-
2
-
-
0036864649
-
Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions
-
Sancho, D. et al. Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions. Immunol. Rev. 189, 84-97 (2002).
-
(2002)
Immunol. Rev
, vol.189
, pp. 84-97
-
-
Sancho, D.1
-
3
-
-
33645165031
-
Vimentin function in lymphocyte adhesion and transcellular migration
-
Nieminen, M. et al. Vimentin function in lymphocyte adhesion and transcellular migration. Nature Cell Biol. 8, 156-162 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 156-162
-
-
Nieminen, M.1
-
4
-
-
0035335987
-
Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments
-
Brown, M. J., Hallam, J. A., Colucci-Guyon, E. & Shaw, S. Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments. J. Immunol. 166, 6640-6646 (2001).
-
(2001)
J. Immunol
, vol.166
, pp. 6640-6646
-
-
Brown, M.J.1
Hallam, J.A.2
Colucci-Guyon, E.3
Shaw, S.4
-
5
-
-
0035879352
-
-
Brown, M. J., Hallam, J. A., Liu, Y., Yamada, K. M. & Shaw, S. Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin. J. Immunol. 167, 641-645 (2001). References 3, 4 and 5 describe a role for intermediate filaments in leukocyte function, and indicate that vimentin is an important structural component of the cytoskeleton during adhesion and migration.
-
Brown, M. J., Hallam, J. A., Liu, Y., Yamada, K. M. & Shaw, S. Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin. J. Immunol. 167, 641-645 (2001). References 3, 4 and 5 describe a role for intermediate filaments in leukocyte function, and indicate that vimentin is an important structural component of the cytoskeleton during adhesion and migration.
-
-
-
-
6
-
-
0035075507
-
Dynamic actin polymerization drives T cell receptor-induced spreading: A role for the signal transduction adaptor LAT
-
Bunnell, S. C., Kapoor, V., Trible, R. P., Zhang, W. & Samelson, L. E. Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity 14, 315-329 (2001).
-
(2001)
Immunity
, vol.14
, pp. 315-329
-
-
Bunnell, S.C.1
Kapoor, V.2
Trible, R.P.3
Zhang, W.4
Samelson, L.E.5
-
7
-
-
0042931251
-
Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization
-
Tskvitaria-Fuller, I., Rozelle, A. L., Yin, H. L. & Wulfing, C. Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization. J. Immunol. 171, 2287-2295 (2003).
-
(2003)
J. Immunol
, vol.171
, pp. 2287-2295
-
-
Tskvitaria-Fuller, I.1
Rozelle, A.L.2
Yin, H.L.3
Wulfing, C.4
-
8
-
-
0028961573
-
Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton
-
Valitutti, S., Dessing, M., Aktories, K., Gallati, H. & Lanzavecchia, A. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181, 577-584 (1995).
-
(1995)
J. Exp. Med
, vol.181
, pp. 577-584
-
-
Valitutti, S.1
Dessing, M.2
Aktories, K.3
Gallati, H.4
Lanzavecchia, A.5
-
9
-
-
0021714772
-
Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells
-
Kupfer, A. & Dennert, G. Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells. J. Immunol. 133, 2762-6 (1984).
-
(1984)
J. Immunol
, vol.133
, pp. 2762-2766
-
-
Kupfer, A.1
Dennert, G.2
-
10
-
-
0023266351
-
The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells
-
Kupfer, A., Swain, S. L. & Singer, S. J. The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells. J. Exp. Med. 165, 1565-1580 (1987).
-
(1987)
J. Exp. Med
, vol.165
, pp. 1565-1580
-
-
Kupfer, A.1
Swain, S.L.2
Singer, S.J.3
-
11
-
-
1842836367
-
The distal pole complex: A novel membrane domain distal to the immunological synapse
-
Cullinan, P., Sperling, A. I. & Burkhardt, J. K. The distal pole complex: a novel membrane domain distal to the immunological synapse. Immunol. Rev. 189, 111-122 (2002).
-
(2002)
Immunol. Rev
, vol.189
, pp. 111-122
-
-
Cullinan, P.1
Sperling, A.I.2
Burkhardt, J.K.3
-
12
-
-
0034714184
-
Differential clustering of CD4 and CD3ζ during T cell recognition
-
Krummel, M. F., Sjaastad, M. D., Wulfing, C. & Davis, M. M. Differential clustering of CD4 and CD3ζ during T cell recognition. Science 289, 1349-1352 (2000).
-
(2000)
Science
, vol.289
, pp. 1349-1352
-
-
Krummel, M.F.1
Sjaastad, M.D.2
Wulfing, C.3
Davis, M.M.4
-
13
-
-
33646150237
-
Immune synapses in T-cell activation
-
Cemerski, S. & Shaw, A. Immune synapses in T-cell activation. Curr. Opin. Immunol. 18, 298-304 (2006).
-
(2006)
Curr. Opin. Immunol
, vol.18
, pp. 298-304
-
-
Cemerski, S.1
Shaw, A.2
-
14
-
-
33646137152
-
Immunological synapse and microclusters: The site for recognition and activation of T cells
-
Saito, T. & Yokosuka, T. Immunological synapse and microclusters: the site for recognition and activation of T cells. Curr. Opin. Immunol. 18, 305-313 (2006).
-
(2006)
Curr. Opin. Immunol
, vol.18
, pp. 305-313
-
-
Saito, T.1
Yokosuka, T.2
-
15
-
-
0032480279
-
Three-dimensional segregation of supramolecular activation clusters in T cells
-
Monks, C. R., Freiberg, B. A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82-86 (1998).
