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Volumn 255, Issue 1, 2013, Pages 110-124

The great balancing act: Regulation and fate of antiviral T-cell interactions

Author keywords

Cytotoxic T cells; immunotherapies; in vivo imaging; Neuroimmunology; T cells; Viral infection

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INDUCIBLE T CELL COSTIMULATOR; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LAT PROTEIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; TRANSCRIPTION FACTOR NFAT;

EID: 84881648473     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12093     Document Type: Review
Times cited : (18)

References (171)
  • 1
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994;12:991-1045.
    • (1994) Annu Rev Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 2
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway CA Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989;54(Pt 1):1-13.
    • (1989) Cold Spring Harb Symp Quant Biol , vol.54 , Issue.PART 1 , pp. 1-13
    • Janeway Jr, C.A.1
  • 3
    • 67651091732 scopus 로고    scopus 로고
    • Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system
    • Vance RE, Isberg RR, Portnoy DA. Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe 2009;6:10-21.
    • (2009) Cell Host Microbe , vol.6 , pp. 10-21
    • Vance, R.E.1    Isberg, R.R.2    Portnoy, D.A.3
  • 4
    • 84875422919 scopus 로고    scopus 로고
    • Effector-triggered versus pattern-triggered immunity: how animals sense pathogens
    • Stuart LM, Paquette N, Boyer L. Effector-triggered versus pattern-triggered immunity: how animals sense pathogens. Nat Rev Immunol 2013;13:199-206.
    • (2013) Nat Rev Immunol , vol.13 , pp. 199-206
    • Stuart, L.M.1    Paquette, N.2    Boyer, L.3
  • 5
    • 0021215865 scopus 로고
    • Isolation of cDNA clones encoding T cell-specific membrane-associated proteins
    • Hedrick SM, Cohen DI, Nielsen EA, Davis MM. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 1984;308:149-153.
    • (1984) Nature , vol.308 , pp. 149-153
    • Hedrick, S.M.1    Cohen, D.I.2    Nielsen, E.A.3    Davis, M.M.4
  • 6
    • 0021223872 scopus 로고
    • Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins
    • Hedrick SM, Nielsen EA, Kavaler J, Cohen DI, Davis MM. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature 1984;308:153-158.
    • (1984) Nature , vol.308 , pp. 153-158
    • Hedrick, S.M.1    Nielsen, E.A.2    Kavaler, J.3    Cohen, D.I.4    Davis, M.M.5
  • 7
    • 0021646330 scopus 로고
    • A murine T cell receptor gene complex: isolation, structure and rearrangement
    • Davis MM, Chien YH, Gascoigne NR, Hedrick SM. A murine T cell receptor gene complex: isolation, structure and rearrangement. Immunol Rev 1984;81:235-258.
    • (1984) Immunol Rev , vol.81 , pp. 235-258
    • Davis, M.M.1    Chien, Y.H.2    Gascoigne, N.R.3    Hedrick, S.M.4
  • 9
    • 0016345568 scopus 로고
    • Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
    • Zinkernagel RM, Doherty PC. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 1974;248:701-702.
    • (1974) Nature , vol.248 , pp. 701-702
    • Zinkernagel, R.M.1    Doherty, P.C.2
  • 11
    • 0023187442 scopus 로고
    • The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
    • Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 1987;329:512-518.
    • (1987) Nature , vol.329 , pp. 512-518
    • Bjorkman, P.J.1    Saper, M.A.2    Samraoui, B.3    Bennett, W.S.4    Strominger, J.L.5    Wiley, D.C.6
  • 12
    • 0023675851 scopus 로고
    • Function of the MHC
    • Simpson E. Function of the MHC. Immunol Suppl 1988;1:27-30.
    • (1988) Immunol Suppl , vol.1 , pp. 27-30
    • Simpson, E.1
  • 13
    • 0025978984 scopus 로고
    • Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells
    • Kupfer A, Mosmann TR, Kupfer H. Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc Natl Acad Sci USA 1991;88:775-779.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 775-779
    • Kupfer, A.1    Mosmann, T.R.2    Kupfer, H.3
  • 14
    • 0000572782 scopus 로고
    • The specific direct interaction of helper T cells and antigen-presenting B cells
    • Kupfer A, Swain SL, Janeway CA, Singer SJ. The specific direct interaction of helper T cells and antigen-presenting B cells. Proc Natl Acad Sci USA 1986;83:6080-6083.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 6080-6083
    • Kupfer, A.1    Swain, S.L.2    Janeway, C.A.3    Singer, S.J.4
  • 15
    • 0023266351 scopus 로고
    • The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells
    • Kupfer A, Swain SL, Singer SJ. The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells. J Exp Med 1987;165:1565-1580.
    • (1987) J Exp Med , vol.165 , pp. 1565-1580
    • Kupfer, A.1    Swain, S.L.2    Singer, S.J.3
  • 16
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998;395:82-86.
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 17
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol 2013;13:227-242.
    • (2013) Nat Rev Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 18
    • 0346244099 scopus 로고    scopus 로고
    • T-cell-antigen recognition and the immunological synapse
    • Huppa JB, Davis MM. T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol 2003;3:973-983.
    • (2003) Nat Rev Immunol , vol.3 , pp. 973-983
    • Huppa, J.B.1    Davis, M.M.2
  • 19
    • 0022653477 scopus 로고
    • Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography
    • Yannelli JR, Sullivan JA, Mandell GL, Engelhard VH. Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography. J Immunol 1986;136:377-382.
    • (1986) J Immunol , vol.136 , pp. 377-382
    • Yannelli, J.R.1    Sullivan, J.A.2    Mandell, G.L.3    Engelhard, V.H.4
  • 20
    • 53749084135 scopus 로고    scopus 로고
    • CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brain
    • Barcia C, et al. CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brain. J Virol 2008;82:9978-9993.
    • (2008) J Virol , vol.82 , pp. 9978-9993
    • Barcia, C.1
  • 21
    • 4644317252 scopus 로고    scopus 로고
    • Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites
    • Boisvert J, Edmondson S, Krummel MF. Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites. J Immunol 2004;173:3647-3652.
    • (2004) J Immunol , vol.173 , pp. 3647-3652
    • Boisvert, J.1    Edmondson, S.2    Krummel, M.F.3
  • 22
    • 0033538574 scopus 로고    scopus 로고
    • The immunological synapse: a molecular machine controlling T cell activation
    • Grakoui A, et al. The immunological synapse: a molecular machine controlling T cell activation. Science 1999;285:221-227.
    • (1999) Science , vol.285 , pp. 221-227
    • Grakoui, A.1
  • 24
    • 33846626054 scopus 로고    scopus 로고
    • Regulation of T-cell activation by the cytoskeleton
    • Billadeau DD, Nolz JC, Gomez TS. Regulation of T-cell activation by the cytoskeleton. Nat Rev Immunol 2007;7:131-143.
