA, Lubas WA, Cooksey RC et al (2002) Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. Proc Natl Acad Sci USA 99:10695-10699. doi: 10.1073/pnas.152346899
20. Marshall S, Okuyama R, Rumberger JM (2005) Turnover and characterization of UDP-N-acetylglucosaminyl transferase in a stably transfected HeLa cell line. Biochem Biophys Res Commun 332:263-270. doi: 10.1016/ j.bbrc.2005.04.122
21. Werstuck GH, Mohammad I et al (2006) Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model. Diabetes 55:93-101. doi: 10.2337/ diabetes.55.01.06.db05-0633
22. Patti ME, Virkamäki A, Landaker EJ et al (1999) Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes 48:1562-1571. doi: 10.2337/diabetes.48.8.1562
23. Vosseller K, Wells L, Lane MD et al (2002) Elevated nucleoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 99:5313-5318. doi: 10.1073/pnas.072072399
24. Eizirik DL, Cardozo AK, Cnop M (2008) The role for endoplasmic reticulum stress in diabetes mellitus. Endocrinol Rev 29:42-61. doi: 10.1210/ er.2007-0015
25. Wells L, Vosseller K, Hart GW (2001) Glycosylation of nucleocytoplasmic proteins: Signal transduction and O-GlcNAc. Science 291:2376-2378. doi: 10.1126/science.1058714
26. Hart GW, Housley MP, Slawson C (2007) Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature 446:1017-1022. doi: 10.1038/nature05815
27. Kaneto H (2005) The JNK pathway as a therapeutic target for diabetes. Expert Opin Ther Targets 9:581-592. doi: 10.1517/14728222.9.3.581
28. Kaneto H et al (2001) Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J Biol Chem 276:1099-1104. doi: 10.1074/jbc.M104115200