Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil

Toxicology

Volumn 130, Issue 2-3, 1998, Pages 79-93

  Ratra, Gurpreet S ^a   Morgan, Winston A ^b   Mullervy, Jenny ^c   Powell, Christopher J ^a   Wright, Matthew C ^a,d  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EAST LONDON   (United Kingdom)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Ca2+ channel blockers; Cyclosporin A; Hepatotoxicity; Methapyrilene; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CYCLOSPORIN A; CYTOCHROME P450; DITHIOTHREITOL; GLUTATHIONE; METHAPYRILENE; METYRAPONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXYGENASE; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM HOMEOSTASIS; CELL CULTURE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; LIVER MICROSOME; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CALCIUM CHANNEL BLOCKERS; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUTATHIONE; HISTAMINE H1 ANTAGONISTS; HYPOPHYSECTOMY; LIVER; MALE; METHAPYRILENE; METYRAPONE; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; RATS; RATS, WISTAR; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; VERAPAMIL;

EID: 18544396602     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(98)00096-1     Document Type: Article

References (62)

1. Baldwin S.J., Bloomer J.C., Smith G.J., Ayrton A.D., Clark S.E., Chenery R.J. Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9. Xenobiotica. 25:1995;261-270.
2. Bernardi P., Broekemeier K.M., Pfeiffer D.R. Recent progress on the regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane. J. Bioenerget. Biomem. 26:1994;509-517.
3. Bernoffsky C., Swan M. An improved cycling assay for nicotinamide adenine dinucleotide. Anal. Biochem. 53:1973;452-458.
4. Buss W.C., Savage D.D., Stepanek J., Little S.A., McGuffee L.J. Effect of calcium channel antagonists on calcium uptake and release by isolated rat cardiac mitochondria. Eur. J. Pharmacol. 152:1988;247-253.
5. Casini A.F., Farber J.L. Dependence of the carbon-tetrachloride-induced death of cultured hepatocytes on the extracellular calcium concentration. Am. J. Pathol. 105:1981;138-148.
6. 2+ channel antagonists. TiPS. 13:1992;256-262.
7. Chang T.K., Gonzalez F.J., Waxman D.J. Evaluation of troleandomycin, alpha-naphtholflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. Arch. Biochem. Biophys. 311:1994;437-442.
8. 2+ dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem. J. 255:1988;357-360.
9. Deakin C.D., Fagan E.A., Williams R. Cytoprotective effects of calcium channel blockers. Mechanisms and potential applications in hepatocellular injury. J. Hepatol. 12:1991;251-255.
10. 2+ plus prooxidants. J. Biol. Chem. 265:1990;19955-19960.
11. Gebhardt R. Metabolic zonation in the liver: regulation and implications for liver function. Pharmac. Ther. 53:1992;275-354.
12. 2+ release from liver mitochondria by inhibiting pyridine nucleotide hydrolysis. Biochem. Biophys. Res. Commun. 185:1992;698-704.
13. Gooding P.E., Chayen J., Sawyer B., Slater T.F. Cytochrome P450 distribution in rat liver and the effect of sodium phenobarbitone treatment. Chem. Biol. Interact. 20:1978;299-310.
14. Graichen M.E., Neptun D.A., Dent J.G., Popp J.A., Leonard T.B. Effects of methapyrilene on rat hepatic xenobiotic enzymes and liver morphology. Fundament. Appl. Toxicol. 5:1985;165-174.
15. Hissin P.J., Hilf R. A fluorimetric method for the determination of oxidised and reduced glutathione in tissues. Anal. Biochem. 74:1976;214-216.