    • (2007) Nat Rev Immunol , vol.7 , pp. 131-143
    • Billadeau, D.D.1    Nolz, J.C.2    Gomez, T.S.3
  • 26
    • 33846031421 scopus 로고    scopus 로고
    • The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation
    • Suzuki J-i, Yamasaki S, Wu J, Koretzky GA, Saito T. The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. Blood 2007;109:168-175.
    • (2007) Blood , vol.109 , pp. 168-175
    • Suzuki, J.-i.1    Yamasaki, S.2    Wu, J.3    Koretzky, G.A.4    Saito, T.5
  • 27
    • 0345257150 scopus 로고    scopus 로고
    • Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold
    • Faroudi M, et al. Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold. Proc Natl Acad Sci USA 2003;100:14145-14150.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14145-14150
    • Faroudi, M.1
  • 28
    • 52649128664 scopus 로고    scopus 로고
    • Shouts, whispers and the kiss of death: directional secretion in T cells
    • Huse M, Quann EJ, Davis MM. Shouts, whispers and the kiss of death: directional secretion in T cells. Nat Immunol 2008;9:1105-1111.
    • (2008) Nat Immunol , vol.9 , pp. 1105-1111
    • Huse, M.1    Quann, E.J.2    Davis, M.M.3
  • 29
    • 0036794559 scopus 로고    scopus 로고
    • Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo
    • McGavern DB, Christen U, Oldstone MB. Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo. Nat Immunol 2002;3:918-925.
    • (2002) Nat Immunol , vol.3 , pp. 918-925
    • McGavern, D.B.1    Christen, U.2    Oldstone, M.B.3
  • 30
    • 33748549010 scopus 로고    scopus 로고
    • In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
    • Barcia C, et al. In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain. J Exp Med 2006;203:2095-2107.
    • (2006) J Exp Med , vol.203 , pp. 2095-2107
    • Barcia, C.1
  • 31
    • 77949528694 scopus 로고    scopus 로고
    • Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo
    • Yang J, Sanderson NS, Wawrowsky K, Puntel M, Castro MG, Lowenstein PR. Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo. Proc Natl Acad Sci USA 2010;107:4716-4721.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4716-4721
    • Yang, J.1    Sanderson, N.S.2    Wawrowsky, K.3    Puntel, M.4    Castro, M.G.5    Lowenstein, P.R.6
  • 33
    • 0033666324 scopus 로고    scopus 로고
    • Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential
    • Gunzer M, et al. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 2000;13:323-332.
    • (2000) Immunity , vol.13 , pp. 323-332
    • Gunzer, M.1
  • 34
    • 0034925767 scopus 로고    scopus 로고
    • Interaction of T cells with APCs: the serial encounter model
    • Friedl P, Gunzer M. Interaction of T cells with APCs: the serial encounter model. Trend Immunol 2001;22:187-191.
    • (2001) Trend Immunol , vol.22 , pp. 187-191
    • Friedl, P.1    Gunzer, M.2
  • 35
    • 5444229324 scopus 로고    scopus 로고
    • Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes
    • Miller MJ, Safrina O, Parker I, Cahalan MD. Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J Exp Med 2004;200:847-856.
    • (2004) J Exp Med , vol.200 , pp. 847-856
    • Miller, M.J.1    Safrina, O.2    Parker, I.3    Cahalan, M.D.4
  • 36
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 2004;427:154-159.
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 37
    • 39449094869 scopus 로고    scopus 로고
    • T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
    • Henrickson SE, et al. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol 2008;9:282-291.
    • (2008) Nat Immunol , vol.9 , pp. 282-291
    • Henrickson, S.E.1
  • 38
    • 0242497659 scopus 로고    scopus 로고
    • The immunological synapse balances T cell receptor signaling and degradation
    • Lee K-H, et al. The immunological synapse balances T cell receptor signaling and degradation. Science 2003;302:1218-1222.
    • (2003) Science , vol.302 , pp. 1218-1222
    • Lee, K.-H.1
  • 39
    • 27144458078 scopus 로고    scopus 로고
    • Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells
    • O'Keefe JP, Gajewski TF. Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells. J Immunol 2005;175:5581-5585.
    • (2005) J Immunol , vol.175 , pp. 5581-5585
    • O'Keefe, J.P.1    Gajewski, T.F.2
  • 40
    • 2442651482 scopus 로고    scopus 로고
    • T cell killing does not require the formation of a stable mature immunological synapse
    • Purbhoo MA, Irvine DJ, Huppa JB, Davis MM. T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol 2004;5:524-530.
    • (2004) Nat Immunol , vol.5 , pp. 524-530
    • Purbhoo, M.A.1    Irvine, D.J.2    Huppa, J.B.3    Davis, M.M.4
  • 41
    • 84874273811 scopus 로고    scopus 로고
    • The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells
    • Marangoni F, et al. The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity 2013;38:237-249.
    • (2013) Immunity , vol.38 , pp. 237-249
    • Marangoni, F.1
  • 42
    • 38949174996 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory
    • Scholer A, Hugues S, Boissonnas A, Fetler L, Amigorena S. Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity 2008;28:258-270.
    • (2008) Immunity , vol.28 , pp. 258-270
    • Scholer, A.1    Hugues, S.2    Boissonnas, A.3    Fetler, L.4    Amigorena, S.5
  • 43
    • 34547135943 scopus 로고    scopus 로고
    • Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
    • Skokos D, et al. Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat Immunol 2007;8:835-844.
    • (2007) Nat Immunol , vol.8 , pp. 835-844
    • Skokos, D.1
  • 44
    • 84865372949 scopus 로고    scopus 로고
    • Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo
    • Moreau HD, et al. Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo. Immunity 2012;37:351-363.
    • (2012) Immunity , vol.37 , pp. 351-363
    • Moreau, H.D.1
  • 45
    • 38949197102 scopus 로고    scopus 로고
    • T-cell activation through immunological synapses and kinapses
    • Dustin ML. T-cell activation through immunological synapses and kinapses. Immunol Rev 2008;221:77-89.
    • (2008) Immunol Rev , vol.221 , pp. 77-89
    • Dustin, M.L.1
  • 46
    • 83155172544 scopus 로고    scopus 로고
    • Visualization of cell-cell interaction contacts: synapses and kinapses
    • Dustin ML. Visualization of cell-cell interaction contacts: synapses and kinapses. Self Nonself 2011;2:85-97.
    • (2011) Self Nonself , vol.2 , pp. 85-97
    • Dustin, M.L.1
  • 47
    • 58149352396 scopus 로고    scopus 로고
    • Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
    • Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature 2009;457:191-195.
