A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Toxicological Sciences

Volumn 115, Issue 1, 2010, Pages 51-65

  Bhattacharya, Sudin ^a   Conolly, Rory B ^b   Kaminski, Norbert E ^c   Thomas, Russell S ^a   Andersen, Melvin E ^a   Zhang, Qiang ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Bistability; Cellular reprogramming; Coupled feedback loops; Dedifferentiation; Immunotoxicity; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; LIPOPOLYSACCHARIDE; PROTEIN BCL 6; TRANSCRIPTION FACTOR PAX5; BCL6 PROTEIN, HUMAN; DNA BINDING PROTEIN; PAX5 PROTEIN, HUMAN; PRDM1 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL DISRUPTION; CELLULAR IMMUNITY; CYTOTOXICITY; GENE ACTIVATION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOTOXICITY; PLASMA CELL; ANIMAL; BIOLOGICAL MODEL; CELL DEDIFFERENTIATION; DRUG EFFECT; FEEDBACK SYSTEM; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; PHYSIOLOGY; POLLUTANT; REGULATOR GENE; SYSTEMS BIOLOGY; TRANSCRIPTION INITIATION;

ANIMALS; B-CELL-SPECIFIC ACTIVATOR PROTEIN; B-LYMPHOCYTES; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; ENVIRONMENTAL POLLUTANTS; FEEDBACK, PHYSIOLOGICAL; GENES, SWITCH; HUMANS; LIPOPOLYSACCHARIDES; MICE; MODELS, BIOLOGICAL; PLASMA CELLS; REPRESSOR PROTEINS; SYSTEMS BIOLOGY; TETRACHLORODIBENZODIOXIN; TRANSCRIPTIONAL ACTIVATION;

EID: 79551684408     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq035     Document Type: Article

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