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Volumn 39, Issue 4, 2013, Pages 343-354

The TRAIL of oncogenes to apoptosis

Author keywords

Apoptosis; Cancer therapy; Kinase inhibitors; RAS oncogenes; TRAIL

Indexed keywords

2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; B RAF KINASE INHIBITOR; BORTEZOMIB; CISPLATIN; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FLUOROURACIL; GELDANAMYCIN; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; IMATINIB; INHIBITOR OF APOPTOSIS PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN INHIBITOR; LEXATUMUMAB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MAPATUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEASOME INHIBITOR; PROTEIN BCL 2 INHIBITOR; PROTEIN INHIBITOR; PROTEIN KINASE B INHIBITOR; QUERCETIN; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; RETINOL ACETATE; TANESPIMYCIN; TRASTUZUMAB; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN INHIBITOR; ANTINEOPLASTIC AGENT;

EID: 84881666221     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1112     Document Type: Review
Times cited : (32)

References (116)
  • 1
    • 17544367410 scopus 로고    scopus 로고
    • Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
    • Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., et al. (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271, 12687-12690.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12687-12690
    • Pitti, R.M.1    Marsters, S.A.2    Ruppert, S.3    Donahue, C.J.4    Moore, A.5
  • 2
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley, S. R., Schooley, K., Smolak, P. J., Din, W.S., Huang, C. P., et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673-682.
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1    Schooley, K.2    Smolak, P.J.3    Din, W.S.4    Huang, C.P.5
  • 4
    • 0032489353 scopus 로고    scopus 로고
    • TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling
    • Pan, G., Ni, J., Yu, G., Wei, Y. F., and Dixit, V. M. (1998). TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett. 424:41-45.
    • (1998) FEBS Lett. , vol.424 , pp. 41-45
    • Pan, G.1    Ni, J.2    Yu, G.3    Wei, Y.F.4    Dixit, V.M.5
  • 5
    • 33749164762 scopus 로고    scopus 로고
    • Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
    • Merino, D., Lalaoui, N., Morizot, A., Schneider, P., Solary, E., et al. (2006). Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol. 26, 7046-7055.
    • (2006) Mol Cell Biol. , vol.26 , pp. 7046-7055
    • Merino, D.1    Lalaoui, N.2    Morizot, A.3    Schneider, P.4    Solary, E.5
  • 6
    • 29144496895 scopus 로고    scopus 로고
    • Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis
    • Clancy, L., Mruk, K., Archer, K., Woelfel, M., Mongkolsapaya, J., et al. (2005). Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc. Natl. Acad. Sci. USA 102, 18099-18104.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 18099-18104
    • Clancy, L.1    Mruk, K.2    Archer, K.3    Woelfel, M.4    Mongkolsapaya, J.5
  • 7
    • 77952784381 scopus 로고    scopus 로고
    • Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation
    • Oberst, A., Pop, C., Tremblay, A. G., Blais, V., Denault, J. B., et al. (2010) Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J. Biol. Chem. 285, 16632-16642.
    • (2010) J. Biol. Chem. , vol.285 , pp. 16632-16642
    • Oberst, A.1    Pop, C.2    Tremblay, A.G.3    Blais, V.4    Denault, J.B.5
  • 9
    • 80052322060 scopus 로고    scopus 로고
    • Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion
    • Shirley, S., Morizot, A., and Micheau, O. (2011) Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion. Recent Pat. Anticancer Drug Discov. 6, 311-323.
    • (2011) Recent Pat. Anticancer Drug Discov. , vol.6 , pp. 311-323
    • Shirley, S.1    Morizot, A.2    Micheau, O.3
  • 10
    • 80053580530 scopus 로고    scopus 로고
    • RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts
    • Green, D. R., Oberst, A., Dillon, C. P., Weinlich, R., and Salvesen, G. S. (2011) RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol. Cell 44, 9-16.
    • (2011) Mol. Cell , vol.44 , pp. 9-16
    • Green, D.R.1    Oberst, A.2    Dillon, C.P.3    Weinlich, R.4    Salvesen, G.S.5
  • 11
    • 0036467427 scopus 로고    scopus 로고
    • Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
    • Cretney, E., Takeda, K., Yagita, H., Glaccum, M., Peschon, J. J., et al. (2002) Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J. Immunol. 168, 1356-1361.
    • (2002) J. Immunol. , vol.168 , pp. 1356-1361
    • Cretney, E.1    Takeda, K.2    Yagita, H.3    Glaccum, M.4    Peschon, J.J.5
  • 12
    • 72449129475 scopus 로고    scopus 로고
    • Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) Receptor-1 and Receptor-2 agonists for cancer therapy
    • Fox, N. L., Humphreys, R., Luster, T. A., Klein, J., and Gallant, G. (2010) Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) Receptor-1 and Receptor-2 agonists for cancer therapy. Expert. Opin. Biol. Ther. 10, 1-18.
    • (2010) Expert. Opin. Biol. Ther. , vol.10 , pp. 1-18
    • Fox, N.L.1    Humphreys, R.2    Luster, T.A.3    Klein, J.4    Gallant, G.5
  • 13
    • 67649300721 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to the brain
    • Bos, P. D., Zhang, X. H., Nadal, C., Shu, W., Gomis, R. R., et al. (2009) Genes that mediate breast cancer metastasis to the brain. Nature 459, 1005-1009.
    • (2009) Nature , vol.459 , pp. 1005-1009
    • Bos, P.D.1    Zhang, X.H.2    Nadal, C.3    Shu, W.4    Gomis, R.R.5
  • 14
    • 0037033005 scopus 로고    scopus 로고
    • FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer
    • Modur, V., Nagarajan, R., Evers, B. M., and Milbrandt, J. (2002) FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J. Biol. Chem. 277, 47928-47937.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47928-47937
    • Modur, V.1    Nagarajan, R.2    Evers, B.M.3    Milbrandt, J.4
  • 15
    • 0037672290 scopus 로고    scopus 로고
    • Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas
    • Koornstra, J. J., Kleibeuker, J. H., van Geelen, C. M., Rijcken, F. E., Hollema, H., et al. (2003) Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas. J. Pathol. 200, 327-335.
