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Volumn 34, Issue 3, 2013, Pages 228-252

Somatostatin receptors: From signaling to clinical practice

Author keywords

Dopastatin; MTOR; Neuroendocrine tumor; Octreotide; Pasireotide; Pituitary; Proliferation; Signal transduction; Somatostatin; Somatostatin receptors

Indexed keywords

ANGIOPEPTIN; ANTIMITOTIC AGENT; BIM 23 A 387; DOPASTATIN; OCTREOTIDE; PASIREOTIDE; SOMATOPRIM; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 84881316730     PISSN: 00913022     EISSN: 10956808     Source Type: Journal    
DOI: 10.1016/j.yfrne.2013.07.005     Document Type: Review
Times cited : (309)

References (436)
  • 3
    • 0019726089 scopus 로고
    • Somatostatin modulates effects of angiotensin II in adrenal glomerulosa zone
    • Aguilera G., Harwood J.P., Catt K.J. Somatostatin modulates effects of angiotensin II in adrenal glomerulosa zone. Nature 1981, 292:262-263.
    • (1981) Nature , vol.292 , pp. 262-263
    • Aguilera, G.1    Harwood, J.P.2    Catt, K.J.3
  • 10
    • 72549097292 scopus 로고    scopus 로고
    • From somatostatin to octreotide LAR: evolution of a somatostatin analogue
    • Anthony L., Freda P.U. From somatostatin to octreotide LAR: evolution of a somatostatin analogue. Curr. Med. Res. Opin. 2009, 25:2989-2999.
    • (2009) Curr. Med. Res. Opin. , vol.25 , pp. 2989-2999
    • Anthony, L.1    Freda, P.U.2
  • 11
    • 34250349188 scopus 로고    scopus 로고
    • Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?
    • Antunes P., Ginj M., Zhang H., Waser B., Baum R.P., Reubi J.C., Maecke H. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?. Eur. J. Nucl. Med. Mol. Imag. 2007, 34:982-993.
    • (2007) Eur. J. Nucl. Med. Mol. Imag. , vol.34 , pp. 982-993
    • Antunes, P.1    Ginj, M.2    Zhang, H.3    Waser, B.4    Baum, R.P.5    Reubi, J.C.6    Maecke, H.7
  • 13
    • 11244289595 scopus 로고    scopus 로고
    • Somatostatin receptor subtype-dependent regulation of nitric oxide release: involvement of different intracellular pathways
    • Arena S., Pattarozzi A., Corsaro A., Schettini G., Florio T. Somatostatin receptor subtype-dependent regulation of nitric oxide release: involvement of different intracellular pathways. Mol. Endocrinol. 2005, 19:255-267.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 255-267
    • Arena, S.1    Pattarozzi, A.2    Corsaro, A.3    Schettini, G.4    Florio, T.5
  • 14
    • 33845969497 scopus 로고    scopus 로고
    • An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phosphotyrosine phosphatase eta
    • Arena S., Pattarozzi A., Massa A., Esteve J.P., Iuliano R., Fusco A., Susini C., Florio T. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phosphotyrosine phosphatase eta. Mol. Endocrinol. 2007, 21:229-246.
    • (2007) Mol. Endocrinol. , vol.21 , pp. 229-246
    • Arena, S.1    Pattarozzi, A.2    Massa, A.3    Esteve, J.P.4    Iuliano, R.5    Fusco, A.6    Susini, C.7    Florio, T.8
  • 17
    • 2342542391 scopus 로고    scopus 로고
    • Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery and/or radiotherapy
    • Ayuk J., Stewart S.E., Stewart P.M., Sheppard M.C. Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery and/or radiotherapy. Clin. Endocrinol. 2004, 60:375-381.
    • (2004) Clin. Endocrinol. , vol.60 , pp. 375-381
    • Ayuk, J.1    Stewart, S.E.2    Stewart, P.M.3    Sheppard, M.C.4
