Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding

Journal of Biological Chemistry

Volumn 282, Issue 38, 2007, Pages 28189-28194

  Bin, Lianghua ^a   Thorburn, Jacqueline ^a   Thomas, Lance R ^b   Clark, Peter E ^b   Humphreys, Robin ^c   Thorburn, Andrew ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Human Genome Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; LIGANDS; PROTEINS; TUMORS;

CYTOKINES; LIGAND BINDING; TRAIL (TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND); TUMOR CELLS;

ENZYME INHIBITION;

DEATH RECEPTOR 4; DEATH RECEPTOR 5; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MECHANICS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR;

BINDING, COMPETITIVE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPORATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; PROTEIN BINDING; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS;

EID: 34948822418     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704210200     Document Type: Article

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