    • (2009) Nature , vol.457 , pp. 191-195
    • Kim, J.V.1    Kang, S.S.2    Dustin, M.L.3    McGavern, D.B.4
  • 48
    • 79955727320 scopus 로고    scopus 로고
    • Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection
    • Kang SS, et al. Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection. J Exp Med 2011;208:747-759.
    • (2011) J Exp Med , vol.208 , pp. 747-759
    • Kang, S.S.1
  • 49
    • 78649396525 scopus 로고    scopus 로고
    • Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics
    • Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel MF. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med 2010;207:2733-2749.
    • (2010) J Exp Med , vol.207 , pp. 2733-2749
    • Friedman, R.S.1    Beemiller, P.2    Sorensen, C.M.3    Jacobelli, J.4    Krummel, M.F.5
  • 50
    • 84880284892 scopus 로고    scopus 로고
    • A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity
    • Lodygin D, et al. A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity. Nat Med 2013;19:784-790.
    • (2013) Nat Med , vol.19 , pp. 784-790
    • Lodygin, D.1
  • 51
    • 84864139002 scopus 로고    scopus 로고
    • Integration of the movement of signaling microclusters with cellular motility in immunological synapses
    • Beemiller P, Jacobelli J, Krummel MF. Integration of the movement of signaling microclusters with cellular motility in immunological synapses. Nat Immunol 2012;13:787-795.
    • (2012) Nat Immunol , vol.13 , pp. 787-795
    • Beemiller, P.1    Jacobelli, J.2    Krummel, M.F.3
  • 52
    • 77649255627 scopus 로고    scopus 로고
    • Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes
    • Azar GA, Lemaitre F, Robey EA, Bousso P. Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes. Proc Natl Acad Sci USA 2010;107:3675-3680.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3675-3680
    • Azar, G.A.1    Lemaitre, F.2    Robey, E.A.3    Bousso, P.4
  • 53
    • 34447339202 scopus 로고    scopus 로고
    • Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse
    • Reichardt P, et al. Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse. Blood 2007;110:1519-1529.
    • (2007) Blood , vol.110 , pp. 1519-1529
    • Reichardt, P.1
  • 54
    • 0033231470 scopus 로고    scopus 로고
    • Vaccination against the major infectious diseases
    • Plotkin SA. Vaccination against the major infectious diseases. C R Acad Sci III 1999;322:943-951.
    • (1999) C R Acad Sci III , vol.322 , pp. 943-951
    • Plotkin, S.A.1
  • 56
    • 33846784031 scopus 로고    scopus 로고
    • Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought
    • Masopust D, Murali-Krishna K, Ahmed R. Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought. J Virol 2007;81:2002-2011.
    • (2007) J Virol , vol.81 , pp. 2002-2011
    • Masopust, D.1    Murali-Krishna, K.2    Ahmed, R.3
  • 57
    • 0024307348 scopus 로고
    • Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    • Pircher H, Bürki K, Lang R, Hengartner H, Zinkernagel RM. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 1989;342:559-561.
    • (1989) Nature , vol.342 , pp. 559-561
    • Pircher, H.1    Bürki, K.2    Lang, R.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 58
    • 0031975635 scopus 로고    scopus 로고
    • Virus-specific major MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection
    • Oxenius A, Bachmann MF, Zinkernagel RM, Hengartner H. Virus-specific major MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol 1998;28:390-400.
    • (1998) Eur J Immunol , vol.28 , pp. 390-400
    • Oxenius, A.1    Bachmann, M.F.2    Zinkernagel, R.M.3    Hengartner, H.4
  • 59
    • 0036891487 scopus 로고    scopus 로고
    • T cells in the central nervous system: the delicate balance between viral clearance and disease
    • McGavern DB, Homann D, Oldstone MBA. T cells in the central nervous system: the delicate balance between viral clearance and disease. J Infect Dis 2002;186(Suppl):S145-S151.
    • (2002) J Infect Dis , vol.186 , Issue.SUPPL
    • McGavern, D.B.1    Homann, D.2    Oldstone, M.B.A.3
  • 60
    • 77955932516 scopus 로고    scopus 로고
    • Microbial induction of vascular pathology in the CNS
    • Kang SS, McGavern DB. Microbial induction of vascular pathology in the CNS. J Neuroimmune Pharmacol 2010;5:370-386.
    • (2010) J Neuroimmune Pharmacol , vol.5 , pp. 370-386
    • Kang, S.S.1    McGavern, D.B.2
  • 61
    • 42549130861 scopus 로고    scopus 로고
    • Lymphocytic choriomeningitis infection of the central nervous system
    • Kang SS, McGavern DB. Lymphocytic choriomeningitis infection of the central nervous system. Front Biosci 2008;13:4529-4543.
    • (2008) Front Biosci , vol.13 , pp. 4529-4543
    • Kang, S.S.1    McGavern, D.B.2
  • 62
    • 69449100611 scopus 로고    scopus 로고
    • Inflammation on the mind: visualizing immunity in the central nervous system
    • Kang SS, McGavern DB. Inflammation on the mind: visualizing immunity in the central nervous system. Curr Top Microbiol Immunol 2009;334:227-263.
    • (2009) Curr Top Microbiol Immunol , vol.334 , pp. 227-263
    • Kang, S.S.1    McGavern, D.B.2
  • 63
    • 79955458125 scopus 로고    scopus 로고
    • Illuminating viral infections in the nervous system
    • McGavern DB, Kang SS. Illuminating viral infections in the nervous system. Nat Rev Immunol 2011;11:318-329.
    • (2011) Nat Rev Immunol , vol.11 , pp. 318-329
    • McGavern, D.B.1    Kang, S.S.2
  • 64
    • 0028292505 scopus 로고
    • Aseptic meningitis caused by the lymphocytic choriomeningitis virus
    • Roebroek RM, Postma BH, Dijkstra UJ. Aseptic meningitis caused by the lymphocytic choriomeningitis virus. Clin Neurol Neurosurg 1994;96:178-180.
    • (1994) Clin Neurol Neurosurg , vol.96 , pp. 178-180
    • Roebroek, R.M.1    Postma, B.H.2    Dijkstra, U.J.3
  • 65
    • 0032551209 scopus 로고    scopus 로고
    • A rash, circulating anticoagulant, then meningitis
    • Schanen A, Gallou G, Hincky JM, Saron MF. A rash, circulating anticoagulant, then meningitis. Lancet 1998;351:1856.
    • (1998) Lancet , vol.351 , pp. 1856
    • Schanen, A.1    Gallou, G.2    Hincky, J.M.3    Saron, M.F.4
  • 66
    • 0025787430 scopus 로고
    • Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure
    • Odermatt B, Eppler M, Leist TP, Hengartner H, Zinkernagel RM. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc Natl Acad Sci USA 1991;88:8252-8256.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8252-8256
    • Odermatt, B.1    Eppler, M.2    Leist, T.P.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 67
    • 0028873681 scopus 로고
    • Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression
    • Borrow P, Evans CF, Oldstone MB. Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J Virol 1995;69:1059-1070.