-
(1998)
Nature
, vol.395
, pp. 82-86
-
-
Monks, C.R.1
Freiberg, B.A.2
Kupfer, H.3
Sciaky, N.4
Kupfer, A.5
-
16
-
-
0037167816
-
Direct observation of ligand recognition by T cells
-
Irvine, D. J., Purbhoo, M. A., Krogsgaard, M. & Davis, M. M. Direct observation of ligand recognition by T cells. Nature 419, 845-849 (2002).
-
(2002)
Nature
, vol.419
, pp. 845-849
-
-
Irvine, D.J.1
Purbhoo, M.A.2
Krogsgaard, M.3
Davis, M.M.4
-
17
-
-
33645288264
-
Lipid rafts in lymphocyte activation and migration
-
Manes, S. & Viola, A. Lipid rafts in lymphocyte activation and migration. Mol. Membr. Biol. 23, 59-69 (2006).
-
(2006)
Mol. Membr. Biol
, vol.23
, pp. 59-69
-
-
Manes, S.1
Viola, A.2
-
18
-
-
33750130964
-
Lipid rafts: Now you see them, now you don't
-
Shaw, A. S. Lipid rafts: now you see them, now you don't. Nature Immunol. 7, 1139-1142 (2006).
-
(2006)
Nature Immunol
, vol.7
, pp. 1139-1142
-
-
Shaw, A.S.1
-
19
-
-
27844473354
-
A dynamic view of the immunological synapse
-
Dustin, M. L. A dynamic view of the immunological synapse. Semin. Immunol. 17, 400-410 (2005).
-
(2005)
Semin. Immunol
, vol.17
, pp. 400-410
-
-
Dustin, M.L.1
-
20
-
-
0035655587
-
The immunological synapse of CTL contains a secretory domain and membrane bridges
-
Stinchcombe, J. C., Bossi, G., Booth, S. & Griffiths, G. M. The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity 15, 751-761 (2001).
-
(2001)
Immunity
, vol.15
, pp. 751-761
-
-
Stinchcombe, J.C.1
Bossi, G.2
Booth, S.3
Griffiths, G.M.4
-
21
-
-
33749185296
-
Centrosome polarization delivers secretory granules to the immunological synapse
-
Stinchcombe, J. C., Majorovits, E., Bossi, G., Fuller, S. & Griffiths, G. M. Centrosome polarization delivers secretory granules to the immunological synapse. Nature 443, 462-465 (2006).
-
(2006)
Nature
, vol.443
, pp. 462-465
-
-
Stinchcombe, J.C.1
Majorovits, E.2
Bossi, G.3
Fuller, S.4
Griffiths, G.M.5
-
22
-
-
33746011209
-
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
-
Varma, R., Campi, G., Yokosuka, T., Saito, T. & Dustin, M. L. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 25, 117-127 (2006).
-
(2006)
Immunity
, vol.25
, pp. 117-127
-
-
Varma, R.1
Campi, G.2
Yokosuka, T.3
Saito, T.4
Dustin, M.L.5
-
23
-
-
0032568580
-
Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels
-
Wulfing, C., Sjaastad, M. D. & Davis, M. M. Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. Proc. Natl Acad. Sci. USA 95, 6302-6307 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 6302-6307
-
-
Wulfing, C.1
Sjaastad, M.D.2
Davis, M.M.3
-
24
-
-
0037144842
-
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
-
Bunnell, S. C. et al. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J. Cell Biol. 158, 1263-1275 (2002).
-
(2002)
J. Cell Biol
, vol.158
, pp. 1263-1275
-
-
Bunnell, S.C.1
-
25
-
-
0037069370
-
Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation
-
Moss, W. C., Irvine, D. J., Davis, M. M. & Krummel, M. F. Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation. Proc. Natl Acad. Sci. USA 99, 15024-15029 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 15024-15029
-
-
Moss, W.C.1
Irvine, D.J.2
Davis, M.M.3
Krummel, M.F.4
-
26
-
-
0034026493
-
Searching for significance in TCR-cytoskeleton interactions
-
Caplan, S. & Baniyash, M. Searching for significance in TCR-cytoskeleton interactions. Immunol. Today 21, 223-228 (2000).
-
(2000)
Immunol. Today
, vol.21
, pp. 223-228
-
-
Caplan, S.1
Baniyash, M.2
-
27
-
-
0028851581
-
Tyrosine-phosphorylated T cell receptor ζ-chain associates with the actin cytoskeleton upon activation of mature T lymphocytes
-
Rozdzial, M. M., Malissen, B. & Finkel, T. H. Tyrosine-phosphorylated T cell receptor ζ-chain associates with the actin cytoskeleton upon activation of mature T lymphocytes. Immunity 3, 623-633 (1995).
-
(1995)
Immunity
, vol.3
, pp. 623-633
-
-
Rozdzial, M.M.1
Malissen, B.2
Finkel, T.H.3
-
28
-
-
0037564489
-
The Wiskott-Aldrich syndrome protein: Forging the link between actin and cell activation
-
Badour, K., Zhang, J. & Siminovitch, K. A. The Wiskott-Aldrich syndrome protein: forging the link between actin and cell activation. Immunol. Rev. 192, 98-112 (2003).
-
(2003)
Immunol. Rev
, vol.192
, pp. 98-112
-
-
Badour, K.1
Zhang, J.2
Siminovitch, K.A.3
-
29
-
-
27544441784
-
-
Campi, G., Varma, R. & Dustin, M. L. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J. Exp. Med. 202, 1031-1036 (2005). This paper, along with references 22 and 80, describes the formation of dynamic and highly motile TCR microclusters at the periphery of the cSMAC, and indicate that they serve as platforms for active signalling during TCR-peptide-MHC interaction. Surprisingly, TCR microclusters move towards the cSMAC from the periphery, and TCR microclusters within the cSMAC were shown not to be associated with signalling molecules, which supports the possibility that the cSMAC is involved in receptor internalization and signal attenuation.
