An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury

Journal of Pharmacology and Experimental Therapeutics

Volumn 342, Issue 2, 2012, Pages 529-540

  Woodhead, Jeffrey L ^a   Howell, Brett A ^a   Yang, Yuching ^a   Harrill, Alison H ^a   Clewell III, Harvey J ^a   Andersen, Melvin E ^a   Siler, Scott Q ^a   Watkins, Paul B ^a,b  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG INTOXICATION; DRUG OVERDOSE; FEMALE; HUMAN; HUMAN CELL; LIVER CELL; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; THERAPY DELAY; TOXIC HEPATITIS; TREATMENT DURATION; TREATMENT RESPONSE;

ACETAMINOPHEN; ACETYLCYSTEINE; ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; BENZOQUINONES; COHORT STUDIES; COMPUTER SIMULATION; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; HUMANS; IMINES; INFUSIONS, INTRAVENOUS; LIVER; PRESCRIPTION DRUG MISUSE; RISK FACTORS;

EID: 84864120350     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.192930     Document Type: Article

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