ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis

Journal of Biological Chemistry

Volumn 283, Issue 36, 2008, Pages 25003-25013

  Song, Jin H ^a   Kandasamy, Karthikeyan ^a   Kraft, Andrew S ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS; CELL CULTURE; TUMORS;

ANTIAPOPTOTIC; ANTICANCER THERAPIES; APOPTOSIS; CASPASE; CELL LINES; DEATH RECEPTORS; FAMILY MEMBERS; HUMAN CANCER CELLS; INDUCED APOPTOSIS; LUCIFERASE REPORTERS; LUNG CANCERS; MUTAGENESIS STUDIES; SIGNALING COMPLEXES; SMALL MOLECULES; TRANSCRIPTIONAL MECHANISMS; TUMOR CELLS; TUMOR NECROSIS FACTORS;

CELL DEATH;

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; CASPASE 8; DEATH RECEPTOR 5; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAX; PROTEIN MCL 1; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; ABT-737; ANTINEOPLASTIC AGENT; BIPHENYL DERIVATIVE; CASP8 PROTEIN, HUMAN; CFLAR PROTEIN, HUMAN; FADD PROTEIN, HUMAN; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NITROPHENOL; PIPERAZINE DERIVATIVE; PROTEIN BCL 2; SULFONAMIDE; TNFSF10 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; DRUG ACTIVITY; KIDNEY CANCER; LUNG CANCER; MUTAGENESIS; PLASMID; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; UPREGULATION; BIOSYNTHESIS; DNA RESPONSIVE ELEMENT; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENETICS; HUMAN; METABOLISM; METHODOLOGY; NEOPLASM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIPHENYL COMPOUNDS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; MUTAGENESIS; NEOPLASMS; NF-KAPPA B; NITROPHENOLS; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RESPONSE ELEMENTS; SULFONAMIDES; TNF-RELATED APOPTOSIS-INDUCING LIGAND; UP-REGULATION;

EID: 54049145970     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802511200     Document Type: Article

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