-
Campi, G., Varma, R. & Dustin, M. L. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J. Exp. Med. 202, 1031-1036 (2005). This paper, along with references 22 and 80, describes the formation of dynamic and highly motile TCR microclusters at the periphery of the cSMAC, and indicate that they serve as platforms for active signalling during TCR-peptide-MHC interaction. Surprisingly, TCR microclusters move towards the cSMAC from the periphery, and TCR microclusters within the cSMAC were shown not to be associated with signalling molecules, which supports the possibility that the cSMAC is involved in receptor internalization and signal attenuation.
-
-
-
-
30
-
-
0036631548
-
VAV proteins as signal integrators for multi-subunit immune-recognition receptors
-
Turner, M. & Billadeau, D. D. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nature Rev. Immunol. 2, 476-486 (2002).
-
(2002)
Nature Rev. Immunol
, vol.2
, pp. 476-486
-
-
Turner, M.1
Billadeau, D.D.2
-
31
-
-
0034730182
-
The VAV exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface
-
Wulfing, C., Bauch, A., Crabtree, G. R. & Davis, M. M. The VAV exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface. Proc. Natl Acad. Sci. USA 97, 10150-10155 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 10150-10155
-
-
Wulfing, C.1
Bauch, A.2
Crabtree, G.R.3
Davis, M.M.4
-
32
-
-
21844450244
-
-
Kinashi, T. Intracellular signalling controlling integrin activation in lymphocytes. Nature Rev. Immunol. 5, 546-559 (2005). Provides an in-depth analysis of many of the current paradigms involved with inside-out signalling leading to integrin activation in lymphocytes.
-
Kinashi, T. Intracellular signalling controlling integrin activation in lymphocytes. Nature Rev. Immunol. 5, 546-559 (2005). Provides an in-depth analysis of many of the current paradigms involved with inside-out signalling leading to integrin activation in lymphocytes.
-
-
-
-
33
-
-
0035889958
-
Superantigen-induced T cell: B cell conjugation is mediated by LFA-1 and requires signaling through LCK, but not ZAP-70
-
Morgan, M. M. et al. Superantigen-induced T cell: B cell conjugation is mediated by LFA-1 and requires signaling through LCK, but not ZAP-70. J. Immunol. 167, 5708-5718 (2001).
-
(2001)
J. Immunol
, vol.167
, pp. 5708-5718
-
-
Morgan, M.M.1
-
34
-
-
19944431032
-
Kinase-independent functions for ITK in TCR-induced regulation of VAV and the actin cytoskeleton
-
Dombroski, D. et al. Kinase-independent functions for ITK in TCR-induced regulation of VAV and the actin cytoskeleton. J. Immunol. 174, 1385-1392 (2005).
-
(2005)
J. Immunol
, vol.174
, pp. 1385-1392
-
-
Dombroski, D.1
-
35
-
-
10744228513
-
ITK functions to control actin polymerization at the immune synapse through localized activation of CDC42 and WASP
-
Labno, C. M. et al. ITK functions to control actin polymerization at the immune synapse through localized activation of CDC42 and WASP. Curr. Biol. 13, 1619-1624 (2003).
-
(2003)
Curr. Biol
, vol.13
, pp. 1619-1624
-
-
Labno, C.M.1
-
36
-
-
0032211713
-
Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76
-
Bubeck Wardenburg, J. et al. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity 9, 607-616 (1998).
-
(1998)
Immunity
, vol.9
, pp. 607-616
-
-
Bubeck Wardenburg, J.1
-
37
-
-
0041845112
-
SLP-76 coordinates NCK-dependent Wiskott-Aldrich syndrome protein recruitment with VAV-1/CDC42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site
-
Zeng, R. et al. SLP-76 coordinates NCK-dependent Wiskott-Aldrich syndrome protein recruitment with VAV-1/CDC42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J. Immunol. 171, 1360-1368 (2003).
-
(2003)
J. Immunol
, vol.171
, pp. 1360-1368
-
-
Zeng, R.1
-
38
-
-
0036198683
-
WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation
-
Anton, I. M. et al. WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity 16, 193-204 (2002).
-
(2002)
Immunity
, vol.16
, pp. 193-204
-
-
Anton, I.M.1
-
39
-
-
0037241232
-
The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse
-
Badour, K. et al. The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. Immunity 18, 141-154 (2003).
-
(2003)
Immunity
, vol.18
, pp. 141-154
-
-
Badour, K.1
-
40
-
-
18844449626
-
VAV-family proteins in T-cell signalling
-
Tybulewicz, V. L. VAV-family proteins in T-cell signalling. Curr. Opin. Immunol. 17, 267-274 (2005).
-
(2005)
Curr. Opin. Immunol
, vol.17
, pp. 267-274
-
-
Tybulewicz, V.L.1
-
41
-
-
33744981370
-
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse
-
Gomez, T. S. et al. HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity 24, 741-752 (2006).
-
(2006)
Immunity
, vol.24
, pp. 741-752
-
-
Gomez, T.S.1
-
42
-
-
33749533257
-
Regulation of cytoskeletal dynamics at the immune synapse: New stars join the actin troupe
-
Billadeau, D. D. & Burkhardt, J. K. Regulation of cytoskeletal dynamics at the immune synapse: new stars join the actin troupe. Traffic 7, 1451-1460 (2006).
-
(2006)
Traffic
, vol.7
, pp. 1451-1460
-
-
Billadeau, D.D.1
Burkhardt, J.K.2
-
43
-
-
33646864565
-
Staying in shape with formins
-
Faix, J. & Grosse, R. Staying in shape with formins. Dev. Cell 10, 693-706 (2006).