  • 18
    • 53049104806 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1
    • Azar R., Najib S., Lahlou H., Susini C., Pyronnet S. Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1. Cell. Mol. Life Sci. 2008, 65:3110-3117.
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 3110-3117
    • Azar, R.1    Najib, S.2    Lahlou, H.3    Susini, C.4    Pyronnet, S.5
  • 19
    • 0037080274 scopus 로고    scopus 로고
    • A randomized, multicenter prospective trial assessing long-acting release octreotide pamoate plus tamoxifen as a first line therapy for advanced breast carcinoma
    • Bajetta E., Procopio G., Ferrari L., Martinetti A., Zilembo N., Catena L., Alu M., la Torre S., Alberti D., Buzzoni R. A randomized, multicenter prospective trial assessing long-acting release octreotide pamoate plus tamoxifen as a first line therapy for advanced breast carcinoma. Cancer 2002, 94:299-304.
    • (2002) Cancer , vol.94 , pp. 299-304
    • Bajetta, E.1    Procopio, G.2    Ferrari, L.3    Martinetti, A.4    Zilembo, N.5    Catena, L.6    Alu, M.7    la Torre, S.8    Alberti, D.9    Buzzoni, R.10
  • 22
    • 50449108845 scopus 로고    scopus 로고
    • Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2
    • Barbieri F., Pattarozzi A., Gatti M., Porcile C., Bajetto A., Ferrari A., Culler M.D., Florio T. Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2. Endocrinology 2008, 149:4736-4746.
    • (2008) Endocrinology , vol.149 , pp. 4736-4746
    • Barbieri, F.1    Pattarozzi, A.2    Gatti, M.3    Porcile, C.4    Bajetto, A.5    Ferrari, A.6    Culler, M.D.7    Florio, T.8
  • 25
    • 0033322617 scopus 로고    scopus 로고
    • Impact of gsp oncogene on the expression of genes coding for G(s)alpha, Pit-1, G(i)2 alpha, and somatostatin receptor 2 in human somatotroph adenomas: involvement in octreotide sensitivity
    • Barlier A., Pellegrini-Bouiller I., Gunz G., Zamora A.J., Jaquet P., Enjalbert A. Impact of gsp oncogene on the expression of genes coding for G(s)alpha, Pit-1, G(i)2 alpha, and somatostatin receptor 2 in human somatotroph adenomas: involvement in octreotide sensitivity. J. Clin. Endocrinol. Metabol. 1999, 84:2759-2765.
    • (1999) J. Clin. Endocrinol. Metabol. , vol.84 , pp. 2759-2765
    • Barlier, A.1    Pellegrini-Bouiller, I.2    Gunz, G.3    Zamora, A.J.4    Jaquet, P.5    Enjalbert, A.6
  • 29
    • 0034254910 scopus 로고    scopus 로고
    • Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238
    • Benali N., Cordelier P., Calise D., Pages P., Rochaix P., Nagy A., Esteve J.P., Pour P.M., Schally A.V., Vaysse N., Susini C., Buscail L. Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:9180-9185.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 9180-9185
    • Benali, N.1    Cordelier, P.2    Calise, D.3    Pages, P.4    Rochaix, P.5    Nagy, A.6    Esteve, J.P.7    Pour, P.M.8    Schally, A.V.9    Vaysse, N.10    Susini, C.11    Buscail, L.12
  • 30
    • 52249106448 scopus 로고    scopus 로고
    • Closo-borane conjugated regulatory peptides retain high biological affinity: synthesis of closo-borane conjugated Tyr(3)-octreotate derivatives for BNCT
    • Betzel T., Hess T., Waser B., Reubi J.C., Roesch F. Closo-borane conjugated regulatory peptides retain high biological affinity: synthesis of closo-borane conjugated Tyr(3)-octreotate derivatives for BNCT. Bioconjug. Chem. 2008, 19:1796-1802.