    • (2003) J. Pathol. , vol.200 , pp. 327-335
    • Koornstra, J.J.1    Kleibeuker, J.H.2    van Geelen, C.M.3    Rijcken, F.E.4    Hollema, H.5
  • 16
    • 82155181730 scopus 로고    scopus 로고
    • TRAIL up-regulation must be accompanied by a reciprocal PKCepsilon down-regulation during differentiation of colonic epithelial cell: implications for colorectal cancer cell differentiation
    • Gobbi, G., Di Marcantonio, D., Micheloni, C., Carubbi, C., Galli, D., et al., (2012) TRAIL up-regulation must be accompanied by a reciprocal PKCepsilon down-regulation during differentiation of colonic epithelial cell: implications for colorectal cancer cell differentiation. J. Cell Physiol. 227, 630-638.
    • (2012) J. Cell Physiol. , vol.227 , pp. 630-638
    • Gobbi, G.1    Di, M.D.2    Micheloni, C.3    Carubbi, C.4    Galli, D.5
  • 17
    • 38149139518 scopus 로고    scopus 로고
    • TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis
    • Finnberg, N., Klein-Szanto, A. J., and El-Deiry, W. S. (2008) TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J. Clin. Invest. 118, 111-123.
    • (2008) J. Clin. Invest. , vol.118 , pp. 111-123
    • Finnberg, N.1    Klein-Szanto, A.J.2    El-Deiry, W.S.3
  • 18
    • 0028329172 scopus 로고
    • Apoptosis. Its significance in cancer and cancer therapy
    • Kerr, J. F., Winterford, C. M., and Harmon, B. V. (1994) Apoptosis. Its significance in cancer and cancer therapy. Cancer 73, 2013-2026.
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.1    Winterford, C.M.2    Harmon, B.V.3
  • 19
    • 54249096028 scopus 로고    scopus 로고
    • Caspases in apoptosis and beyond
    • Li, J. and Yuan, J. (2008) Caspases in apoptosis and beyond. Oncogene 27, 6194-6206.
    • (2008) Oncogene , vol.27 , pp. 6194-6206
    • Li, J.1    Yuan, J.2
  • 20
    • 18144416611 scopus 로고    scopus 로고
    • The transcriptional targets of p53 in apoptosis control
    • Yu, J. and Zhang, L. (2005) The transcriptional targets of p53 in apoptosis control. Biochem. Biophys. Res. Commun. 331, 851-858.
    • (2005) Biochem. Biophys. Res. Commun. , vol.331 , pp. 851-858
    • Yu, J.1    Zhang, L.2
  • 21
    • 0032713075 scopus 로고    scopus 로고
    • Safety and antitumor activity of recombinant soluble Apo2 ligand
    • Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A. et al. (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155-162.
    • (1999) J. Clin. Invest. , vol.104 , pp. 155-162
    • Ashkenazi, A.1    Pai, R.C.2    Fong, S.3    Leung, S.4    Lawrence, D.A.5
  • 22
    • 58149456883 scopus 로고    scopus 로고
    • Death receptors as targets for anti-cancer therapy
    • Papenfuss, K., Cordier, S. M., and Walczak, H. (2008) Death receptors as targets for anti-cancer therapy. J. Cell Mol. Med. 12, 2566-2585.
    • (2008) J. Cell Mol. Med. , vol.12 , pp. 2566-2585
    • Papenfuss, K.1    Cordier, S.M.2    Walczak, H.3
  • 23
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. and Weinberg, R. A. (2000) The hallmarks of cancer. Cell 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 24
    • 0037013147 scopus 로고    scopus 로고
    • Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    • Pelengaris, S., Khan, M., and Evan, G. I. (2002) Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 109, 321-334.
    • (2002) Cell , vol.109 , pp. 321-334
    • Pelengaris, S.1    Khan, M.2    Evan, G.I.3
  • 25
    • 77952829835 scopus 로고    scopus 로고
    • Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells
    • Hoogwater, F. J., Nijkamp, M. W., Smakman, N., Steller, E. J., Emmink, B. L., et al. (2010) Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells. Gastroenterology 138, 2357-2367.
    • (2010) Gastroenterology , vol.138 , pp. 2357-2367
    • Hoogwater, F.J.1    Nijkamp, M.W.2    Smakman, N.3    Steller, E.J.4    Emmink, B.L.5
  • 26
    • 20744450585 scopus 로고    scopus 로고
    • Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway
    • Drosopoulos, K. G., Roberts, M. L., Cermak, L., Sasazuki, T., Shirasawa, S. et al. (2005) Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. J. Biol. Chem. 280, 22856-22867.
    • (2005) J. Biol. Chem. , vol.280 , pp. 22856-22867
    • Drosopoulos, K.G.1    Roberts, M.L.2    Cermak, L.3    Sasazuki, T.4    Shirasawa, S.5
  • 27
    • 2542611366 scopus 로고    scopus 로고
    • Oncogenic Ras sensitizes normal human cells to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis
    • Nesterov, A., Nikrad, M., Johnson, T., and Kraft, A. S. (2004) Oncogenic Ras sensitizes normal human cells to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis. Cancer Res. 64, 3922-3927.
    • (2004) Cancer Res. , vol.64 , pp. 3922-3927
    • Nesterov, A.1    Nikrad, M.2    Johnson, T.3    Kraft, A.S.4
  • 28
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood, L. D., Parsons, D. W., Jones, S., Lin, J., Sjöblom, T., et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318, 1108-1113.