-
(2006)
Dev. Cell
, vol.10
, pp. 693-706
-
-
Faix, J.1
Grosse, R.2
-
44
-
-
0037351084
-
VAV1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse
-
Ardouin, L. et al. VAV1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse. Eur. J. Immunol. 33, 790-797 (2003).
-
(2003)
Eur. J. Immunol
, vol.33
, pp. 790-797
-
-
Ardouin, L.1
-
45
-
-
0037092038
-
Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K- and VAV-dependent pathway, but does not absolutely require phospholipase C
-
Villalba, M. et al. Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K- and VAV-dependent pathway, but does not absolutely require phospholipase C. J. Cell Biol. 157, 253-263 (2002).
-
(2002)
J. Cell Biol
, vol.157
, pp. 253-263
-
-
Villalba, M.1
-
46
-
-
0035851918
-
VAV1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells
-
Villalba, M. et al. VAV1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. J. Cell Biol. 155, 331-338 (2001).
-
(2001)
J. Cell Biol
, vol.155
, pp. 331-338
-
-
Villalba, M.1
-
47
-
-
1542377326
-
ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation
-
Faure, S. et al. ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation. Nature Immunol. 5, 272-279 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 272-279
-
-
Faure, S.1
-
48
-
-
32844474692
-
Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling
-
Charrin, S. & Alcover, A. Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling. Front. Biosci. 11, 1987-1997 (2006).
-
(2006)
Front. Biosci
, vol.11
, pp. 1987-1997
-
-
Charrin, S.1
Alcover, A.2
-
49
-
-
0035654721
-
The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation
-
Roumier, A. et al. The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. Immunity 15, 715-728 (2001).
-
(2001)
Immunity
, vol.15
, pp. 715-728
-
-
Roumier, A.1
-
50
-
-
33746215226
-
Specific patterns of CDC42 activity are related to distinct elements of T cell polarization
-
Tskvitaria-Fuller, I. et al. Specific patterns of CDC42 activity are related to distinct elements of T cell polarization. J. Immunol. 177, 1708-1720 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 1708-1720
-
-
Tskvitaria-Fuller, I.1
-
51
-
-
3242762840
-
Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production
-
Cannon, J. L. & Burkhardt, J. K. Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production. J. Immunol. 173, 1658-1662 (2004).
-
(2004)
J. Immunol
, vol.173
, pp. 1658-1662
-
-
Cannon, J.L.1
Burkhardt, J.K.2
-
52
-
-
0036199184
-
VAV1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells
-
Krawczyk, C. et al. VAV1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16, 331-343 (2002).
-
(2002)
Immunity
, vol.16
, pp. 331-343
-
-
Krawczyk, C.1
-
53
-
-
30044446991
-
-
Nolz, J. C. et al. The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr. Biol. 16, 24-34 (2006). Using RNAi and Abi1/Abi2-knockout mice, this article and reference 55 were the first to characterize the function of the WAVE2 complex in T cells.
-
Nolz, J. C. et al. The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr. Biol. 16, 24-34 (2006). Using RNAi and Abi1/Abi2-knockout mice, this article and reference 55 were the first to characterize the function of the WAVE2 complex in T cells.
-
-
-
-
54
-
-
0033230229
-
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes
-
Zhang, J. et al. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J. Exp. Med. 190, 1329-1342 (1999).
-
(1999)
J. Exp. Med
, vol.190
, pp. 1329-1342
-
-
Zhang, J.1
-
55
-
-
30044438580
-
Role for the ABI/WAVE protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling
-
Zipfel, P. A. et al. Role for the ABI/WAVE protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. Curr. Biol. 16, 35-46 (2006).
-
(2006)
Curr. Biol
, vol.16
, pp. 35-46
-
-
Zipfel, P.A.1
-
56
-
-
20144372910
-
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
-
Gomez, T. S. et al. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nature Immunol. 6, 261-270 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 261-270
-
-
Gomez, T.S.1
-
57
-
-
21044451441
-
-
Su, I. H. et al. Polycomb group protein EZH2 controls actin polymerization and cell signaling. Cell 121, 425-436 (2005). This study indicates that cytosolic EZH2 methyltransferase complexes associate with VAV1 and control receptor-induced actin polymerization in a methylation-dependent manner in T cells, indicating that lysine methylation of some actin regulators might be crucial for actin remodelling.
-
Su, I. H. et al. Polycomb group protein EZH2 controls actin polymerization and cell signaling. Cell 121, 425-436 (2005). This study indicates that cytosolic EZH2 methyltransferase complexes associate with VAV1 and control receptor-induced actin polymerization in a methylation-dependent manner in T cells, indicating that lysine methylation of some actin regulators might be crucial for actin remodelling.
-
-
-
-
58
-
-
23344447783
-
HIP-55 is important for T-cell proliferation, cytokine production, and immune responses
-
Han, J. et al. HIP-55 is important for T-cell proliferation, cytokine production, and immune responses. Mol. Cell. Biol. 25, 6869-6878 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 6869-6878
-
-
Han, J.1
-
59
-
-
2442461214
-
Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis
-
Le Bras, S. et al. Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. J. Biol. Chem. 279, 15550-15560 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 15550-15560
-
-
Le Bras, S.1
-
60
-
-
13644268540
-
DLGH1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells
-
Round, J. L. et al. DLGH1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells. J. Exp. Med. 201, 419-430 (2005).
-
(2005)
J. Exp. Med
, vol.201
, pp. 419-430
-
-
Round, J.L.1
-
61
-
-
20444445916
-
-
Ludford-Menting, M. J. et al. A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity 22, 737-748 (2005). This article provides evidence that protein complexes previously shown to regulate polarity in epithelial cells are also present in T cells, and have a fundamental role in T-cell polarization.
