-
1
-
-
11144230063
-
The CD28 family: A T-cell rheostat for therapeutic control of T-cell activation
-
Riley, J. L. & June, C. H. The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation. Blood 105, 13-21 (2005).
-
(2005)
Blood
, vol.105
, pp. 13-21
-
-
Riley, J.L.1
June, C.H.2
-
2
-
-
0030300139
-
The role of CTLA-4 in the regulation and initiation of T-cell responses
-
Chambers, C. A. et al. The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol. Rev. 153, 27-46 (1996).
-
(1996)
Immunol. Rev
, vol.153
, pp. 27-46
-
-
Chambers, C.A.1
-
3
-
-
8844250178
-
T cell tolerance and autoimmunity
-
Abbas, A. K., Lohr, J., Knoechel, B. & Nagabhushanam, V. T cell tolerance and autoimmunity. Autoimmun. Rev. 3, 471-475 (2004).
-
(2004)
Autoimmun. Rev
, vol.3
, pp. 471-475
-
-
Abbas, A.K.1
Lohr, J.2
Knoechel, B.3
Nagabhushanam, V.4
-
4
-
-
0036604902
-
Negative co-receptors on lymphocytes
-
Greenwald, R. J., Latchman, Y. E. & Sharpe, A. H. Negative co-receptors on lymphocytes. Curr. Opin. Immunol. 14, 391-396 (2002).
-
(2002)
Curr. Opin. Immunol
, vol.14
, pp. 391-396
-
-
Greenwald, R.J.1
Latchman, Y.E.2
Sharpe, A.H.3
-
5
-
-
0142259712
-
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
-
Rudd, C. E. & Schneider, H. Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nature Rev. Immunol. 3, 544-556 (2003).
-
(2003)
Nature Rev. Immunol
, vol.3
, pp. 544-556
-
-
Rudd, C.E.1
Schneider, H.2
-
6
-
-
0035757397
-
T-cell regulation by CD28 and CTLA-4
-
Alegre, M. L., Frauwirth, K. A. & Thompson, C. B. T-cell regulation by CD28 and CTLA-4. Nature Rev. Immunol. 1, 220-228 (2001).
-
(2001)
Nature Rev. Immunol
, vol.1
, pp. 220-228
-
-
Alegre, M.L.1
Frauwirth, K.A.2
Thompson, C.B.3
-
7
-
-
0037418274
-
Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling
-
Zhang, X., Schwartz, J. C., Almo, S. C. & Nathenson, S. G. Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. Proc. Natl Acad. Sci. USA 100, 2586-2591 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 2586-2591
-
-
Zhang, X.1
Schwartz, J.C.2
Almo, S.C.3
Nathenson, S.G.4
-
8
-
-
0035967146
-
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
-
Stamper, C. C. et al. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature 410, 608-611 (2001).
-
(2001)
Nature
, vol.410
, pp. 608-611
-
-
Stamper, C.C.1
-
9
-
-
0031054242
-
-
van der Merwe, P. A., Bodian, D., Daenke, S., Linsley, P. & Davis, S. J. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 185, 393-403 (1997).
-
van der Merwe, P. A., Bodian, D., Daenke, S., Linsley, P. & Davis, S. J. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J. Exp. Med. 185, 393-403 (1997).
-
-
-
-
10
-
-
0030176371
-
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
-
Linsley, P. S. et al. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4, 535-543 (1996).
-
(1996)
Immunity
, vol.4
, pp. 535-543
-
-
Linsley, P.S.1
-
11
-
-
0036172220
-
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
-
Egen, J. G. & Allison, J. P. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 16, 23-35 (2002).
-
(2002)
Immunity
, vol.16
, pp. 23-35
-
-
Egen, J.G.1
Allison, J.P.2
-
12
-
-
33846391306
-
T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor
-
Valk, E. et al. T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor. Immunity 25, 807-821 (2006).
-
(2006)
Immunity
, vol.25
, pp. 807-821
-
-
Valk, E.1
-
13
-
-
0030611358
-
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
-
Zhang, Y. & Allison, J. P. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc. Natl Acad. Sci. USA 94, 9273-9278 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 9273-9278
-
-
Zhang, Y.1
Allison, J.P.2
-
14
-
-
0033567050
-
Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2
-
Schneider, H. et al. Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J. Immunol. 163, 1868-1879 (1999).