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3    Lin, J.4    Sjöblom, T.5
  • 29
    • 80053172696 scopus 로고    scopus 로고
    • BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
    • Makrodouli, E., Oikonomou, E., Koc, M., Andera, L., Sasazuki, T., et al. (2011) BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. Mol. Cancer 10, 118.
    • (2011) Mol. Cancer , vol.10 , pp. 118
    • Makrodouli, E.1    Oikonomou, E.2    Koc, M.3    Andera, L.4    Sasazuki, T.5
  • 31
    • 0035911242 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis
    • Smyth, M. J., Cretney, E., Takeda, K., Wiltrout, R. H., Sedger, L. M., et al. (2001) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J. Exp. Med. 193, 661-670.
    • (2001) J. Exp. Med. , vol.193 , pp. 661-670
    • Smyth, M.J.1    Cretney, E.2    Takeda, K.3    Wiltrout, R.H.4    Sedger, L.M.5
  • 32
    • 0037273848 scopus 로고    scopus 로고
    • Apo2L/TRAIL and its death and decoy receptors
    • LeBlanc, H. N. and Ashkenazi, A. (2003) Apo2L/TRAIL and its death and decoy receptors. Cell Death. Differ. 10, 66-75.
    • (2003) Cell Death. Differ. , vol.10 , pp. 66-75
    • LeBlanc, H.N.1    Ashkenazi, A.2
  • 33
    • 0042845974 scopus 로고    scopus 로고
    • Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy
    • Bouralexis, S., Findlay, D. M., Atkins, G. J., Labrinidis, A., Hay, S., et al. (2003). Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. Br. J. Cancer. 89, 206-214.
    • (2003) Br. J. Cancer. , vol.89 , pp. 206-214
    • Bouralexis, S.1    Findlay, D.M.2    Atkins, G.J.3    Labrinidis, A.4    Hay, S.5
  • 34
    • 47049096316 scopus 로고    scopus 로고
    • P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells
    • Toscano, F., Fajoui, Z. E., Gay, F., Lalaoui, N., Parmentier, B., et al. (2008) P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells. Oncogene 27, 4161-4171.
    • (2008) Oncogene , vol.27 , pp. 4161-4171
    • Toscano, F.1    Fajoui, Z.E.2    Gay, F.3    Lalaoui, N.4    Parmentier, B.5
  • 35
    • 28944449421 scopus 로고    scopus 로고
    • Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy
    • Sayers, T. J. and Murphy, W. J. (2006) Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer Immunol. Immunother. 55, 76-84.
    • (2006) Cancer Immunol. Immunother. , vol.55 , pp. 76-84
    • Sayers, T.J.1    Murphy, W.J.2
  • 36
    • 0030792712 scopus 로고    scopus 로고
    • Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
    • Sheridan, J. P., Marsters, S. A., Pitti, R. M., Gurney, A., Skubatch, M., et al. (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277, 818-821.
    • (1997) Science , vol.277 , pp. 818-821
    • Sheridan, J.P.1    Marsters, S.A.2    Pitti, R.M.3    Gurney, A.4    Skubatch, M.5
  • 37
    • 0033974084 scopus 로고    scopus 로고
    • Molecular determinants of response to TRAIL in killing of normal and cancer cells
    • Kim, K., Fisher, M. J., Xu, S. Q., and el-Deiry, W. S. (2000) Molecular determinants of response to TRAIL in killing of normal and cancer cells. Clin. Cancer Res. 6, 335-346.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 335-346
    • Kim, K.1    Fisher, M.J.2    Xu, S.Q.3    el-Deiry, W.S.4
  • 38
    • 0034776231 scopus 로고    scopus 로고
    • TRAIL-induced eradication of primary tumour cells from multiple myeloma patient bone marrows is not related to TRAIL receptor expression or prior chemotherapy
    • Lincz, L. F., Yeh, T. X., and Spencer, A. (2001) TRAIL-induced eradication of primary tumour cells from multiple myeloma patient bone marrows is not related to TRAIL receptor expression or prior chemotherapy. Leukemia 15, 1650-1657.
    • (2001) Leukemia , vol.15 , pp. 1650-1657
    • Lincz, L.F.1    Yeh, T.X.2    Spencer, A.3
  • 39
    • 29144479989 scopus 로고    scopus 로고
    • Adenovirus-mediated IKKβKA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis
    • Sanlioglu, A. D., Koksal, I. T., Karacay, B., Baykara, M., Luleci, G., et al. (2005) Adenovirus-mediated IKKβKA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Cancer Gene Therapy. 13, 21-31.
    • (2005) Cancer Gene Therapy. , vol.13 , pp. 21-31
    • Sanlioglu, A.D.1    Koksal, I.T.2    Karacay, B.3    Baykara, M.4    Luleci, G.5
  • 40
    • 0030800070 scopus 로고    scopus 로고
    • Inhibition of death receptor signals by cellular FLIP
    • Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., et al. (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388, 190-195.
    • (1997) Nature , vol.388 , pp. 190-195
    • Irmler, M.1    Thome, M.2    Hahne, M.3    Schneider, P.4    Hofmann, K.5
  • 41
    • 0030810926 scopus 로고    scopus 로고
    • X-linked IAP is a direct inhibitor of cell-death proteases
    • Deveraux, Q. L., Takahashi, R., Salvesen, G. S., Reed, J. C. (1997). X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388, 300-304.
    • (1997) Nature , vol.388 , pp. 300-304
    • Deveraux, Q.L.1    Takahashi, R.2    Salvesen, G.S.3    Reed, J.C.4
  • 42
    • 9144234685 scopus 로고    scopus 로고
    • Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
    • Schimmer, A. D., Welsh, K., Pinilla, C., Wang, Z., Krajewska, M., et al. (2004) Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell 5, 25-35.