16. Hodgson E., Levi P.E. The role of the flavin-containing monooxygenase in the metabolism and mode of action of agricultural chemicals. Xenobiotica. 22:1992;1175-1183.
17. 2+ channels. Biochem. Pharmacol. 35:1986;3045-3052.
18. 2+ pool in isolated hepatocytes. FEBS Lett. 313:1992;39-42.
19. Kammerer R.C., Schmitz D.A. Metabolism of methapyrilene by rat liver homogenate. Xenobiotica. 16:1986;671-680.
20. Kammerer R.C., Schmitz D.A. Species differences in the in vitro metabolism of methapyrilene. Xenobiotica. 17:1987;1120-1130.
21. Kammerer R.C., Schmitz D.A., Lampe M.A., Kloc K. The in vivo metabolism of methapyrilene, a hepatocarcingen, in the rat. Xenobiotica. 18:1988;869-881.
22. Kass G.E.N., Llopis J., Chow S.C., Duddy S.K., Orrenius S. Receptor-operated calcium influx in rat hepatocytes. Identification and characterisation using manganese. J. Biol. Chem. 265:1990;17486-17492.
23. Kass G.E.N., Jeudes M.J., Orrenius S. Cyclosporin A protects hepatocytes against prooxidant-induced cell killing. Biochem. Pharmacol. 4:1992;1995-2003.
24. 1 mouse hepatocytes. Xenobiotica. 22:1992;1367-1381.
25. Kutty R.K., Singh Y., Santostasi G., Krishna G. Maitotoxin-induced liver cell death involving loss of cell ATP following influx of calcium. Toxicol. Appl. Pharmacol. 101:1989;1-10.
26. Laemmli UK. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature. 227:1971;680-685.
27. Lampe M.A., Kammerer R.C. Species differences in the metabolism and macromolecular binding of methapyrilene: a comparison of rat, mouse and hamster. Xenobiotica. 20:1990;1269-1280.
28. Lewis W., Griniuviene B., Tankersley K.O., Levine E.S., Montione R., Engelman L., de Courten-Myers G., Ascenzi M.A., Hornbuckle W.E., Gerin J.L., Tennant B.C. Depletion of mitochondrial DNA, destruction of mitochondria, and accumulation of lipid droplets result from fialuridine treatment in woodchucks (Marmota monax). Lab. Invest. 76:1997;77-87.
29. Liang D., Thurman R.G. Protective effects of the calcium antagonists diltiazem and TA3090 against hepatic injury due to hypoxia. Biochem. Pharmacol. 44:1992;2207-2211.
30. Loesberg C., Van Rooij H., Smets L.A. Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono (ADP-ribosylation). Biochim. Biophys. Acta. 1037:1990;92-99.
31. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
32. Mahler H., Pasi A., Kramer J.M., Schulte P., Scoging A.C., Bär W., Krähenbühl S. Fulminant liver failure in association with the emetic toxin of Bacillus Cereus. N. Engl. J. Med. 336:1997;1142-1148.
33. Maser E., Netter K.J. Reductive metabolism of metyrapone by a quercitrin-sensitive ketone reductase in mouse liver cytosol. Biochem. Pharmacol. 41:1991;1595-1599.
34. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 6:1996;1-42.
35. Oppermann U.D.T., Maser E., Mangoura S.A., Netter K.J. Heterogeneity of carbonyl reduction in subcellular fractions and different organs in rodents. Biochem Pharmacol. 42:1991;S189-S195.
36. Paine A.J. The maintenance of cytochrome P450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P450 system. Chem. Biol. Interact. 74:1990;1-31.
37. 2+ channels. TiPS. 11:1990;112-115.
38. Ratra GS. (1997). Studies on the mechanisms of methapyrilene hepatotoxicity (Ph.D. Thesis), University of London.
39. Ratra G.S., Cottrell S., Powell C.J. Effects of induction and inhibition of cytochrome P450 on the metabolism and hepatotoxicity of methapyrilene hydrochloride. Hum. Exp. Toxicol. 16:1997;53.
40. 2+ antagonists inhibit DNA fragmentation and toxic cell death. FASEB J. 7:1993;453-463.