    • (1995) J Virol , vol.69 , pp. 1059-1070
    • Borrow, P.1    Evans, C.F.2    Oldstone, M.B.3
  • 68
    • 85027948869 scopus 로고    scopus 로고
    • Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
    • Guy CS, et al. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol 2013;14:262-270.
    • (2013) Nat Immunol , vol.14 , pp. 262-270
    • Guy, C.S.1
  • 69
    • 0032005477 scopus 로고    scopus 로고
    • Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection
    • Murali-Krishna K, et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 1998;8:177-187.
    • (1998) Immunity , vol.8 , pp. 177-187
    • Murali-Krishna, K.1
  • 70
    • 84869885852 scopus 로고    scopus 로고
    • Capture, crawl, cross: the T cell code to breach the blood-brain barriers
    • Engelhardt B, Ransohoff RM. Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends Immunol 2012;33:579-589.
    • (2012) Trends Immunol , vol.33 , pp. 579-589
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 71
    • 0017409712 scopus 로고
    • Interferon production during lymphocytic choriomeningitis virus infection of nude and normal mice
    • Merigan TC, Oldstone MB, Welsh RM. Interferon production during lymphocytic choriomeningitis virus infection of nude and normal mice. Nature 1977;268:67-68.
    • (1977) Nature , vol.268 , pp. 67-68
    • Merigan, T.C.1    Oldstone, M.B.2    Welsh, R.M.3
  • 72
    • 46249115827 scopus 로고    scopus 로고
    • Interferon-inducible antiviral effectors
    • Sadler AJ, Williams BR. Interferon-inducible antiviral effectors. Nat Rev Immunol 2008;8:559-568.
    • (2008) Nat Rev Immunol , vol.8 , pp. 559-568
    • Sadler, A.J.1    Williams, B.R.2
  • 73
    • 79955542915 scopus 로고    scopus 로고
    • A diverse range of gene products are effectors of the type I interferon antiviral response
    • Schoggins JW, et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 2011;472:481-485.
    • (2011) Nature , vol.472 , pp. 481-485
    • Schoggins, J.W.1
  • 74
    • 18344362061 scopus 로고    scopus 로고
    • Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation
    • Curtsinger JM, Valenzuela JO, Agarwal P, Lins D, Mescher MF. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol 2005;174:4465-4469.
    • (2005) J Immunol , vol.174 , pp. 4465-4469
    • Curtsinger, J.M.1    Valenzuela, J.O.2    Agarwal, P.3    Lins, D.4    Mescher, M.F.5
  • 75
    • 24344478196 scopus 로고    scopus 로고
    • Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
    • Kolumam GA, Thomas S, Thompson LJ, Sprent J, Murali-Krishna K. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med 2005;202:637-650.
    • (2005) J Exp Med , vol.202 , pp. 637-650
    • Kolumam, G.A.1    Thomas, S.2    Thompson, L.J.3    Sprent, J.4    Murali-Krishna, K.5
  • 76
    • 70349303956 scopus 로고    scopus 로고
    • Persistent viral infection elevates central nervous system MHC class I through chronic production of interferons
    • Truong P, Heydari S, Garidou L, McGavern DB. Persistent viral infection elevates central nervous system MHC class I through chronic production of interferons. J Immunol 2009;183:3895-3905.
    • (2009) J Immunol , vol.183 , pp. 3895-3905
    • Truong, P.1    Heydari, S.2    Garidou, L.3    McGavern, D.B.4
  • 77
    • 84860333171 scopus 로고    scopus 로고
    • Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells
    • Sage PT, et al. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J Immunol 2012;188:3686-3699.
    • (2012) J Immunol , vol.188 , pp. 3686-3699
    • Sage, P.T.1
  • 79
    • 18244389686 scopus 로고    scopus 로고
    • T cell costimulation by chemokine receptors
    • Molon B, et al. T cell costimulation by chemokine receptors. Nat Immunol 2005;6:465-471.
    • (2005) Nat Immunol , vol.6 , pp. 465-471
    • Molon, B.1
  • 81
    • 0032751160 scopus 로고    scopus 로고
    • Modulation of TCR signaling by beta1 integrins: role of the tyrosine phosphatase SHP-1
    • Mary F, Moon C, Venaille T, Thomas ML, Mary D, Bernard A. Modulation of TCR signaling by beta1 integrins: role of the tyrosine phosphatase SHP-1. Eur J Immunol 1999;29:3887-3897.
    • (1999) Eur J Immunol , vol.29 , pp. 3887-3897
    • Mary, F.1    Moon, C.2    Venaille, T.3    Thomas, M.L.4    Mary, D.5    Bernard, A.6
  • 82
    • 6344233225 scopus 로고    scopus 로고
    • Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells
    • McGavern DB, Truong P. Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells. J Immunol 2004;173:4779-4790.
    • (2004) J Immunol , vol.173 , pp. 4779-4790
    • McGavern, D.B.1    Truong, P.2
  • 83
    • 30444457199 scopus 로고    scopus 로고
    • The role of bystander T cells in CNS pathology and pathogen clearance
    • McGavern DB. The role of bystander T cells in CNS pathology and pathogen clearance. Crit Rev Immunol 2005;25:289-303.
    • (2005) Crit Rev Immunol , vol.25 , pp. 289-303
    • McGavern, D.B.1
  • 85
    • 0025720569 scopus 로고
    • Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression
    • Fung-Leung WP, Kundig TM, Zinkernagel RM, Mak TW. Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J Exp Med 1991;174:1425-1429.
    • (1991) J Exp Med , vol.174 , pp. 1425-1429
    • Fung-Leung, W.P.1    Kundig, T.M.2    Zinkernagel, R.M.3    Mak, T.W.4
  • 86
    • 0033541378 scopus 로고    scopus 로고
    • Use of a high-affinity peptide that aborts MHC-restricted cytotoxic T lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo
    • Oldstone MB, von Herrath M, Lewicki H, Hudrisier D, Whitton JL, Gairin JE. Use of a high-affinity peptide that aborts MHC-restricted cytotoxic T lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo. Virology 1999;256:246-257.
    • (1999) Virology , vol.256 , pp. 246-257
    • Oldstone, M.B.1    von Herrath, M.2    Lewicki, H.3    Hudrisier, D.4    Whitton, J.L.5    Gairin, J.E.6
  • 88
    • 0025342635 scopus 로고
    • Two-photon laser scanning fluorescence microscopy
    • Denk W, Strickler JH, Webb WW. Two-photon laser scanning fluorescence microscopy. Science 1990;248:73-76.