    • (2004) Cancer Cell , vol.5 , pp. 25-35
    • Schimmer, A.D.1    Welsh, K.2    Pinilla, C.3    Wang, Z.4    Krajewska, M.5
  • 43
    • 79952630372 scopus 로고    scopus 로고
    • Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level
    • Morizot, A., Mérino, D., Lalaoui, N., Jacquemin, G., Granci, V., et al. (2011) Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level. Cell Death Differ. 18, 700-711.
    • (2011) Cell Death Differ. , vol.18 , pp. 700-711
    • Morizot, A.1    Mérino, D.2    Lalaoui, N.3    Jacquemin, G.4    Granci, V.5
  • 44
    • 84855228668 scopus 로고    scopus 로고
    • Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells
    • Jacquemin, G., Granci, V., Gallouet, A. S., Lalaoui, N., Morlé, A., et al. (2012) Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells. Haematologica 97, 38-46.
    • (2012) Haematologica , vol.97 , pp. 38-46
    • Jacquemin, G.1    Granci, V.2    Gallouet, A.S.3    Lalaoui, N.4    Morlé, A.5
  • 45
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M., Sorger, P. K. (2009). Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis Nature 459, 428-432.
    • (2009) Nature , vol.459 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3    Burke, J.M.4    Sorger, P.K.5
  • 46
    • 21344474349 scopus 로고    scopus 로고
    • Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer
    • Horak, P., Pils, D., Haller, G., Pribill, I., Roessler, M., et al. (2005) Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer. Mol. Cancer Res. 3, 335-343.
    • (2005) Mol. Cancer Res. , vol.3 , pp. 335-343
    • Horak, P.1    Pils, D.2    Haller, G.3    Pribill, I.4    Roessler, M.5
  • 47
    • 0033621956 scopus 로고    scopus 로고
    • The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L
    • Chen, C., Edelstein, L. C., and Gelinas, C. (2000) The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol. Cell Biol. 20, 2687-2695.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 2687-2695
    • Chen, C.1    Edelstein, L.C.2    Gelinas, C.3
  • 48
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • Wang, C. Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V., and Baldwin, A. S., Jr. (1998) NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 1680-1683.
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin Jr., A.S.5
  • 49
    • 78751487532 scopus 로고    scopus 로고
    • FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
    • Pop, C., Oberst, A., Drag, M., Van Raam, B. J., Riedl, S. J., et al. (2011) FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem. J. 433, 447-457.
    • (2011) Biochem. J. , vol.433 , pp. 447-457
    • Pop, C.1    Oberst, A.2    Drag, M.3    Van Raam, B.J.4    Riedl, S.J.5
  • 50
    • 33344476184 scopus 로고    scopus 로고
    • cFLIP regulation of lymphocyte activation and development
    • Budd, R. C., Yeh, W. C., and Tschopp, J. (2006) cFLIP regulation of lymphocyte activation and development. Nat. Rev. Immunol. 6, 196-204.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 196-204
    • Budd, R.C.1    Yeh, W.C.2    Tschopp, J.3
  • 51
    • 33646688191 scopus 로고    scopus 로고
    • The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation
    • Golks, A., Brenner, D., Krammer, P. H., and Lavrik, I. N. (2006) The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation. J. Exp. Med. 203, 1295-1305.
    • (2006) J. Exp. Med. , vol.203 , pp. 1295-1305
    • Golks, A.1    Brenner, D.2    Krammer, P.H.3    Lavrik, I.N.4
  • 52
    • 41949094367 scopus 로고    scopus 로고
    • FLIP as an anti-cancer therapeutic target
    • Yang, J. K. (2008) FLIP as an anti-cancer therapeutic target. Yonsei Med. J. 49, 19-27.
    • (2008) Yonsei Med. J. , vol.49 , pp. 19-27
    • Yang, J.K.1
  • 53
    • 0346399569 scopus 로고    scopus 로고
    • Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers
    • Nam, S. Y., Jung, G. A., Hur, G. C., Chung, H. Y., Kim, W. H., et al. (2003) Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers. Cancer Sci. 94, 1066-1073.
    • (2003) Cancer Sci. , vol.94 , pp. 1066-1073
    • Nam, S.Y.1    Jung, G.A.2    Hur, G.C.3    Chung, H.Y.4    Kim, W.H.5
  • 54
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du, C., Fang, M., Li, Y., Li, L., and Wang, X. (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102, 33-42.
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 55
    • 77949703295 scopus 로고    scopus 로고
    • Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma
    • Gillissen, B., Wendt, J., Richter, A., Richter, A., Müer, A., et al. (2010) Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. J. Cell Biol. 188, 851-862.
    • (2010) J. Cell Biol. , vol.188 , pp. 851-862
    • Gillissen, B.1    Wendt, J.2    Richter, A.3    Richter, A.4    Müer, A.5
  • 56
    • 2442663096 scopus 로고    scopus 로고
    • Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells
    • Taniai, M., Grambihler, A., Higuchi, H., Werneburg, N., Bronk, S. F., et al. (2004) Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells. Cancer Res. 64, 3517-3524.
    • (2004) Cancer Res. , vol.64 , pp. 3517-3524
    • Taniai, M.1    Grambihler, A.2    Higuchi, H.3    Werneburg, N.4    Bronk, S.F.5
  • 57
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., et al. (2000) Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102, 43-53.
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1    Ekert, P.G.2    Pakusch, M.3    Silke, J.4    Connolly, L.M.5
  • 58
    • 0037018277 scopus 로고    scopus 로고
    • Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression
    • Fulda, S., Meyer, E., and Debatin, K. M. (2002) Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. Oncogene 21, 2283-2294.
