CTLA-4 trafficking and surface expression

Trends in Immunology

Volumn 29, Issue 6, 2008, Pages 272-279

  Valk, Elke ^a   Rudd, Christopher E ^a   Schneider, Helga ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; CELL PROTEIN; COMPLEMENTARY DNA; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PHOSPHOLIPASE D; PROTEIN TIRC7; T LYMPHOCYTE RECEPTOR INTERACTING MOLECULE;

ANTIGEN EXPRESSION; AUTOIMMUNITY; CELL SURFACE; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INTERNALIZATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD; GENE EXPRESSION REGULATION; HUMANS; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 44549085250     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2008.02.011     Document Type: Review

References (78)

1. Tivol E.A., et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3 (1995) 541-547
2. Waterhouse P., et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270 (1995) 985-988
3. Chambers C.A., et al. Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity 7 (1997) 885-895
4. Thompson C.B., and Allison J.P. The emerging role of CTLA-4 as an immune attenuator. Immunity 7 (1997) 445-450
5. Fraser J.H., et al. CTLA4 ligation attenuates AP-1, NF-AT and NF-kappaB activity in activated T cells. Eur. J. Immunol. 29 (1999) 838-844
6. Olsson C., et al. CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts. J. Biol. Chem. 274 (1999) 14400-14405
7. Zheng S.G., et al. TGF-β requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J. Immunol. 176 (2006) 3321-3329
8. Chen W., et al. Conversion of peripheral CD4+CD25- naïve T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198 (2003) 1875-1886
9. Chen W., et al. Engagement of cytotoxic T lymphocyte-associated antigen4 (CTLA-4) induces transforming growth factor b (TGF-β) production by murine CD4+ T cells. J. Exp. Med. 188 (1998) 1849-1857
10. Wahl S.M., et al. TGF-β: the perpetrator of immune suppression by regulatory T cells and suicidal T cells. J. Leukoc. Biol. 76 (2004) 15-24
11. Li R., et al. Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25-TGF-β1+ adaptive regulatory T cells. J. Immunol. 179 (2007) 5191-5203
12. Masteller E.L., et al. Structural analysis of CTLA-4 function in vivo. J. Immunol. 164 (2000) 5319-5327
13. Pentcheva-Hoang T., et al. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity 21 (2004) 401-413
14. Chuang E., et al. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity 13 (2000) 313-322
15. Chuang E., et al. Regulation of cytotoxic T lymphocyte-associated molecule-4 by src kinases. J. Immunol. 162 (1999) 1270-1277
16. Cilio C.M., et al. Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes. J. Exp. Med. 188 (1998) 1239-1246
17. Lee K.M., et al. Molecular basis of T cell inactivation by CTLA-4. Science 282 (1998) 2263-2266
18. Marengère L.E., et al. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272 (1996) 1170-1173
19. Chikuma S., et al. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 197 (2003) 129-135
20. Darlington P.J., et al. Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. J. Exp. Med. 195 (2002) 1337-1347
21. Martin M., et al. Cytotoxic T lymphocyte antigen 4 potently inhibits cell surface raft expression in its regulation of T cell function. J. Exp. Med. 194 (2001) 1675-1681
22. Rudd C.E., et al. CTLA-4 negative signaling via lipid rafts: a new perspective. Sci. STKE 2002 (2002) PE18
23. Boasso A., et al. Regulation of indoleamine 2. 3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells. Blood 105 (2004) 1574-1581
24. Fallarino F., et al. Modulation of tryptophan catabolism by regulatory T cells. Nat. Immunol. 4 (2003) 1206-1212
25. Schneider H., et al. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J. Immunol. 169 (2002) 3475-3479
26. Dillon T.J., et al. Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4. Mol. Cell. Biol. 25 (2005) 4117-4128
27. Schneider H., et al. CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 12861-12866
28. Schneider H., et al. Reversal of the TCR stop signal by CTLA-4. Science 313 (2006) 1972-1975
29. Rudd C.E., and Schneider H. Unifying concepts in CD28, ICOS and CTLA-4 co-receptor signalling. Nat. Rev. Immunol. 3 (2003) 544-556
30. Schneider H., et al. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 181 (1995) 351-355
31. Chuang E., et al. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J. Immunol. 159 (1997) 144-151
32. Schneider H., et al. Cytolytic T lymphocyte-associated antigen-4 and the TcRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J. Immunol. 163 (1999) 1868-1879
33. Zhang Y., and Allison J.P. Interaction of CTLA-4 with AP-50, a clathrin-coated pit adaptor protein. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 9273-9278
34. Alegre M.-L., et al. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J. Immunol. 157 (1996) 4762-4770
35. Linsley P.S., et al. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4 (1996) 535-543
36. Maszyna F., et al. Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes. J. Immunol. 171 (2003) 3459-3466
37. Ling V., et al. Complete sequence determination of the mouse and human CTLA-4 gene loci: cross-species DNA sequence similarity beyond exon borders. Genomics 60 (1999) 341-355