-
(1999)
J. Immunol
, vol.163
, pp. 1868-1879
-
-
Schneider, H.1
-
15
-
-
0030917081
-
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
-
Shiratori, T. et al. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 6, 583-589 (1997).
-
(1997)
Immunity
, vol.6
, pp. 583-589
-
-
Shiratori, T.1
-
16
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 985-988 (1995).
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
-
17
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol, E. A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
-
19
-
-
0035863805
-
Cutting edge: Two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice
-
Gozalo-Sanmillan, S., McNally, J. M., Lin, M. Y., Chambers, C. A. & Berg, L. J. Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice. J. Immunol. 166, 727-730 (2001).
-
(2001)
J. Immunol
, vol.166
, pp. 727-730
-
-
Gozalo-Sanmillan, S.1
McNally, J.M.2
Lin, M.Y.3
Chambers, C.A.4
Berg, L.J.5
-
20
-
-
0037648405
-
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
-
Ueda, H. et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423, 506-511 (2003).
-
(2003)
Nature
, vol.423
, pp. 506-511
-
-
Ueda, H.1
-
21
-
-
33750824739
-
Modeling CTLA4-linked autoimmunity with RNA interference in mice
-
Chen, Z., Stockton, J., Mathis, D. & Benoist, C. Modeling CTLA4-linked autoimmunity with RNA interference in mice. Proc. Natl Acad. Sci. USA 103, 16400-16405 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 16400-16405
-
-
Chen, Z.1
Stockton, J.2
Mathis, D.3
Benoist, C.4
-
22
-
-
0344299189
-
Cutting edge: Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous
-
Bachmann, M. F., Kohler, G., Ecabert, B., Mak, T. W. & Kopf, M. Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J. Immunol. 163, 1128-1131 (1999).
-
(1999)
J. Immunol
, vol.163
, pp. 1128-1131
-
-
Bachmann, M.F.1
Kohler, G.2
Ecabert, B.3
Mak, T.W.4
Kopf, M.5
-
23
-
-
0031905627
-
Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells
-
Bachmann, M. F. et al. Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells. J. Immunol. 160, 95-100 (1998).
-
(1998)
J. Immunol
, vol.160
, pp. 95-100
-
-
Bachmann, M.F.1
-
24
-
-
34547749066
-
Emerging challenges in regulatory T cell function and biology
-
Sakaguchi, S. & Powrie, F. Emerging challenges in regulatory T cell function and biology. Science 317, 627-629 (2007).
-
(2007)
Science
, vol.317
, pp. 627-629
-
-
Sakaguchi, S.1
Powrie, F.2
-
27
-
-
33749132564
-
+ regulatory T cells abrogates their function in vivo
-
+ regulatory T cells abrogates their function in vivo. J. Immunol. 177, 4376-4383 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 4376-4383
-
-
Read, S.1
-
29
-
-
33746377279
-
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
-
Izcue, A., Coombes, J. L. & Powrie, F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev. 212, 256-271 (2006).
-
(2006)
Immunol. Rev
, vol.212
, pp. 256-271
-
-
Izcue, A.1
Coombes, J.L.2
Powrie, F.3
-
30
-
-
0035956905
-
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
-
Sullivan, T. J. et al. Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation. Proc. Natl Acad. Sci. USA 98, 2587-2592 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 2587-2592
-
-
Sullivan, T.J.1
-
31
-
-
1642396607
-
+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells
-
+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J. Immunol. 172, 4100-4110 (2004).
-
(2004)
J. Immunol
, vol.172
, pp. 4100-4110
-
-
Munn, D.H.1
Sharma, M.D.2
Mellor, A.L.3
-
32
-
-
5044220930
-
IDO expression by dendritic cells: Tolerance and tryptophan catabolism
-
Mellor, A. L. & Munn, D. H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nature Rev. Immunol. 4, 762-774 (2004).
-
(2004)
Nature Rev. Immunol
, vol.4
, pp. 762-774
-
-
Mellor, A.L.1
Munn, D.H.2
-
33
-
-
0029899783
-
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
-
Krummel, M. F. & Allison, J. P. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183, 2533-2540 (1996).
-
(1996)
J. Exp. Med
, vol.183
, pp. 2533-2540
-
-
Krummel, M.F.1
Allison, J.P.2
-
34
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas, T. L. et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405-413 (1994).