    • (2002) Oncogene , vol.21 , pp. 2283-2294
    • Fulda, S.1    Meyer, E.2    Debatin, K.M.3
  • 59
    • 0037379739 scopus 로고    scopus 로고
    • Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release
    • Kandasamy, K., Srinivasula, S. M., Alnemri, E. S., Thompson, C. B., Korsmeyer, S. J., et al. (2003) Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release. Cancer Res. 63, 1712-1721.
    • (2003) Cancer Res. , vol.63 , pp. 1712-1721
    • Kandasamy, K.1    Srinivasula, S.M.2    Alnemri, E.S.3    Thompson, C.B.4    Korsmeyer, S.J.5
  • 60
    • 77956321948 scopus 로고    scopus 로고
    • Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells
    • Xu, J., Zhou, J. Y., Wei, W. Z., and Wu, G. S. (2010) Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells. PLoS One 5, e10226.
    • (2010) PLoS One , vol.5
    • Xu, J.1    Zhou, J.Y.2    Wei, W.Z.3    Wu, G.S.4
  • 61
    • 0036731976 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells
    • Kandasamy, K. and Srivastava, R. K. (2002) Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells. Cancer Res. 62, 4929-4937.
    • (2002) Cancer Res. , vol.62 , pp. 4929-4937
    • Kandasamy, K.1    Srivastava, R.K.2
  • 62
    • 34948822418 scopus 로고    scopus 로고
    • Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding
    • Bin, L., Thorburn, J., Thomas, L. R., Clark, P. E., Humphreys, R., et al. (2007) Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding. J. Biol. Chem. 282, 28189-28194.
    • (2007) J. Biol. Chem. , vol.282 , pp. 28189-28194
    • Bin, L.1    Thorburn, J.2    Thomas, L.R.3    Clark, P.E.4    Humphreys, R.5
  • 63
    • 62449196599 scopus 로고    scopus 로고
    • LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors
    • Shenoy, K., Wu, Y., and Pervaiz, S. (2009) LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res. 69, 1941-1950.
    • (2009) Cancer Res. , vol.69 , pp. 1941-1950
    • Shenoy, K.1    Wu, Y.2    Pervaiz, S.3
  • 64
    • 31544432335 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells
    • Earel, J. K., Jr., VanOosten, R. L., and Griffith, T. S. (2006) Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells. Cancer Res. 66, 499-507.
    • (2006) Cancer Res. , vol.66 , pp. 499-507
    • Earel Jr., J.K.1    VanOosten, R.L.2    Griffith, T.S.3
  • 65
    • 2342667387 scopus 로고    scopus 로고
    • The development of proteasome inhibitors as anticancer drugs
    • Adams, J. (2004) The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5, 417-421.
    • (2004) Cancer Cell , vol.5 , pp. 417-421
    • Adams, J.1
  • 66
    • 11144230279 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells
    • Sinicrope, F. A., Penington, R. C., and Tang, X. M. (2004) Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. Clin. Cancer Res. 10, 8284-8292.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 8284-8292
    • Sinicrope, F.A.1    Penington, R.C.2    Tang, X.M.3
  • 67
    • 0035851189 scopus 로고    scopus 로고
    • Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach
    • Burns, T. F. and El-Deiry, W. S. (2001) Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. J. Biol. Chem. 276, 37879-37886.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37879-37886
    • Burns, T.F.1    El-Deiry, W.S.2
  • 68
    • 9144234685 scopus 로고    scopus 로고
    • Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
    • Schimmer, A. D., Welsh, K., Pinilla, C., Wang, Z., Krajewska, M., et al. (2004) Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell 5, 25-35.
    • (2004) Cancer Cell , vol.5 , pp. 25-35
    • Schimmer, A.D.1    Welsh, K.2    Pinilla, C.3    Wang, Z.4    Krajewska, M.5
  • 69
    • 4143115887 scopus 로고    scopus 로고
    • Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis
    • Jin, Z., McDonald, E. R., III, Dicker, D. T., and El-Deiry, W. S. (2004) Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. J. Biol. Chem. 279, 35829-35839.
    • (2004) J. Biol. Chem. , vol.279 , pp. 35829-35839
    • Jin, Z.1    McDonald III, E.R.2    Dicker, D.T.3    El-Deiry, W.S.4
  • 70
    • 17744364468 scopus 로고    scopus 로고
    • Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma
    • Lee, S. H., Shin, M. S., Kim, H. S., Lee, H. K., Park, W. S., et al. (2001) Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma. Oncogene 20, 399 - 403.
    • (2001) Oncogene , vol.20
    • Lee, S.H.1    Shin, M.S.2    Kim, H.S.3    Lee, H.K.4    Park, W.S.5
  • 71
    • 5444227865 scopus 로고    scopus 로고
    • Guilty as charged: BRAF is a human oncogene
    • Garnett, M. J. and Marais, R. (2004) Guilty as charged: BRAF is a human oncogene. Cancer Cell 6, 313-319.
    • (2004) Cancer Cell , vol.6 , pp. 313-319
    • Garnett, M.J.1    Marais, R.2
  • 72
    • 70350738477 scopus 로고    scopus 로고
    • BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells
    • Oikonomou, E., Makrodouli, E., Evagelidou, M., Joyce, T., Probert, L., et al. (2009) BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells. Neoplasia 11, 1116-1131.
    • (2009) Neoplasia , vol.11 , pp. 1116-1131
    • Oikonomou, E.1    Makrodouli, E.2    Evagelidou, M.3    Joyce, T.4    Probert, L.5
  • 73
    • 0035913161 scopus 로고    scopus 로고
    • P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells
    • Chang, F. and McCubrey, J. A. (2001) P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells. Oncogene 20, 4354-4364.