38. Miller R.E., et al. Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes. Exp. Hematol. 30 (2002) 738-744
39. Finn P.W., et al. Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability. J. Immunol. 158 (1997) 4074-4081
40. Gibson H.M., et al. Induction of the CTLA-4 gene in human lymphocytes is dependent on NF-AT binding the proximal promoter. J. Immunol. 179 (2007) 3831-3840
41. Teft W.A., et al. A molecular perspective of CTLA-4 function. Annu. Rev. Immunol. 24 (2006) 65-97
42. Lindsten T., et al. Characterization of CTLA-4 structure and expression on human T cells. J. Immunol. 151 (1993) 3489-3499
43. Perkins D., et al. Regulation of CTLA-4 expression during T cell activation. J. Immunol. 156 (1996) 4154-4159
44. Oaks M.K., et al. A native soluble form of CTLA-4. Cell. Immunol. 201 (2000) 144-153
45. Huurman V.A.L., et al. Differential inhibition of autoreactive memory- and alloreactive na•ve T cell responses by soluble cytotoxic T lymphocyte antigen 4 (sCTLA-4), CTLA4Ig and LEA29Y. Clin. Exp. Immunol. 150 (2007) 487-493
46. Wang X.B., et al. Regulation of surface and intracellular expression of CTLA-4 on human peripheral T cells. Scand. J. Immunol. 54 (2001) 453-458
47. Ueda H., et al. Association of the T cell regulatory gene CTLA-4 with susceptibility to autoimmune disease. Nature 423 (2003) 506-511
48. Vijayakrishnan L., et al. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity 20 (2004) 563-575
49. Kristiansen O.P., et al. CTLA-4 in autoimmune diseases-a general susceptibility gene to autoimmunity?. Genes Immun. 1 (2000) 170-184
50. Jago C.B., et al. Differential expression of CTLA-4 among T cell subsets. Clin. Exp. Immunol. 136 (2004) 463-471
51. Takahashi T., et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192 (2000) 303-310
52. Leung H.T., et al. Cytotoxic T lymphocyte-associated molecule-4, a high avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplamic tail. J. Biol. Chem. 270 (1995) 25107-25114
53. Valk E., et al. T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor. Immunity 25 (2006) 807-821
54. Mead K.I., et al. Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells. J. Immunol. 174 (2005) 4803-4811
55. Iida T., et al. Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells. J. Immunol. 165 (2000) 5062-5068
56. Barrat F.J., et al. Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 8645-8650
57. Egen J.G., and Allison J.P. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 16 (2002) 23-35
58. Bradshaw J.D., et al. Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation. Biochemistry 36 (1997) 15975-15982
59. Shiratori T., et al. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 6 (1997) 583-589
60. Oki S., et al. Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4. Int. Immunol. 11 (1999) 1563-1571
61. Cefai D., et al. CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation. J. Immunol. 160 (1998) 2223-2230
62. Joly M., et al. Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. J. Biol. Chem. 270 (1995) 13225-13230
63. Bruyns E., et al. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane. J. Exp. Med. 188 (1998) 561-575
64. Kirchgessner H., et al. The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J. Exp. Med. 193 (2001) 1269-1284
65. Kölsch U., et al. Normal T cell development and immune functions in TRIM-deficient mice. Mol. Cell. Biol. 26 (2006) 3639-3648
66. Zhu M., et al. Negative regulation of lymphocyte activation by the adaptor protein LAX. J. Immunol. 174 (2005) 5612-5619
67. Simeoni L., et al. The transmembrane adapter protein SIT regulates thymic development and peripheral T cell functions. Mol. Cell. Biol. 25 (2005) 7557-7568
68. Utku N., et al. TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response. J. Immunol. 173 (2004) 2342-2352
69. Utku N., et al. Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein. Immunity 9 (1998) 509-518
70. Bulwin G.C., et al. TIRC7 inhibits T cell proliferation by modulation of CTLA-e Expression. J. Immunol. 177 (2006) 6833-6841
71. Béraud-Dufour S., and Balch W. A journey through the exocytic pathway. J. Cell. Sci. 115 (2002) 1779-1780
72. D'Souza-Schorey C., and Chavrier P. ARF proteins: roles in membrane traffic and beyond. Nat. Rev. Mol. Cell Biol. 7 (2006) 347-358
73. Freyberg Z., et al. "Slip, sliding away": phospholipase D and the Golgi apparatus. Trends Cell Biol. 13 (2003) 540-546
74. Wheatley M., and Hawtin S.R. Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role. Hum. Reprod. Update 5 (1999) 356-364
75. Kouki T., et al. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease. J. Immunol. 165 (2000) 6606-6611
76. Mäurer M., et al. A polymorphism in the human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (exon 1+49) alters T cell activation. Immunogenetics 54 (2002) 1-8
77. Anjos S., et al. A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele. J. Biol. Chem. 277 (2002) 46478-46486
78. Bonifacino J.S., and Rojas R. Retrograde transport from endosomes to the trans-Golgi network. Nat. Rev. Mol. Cell Biol. 7 (2006) 568-579