    • (1990) Science , vol.248 , pp. 73-76
    • Denk, W.1    Strickler, J.H.2    Webb, W.W.3
  • 89
    • 84864743237 scopus 로고    scopus 로고
    • Two-photon imaging of microbial immunity in living tissues
    • Herz J, Zinselmeyer BH, McGavern DB. Two-photon imaging of microbial immunity in living tissues. Microsc Microanal 2012;18:730-741.
    • (2012) Microsc Microanal , vol.18 , pp. 730-741
    • Herz, J.1    Zinselmeyer, B.H.2    McGavern, D.B.3
  • 91
    • 34247494316 scopus 로고    scopus 로고
    • Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex
    • Xu HT, Pan F, Yang G, Gan WB. Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat Neurosci 2007;10:549-551.
    • (2007) Nat Neurosci , vol.10 , pp. 549-551
    • Xu, H.T.1    Pan, F.2    Yang, G.3    Gan, W.B.4
  • 92
    • 76649121846 scopus 로고    scopus 로고
    • Thinned-skull cranial window technique for long-term imaging of the cortex in live mice
    • Yang G, Pan F, Parkhurst CN, Grutzendler J, Gan WB. Thinned-skull cranial window technique for long-term imaging of the cortex in live mice. Nat Protoc 2010;5:201-208.
    • (2010) Nat Protoc , vol.5 , pp. 201-208
    • Yang, G.1    Pan, F.2    Parkhurst, C.N.3    Grutzendler, J.4    Gan, W.B.5
  • 93
    • 0035348246 scopus 로고    scopus 로고
    • Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
    • van Stipdonk MJ, Lemmens EE, Schoenberger SP. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat Immunol 2001;2:423-429.
    • (2001) Nat Immunol , vol.2 , pp. 423-429
    • van Stipdonk, M.J.1    Lemmens, E.E.2    Schoenberger, S.P.3
  • 94
    • 34247353624 scopus 로고    scopus 로고
    • Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis
    • Crozat K, et al. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med 2007;204:853-863.
    • (2007) J Exp Med , vol.204 , pp. 853-863
    • Crozat, K.1
  • 95
    • 0021243823 scopus 로고
    • The permeability of the blood-brain barrier in mice suffering from fatal lymphocytic choriomeningitis virus infection
    • Marker O, Nielsen MH, Diemer NH. The permeability of the blood-brain barrier in mice suffering from fatal lymphocytic choriomeningitis virus infection. Acta Neuropathol 1984;63:229-239.
    • (1984) Acta Neuropathol , vol.63 , pp. 229-239
    • Marker, O.1    Nielsen, M.H.2    Diemer, N.H.3
  • 96
    • 72849115197 scopus 로고    scopus 로고
    • Lymphocytic choriomeningitis virus-induced mortality in mice is triggered by edema and brain herniation
    • Matullo CM, O'Regan KJ, Hensley H, Curtis M, Rall GF. Lymphocytic choriomeningitis virus-induced mortality in mice is triggered by edema and brain herniation. J Virol 2010;84:312-320.
    • (2010) J Virol , vol.84 , pp. 312-320
    • Matullo, C.M.1    O'Regan, K.J.2    Hensley, H.3    Curtis, M.4    Rall, G.F.5
  • 97
    • 0017327667 scopus 로고
    • Anticonvulsant prolongation of survival in adult murine lymphocytic choriomeningitis. I. Drug treatment and virologic studies
    • Camenga DL, Walker DH, Murphy FA. Anticonvulsant prolongation of survival in adult murine lymphocytic choriomeningitis. I. Drug treatment and virologic studies. J Neuropathol Exp Neurol 1977;36:9-20.
    • (1977) J Neuropathol Exp Neurol , vol.36 , pp. 9-20
    • Camenga, D.L.1    Walker, D.H.2    Murphy, F.A.3
  • 98
    • 0017359285 scopus 로고
    • Anticonvulsant prolongation of survival in adult murine lymphocytic choriomeningitis. II. Ultrastructural observations of pathogenetic events
    • Walker DH, Camenga DL, Whitfield S, Murphy FA. Anticonvulsant prolongation of survival in adult murine lymphocytic choriomeningitis. II. Ultrastructural observations of pathogenetic events. J Neuropathol Exp Neurol 1977;36:21-40.
    • (1977) J Neuropathol Exp Neurol , vol.36 , pp. 21-40
    • Walker, D.H.1    Camenga, D.L.2    Whitfield, S.3    Murphy, F.A.4
  • 99
    • 0029914331 scopus 로고    scopus 로고
    • Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo
    • Kagi D, Ledermann B, Burki K, Zinkernagel RM, Hengartner H. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 1996;14:207-232.
    • (1996) Annu Rev Immunol , vol.14 , pp. 207-232
    • Kagi, D.1    Ledermann, B.2    Burki, K.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 100
    • 78649364068 scopus 로고    scopus 로고
    • Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes
    • Bao X, et al. Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes. Immunity 2010;33:817-829.
    • (2010) Immunity , vol.33 , pp. 817-829
    • Bao, X.1
  • 101
    • 33344458030 scopus 로고    scopus 로고
    • Lillemeier BorF, Kuhns MS, Chen DS, Davis MM. T cells use two directionally distinct pathways for cytokine secretion
    • Huse M. Lillemeier BorF, Kuhns MS, Chen DS, Davis MM. T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol 2006;7:247-255.
    • (2006) Nat Immunol , vol.7 , pp. 247-255
    • Huse, M.1
  • 102
    • 40749085632 scopus 로고    scopus 로고
    • In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells
    • Barcia C, Wawrowsky K, Barrett RJ, Liu C, Castro MG, Lowenstein PR. In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells. J Immunol 2008;180:1344-1352.
    • (2008) J Immunol , vol.180 , pp. 1344-1352
    • Barcia, C.1    Wawrowsky, K.2    Barrett, R.J.3    Liu, C.4    Castro, M.G.5    Lowenstein, P.R.6
  • 103
    • 84861215464 scopus 로고    scopus 로고
    • Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells
    • Sanderson NSR, et al. Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells. Proc Natl Acad Sci USA 2012;109:7835-7840.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7835-7840
    • Sanderson, N.S.R.1
  • 104
    • 0026055288 scopus 로고
    • Viral persistence in neurons explained by lack of major histocompatibility class I expression
    • Joly E, Mucke L, Oldstone MB. Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science 1991;253:1283-1285.
    • (1991) Science , vol.253 , pp. 1283-1285
    • Joly, E.1    Mucke, L.2    Oldstone, M.B.3
  • 105
    • 0026632867 scopus 로고
    • Neuronal cells are deficient in loading peptides onto MHC class I molecules
    • Joly E, Oldstone MB. Neuronal cells are deficient in loading peptides onto MHC class I molecules. Neuron 1992;8:1185-1190.