-
Ludford-Menting, M. J. et al. A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity 22, 737-748 (2005). This article provides evidence that protein complexes previously shown to regulate polarity in epithelial cells are also present in T cells, and have a fundamental role in T-cell polarization.
-
-
-
-
62
-
-
12344272845
-
Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton
-
Barda-Saad, M. et al. Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nature Immunol. 6, 80-89 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 80-89
-
-
Barda-Saad, M.1
-
63
-
-
33747106194
-
-
Foger, N., Rangell, L., Danilenko, D. M. & Chan, A. C. Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science 313, 839-142 (2006). This is the first study characterizing T cells from coronin-1-deficient mice, indicating that coronin-1 inhibits ARP2/3-driven actin polymerization leading to defects in migration and cell survival.
-
Foger, N., Rangell, L., Danilenko, D. M. & Chan, A. C. Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science 313, 839-142 (2006). This is the first study characterizing T cells from coronin-1-deficient mice, indicating that coronin-1 inhibits ARP2/3-driven actin polymerization leading to defects in migration and cell survival.
-
-
-
-
64
-
-
1242341975
-
Cofilin peptide homologs interfere with immunological synapse formation and T cell activation
-
Eibert, S. M. et al. Cofilin peptide homologs interfere with immunological synapse formation and T cell activation. Proc. Natl Acad. Sci. USA 101, 1957-1962 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 1957-1962
-
-
Eibert, S.M.1
-
65
-
-
27544502276
-
Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration
-
Nishita, M. et al. Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. J. Cell Biol. 171, 349-359 (2005).
-
(2005)
J. Cell Biol
, vol.171
, pp. 349-359
-
-
Nishita, M.1
-
66
-
-
9744264059
-
Gelsolin superfamily proteins: Key regulators of cellular functions
-
Silacci, P. et al. Gelsolin superfamily proteins: key regulators of cellular functions. Cell. Mol. Life Sci. 61, 2614-2623 (2004).
-
(2004)
Cell. Mol. Life Sci
, vol.61
, pp. 2614-2623
-
-
Silacci, P.1
-
67
-
-
0020365635
-
Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells
-
Geiger, B., Rosen, D. & Berke, G. Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells. J. Cell Biol. 95, 137-143 (1982).
-
(1982)
J. Cell Biol
, vol.95
, pp. 137-143
-
-
Geiger, B.1
Rosen, D.2
Berke, G.3
-
68
-
-
0036166541
-
Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing
-
Kuhn, J. R. & Poenie, M. Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. Immunity 16, 111-121 (2002).
-
(2002)
Immunity
, vol.16
, pp. 111-121
-
-
Kuhn, J.R.1
Poenie, M.2
-
69
-
-
0038445896
-
Linker for activation of T cells, ζ-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization
-
Kuhne, M. R. et al. Linker for activation of T cells, ζ-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. J. Immunol. 171, 860-866 (2003).
-
(2003)
J. Immunol
, vol.171
, pp. 860-866
-
-
Kuhne, M.R.1
-
70
-
-
0032559586
-
Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism
-
Lowin-Kropf, B., Shapiro, V. S. & Weiss, A. Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism. J. Cell Biol. 140, 861-871 (1998).
-
(1998)
J. Cell Biol
, vol.140
, pp. 861-871
-
-
Lowin-Kropf, B.1
Shapiro, V.S.2
Weiss, A.3
-
71
-
-
33646038284
-
Role of FYN in the rearrangement of tubulin cytoskeleton induced through TCR
-
Martin-Cofreces, N. B. et al. Role of FYN in the rearrangement of tubulin cytoskeleton induced through TCR. J. Immunol. 176, 4201-4207 (2006).
-
(2006)
J. Immunol
, vol.176
, pp. 4201-4207
-
-
Martin-Cofreces, N.B.1
-
72
-
-
0029008280
-
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42
-
Stowers, L., Yelon, D., Berg, L. J. & Chant, J. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc. Natl Acad. Sci. USA 92, 5027-5031 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5027-5031
-
-
Stowers, L.1
Yelon, D.2
Berg, L.J.3
Chant, J.4
-
73
-
-
0025978984
-
Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells
-
Kupfer, A., Mosmann, T. R. & Kupfer, H. Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc. Natl Acad. Sci. USA 88, 775-779 (1991).
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 775-779
-
-
Kupfer, A.1
Mosmann, T.R.2
Kupfer, H.3
-
74
-
-
0035313266
-
Cutting edge: In vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells
-
Reichert, P., Reinhardt, R. L., Ingulli, E. & Jenkins, M. K. Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells. J. Immunol. 166, 4278-4281 (2001).
-
(2001)
J. Immunol
, vol.166
, pp. 4278-4281
-
-
Reichert, P.1
Reinhardt, R.L.2
Ingulli, E.3
Jenkins, M.K.4
-
75
-
-
0345257150
-
Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold
-
Faroudi, M. et al. Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold. Proc. Natl Acad. Sci. USA 100, 14145-14150 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 14145-14150
-
-
Faroudi, M.1
-
76
-
-
33749533276
-
Recruitment of dynein to the Jurkat immunological synapse
-
Combs, J. et al. Recruitment of dynein to the Jurkat immunological synapse. Proc. Natl Acad. Sci. USA 103, 14883-14888 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 14883-14888
-
-
Combs, J.1
-
77
-
-
1842684989
-
-
Serrador, J. M. et al. HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization. Immunity 20, 417-428 (2004). This paper shows that HDAC6 is activated downstream of the TCR and is essential for MTOC polarity and immunological-synapse formation through its effects on microtubule stability.
-
Serrador, J. M. et al. HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization. Immunity 20, 417-428 (2004). This paper shows that HDAC6 is activated downstream of the TCR and is essential for MTOC polarity and immunological-synapse formation through its effects on microtubule stability.