-
(1994)
Immunity
, vol.1
, pp. 405-413
-
-
Walunas, T.L.1
-
35
-
-
0035865522
-
CTLA-4 blockade of antigen-induced cell death
-
da Rocha Dias, S. & Rudd, C. E. CTLA-4 blockade of antigen-induced cell death. Blood 97, 1134-1137 (2001).
-
(2001)
Blood
, vol.97
, pp. 1134-1137
-
-
da Rocha Dias, S.1
Rudd, C.E.2
-
36
-
-
1842854703
-
Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo
-
Yi, L. A., Hajialiasgar, S. & Chuang, E. Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo. Int. Immunol. 16, 539-547 (2004).
-
(2004)
Int. Immunol
, vol.16
, pp. 539-547
-
-
Yi, L.A.1
Hajialiasgar, S.2
Chuang, E.3
-
37
-
-
0037245125
-
Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor
-
Yin, L., Schneider, H. & Rudd, C. E. Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor. J. Leukoc. Bio. 73, 178-182 (2003).
-
(2003)
J. Leukoc. Bio
, vol.73
, pp. 178-182
-
-
Yin, L.1
Schneider, H.2
Rudd, C.E.3
-
38
-
-
0034658408
-
Structural analysis of CTLA-4 function in vivo
-
Masteller, E. L., Chuang, E., Mullen, A. C., Reiner, S. L. & Thompson, C. B. Structural analysis of CTLA-4 function in vivo. J. Immunol. 164, 5319-5327 (2000).
-
(2000)
J. Immunol
, vol.164
, pp. 5319-5327
-
-
Masteller, E.L.1
Chuang, E.2
Mullen, A.C.3
Reiner, S.L.4
Thompson, C.B.5
-
39
-
-
33745860066
-
CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism
-
Engelhardt, J. J., Sullivan, T. J. & Allison, J. P. CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism. J. Immunol. 177, 1052-1061 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 1052-1061
-
-
Engelhardt, J.J.1
Sullivan, T.J.2
Allison, J.P.3
-
40
-
-
0031154577
-
CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice
-
Tivol, E. A. et al. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J. Immunol. 158, 5091-5094 (1997).
-
(1997)
J. Immunol
, vol.158
, pp. 5091-5094
-
-
Tivol, E.A.1
-
42
-
-
0030001318
-
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
-
Marengere, L. E. et al. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272, 1170-1173 (1996).
-
(1996)
Science
, vol.272
, pp. 1170-1173
-
-
Marengere, L.E.1
-
43
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
Parry, R. V. et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell. Biol. 25, 9543-9553 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 9543-9553
-
-
Parry, R.V.1
-
44
-
-
4444369694
-
-
Pentcheva-Hoang, T., Egen, J. G., Wojnoonski, K. & Allison, J. P. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity 21, 401-413 (2004).
-
Pentcheva-Hoang, T., Egen, J. G., Wojnoonski, K. & Allison, J. P. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity 21, 401-413 (2004).
-
-
-
-
45
-
-
0032490620
-
Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28
-
Lin, H. et al. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J. Exp. Med. 188, 199-204 (1998).
-
(1998)
J. Exp. Med
, vol.188
, pp. 199-204
-
-
Lin, H.1
-
46
-
-
6344275307
-
Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice
-
Hwang, K. W. et al. Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice. J. Immunol. 173, 5415-5424 (2004).
-
(2004)
J. Immunol
, vol.173
, pp. 5415-5424
-
-
Hwang, K.W.1
-
47
-
-
0032490629
-
-
Fallarino, F., Fields, P. E. & Gajewski, T. F. B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28. J. Exp. Med. 188, 205-210 (1998).
-
Fallarino, F., Fields, P. E. & Gajewski, T. F. B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28. J. Exp. Med. 188, 205-210 (1998).
-
-
-
-
48
-
-
0032545452
-
Molecular basis of T cell inactivation by CTLA-4
-
Lee, K. M. et al. Molecular basis of T cell inactivation by CTLA-4. Science 282, 2263-2266 (1998).