    • (1992) Neuron , vol.8 , pp. 1185-1190
    • Joly, E.1    Oldstone, M.B.2
  • 107
    • 0030002902 scopus 로고    scopus 로고
    • Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy
    • Valitutti S, Müller S, Dessing M, Lanzavecchia A. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J Exp Med 1996;183:1917-1921.
    • (1996) J Exp Med , vol.183 , pp. 1917-1921
    • Valitutti, S.1    Müller, S.2    Dessing, M.3    Lanzavecchia, A.4
  • 108
    • 16544383331 scopus 로고    scopus 로고
    • Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity
    • Hugues S, Fetler L, Bonifaz L, Helft J, Amblard F, Amigorena S. Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity. Nat Immunol 2004;5:1235-1242.
    • (2004) Nat Immunol , vol.5 , pp. 1235-1242
    • Hugues, S.1    Fetler, L.2    Bonifaz, L.3    Helft, J.4    Amblard, F.5    Amigorena, S.6
  • 109
    • 0347364690 scopus 로고    scopus 로고
    • Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes
    • Benvenuti F, et al. Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes. J Immunol 2004;172:292-301.
    • (2004) J Immunol , vol.172 , pp. 292-301
    • Benvenuti, F.1
  • 110
    • 84875461917 scopus 로고    scopus 로고
    • Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells
    • Gérard A, et al. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol 2013;14:356-363.
    • (2013) Nat Immunol , vol.14 , pp. 356-363
    • Gérard, A.1
  • 111
    • 48749084864 scopus 로고    scopus 로고
    • A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction
    • Sabatos CA, et al. A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction. Immunity 2008;29:238-248.
    • (2008) Immunity , vol.29 , pp. 238-248
    • Sabatos, C.A.1
  • 112
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola A, Lanzavecchia A. T cell activation determined by T cell receptor number and tunable thresholds. Science 1996;273:104-106.
    • (1996) Science , vol.273 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2
  • 113
    • 0034176037 scopus 로고    scopus 로고
    • Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses
    • Andreasen SO, Christensen JE, Marker O, Thomsen AR. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 2000;164:3689-3697.
    • (2000) J Immunol , vol.164 , pp. 3689-3697
    • Andreasen, S.O.1    Christensen, J.E.2    Marker, O.3    Thomsen, A.R.4
  • 114
    • 0035889910 scopus 로고    scopus 로고
    • Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes
    • Mittrücker HW, Kursar M, Köhler A, Hurwitz R, Kaufmann SH. Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes. J Immunol 2001;167:5620-5627.
    • (2001) J Immunol , vol.167 , pp. 5620-5627
    • Mittrücker, H.W.1    Kursar, M.2    Köhler, A.3    Hurwitz, R.4    Kaufmann, S.H.5
  • 115
    • 0031047824 scopus 로고    scopus 로고
    • Antiviral immune responses in CTLA4 transgenic mice
    • Zimmermann C, Seiler P, Lane P, Zinkernagel RM. Antiviral immune responses in CTLA4 transgenic mice. J Virol 1997;71:1802-1807.
    • (1997) J Virol , vol.71 , pp. 1802-1807
    • Zimmermann, C.1    Seiler, P.2    Lane, P.3    Zinkernagel, R.M.4
  • 116
    • 38449119281 scopus 로고    scopus 로고
    • Memory CD8+ T cells require CD28 costimulation
    • Borowski AB, et al. Memory CD8+ T cells require CD28 costimulation. J Immunol 2007;179:6494-6503.
    • (2007) J Immunol , vol.179 , pp. 6494-6503
    • Borowski, A.B.1
  • 117
    • 69249220258 scopus 로고    scopus 로고
    • Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection
    • Garidou L, Heydari S, Truong P, Brooks DG, Mcgavern DB. Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection. J Virol 2009;83:8905-8915.
    • (2009) J Virol , vol.83 , pp. 8905-8915
    • Garidou, L.1    Heydari, S.2    Truong, P.3    Brooks, D.G.4    Mcgavern, D.B.5
  • 118
    • 0034327808 scopus 로고    scopus 로고
    • Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells
    • McAdam AJ, et al. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol 2000;165:5035-5040.
    • (2000) J Immunol , vol.165 , pp. 5035-5040
    • McAdam, A.J.1
  • 119
    • 0033696961 scopus 로고    scopus 로고
    • The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
    • Coyle AJ, et al. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 2000;13:95-105.
    • (2000) Immunity , vol.13 , pp. 95-105
    • Coyle, A.J.1
  • 120
    • 0035804268 scopus 로고    scopus 로고
    • ICOS is critical for CD40-mediated antibody class switching
    • McAdam AJ, et al. ICOS is critical for CD40-mediated antibody class switching. Nature 2001;409:102-105.
    • (2001) Nature , vol.409 , pp. 102-105
    • McAdam, A.J.1
  • 121
    • 0035399581 scopus 로고    scopus 로고
    • Enhancement of CD8+ T cell responses by ICOS/B7 h costimulation
    • Wallin JJ, Liang L, Bakardjiev A, Sha WC. Enhancement of CD8+ T cell responses by ICOS/B7 h costimulation. J Immunol 2001;167:132-139.
    • (2001) J Immunol , vol.167 , pp. 132-139
    • Wallin, J.J.1    Liang, L.2    Bakardjiev, A.3    Sha, W.C.4
  • 122
    • 0034600567 scopus 로고    scopus 로고
    • Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
    • Kopf M, et al. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection. J Exp Med 2000;192:53-61.
    • (2000) J Exp Med , vol.192 , pp. 53-61
    • Kopf, M.1
  • 123
    • 0027282960 scopus 로고
    • Characterization of CTLA-4 structure and expression on human T cells
    • Lindsten T, et al. Characterization of CTLA-4 structure and expression on human T cells. J Immunol 1993;151:3489-3499.
    • (1993) J Immunol , vol.151 , pp. 3489-3499
    • Lindsten, T.1
  • 124
    • 44549085250 scopus 로고    scopus 로고
    • CTLA-4 trafficking and surface expression
    • Valk E, Rudd CE, Schneider H. CTLA-4 trafficking and surface expression. Trends Immunol 2008;29:272-279.
    • (2008) Trends Immunol , vol.29 , pp. 272-279
    • Valk, E.1    Rudd, C.E.2    Schneider, H.3
  • 125
    • 0036172220 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
    • Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 2002;16:23-35.
    • (2002) Immunity , vol.16 , pp. 23-35
    • Egen, J.G.1    Allison, J.P.2
  • 126
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • Rudd CE, Taylor A, Schneider H. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 2009;229:12-26.
    • (2009) Immunol Rev , vol.229 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 127
    • 38549089084 scopus 로고    scopus 로고
    • The reverse stop-signal model for CTLA4 function
    • Rudd CE. The reverse stop-signal model for CTLA4 function. Nat Rev Immunol 2008;8:153-160.