-
-
-
-
78
-
-
0033538574
-
The immunological synapse: A molecular machine controlling T cell activation
-
Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221-227 (1999).
-
(1999)
Science
, vol.285
, pp. 221-227
-
-
Grakoui, A.1
-
79
-
-
25444486136
-
-
Shen, A., Puente, L. G. & Ostergaard, H. L. Tyrosine kinase activity and remodelling of the actin cytoskeleton are co-temporally required for degranulation by cytotoxic T lymphocytes. Immunology 116, 276-286 (2005). This study shows that continuous actin polymerization and depolymerization is required for ongoing tyrosine kinase activity, which leads to degranulation by CTLs.
-
Shen, A., Puente, L. G. & Ostergaard, H. L. Tyrosine kinase activity and remodelling of the actin cytoskeleton are co-temporally required for degranulation by cytotoxic T lymphocytes. Immunology 116, 276-286 (2005). This study shows that continuous actin polymerization and depolymerization is required for ongoing tyrosine kinase activity, which leads to degranulation by CTLs.
-
-
-
-
80
-
-
30044441433
-
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of ZAP70 and SLP-76
-
Yokosuka, T. et al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of ZAP70 and SLP-76. Nature Immunol. 6, 1253-1262 (2005).
-
(2005)
Nature Immunol
, vol.6
, pp. 1253-1262
-
-
Yokosuka, T.1
-
81
-
-
0242497659
-
The immunological synapse balances T cell receptor signaling and degradation
-
Lee, K. H. et al. The immunological synapse balances T cell receptor signaling and degradation. Science 302, 1218-1222 (2003).
-
(2003)
Science
, vol.302
, pp. 1218-1222
-
-
Lee, K.H.1
-
82
-
-
85117737468
-
-
Paccani, S. R. et al. Defective VAV expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects. Blood 106, 626-634 (2005). Describes a subset of T-cell defective patients with CVID whose syndrome is caused by the loss of expression of the RHO-family GEF and adaptor molecule VAV1. Patients showed loss of TCR-induced cell signalling, F-actin reorganization and upregulation of the lipid-raft constituent GM1 following TCR-CD28 engagement.
-
Paccani, S. R. et al. Defective VAV expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects. Blood 106, 626-634 (2005). Describes a subset of T-cell defective patients with CVID whose syndrome is caused by the loss of expression of the RHO-family GEF and adaptor molecule VAV1. Patients showed loss of TCR-induced cell signalling, F-actin reorganization and upregulation of the lipid-raft constituent GM1 following TCR-CD28 engagement.
-
-
-
-
83
-
-
0032981244
-
The Rho-family GTP exchange factor VAV is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways
-
Costello, P. S. et al. The Rho-family GTP exchange factor VAV is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways. Proc. Natl Acad. Sci. USA 96, 3035-3040 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 3035-3040
-
-
Costello, P.S.1
-
84
-
-
33845981504
-
VAV1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation
-
Miletic, A. V. et al. VAV1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation. J. Biol. Chem. 281, 38257-38265 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 38257-38265
-
-
Miletic, A.V.1
-
85
-
-
0037029653
-
VAV1 transduces T cell receptor signals to the activation of phospholipase C-γ via phosphoinositide 3-kinase-dependent and -independent pathways
-
Reynolds, L. F. et al. VAV1 transduces T cell receptor signals to the activation of phospholipase C-γ via phosphoinositide 3-kinase-dependent and -independent pathways. J. Exp. Med. 195, 1103-1114 (2002).
-
(2002)
J. Exp. Med
, vol.195
, pp. 1103-1114
-
-
Reynolds, L.F.1
-
86
-
-
0024443411
-
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
-
Dustin, M. L. & Springer, T. A. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341, 619-624 (1989).
-
(1989)
Nature
, vol.341
, pp. 619-624
-
-
Dustin, M.L.1
Springer, T.A.2
-
87
-
-
3342901590
-
VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses
-
Mittelbrunn, M. et al. VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses. Proc. Natl Acad. Sci. USA 101, 11058-11063 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 11058-11063
-
-
Mittelbrunn, M.1
-
88
-
-
2142659430
-
Control of TCR-mediated activation of β1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein
-
Goda, S., Quale, A. C., Woods, M. L., Felthauser, A. & Shimizu, Y. Control of TCR-mediated activation of β1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein. J. Immunol. 172, 5379-5387 (2004).
-
(2004)
J. Immunol
, vol.172
, pp. 5379-5387
-
-
Goda, S.1
Quale, A.C.2
Woods, M.L.3
Felthauser, A.4
Shimizu, Y.5
-
89
-
-
1642482866
-
RAP1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-γ1
-
Katagiri, K., Shimonaka, M. & Kinashi, T. RAP1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-γ1. J. Biol. Chem. 279, 11875-11881 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 11875-11881
-
-
Katagiri, K.1
Shimonaka, M.2
Kinashi, T.3
-
90
-
-
0035868761
-
A novel function for the TEC family tyrosine kinase ITK in activation of β1 integrins by the T-cell receptor
-
Woods, M. L. et al. A novel function for the TEC family tyrosine kinase ITK in activation of β1 integrins by the T-cell receptor. EMBO J. 20, 1232-1244 (2001).
-
(2001)
EMBO J
, vol.20
, pp. 1232-1244
-
-
Woods, M.L.1
-
91
-
-
27144446657
-
TEC kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion
-
Finkelstein, L. D., Shimizu, Y. & Schwartzberg, P. L. TEC kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion. J. Immunol. 175, 5923-5930 (2005).