-
(1998)
Science
, vol.282
, pp. 2263-2266
-
-
Lee, K.M.1
-
49
-
-
0034607131
-
Tyrosine phosphatase SHP-2 binding to CTLA-4: Absence of direct YVKM/YFIP motif recognition
-
Schneider, H. & Rudd, C. E. Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition. Biochem. Biophys. Res. Commun. 269, 279-283 (2000).
-
(2000)
Biochem. Biophys. Res. Commun
, vol.269
, pp. 279-283
-
-
Schneider, H.1
Rudd, C.E.2
-
50
-
-
33646205150
-
A molecular perspective of CTLA-4 function
-
Teft, W. A., Kirchhof, M. G. & Madrenas, J. A molecular perspective of CTLA-4 function. Annu. Rev. Immunol. 24, 65-97 (2006).
-
(2006)
Annu. Rev. Immunol
, vol.24
, pp. 65-97
-
-
Teft, W.A.1
Kirchhof, M.G.2
Madrenas, J.3
-
51
-
-
0033662376
-
The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A
-
Chuang, E. et al. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity 13, 313-322 (2000).
-
(2000)
Immunity
, vol.13
, pp. 313-322
-
-
Chuang, E.1
-
52
-
-
0036784567
-
+ T cells from receptor/ligand-deficient mice
-
+ T cells from receptor/ligand-deficient mice. J. Immunol. 169, 3475-3479 (2002).
-
(2002)
J. Immunol
, vol.169
, pp. 3475-3479
-
-
Schneider, H.1
-
53
-
-
0035803552
-
Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function
-
Martin, M., Schneider, H., Azouz, A. & Rudd, C. E. Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function. J. Exp. Med. 194, 1675-1681 (2001).
-
(2001)
J. Exp. Med
, vol.194
, pp. 1675-1681
-
-
Martin, M.1
Schneider, H.2
Azouz, A.3
Rudd, C.E.4
-
54
-
-
0032482171
-
The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells
-
Frearson, J. A. & Alexander, D. R. The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J. Exp. Med. 187, 1417-1426 (1998).
-
(1998)
J. Exp. Med
, vol.187
, pp. 1417-1426
-
-
Frearson, J.A.1
Alexander, D.R.2
-
55
-
-
0032931973
-
Costimulatory regulation of T cell function
-
Chambers, C. A. & Allison, J. P. Costimulatory regulation of T cell function. Curr. Opin. Cell Biol. 11, 203-210 (1999).
-
(1999)
Curr. Opin. Cell Biol
, vol.11
, pp. 203-210
-
-
Chambers, C.A.1
Allison, J.P.2
-
56
-
-
10344259631
-
Cutting Edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation
-
Li, D. et al. Cutting Edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. J. Immunol. 173, 7135-7139 (2004).
-
(2004)
J. Immunol
, vol.173
, pp. 7135-7139
-
-
Li, D.1
-
57
-
-
0034642534
-
Cbl-b regulates the CD28 dependence of T-cell activation
-
Chiang, Y. J. et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403, 216-220 (2000).
-
(2000)
Nature
, vol.403
, pp. 216-220
-
-
Chiang, Y.J.1
-
58
-
-
0034642499
-
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
-
Bachmaier, K. et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403, 211-216 (2000).
-
(2000)
Nature
, vol.403
, pp. 211-216
-
-
Bachmaier, K.1
-
59
-
-
34247387485
-
+ T cells
-
+ T cells. J. Exp. Med. 204, 879-891 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 879-891
-
-
Loeser, S.1
-
60
-
-
0037117823
-
CTLA-4 negative signaling via lipid rafts: A new perspective
-
Rudd, C. E., Martin, M. & Schneider, H. CTLA-4 negative signaling via lipid rafts: A new perspective. Sci. STKE 2002, PE18 (2002).
-
(2002)
Sci. STKE
, vol.2002
-
-
Rudd, C.E.1
Martin, M.2
Schneider, H.3
-
61
-
-
0037244012
-
Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4
-
Chikuma, S., Imboden, J. B. & Bluestone, J. A. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 197, 129-135 (2003).
-
(2003)
J. Exp. Med
, vol.197
, pp. 129-135
-
-
Chikuma, S.1
Imboden, J.B.2
Bluestone, J.A.3
-
62
-
-
0033613826
-
T lymphocyte costimulation mediated by reorganization of membrane microdomains
-
Viola, A., Schroeder, S., Sakakibara, Y. & Lanzavecchia, A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 283, 680-682 (1999).
