Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches

Frontiers in Physiology

Volumn 3 DEC, Issue , 2012, Pages

  Bhattacharya, Sudin ^a   Shoda, Lisl K M ^a   Zhang, Qiang ^a   Woods, Courtney G ^a   Howell, Brett A ^a   Siler, Scott Q ^a   Woodhead, Jeffrey L ^a   Yang, Yuching ^a   McMullen, Patrick ^a   Watkins, Paul B ^a   Melvin E Andersen, ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

Chemical toxicity; Computational toxicology; Drug toxicity; Multi scale modeling; Systems toxicology; Toxicity pathways; Virtual liver

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; PARACETAMOL;

ARTICLE; BIOINFORMATICS; CELL INTERACTION; COMPUTER MODEL; GENE EXPRESSION; GENE MAPPING; GENE REGULATORY NETWORK; GENETIC ASSOCIATION; HUMAN; LIVER CELL; LIVER INJURY; LIVER SINUSOID; MOLECULAR MODEL; PREDICTIVE VALUE; PROTEIN DNA INTERACTION; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TOXIC HEPATITIS; TOXICITY TESTING; TRANSCRIPTION REGULATION;

EID: 84882574224     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00462     Document Type: Article

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