41. Richardson F.C., Horn D.M., Anderson N.L. Dose-responses in rat hepatic protein modification and expression following exposure to the rat hepatocarcinogen methapyrilene. Carcinogenesis. 15:1994;325-329.
42. 2+ release from mitochondria induced by prooxidants. Free Radic. Biol. Med. 4:1988;365-375.
43. Richter C., Theus M., Schlegel J. Cyclosporin A inhibits mitochondrial pyridine nucleotide hydrolysis and calcium release. Biochem. Pharmacol. 40:1990;779-782.
44. Shimada M., Murayama N., Yamauchi K., Yamazoe Y., Kato R. Suppression in the expression of a male-specific cytochrome P-450, P-450-male: difference in the effect of chemical inducers on P-450-male mRNA and protein in rat livers. Arch. Biochem. Biophys. 270:1989;578-587.
45. 1 antagonist N,N-dimethyl-N'(2-thienylmethyl)-1,2-ethanediamine (methapyrilene) in the rat. Xenobiotica. 17:1987;1279-1291.
46. Sippel H., Stauffert I., Estler C J. Protective effect of various calcium antagonists against an experimentally induced calcium overload in isolated hepatocytes. Biochem. Pharmacol. 46:1993;1937-1944.
47. Smets L.A., Loesberg C., Janssen M., Van Rooij H. Intracellular inhibition of mono(ADP-ribosylation) by meta-iodobenzylguanidine: specificity, intracellular concentration and effects on glucocorticoid-mediated cell lysis. Biochim. Biophys. Acta. 1054:1990;49-55.
48. Stein H.J., Oosthuizen H.M., Hinder R.A., Lamprechts H. Effect of verapamil on hepatic ischemia/reperfusion injury. Am. J. Surg. 165:1993;96-100.
49. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulase sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
50. i in apoptosis, oncosis, and necrosis. Biochim. Biophys. Acta. 1313:1996;173-178.
51. 2+ and their association with cytotoxicity to renal cells. Biochem. Pharmacol. 44:1992;1131-1138.
52. Waxman D.J., LeBlanc G.A., Morrissey J.J., Staunton J., Lapenson D.P. Adult male-specific and neonatally programmed rat hepatic P450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. J. Biol. Chem. 263:1988;11396-11406.
53. Waxman D.J., Ram P.A., Notani G., LeBlanc G.A., Alberta J.A., Morrissey J.J., Sundseth S.S. Pituitary regulation of the male-specific steroid 6β-hydroxylase P450 2a (gene product IIIA2) in adult rat liver. Suppresive influence of growth hormone and thyroxine acting at a pre-translational level. Mol. Endocrinol. 4:1990;447-454.
54. 2+ release from mitochondria by stimulating pyridine nucleotide hydrolysis. J. Biol. Chem. 267:1992;804-809.
55. 2+ release and pore formation by prooxidants. Biochem. Pharmacol. 47:1994;2147-2156.
56. pb1 gene expression. Mol. Pharmacol. 38:1990;192-197.
57. Wright M.C., Edwards R.J., Pimenta M., Ribeiro V., Ratra G.S., Lechner M.C., Paine A.J. Developmental changes in the constitutive and inducible expression of cytochrome P450 3A2. Biochem. Pharmacol. 54:1997;841-846.
58. Wright M.C., Paine A.J., Skett P., Auld R. Induction of rat hepatic glucocorticoid-inducible cytochrome P450 3A by metyrapone. J. Steroid Biochem. Molec. Biol. 48:1994;271-276.
59. Wright M.C., Paine A.J. Evidence that the loss of rat liver cytochrome P450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrix. Biochem. Pharmacol. 43:1992;237-243.
60. Wright M.C., Paine A.J. Resistance of precision-cut liver slices to the toxic effects of menadione. Toxicol. In Vitro. 6:1992;475-481.
61. Wrighton S.A., Vandenbranden M., Brown T.J., Van Pelt C.S., Thomas P.E., Shipley L.A. Modulation of rat hepatic cytochromes P450 by chronic methapyrilene treatment. Biochem. Pharmacol. 42:1991;1093-1097.
62. Zoratti M., Szabo I. The mitochondrial permeability transition. Biochim. Biophys. Acta. 1241:1995;139-176.