-
(1999)
Science
, vol.283
, pp. 680-682
-
-
Viola, A.1
Schroeder, S.2
Sakakibara, Y.3
Lanzavecchia, A.4
-
63
-
-
30044441433
-
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
-
Yokosuka, T. et al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nature Immunol. 6, 1253-1262 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 1253-1262
-
-
Yokosuka, T.1
-
64
-
-
33749171235
-
Persistence of cooperatively stabilized signaling clusters drives T-cell activation
-
Bunnell, S. C. et al. Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol. Cell Biol. 26, 7155-7166 (2006).
-
(2006)
Mol. Cell Biol
, vol.26
, pp. 7155-7166
-
-
Bunnell, S.C.1
-
65
-
-
38349074305
-
CTLA-4 expression disrupts ZAP-70 microcluster formation, T-cell/APC conjugation and calcium mobilization
-
Schneider, H., Smith, X., Liu, H., Bismuth, G. & Rudd, C. E. CTLA-4 expression disrupts ZAP-70 microcluster formation, T-cell/APC conjugation and calcium mobilization. Eur. J. Immunol. 38, 40-47 (2007).
-
(2007)
Eur. J. Immunol
, vol.38
, pp. 40-47
-
-
Schneider, H.1
Smith, X.2
Liu, H.3
Bismuth, G.4
Rudd, C.E.5
-
66
-
-
0028910221
-
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
-
Schneider, H., Prasad, K. V., Shoelson, S. E. & Rudd, C. E. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 181, 351-355 (1995).
-
(1995)
J. Exp. Med
, vol.181
, pp. 351-355
-
-
Schneider, H.1
Prasad, K.V.2
Shoelson, S.E.3
Rudd, C.E.4
-
67
-
-
24644506094
-
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function
-
Schneider, H., Valk, E., da Rocha Dias, S., Wei, B. & Rudd, C. E. CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. Proc. Natl Acad. Sci. USA 102, 12861-12866 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 12861-12866
-
-
Schneider, H.1
Valk, E.2
da Rocha Dias, S.3
Wei, B.4
Rudd, C.E.5
-
68
-
-
0034004457
-
Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase
-
Katagiri, K. et al. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol. Cell Biol. 20, 1956-1969 (2000).
-
(2000)
Mol. Cell Biol
, vol.20
, pp. 1956-1969
-
-
Katagiri, K.1
-
69
-
-
18044405159
-
Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4
-
Dillon, T. J., Carey, K. D., Wetzel, S. A., Parker, D. C. & Stork, P. J. Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4. Mol. Cell Biol. 25, 4117-4128 (2005).
-
(2005)
Mol. Cell Biol
, vol.25
, pp. 4117-4128
-
-
Dillon, T.J.1
Carey, K.D.2
Wetzel, S.A.3
Parker, D.C.4
Stork, P.J.5
-
70
-
-
34250886841
-
CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase
-
Wei, B., da Rocha Dias, S., Wang, H. & Rudd, C. E. CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase. J. Immunol. 179, 400-408 (2007).
-
(2007)
J. Immunol
, vol.179
, pp. 400-408
-
-
Wei, B.1
da Rocha Dias, S.2
Wang, H.3
Rudd, C.E.4
-
71
-
-
33749038866
-
Reversal of the TCR stop signal by CTLA-4
-
Schneider, H. et al. Reversal of the TCR stop signal by CTLA-4. Science 313, 1972-1975 (2006).
-
(2006)
Science
, vol.313
, pp. 1972-1975
-
-
Schneider, H.1
-
72
-
-
0030888235
-
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes
-
Dustin, M. L., Bromley, S. K., Kan, Z., Peterson, D. A. & Unanue, E. R. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc. Natl Acad. Sci. USA 94, 3909-3913 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 3909-3913
-
-
Dustin, M.L.1
Bromley, S.K.2
Kan, Z.3
Peterson, D.A.4
Unanue, E.R.5
-
73
-
-
0037501371
-
+ T cell priming by dendritic cells in intact lymph nodes
-
+ T cell priming by dendritic cells in intact lymph nodes. Nature Immunol. 4, 579-585 (2003).