    • (2001) Oncogene , vol.20 , pp. 4354-4364
    • Chang, F.1    McCubrey, J.A.2
  • 74
    • 0030950537 scopus 로고    scopus 로고
    • Cooperating oncogenes converge to regulate cyclin/cdk complexes
    • Lloyd, A. C., Obermuller, F., Staddon, S., Barth, C. F., McMahon, M., et al. (1997) Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes Dev. 11, 663-677.
    • (1997) Genes Dev. , vol.11 , pp. 663-677
    • Lloyd, A.C.1    Obermuller, F.2    Staddon, S.3    Barth, C.F.4    McMahon, M.5
  • 75
  • 76
    • 2342495721 scopus 로고    scopus 로고
    • Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway
    • Wang, Y., Engels, I. H., Knee, D. A., Nasoff, M., Deveraux, Q. L., et al. (2004) Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway. Cancer Cell 5, 501-512.
    • (2004) Cancer Cell , vol.5 , pp. 501-512
    • Wang, Y.1    Engels, I.H.2    Knee, D.A.3    Nasoff, M.4    Deveraux, Q.L.5
  • 77
    • 70249144378 scopus 로고    scopus 로고
    • TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors
    • Oikonomou, E., Kosmidou, V., Katseli, A., Kothonidis, K., Mourtzoukou, D., et al. (2009) TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors. Int. J. Cancer 125, 2127-2135.
    • (2009) Int. J. Cancer , vol.125 , pp. 2127-2135
    • Oikonomou, E.1    Kosmidou, V.2    Katseli, A.3    Kothonidis, K.4    Mourtzoukou, D.5
  • 78
    • 72249091662 scopus 로고    scopus 로고
    • Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma
    • Abubaker, J., Bavi, P., Al-Haqawi, W., Sultana, M., Al-Harbi, S., et al. (2009) Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma. J. Pathol. 219, 435-445.
    • (2009) J. Pathol. , vol.219 , pp. 435-445
    • Abubaker, J.1    Bavi, P.2    Al-Haqawi, W.3    Sultana, M.4    Al-Harbi, S.5
  • 79
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre, A., Bachet, J. B., Le, C. D., Boige, V., Landi, B., et al. (2006) KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66, 3992-3995.
    • (2006) Cancer Res. , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le, C.D.3    Boige, V.4    Landi, B.5
  • 80
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • Sartore-Bianchi, A., Martini, M., Molinari, F., Veronese, S., Nichelatti, M., et al. (2009) PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res. 69, 1851-1857.
    • (2009) Cancer Res. , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3    Veronese, S.4    Nichelatti, M.5
  • 81
    • 0034699336 scopus 로고    scopus 로고
    • Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformation
    • Welman, A., Burger, M. M., and Hagmann, J. (2000) Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformation. Oncogene 19, 4582-4591.
    • (2000) Oncogene , vol.19 , pp. 4582-4591
    • Welman, A.1    Burger, M.M.2    Hagmann, J.3
  • 82
    • 27944488016 scopus 로고    scopus 로고
    • The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice
    • Plowman, S. J., Arends, M. J., Brownstein, D. G., Luo, F., Devenney, P. S., et al. (2006) The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice. Exp. Cell Res. 312, 16-26.
    • (2006) Exp. Cell Res. , vol.312 , pp. 16-26
    • Plowman, S.J.1    Arends, M.J.2    Brownstein, D.G.3    Luo, F.4    Devenney, P.S.5
  • 83
    • 4544253226 scopus 로고    scopus 로고
    • Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity
    • Ricci, M. S., Jin, Z., Dews, M., Yu, D., Thomas-Tikhonenko, A., et al. (2004) Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity. Mol Cell Biol. 24, 8541-8555.
    • (2004) Mol Cell Biol. , vol.24 , pp. 8541-8555
    • Ricci, M.S.1    Jin, Z.2    Dews, M.3    Yu, D.4    Thomas-Tikhonenko, A.5
  • 84
    • 84869087920 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP
    • Bangert, A., Cristofanon, S., Eckhardt, I., Abhari, B. A., Kolodziej, S., et al. (2012) Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP. Oncogene 31, 4677-4688
    • (2012) Oncogene , vol.31 , pp. 4677-4688
    • Bangert, A.1    Cristofanon, S.2    Eckhardt, I.3    Abhari, B.A.4    Kolodziej, S.5
  • 85
    • 0036781812 scopus 로고    scopus 로고
    • Review c-MYC: more than just a matter of life and death
    • Pelengaris, S., Khan, M., and Evan, G. (2002) Review c-MYC: more than just a matter of life and death. Nat. Rev. Cancer 2, 764-776
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 764-776
    • Pelengaris, S.1    Khan, M.2    Evan, G.3
  • 86
    • 0038413713 scopus 로고    scopus 로고
    • c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner
    • Iaccarino, I., Hancock, D., Evan, G., Downward, J. (2003) c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner. Cell Death Differ. 10, 599-608.
    • (2003) Cell Death Differ. , vol.10 , pp. 599-608
    • Iaccarino, I.1    Hancock, D.2    Evan, G.3    Downward, J.4
  • 87
    • 21844464054 scopus 로고    scopus 로고
    • Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
    • Annis, M. G., Soucie, E. L., Dlugosz, P. J., Cruz-Aguado, J. A., Penn, L. Z., et al. (2005) Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. EMBO J. 24, 2096-2103.
    • (2005) EMBO J. , vol.24 , pp. 2096-2103
    • Annis, M.G.1    Soucie, E.L.2    Dlugosz, P.J.3    Cruz-Aguado, J.A.4    Penn, L.Z.5
  • 88
    • 33847218950 scopus 로고    scopus 로고
    • c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis
    • Nieminen, A. I., Partanen, J. I., Hau, A., and Klefstrom, J. (2007) c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis EMBO J. 26, 1055-1067.