-
(2005)
J. Immunol
, vol.175
, pp. 5923-5930
-
-
Finkelstein, L.D.1
Shimizu, Y.2
Schwartzberg, P.L.3
-
92
-
-
13144259727
-
VAV is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
-
Fischer, K. D. et al. VAV is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol. 8, 554-562 (1998).
-
(1998)
Curr. Biol
, vol.8
, pp. 554-562
-
-
Fischer, K.D.1
-
93
-
-
17144392216
-
TEC-family kinases: Regulators of T-helper-cell differentiation
-
Schwartzberg, P. L., Finkelstein, L. D. & Readinger, J. A. TEC-family kinases: regulators of T-helper-cell differentiation. Nature Rev. Immunol. 5, 284-295 (2005).
-
(2005)
Nature Rev. Immunol
, vol.5
, pp. 284-295
-
-
Schwartzberg, P.L.1
Finkelstein, L.D.2
Readinger, J.A.3
-
94
-
-
0030812812
-
Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated RAP1
-
Boussiotis, V. A., Freeman, G. J., Berezovskaya, A., Barber, D. L. & Nadler, L. M. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated RAP1. Science 278, 124-128 (1997).
-
(1997)
Science
, vol.278
, pp. 124-128
-
-
Boussiotis, V.A.1
Freeman, G.J.2
Berezovskaya, A.3
Barber, D.L.4
Nadler, L.M.5
-
95
-
-
0036009116
-
RAP1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling
-
Sebzda, E., Bracke, M., Tugal, T., Hogg, N. & Cantrell, D. A. RAP1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling. Nature Immunol. 3, 251-258 (2002).
-
(2002)
Nature Immunol
, vol.3
, pp. 251-258
-
-
Sebzda, E.1
Bracke, M.2
Tugal, T.3
Hogg, N.4
Cantrell, D.A.5
-
96
-
-
30644470778
-
RAP1A-deficient T and B cells show impaired integrin-mediated cell adhesion
-
Duchniewicz, M. et al. RAP1A-deficient T and B cells show impaired integrin-mediated cell adhesion. Mol. Cell. Biol. 26, 643-653 (2006).
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 643-653
-
-
Duchniewicz, M.1
-
97
-
-
0037592093
-
Negative regulation of T cell antigen receptor-mediated CRK-L-C3G signaling and cell adhesion by CBL-B
-
Zhang, W. et al. Negative regulation of T cell antigen receptor-mediated CRK-L-C3G signaling and cell adhesion by CBL-B. J. Biol. Chem. 278, 23978-23983 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 23978-23983
-
-
Zhang, W.1
-
98
-
-
0242335092
-
T cell development and function in CRKL-deficient mice
-
Peterson, A. C., Marks, R. E., Fields, P. E., Imamoto, A. & Gajewski, T. F. T cell development and function in CRKL-deficient mice. Eur. J. Immunol. 33, 2687-2695 (2003).
-
(2003)
Eur. J. Immunol
, vol.33
, pp. 2687-2695
-
-
Peterson, A.C.1
Marks, R.E.2
Fields, P.E.3
Imamoto, A.4
Gajewski, T.F.5
-
99
-
-
0042490495
-
RAPL, a RAP1-binding molecule that mediates RAP1-induced adhesion through spatial regulation of LFA-1
-
Katagiri, K., Maeda, A., Shimonaka, M. & Kinashi, T. RAPL, a RAP1-binding molecule that mediates RAP1-induced adhesion through spatial regulation of LFA-1. Nature Immunol. 4, 741-748 (2003).
-
(2003)
Nature Immunol
, vol.4
, pp. 741-748
-
-
Katagiri, K.1
Maeda, A.2
Shimonaka, M.3
Kinashi, T.4
-
100
-
-
33747623042
-
-
Katagiri, K., Imamura, M. & Kinashi, T. Spatiotemporal regulation of the kinase MST1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nature Immunol. 7, 919-928 (2006). This report identifies the serine/threonine kinase MST1 as a RAP1/RAPL effector and shows the importance of this protein in regulating TCR-mediated integrin activation.
-
Katagiri, K., Imamura, M. & Kinashi, T. Spatiotemporal regulation of the kinase MST1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nature Immunol. 7, 919-928 (2006). This report identifies the serine/threonine kinase MST1 as a RAP1/RAPL effector and shows the importance of this protein in regulating TCR-mediated integrin activation.
-
-
-
-
101
-
-
23844509495
-
Protein kinase D1 and the β1 integrin cytoplasmic domain control β1 integrin function via regulation of RAP1 activation
-
Medeiros, R. B. et al. Protein kinase D1 and the β1 integrin cytoplasmic domain control β1 integrin function via regulation of RAP1 activation. Immunity 23, 213-226 (2005).
-
(2005)
Immunity
, vol.23
, pp. 213-226
-
-
Medeiros, R.B.1
-
102
-
-
5044241734
-
RIAM, an Ena/VASP and Profilin ligand, interacts with RAP1-GTP and mediates RAP1-induced adhesion
-
Lafuente, E. M. et al. RIAM, an Ena/VASP and Profilin ligand, interacts with RAP1-GTP and mediates RAP1-induced adhesion. Dev. Cell 7, 585-595 (2004).
-
(2004)
Dev. Cell
, vol.7
, pp. 585-595
-
-
Lafuente, E.M.1
-
103
-
-
33748454742
-
Reconstructing and deconstructing agonist-induced activation of integrin αIIbβ3
-
Han, J. et al. Reconstructing and deconstructing agonist-induced activation of integrin αIIbβ3. Curr. Biol. 16, 1796-1806 (2006).
-
(2006)
Curr. Biol
, vol.16
, pp. 1796-1806
-
-
Han, J.1
-
104
-
-
0037385961
-
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates
-
Wang, H. et al. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nature Immunol. 4, 366-374 (2003).