-
(2003)
Nature Immunol
, vol.4
, pp. 579-585
-
-
Bousso, P.1
Robey, E.2
-
74
-
-
0037036142
-
Two-photon imaging of lymphocyte motility and antigen response in intact lymph node
-
Miller, M. J., Wei, S. H., Parker, I. & Cahalan, M. D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296, 1869-1873 (2002).
-
(2002)
Science
, vol.296
, pp. 1869-1873
-
-
Miller, M.J.1
Wei, S.H.2
Parker, I.3
Cahalan, M.D.4
-
75
-
-
16544383331
-
Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity
-
Hugues, S. et al. Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity. Nature Immunol. 5, 1235-1242 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 1235-1242
-
-
Hugues, S.1
-
76
-
-
0035102196
-
CTLA-4 regulates induction of anergy in vivo
-
Greenwald, R. J., Boussiotis, V. A., Lorsbach, R. B., Abbas, A. K. & Sharpe, A. H. CTLA-4 regulates induction of anergy in vivo. Immunity 14, 145-155 (2001).
-
(2001)
Immunity
, vol.14
, pp. 145-155
-
-
Greenwald, R.J.1
Boussiotis, V.A.2
Lorsbach, R.B.3
Abbas, A.K.4
Sharpe, A.H.5
-
78
-
-
22144459813
-
Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo
-
Shakhar, G. et al. Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nature Immunol. 6, 707-714 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 707-714
-
-
Shakhar, G.1
-
79
-
-
22344450705
-
+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance
-
+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. J. Exp. Med. 201, 1815-1823 (2005).
-
(2005)
J. Exp. Med
, vol.201
, pp. 1815-1823
-
-
Zinselmeyer, B.H.1
-
80
-
-
0025339511
-
A cell culture model for T lymphocyte clonal anergy
-
Schwartz, R. H. A cell culture model for T lymphocyte clonal anergy. Science 248, 1349-1356 (1990).
-
(1990)
Science
, vol.248
, pp. 1349-1356
-
-
Schwartz, R.H.1
-
81
-
-
0348036122
-
T-cell integrins: More than just sticking points
-
Hogg, N., Laschinger, M., Giles, K. & McDowall, A. T-cell integrins: more than just sticking points. J. Cell Sci. 116, 4695-4705 (2003).
-
(2003)
J. Cell Sci
, vol.116
, pp. 4695-4705
-
-
Hogg, N.1
Laschinger, M.2
Giles, K.3
McDowall, A.4
-
82
-
-
4344691642
-
Membranes as messengers in T cell adhesion signaling
-
Dustin, M. L., Bivona, T. G. & Philips, M. R. Membranes as messengers in T cell adhesion signaling. Nature Immunol. 5, 363-372 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 363-372
-
-
Dustin, M.L.1
Bivona, T.G.2
Philips, M.R.3
-
83
-
-
37449033708
-
TcR/CD3 mediated stop-signal is decoupled in T-cells from CTLA-4 deficient mice
-
Downey, J., Smith, A., Schneider, H., Hogg, N. & Rudd, C. E. TcR/CD3 mediated stop-signal is decoupled in T-cells from CTLA-4 deficient mice. Immunol. Lett. 115, 70-72 (2008).
-
(2008)
Immunol. Lett
, vol.115
, pp. 70-72
-
-
Downey, J.1
Smith, A.2
Schneider, H.3
Hogg, N.4
Rudd, C.E.5
-
84
-
-
34848831575
-
The b7 family and cancer therapy: Costimulation and coinhibition
-
Zang, X. & Allison, J. P. The b7 family and cancer therapy: costimulation and coinhibition. Clin. Cancer Res. 13, 5271-5279 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 5271-5279
-
-
Zang, X.1
Allison, J.P.2
-
85
-
-
21244437086
-
-
Chikuma, S., Abbas, A. K. & Bluestone, J. A. B7-independent inhibition of T cells by CTLA-4. J. Immunol. 175, 177-181 (2005).
-
Chikuma, S., Abbas, A. K. & Bluestone, J. A. B7-independent inhibition of T cells by CTLA-4. J. Immunol. 175, 177-181 (2005).
-
-
-
-
86
-
-
4444288465
-
Stop and go traffic to tune T cell responses
-
Dustin, M. L. Stop and go traffic to tune T cell responses. Immunity 21, 305-314 (2004).
-
(2004)
Immunity
, vol.21
, pp. 305-314
-
-
Dustin, M.L.1
|