    • (2007) EMBO J. , vol.26 , pp. 1055-1067
    • Nieminen, A.I.1    Partanen, J.I.2    Hau, A.3    Klefstrom, J.4
  • 89
    • 27244444199 scopus 로고    scopus 로고
    • A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3β/FBW7 loss of function
    • Rottmann, S., Wang, Y., Nasoff, M., Deveraux, Q. L., and Quon, K. C. (2005) A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3β/FBW7 loss of function. Proc. Natl. Acad. Sci. USA 102, 15195-15200.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15195-15200
    • Rottmann, S.1    Wang, Y.2    Nasoff, M.3    Deveraux, Q.L.4    Quon, K.C.5
  • 90
    • 0026739541 scopus 로고
    • Transformation mediated by the human HER-2 gene independent of the epidermal growth factor receptor
    • Chazin, V. R., Kaleko, M., Miller, A. D., and Slamon, D. J. (1992) Transformation mediated by the human HER-2 gene independent of the epidermal growth factor receptor. Oncogene 7, 1859-1866.
    • (1992) Oncogene , vol.7 , pp. 1859-1866
    • Chazin, V.R.1    Kaleko, M.2    Miller, A.D.3    Slamon, D.J.4
  • 91
    • 0035874898 scopus 로고    scopus 로고
    • Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2
    • Cuello, M., Ettenberg, S. A., Clark, A. S., Keane, M. M., Posner, R. H., et al. (2001) Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer Res. 61, 4892-4900.
    • (2001) Cancer Res. , vol.61 , pp. 4892-4900
    • Cuello, M.1    Ettenberg, S.A.2    Clark, A.S.3    Keane, M.M.4    Posner, R.H.5
  • 92
    • 3042824992 scopus 로고    scopus 로고
    • Epidermal growth factor and trail interactions in epithelial-derived cells
    • Gibson, S. B. (2004) Epidermal growth factor and trail interactions in epithelial-derived cells. Vitam. Horm. 67, 207-227.
    • (2004) Vitam. Horm. , vol.67 , pp. 207-227
    • Gibson, S.B.1
  • 93
    • 0036064773 scopus 로고    scopus 로고
    • Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis
    • Park, S. Y. and Seol, D. W. (2002) Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis. Biochem. Biophys. Res. Commun. 295, 515-518.
    • (2002) Biochem. Biophys. Res. Commun. , vol.295 , pp. 515-518
    • Park, S.Y.1    Seol, D.W.2
  • 94
    • 0035914394 scopus 로고    scopus 로고
    • Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance
    • Thakkar, H., Chen, X., Tyan, F., Gim, S., Robinson, H., et al. (2001) Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance. J. Biol. Chem. 276, 38361-38369.
    • (2001) J. Biol. Chem. , vol.276 , pp. 38361-38369
    • Thakkar, H.1    Chen, X.2    Tyan, F.3    Gim, S.4    Robinson, H.5
  • 95
    • 26444560914 scopus 로고    scopus 로고
    • mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells
    • Panner, A., James, C. D., Berger, M. S., and Pieper, R. O. (2005) mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol. Cell Biol. 25, 8809-8823.
    • (2005) Mol. Cell Biol. , vol.25 , pp. 8809-8823
    • Panner, A.1    James, C.D.2    Berger, M.S.3    Pieper, R.O.4
  • 96
    • 8544230666 scopus 로고    scopus 로고
    • Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells
    • Lee, J. T., Jr., Steelman, L. S., and McCubrey, J. A. (2004) Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells. Cancer Res. 64, 8397-8404.
    • (2004) Cancer Res. , vol.64 , pp. 8397-8404
    • Lee Jr., J.T.1    Steelman, L.S.2    McCubrey, J.A.3
  • 97
    • 1142273472 scopus 로고    scopus 로고
    • Altered states: selectively drugging the Hsp90 cancer chaperone
    • Workman, P. (2004) Altered states: selectively drugging the Hsp90 cancer chaperone. Trends Mol. Med. 10, 47-51.
    • (2004) Trends Mol. Med. , vol.10 , pp. 47-51
    • Workman, P.1
  • 98
    • 58249137998 scopus 로고    scopus 로고
    • 17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis
    • Siegelin, M. D., Habel, A., and Gaiser, T. (2009) 17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis. Neurobiol. Dis. 33, 243-249.
    • (2009) Neurobiol. Dis. , vol.33 , pp. 243-249
    • Siegelin, M.D.1    Habel, A.2    Gaiser, T.3
  • 99
    • 79959594837 scopus 로고    scopus 로고
    • Selective BRAFV600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance
    • Oikonomou, E., Koc, M., Sourkova, V., Andera, L., and Pintzas, A. (2011) Selective BRAFV600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance. PLoS. One. 6, e21632.
    • (2011) PLoS. One. , vol.6
    • Oikonomou, E.1    Koc, M.2    Sourkova, V.3    Andera, L.4    Pintzas, A.5
  • 100
    • 22144462525 scopus 로고    scopus 로고
    • 17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines
    • Vasilevskaya, I. A. and O'Dwyer, P. J. (2005) 17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines. Biochem. Pharmacol. 70, 580-589.
    • (2005) Biochem. Pharmacol. , vol.70 , pp. 580-589
    • Vasilevskaya, I.A.1    O'Dwyer, P.J.2
  • 101
    • 77149128046 scopus 로고    scopus 로고
    • Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis
    • Chen, W., Bai, L., Wang, X., Xu, S., Belinsky, S. A., et al. (2010) Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. Mol. Pharmacol. 77, 416-423.