    • (2008) Nat Rev Immunol , vol.8 , pp. 153-160
    • Rudd, C.E.1
  • 128
    • 33749038866 scopus 로고    scopus 로고
    • Reversal of the TCR stop signal by CTLA-4
    • Schneider H, et al. Reversal of the TCR stop signal by CTLA-4. Science 2006;313:1972-1975.
    • (2006) Science , vol.313 , pp. 1972-1975
    • Schneider, H.1
  • 129
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 130
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
    • Waterhouse P, et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995;270:985-988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1
  • 132
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006;439:682-687.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1
  • 133
    • 27144496045 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    • Parry RV, et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol 2005;25:9543-9553.
    • (2005) Mol Cell Biol , vol.25 , pp. 9543-9553
    • Parry, R.V.1
  • 134
    • 84864324543 scopus 로고    scopus 로고
    • Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
    • Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, Hashimoto-Tane A, Azuma M, Saito T. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med 2012;209:1201-1217.
    • (2012) J Exp Med , vol.209 , pp. 1201-1217
    • Yokosuka, T.1    Takamatsu, M.2    Kobayashi-Imanishi, W.3    Hashimoto-Tane, A.4    Azuma, M.5    Saito, T.6
  • 135
    • 84878625979 scopus 로고    scopus 로고
    • PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
    • Zinselmeyer BH, et al. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med 2013;210:757-774.
    • (2013) J Exp Med , vol.210 , pp. 757-774
    • Zinselmeyer, B.H.1
  • 136
    • 70350433514 scopus 로고    scopus 로고
    • Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal
    • Fife BT, et al. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol 2009;10:1185-1192.
    • (2009) Nat Immunol , vol.10 , pp. 1185-1192
    • Fife, B.T.1
  • 137
    • 0023908516 scopus 로고
    • Organ-specific selection of viral variants during chronic infection
    • Ahmed R, Oldstone MB. Organ-specific selection of viral variants during chronic infection. J Exp Med 1988;167:1719-1724.
    • (1988) J Exp Med , vol.167 , pp. 1719-1724
    • Ahmed, R.1    Oldstone, M.B.2
  • 138
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry EJ. T cell exhaustion. Nat Immunol 2011;12:492-499.
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 139
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • Josefowicz SZ, Lu L-F, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012;30:531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.-F.2    Rudensky, A.Y.3
  • 140
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001;27:68-73.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1
  • 141
    • 34748873441 scopus 로고    scopus 로고
    • cells and infection: a dangerous necessity
    • Belkaid Y, Regulatory T. cells and infection: a dangerous necessity. Nat Rev Immunol 2007;7:875-888.
    • (2007) Nat Rev Immunol , vol.7 , pp. 875-888
    • Belkaid, Y.1    Regulatory, T.2
  • 142
    • 33745978399 scopus 로고    scopus 로고
    • Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    • Mempel TR, et al. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 2006;25:129-141.
    • (2006) Immunity , vol.25 , pp. 129-141
    • Mempel, T.R.1
  • 143
    • 33645067654 scopus 로고    scopus 로고
    • Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo
    • Tadokoro CE, et al. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med 2006;203:505-511.
    • (2006) J Exp Med , vol.203 , pp. 505-511
    • Tadokoro, C.E.1
  • 144
    • 29244482759 scopus 로고    scopus 로고
    • Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
    • Tang Q, et al. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 2006;7:83-92.
    • (2006) Nat Immunol , vol.7 , pp. 83-92
    • Tang, Q.1
  • 145
    • 0001033801 scopus 로고
    • Persistence of lymphocytic choriomeningitis virus in immune animals and its relation to immunity
    • Traub E. Persistence of lymphocytic choriomeningitis virus in immune animals and its relation to immunity. J Exp Med 1936;63:847-861.
    • (1936) J Exp Med , vol.63 , pp. 847-861
    • Traub, E.1
  • 146
    • 0000673292 scopus 로고
    • Lymphocytic choriomeningitis infection of mice as a model for the study of latent virus infection
    • Hotchin JE, Cinits M. Lymphocytic choriomeningitis infection of mice as a model for the study of latent virus infection. Can J Microbiol 1958;4:149-163.
    • (1958) Can J Microbiol , vol.4 , pp. 149-163
    • Hotchin, J.E.1    Cinits, M.2
  • 147
    • 0025785045 scopus 로고
    • High resolution in situ hybridization to determine the cellular distribution of lymphocytic choriomeningitis virus RNA in the tissues of persistently infected mice: relevance to arenavirus disease and mechanisms of viral persistence
    • Fazakerley JK, Southern P, Bloom F, Buchmeier MJ. High resolution in situ hybridization to determine the cellular distribution of lymphocytic choriomeningitis virus RNA in the tissues of persistently infected mice: relevance to arenavirus disease and mechanisms of viral persistence. J Gen Virol 1991;72:1611-1625.
    • (1991) J Gen Virol , vol.72 , pp. 1611-1625
    • Fazakerley, J.K.1    Southern, P.2    Bloom, F.3    Buchmeier, M.J.4
  • 148
    • 0017836055 scopus 로고
    • Immunological tolerance to lymphocytic choriomeningitis virus in neonatally infected virus carrier mice: evidence supporting a clonal inactivation mechanism
    • Cihak J, Lehmann-Grube F. Immunological tolerance to lymphocytic choriomeningitis virus in neonatally infected virus carrier mice: evidence supporting a clonal inactivation mechanism. Immunology 1978;34:265-275.
    • (1978) Immunology , vol.34 , pp. 265-275
    • Cihak, J.1    Lehmann-Grube, F.2
  • 149
    • 0024121606 scopus 로고
    • T-cell tolerance: exposure to virus in utero does not cause a permanent deletion of specific T cells
    • Jamieson BD, Ahmed R. T-cell tolerance: exposure to virus in utero does not cause a permanent deletion of specific T cells. Proc Natl Acad Sci USA 1988;85:2265-2268.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 2265-2268
    • Jamieson, B.D.1    Ahmed, R.2
  • 150
    • 0000706211 scopus 로고
    • Studies on immunological tolerance to LCM virus. 2. Treatment of virus carrier mice by adoptive immunization
    • Volkert M. Studies on immunological tolerance to LCM virus. 2. Treatment of virus carrier mice by adoptive immunization. Acta Pathol Microbiol Scand 1963;57:465-487.
    • (1963) Acta Pathol Microbiol Scand , vol.57 , pp. 465-487
    • Volkert, M.1
  • 151
    • 0034688296 scopus 로고    scopus 로고
    • Defining parameters for successful immunocytotherapy of persistent viral infection
    • Berger DP, Homann D, Oldstone MB. Defining parameters for successful immunocytotherapy of persistent viral infection. Virology 2000;266:257-263.
