Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy

Journal of Experimental Medicine

Volumn 183, Issue 4, 1996, Pages 1917-1921

  Valitutti, Salvatore ^a   Müller, Sabina ^a   Dessing, Mark ^a   Lanzavecchia, Antonio ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RESPONSE; ANTIGEN DETECTION; ANTIGEN PRESENTATION; ARTICLE; CALCIUM TRANSPORT; CELL KILLING; CELL MATURATION; CELL PROLIFERATION; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR OCCUPANCY;

CALCIUM; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; ORTHOMYXOVIRIDAE; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER; VIRAL MATRIX PROTEINS;

EID: 0030002902     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.4.1917     Document Type: Article

References (15)

1. Doherty, P.C., W. Allan, and M. Eichelberger. 1992. Role of αβ and γδ T cell subsets in viral immunity. Annu. Rev. Immunol. 10:123-151.
2. De Bruijn, M.L.H., T.N.M. Schumacher, J.D. Nicland, H.L. Ploegh, W.M. Kast, and C.J.M. Melief. 1991. Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses. Eur. J. Immunol. 21:2963-2970.
3. d-restricted cytotoxic T lymphocytes. J. Exp. Med. 173:849-858.
4. + cytotoxic T lymphocytes by dendritic cells. J. Exp. Med. 166:182-194.
5. De Bruijn, M.L.H., J.D. Nieland, T.N.M. Schumacher, H.L. Ploegh, W.M. Kast, and C.J.M. Melief. 1992. Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses. Eur. J. Immunol. 22:3013-3020.
6. + T-cell-deficient mice. J. Virol. 68:4700-4704.
7. von Boehmer, H., and W. Haas. 1979. Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen. J. Exp. Med. 150:1134-1142.
8. + helper cell requirement in cytotoxic T lymphocyte responses. Eur. J. Immunol. 18:219-223.
9. Kageyama, S., T.J. Tsomides, Y. Sykulev, and H.N. Eisen. 1995. Variation in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses. J. Immunol 154:567-576.
10. Demotz, S., H.M. Grey, and A. Sette. 1990. The minimal number of class II MHC-antigen complexes needed for T cell activation. Science (Wash. DC). 249:1028-1030.
11. Harding, C.V., and E.R. Unanue. 1990. Qnantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature (Lond.). 346:574-576.
12. Valitutti, S., S. Müller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature (Lond.). 375:148-151.
13. Gotch, F., A. McMichael, and J. Rothbard. 1988. Recognition of influenza A matrix protein by HLA-A2-restricted cytotoxic T lymphocytes. Use of analogues to orientate the matrix peptide in the HLA-A2 binding site. J. Exp. Med. 168: 2045-2057.
14. Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181:577-584.
15. Moskophidis, D., F. Lechner, H. Pircher, and R.M. Zinkernagel. 1993. Virus persistence in acutely infected immuno-competent mice by exhaustion of antiviral cytotoxic. effector T cells. Nature (Lond.). 362:758-761.