    • (2010) Mol. Pharmacol. , vol.77 , pp. 416-423
    • Chen, W.1    Bai, L.2    Wang, X.3    Xu, S.4    Belinsky, S.A.5
  • 102
    • 31544454764 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death
    • Georgakis, G. V., Li, Y., Rassidakis, G. Z., Martinez-Valdez, H., Medeiros, L. J., et al. (2006) Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death. Clin. Cancer Res. 12, 584-590.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 584-590
    • Georgakis, G.V.1    Li, Y.2    Rassidakis, G.Z.3    Martinez-Valdez, H.4    Medeiros, L.J.5
  • 103
    • 34447092454 scopus 로고    scopus 로고
    • Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells
    • Psahoulia, F. H., Moumtzi, S., Roberts, M. L., Sasazuki, T., Shirasawa, S., et al. (2007) Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis 28, 1021-1031.
    • (2007) Carcinogenesis , vol.28 , pp. 1021-1031
    • Psahoulia, F.H.1    Moumtzi, S.2    Roberts, M.L.3    Sasazuki, T.4    Shirasawa, S.5
  • 104
    • 34748906001 scopus 로고    scopus 로고
    • Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts
    • Psahoulia, F. H., Drosopoulos K. G., Doubravska, L., Andera, L. and Pintzas, A. (2007). Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. Mol. Cancer Ther. 6, 2591-2599.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 2591-2599
    • Psahoulia, F.H.1    Drosopoulos, K.G.2    Doubravska, L.3    Andera, L.4    Pintzas, A.5
  • 105
    • 77951134107 scopus 로고    scopus 로고
    • Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis
    • Zhang, L., Ren, X., Alt, E., Bai, X., Huang, S., et al. (2010) Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature 464, 1058-1061.
    • (2010) Nature , vol.464 , pp. 1058-1061
    • Zhang, L.1    Ren, X.2    Alt, E.3    Bai, X.4    Huang, S.5
  • 107
    • 77953474730 scopus 로고    scopus 로고
    • Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways
    • Seki, N., Toh, U., Sayers, T. J., Fujii, T., Miyagi, M., et al. (2010) Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways. Mol. Cancer Ther. 9, 1842-1851.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 1842-1851
    • Seki, N.1    Toh, U.2    Sayers, T.J.3    Fujii, T.4    Miyagi, M.5
  • 108
    • 78751483373 scopus 로고    scopus 로고
    • Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway
    • Jane, E. P., Premkumar, D. R., and Pollack, I. F. (2011) Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway. Mol. Cancer Ther. 10, 198-208.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 198-208
    • Jane, E.P.1    Premkumar, D.R.2    Pollack, I.F.3
  • 109
    • 82355180992 scopus 로고    scopus 로고
    • Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells
    • Zhao, J., Lu, Y., and Shen, H. M. (2012) Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells. Cancer Lett. 314, 8-23.
    • (2012) Cancer Lett. , vol.314 , pp. 8-23
    • Zhao, J.1    Lu, Y.2    Shen, H.M.3
  • 110
    • 54049145970 scopus 로고    scopus 로고
    • ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis
    • Song, J. H., Kandasamy, K., and Kraft, A. S. (2008) ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis. J. Biol. Chem. 283, 25003-25013.
    • (2008) J. Biol. Chem. , vol.283 , pp. 25003-25013
    • Song, J.H.1    Kandasamy, K.2    Kraft, A.S.3
  • 111
    • 4344607589 scopus 로고    scopus 로고
    • Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
    • Ganten, T. M., Haas, T. L., Sykora, J., Stahl, H., Sprick, M. R., et al. (2004) Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death. Differ. 11 (Suppl 1), S86-S96.
    • (2004) Cell Death. Differ. , vol.11 , Issue.SUPPL 1
    • Ganten, T.M.1    Haas, T.L.2    Sykora, J.3    Stahl, H.4    Sprick, M.R.5
  • 112
    • 0038240386 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP
    • Sayers, T. J., Brooks, A. D., Koh, C. Y., Ma, W., Seki, N., et al. (2003) The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP. Blood 102, 303-310.
    • (2003) Blood , vol.102 , pp. 303-310
    • Sayers, T.J.1    Brooks, A.D.2    Koh, C.Y.3    Ma, W.4    Seki, N.5
  • 113
    • 33645243818 scopus 로고    scopus 로고
    • Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis
    • Hougardy, B. M., Maduro, J. H., van der Zee, A. G., de Groot, D.J., van den Heuvel, F. A., et al. (2006) Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis. Int. J. Cancer 118, 1892-1900.
    • (2006) Int. J. Cancer , vol.118 , pp. 1892-1900
    • Hougardy, B.M.1    Maduro, J.H.2    van der Zee, A.G.3    de Groot, D.J.4    Van Den Heuvel, F.A.5
  • 114
    • 34147144169 scopus 로고    scopus 로고
    • Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein
    • Karikari, C. A., Roy, I., Tryggestad, E., Feldmann, G., Pinilla, C., et al. (2007) Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein. Mol. Cancer Ther. 6, 957-966.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 957-966
    • Karikari, C.A.1    Roy, I.2    Tryggestad, E.3    Feldmann, G.4    Pinilla, C.5
  • 115
    • 2442685708 scopus 로고    scopus 로고
    • Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells
    • Hao, J. H., Yu, M., Liu, F. T., Newland, A. C., and Jia, L. (2004) Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells. Cancer Res. 64, 3607-3616.
    • (2004) Cancer Res. , vol.64 , pp. 3607-3616
    • Hao, J.H.1    Yu, M.2    Liu, F.T.3    Newland, A.C.4    Jia, L.5
  • 116
    • 11144358387 scopus 로고    scopus 로고
    • Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells
    • Guo, F., Sigua, C., Tao, J., Bali, P., George, P., et al. (2004) Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells. Cancer Res. 64, 2580-2589.
    • (2004) Cancer Res. , vol.64 , pp. 2580-2589
    • Guo, F.1    Sigua, C.2    Tao, J.3    Bali, P.4    George, P.5


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