    • (2000) Virology , vol.266 , pp. 257-263
    • Berger, D.P.1    Homann, D.2    Oldstone, M.B.3
  • 152
    • 0023510286 scopus 로고
    • Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells
    • Jamieson BD, Butler LD, Ahmed R. Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells. J Virol 1987;61:3930-3937.
    • (1987) J Virol , vol.61 , pp. 3930-3937
    • Jamieson, B.D.1    Butler, L.D.2    Ahmed, R.3
  • 153
    • 0023492065 scopus 로고
    • Immune therapy of a persistent and disseminated viral infection
    • Ahmed R, Jamieson BD, Porter DD. Immune therapy of a persistent and disseminated viral infection. J Virol 1987;61:3920-3929.
    • (1987) J Virol , vol.61 , pp. 3920-3929
    • Ahmed, R.1    Jamieson, B.D.2    Porter, D.D.3
  • 154
    • 0022508921 scopus 로고
    • Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system
    • Oldstone MB, Blount P, Southern PJ, Lampert PW. Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature 1986;321:239-243.
    • (1986) Nature , vol.321 , pp. 239-243
    • Oldstone, M.B.1    Blount, P.2    Southern, P.J.3    Lampert, P.W.4
  • 155
    • 33746905859 scopus 로고    scopus 로고
    • Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection
    • Lauterbach H, Zuniga EI, Truong P, Oldstone MBA, McGavern DB. Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. J Exp Med 2006;203:1963-1975.
    • (2006) J Exp Med , vol.203 , pp. 1963-1975
    • Lauterbach, H.1    Zuniga, E.I.2    Truong, P.3    Oldstone, M.B.A.4    McGavern, D.B.5
  • 156
    • 35448965261 scopus 로고    scopus 로고
    • Fas ligand interactions contribute to CD8+ T-cell-mediated control of West Nile virus infection in the central nervous system
    • Shrestha B, Diamond MS. Fas ligand interactions contribute to CD8+ T-cell-mediated control of West Nile virus infection in the central nervous system. J Virol 2007;81:11749-11757.
    • (2007) J Virol , vol.81 , pp. 11749-11757
    • Shrestha, B.1    Diamond, M.S.2
  • 157
    • 33646738698 scopus 로고    scopus 로고
    • Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection
    • Shrestha B, et al. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol 2006;80:5338-5348.
    • (2006) J Virol , vol.80 , pp. 5338-5348
    • Shrestha, B.1
  • 158
    • 33646555810 scopus 로고    scopus 로고
    • Type 1 interferons and the virus-host relationship: a lesson in detente
    • Garcia-Sastre A, Biron CA. Type 1 interferons and the virus-host relationship: a lesson in detente. Science 2006;312:879-882.
    • (2006) Science , vol.312 , pp. 879-882
    • Garcia-Sastre, A.1    Biron, C.A.2
  • 159
    • 0035062597 scopus 로고    scopus 로고
    • Noncytolytic control of viral infections by the innate and adaptive immune response
    • Guidotti LG, Chisari FV. Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 2001;19:65-91.
    • (2001) Annu Rev Immunol , vol.19 , pp. 65-91
    • Guidotti, L.G.1    Chisari, F.V.2
  • 160
    • 0028855993 scopus 로고
    • Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo
    • Rall GF, Mucke L, Oldstone MB. Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo. J Exp Med 1995;182:1201-1212.
    • (1995) J Exp Med , vol.182 , pp. 1201-1212
    • Rall, G.F.1    Mucke, L.2    Oldstone, M.B.3
  • 161
    • 0033577852 scopus 로고    scopus 로고
    • Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte
    • Guidotti LG, Borrow P, Brown A, McClary H, Koch R, Chisari FV. Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte. J Exp Med 1999;189:1555-1564.
    • (1999) J Exp Med , vol.189 , pp. 1555-1564
    • Guidotti, L.G.1    Borrow, P.2    Brown, A.3    McClary, H.4    Koch, R.5    Chisari, F.V.6
  • 162
    • 0842282849 scopus 로고    scopus 로고
    • Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells
    • Bergmann CC, Parra B, Hinton DR, Ramakrishna C, Dowdell KC, Stohlman SA. Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells. J Virol 2004;78:1739-1750.
    • (2004) J Virol , vol.78 , pp. 1739-1750
    • Bergmann, C.C.1    Parra, B.2    Hinton, D.R.3    Ramakrishna, C.4    Dowdell, K.C.5    Stohlman, S.A.6
  • 163
    • 23844435550 scopus 로고    scopus 로고
    • Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis
    • Klein RS, et al. Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. J Virol 2005;79:11457-11466.
    • (2005) J Virol , vol.79 , pp. 11457-11466
    • Klein, R.S.1
  • 164
    • 0034235794 scopus 로고    scopus 로고
    • Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation
    • Bromley SK, Peterson DA, Gunn MD, Dustin ML. Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. J Immunol 2000;165:15-19.
    • (2000) J Immunol , vol.165 , pp. 15-19
    • Bromley, S.K.1    Peterson, D.A.2    Gunn, M.D.3    Dustin, M.L.4
  • 165
    • 49049111874 scopus 로고    scopus 로고
    • A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells
    • Truong P, McGavern DB. A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells. J Immunol 2008;181:1161-1169.
    • (2008) J Immunol , vol.181 , pp. 1161-1169
    • Truong, P.1    McGavern, D.B.2
  • 166
    • 13944266418 scopus 로고    scopus 로고
    • Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment
    • Bhakta NR, Oh DY, Lewis RS. Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. Nat Immunol 2005;6:143-151.
    • (2005) Nat Immunol , vol.6 , pp. 143-151
    • Bhakta, N.R.1    Oh, D.Y.2    Lewis, R.S.3
  • 167
    • 0036225013 scopus 로고    scopus 로고
    • Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection
    • Richie LI, Ebert PJR, Wu LC, Krummel MF, Owen JJT, Davis MM. Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection. Immunity 2002;16:595-606.
    • (2002) Immunity , vol.16 , pp. 595-606
    • Richie, L.I.1    Ebert, P.J.R.2    Wu, L.C.3    Krummel, M.F.4    Owen, J.J.T.5    Davis, M.M.6
  • 168
    • 0034769286 scopus 로고    scopus 로고
    • Functional antigen-independent synapses formed between T cells and dendritic cells
    • Revy P, Sospedra M, Barbour B, Trautmann A. Functional antigen-independent synapses formed between T cells and dendritic cells. Nat Immunol 2001;2:925-931.
    • (2001) Nat Immunol , vol.2 , pp. 925-931
    • Revy, P.1    Sospedra, M.2    Barbour, B.3    Trautmann, A.4
  • 169
    • 33947730608 scopus 로고    scopus 로고
    • Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    • Chang JT, et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 2007;315:1687-1691.
    • (2007) Science , vol.315 , pp. 1687-1691
    • Chang, J.T.1
  • 170


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