-
(2003)
Nature Immunol
, vol.4
, pp. 366-374
-
-
Wang, H.1
-
105
-
-
0035929128
-
Positive regulation of T cell activation and integrin adhesion by the adapter FYB/SLAP
-
Griffiths, E. K. et al. Positive regulation of T cell activation and integrin adhesion by the adapter FYB/SLAP. Science 293, 2260-2263 (2001).
-
(2001)
Science
, vol.293
, pp. 2260-2263
-
-
Griffiths, E.K.1
-
106
-
-
0035929222
-
Coupling of the TCR to integrin activation by SLAP-130/FYB
-
Peterson, E. J. et al. Coupling of the TCR to integrin activation by SLAP-130/FYB. Science 293, 2263-2265 (2001).
-
(2001)
Science
, vol.293
, pp. 2263-2265
-
-
Peterson, E.J.1
-
107
-
-
33749172382
-
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of RAP1
-
Kliche, S. et al. The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of RAP1. Mol. Cell. Biol. 26, 7130-7144 (2006).
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 7130-7144
-
-
Kliche, S.1
-
108
-
-
0032475935
-
Molecular interaction between the FYN-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130
-
Marie-Cardine, A. et al. Molecular interaction between the FYN-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. J. Biol. Chem. 273, 25789-25795 (1998).
-
(1998)
J. Biol. Chem
, vol.273
, pp. 25789-25795
-
-
Marie-Cardine, A.1
-
109
-
-
0032555211
-
FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells
-
Liu, J. et al. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. Proc. Natl Acad. Sci. USA 95, 8779-8784 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 8779-8784
-
-
Liu, J.1
-
110
-
-
21244492894
-
Deficiency of ADAP/FYB/SLAP-130 destabilizes SKAP55 in Jurkat T cells
-
Huang, Y. et al. Deficiency of ADAP/FYB/SLAP-130 destabilizes SKAP55 in Jurkat T cells. J. Biol. Chem. 280, 23576-23583 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23576-23583
-
-
Huang, Y.1
-
111
-
-
0034599541
-
FYN-binding protein (FYB)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
-
Krause, M. et al. FYN-binding protein (FYB)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J. Cell Biol. 149, 181-194 (2000).
-
(2000)
J. Cell Biol
, vol.149
, pp. 181-194
-
-
Krause, M.1
-
112
-
-
33751578411
-
Talin1 regulates TCR-mediated LFA-1 function
-
Simonson, W. T., Franco, S. J. & Huttenlocher, A. Talin1 regulates TCR-mediated LFA-1 function. J. Immunol. 177, 7707-7714 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 7707-7714
-
-
Simonson, W.T.1
Franco, S.J.2
Huttenlocher, A.3
-
113
-
-
33846031421
-
Actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T cell activation
-
Suzuki, J. I., Yamasaki, S., Wu, J., Koretzky, G. A. & Saito, T. Actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T cell activation. Blood 109, 168-175 (2006).
-
(2006)
Blood
, vol.109
, pp. 168-175
-
-
Suzuki, J.I.1
Yamasaki, S.2
Wu, J.3
Koretzky, G.A.4
Saito, T.5
-
114
-
-
0034755942
-
Molecular complexity and dynamics of cell-matrix adhesions
-
Zamir, E. & Geiger, B. Molecular complexity and dynamics of cell-matrix adhesions. J. Cell Sci. 114, 3583-3590 (2001).
-
(2001)
J. Cell Sci
, vol.114
, pp. 3583-3590
-
-
Zamir, E.1
Geiger, B.2
-
115
-
-
28844490120
-
Genetic, biochemical and structural approaches to talin function
-
Critchley, D. R. Genetic, biochemical and structural approaches to talin function. Biochem. Soc. Trans. 33, 1308-1312 (2005).
-
(2005)
Biochem. Soc. Trans
, vol.33
, pp. 1308-1312
-
-
Critchley, D.R.1
-
116
-
-
0033962672
-
Focal adhesions - the cytoskeletal connection
-
Critchley, D. R. Focal adhesions - the cytoskeletal connection. Curr. Opin. Cell Biol. 12, 133-139 (2000).
-
(2000)
Curr. Opin. Cell Biol
, vol.12
, pp. 133-139
-
-
Critchley, D.R.1
-
117
-
-
0037049555
-
Recruitment of the ARP2/3 complex to vinculin: Coupling membrane protrusion to matrix adhesion
-
DeMali, K. A., Barlow, C. A. & Burridge, K. Recruitment of the ARP2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J. Cell Biol. 159, 881-891 (2002).
-
(2002)
J. Cell Biol
, vol.159
, pp. 881-891
-
-
DeMali, K.A.1
Barlow, C.A.2
Burridge, K.3
-
118
-
-
0030669961
-
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of CRK-associated substrates
-
Tachibana, K. et al. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of CRK-associated substrates. J. Biol. Chem. 272, 29083-29090 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 29083-29090
-
-
Tachibana, K.1
-
119
-
-
0842281489
-
Multiple connections link FAK to cell motility and invasion
-
Schlaepfer, D. D. & Mitra, S. K. Multiple connections link FAK to cell motility and invasion. Curr. Opin. Genet. Dev. 14, 92-101 (2004).
-
(2004)
Curr. Opin. Genet. Dev
, vol.14
, pp. 92-101
-
-
Schlaepfer, D.D.1
Mitra, S.K.2
-
120
-
-
0037509990
-
Focal adhesion kinase: The first ten years
-
Parsons, J. T. Focal adhesion kinase: the first ten years. J. Cell Sci. 116, 1409-1416 (2003).
-
(2003)
J. Cell Sci
, vol.116
, pp. 1409-1416
-
-
Parsons, J.T.1
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