    • (2008) Bioconjug. Chem. , vol.19 , pp. 1796-1802
    • Betzel, T.1    Hess, T.2    Waser, B.3    Reubi, J.C.4    Roesch, F.5
  • 31
    • 15944427116 scopus 로고    scopus 로고
    • Clinical review: the antitumoral effects of somatostatin analog therapy in acromegaly
    • Bevan J.S. Clinical review: the antitumoral effects of somatostatin analog therapy in acromegaly. J. Clin. Endocrinol. Metabol. 2005, 90:1856-1863.
    • (2005) J. Clin. Endocrinol. Metabol. , vol.90 , pp. 1856-1863
    • Bevan, J.S.1
  • 34
    • 27544470454 scopus 로고    scopus 로고
    • The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly
    • Bhayana S., Booth G.L., Asa S.L., Kovacs K., Ezzat S. The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly. J. Clin. Endocrinol. Metabol. 2005, 90:6290-6295.
    • (2005) J. Clin. Endocrinol. Metabol. , vol.90 , pp. 6290-6295
    • Bhayana, S.1    Booth, G.L.2    Asa, S.L.3    Kovacs, K.4    Ezzat, S.5
  • 35
    • 0028336973 scopus 로고
    • Functional coupling of Sstr4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release, and activation of the mitogen-activated protein kinase cascade
    • Bito H., Mori M., Sakanaka C., Takano T., Honda Z., Gotoh Y., Nishida E., Shimizu T. Functional coupling of Sstr4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release, and activation of the mitogen-activated protein kinase cascade. J. Biol. Chem. 1994, 269:12722-12730.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12722-12730
    • Bito, H.1    Mori, M.2    Sakanaka, C.3    Takano, T.4    Honda, Z.5    Gotoh, Y.6    Nishida, E.7    Shimizu, T.8
  • 36
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: a target for cancer therapy
    • Bjornsti M.A., Houghton P.J. The TOR pathway: a target for cancer therapy. Nat. Rev. Cancer 2004, 4:335-348.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 40
    • 0022623967 scopus 로고
    • Treatment of inoperable glucagonoma with the long-acting somatostatin analog SMS 201-995
    • Boden G., Ryan I.G., Eisenschmid B.L., Shelmet J.J., Owen O.E. Treatment of inoperable glucagonoma with the long-acting somatostatin analog SMS 201-995. N. Eng. J. Med. 1986, 314:1686-1689.
    • (1986) N. Eng. J. Med. , vol.314 , pp. 1686-1689
    • Boden, G.1    Ryan, I.G.2    Eisenschmid, B.L.3    Shelmet, J.J.4    Owen, O.E.5
  • 41
    • 0016764748 scopus 로고
    • Somatostatin suppresses secretin and pancreatic exocrine secretion
    • Boden G., Sivitz M.C., Owen O.E., Essakoumar N., Landor J.H. Somatostatin suppresses secretin and pancreatic exocrine secretion. Science 1975, 190:163-165.
    • (1975) Science , vol.190 , pp. 163-165
    • Boden, G.1    Sivitz, M.C.2    Owen, O.E.3    Essakoumar, N.4    Landor, J.H.5
  • 43
    • 84867396388 scopus 로고    scopus 로고
    • Long-term treatment of Cushing's disease with pasireotide (SOM230): results from a Phase II extension study
    • (abst P1-274)
    • Boscaro M., Zhang Y., Sen K., Maldonado M., Schoenherr U., Findling J.W. Long-term treatment of Cushing's disease with pasireotide (SOM230): results from a Phase II extension study. Endocr. Rev. 2010, 31(3 Suppl. 1):S333. (abst P1-274).
    • (2010) Endocr. Rev. , vol.31 , Issue.3 SUPPL. 1
    • Boscaro, M.1    Zhang, Y.2    Sen, K.3    Maldonado, M.4    Schoenherr, U.5    Findling, J.W.6
  • 45
    • 0035084694 scopus 로고    scopus 로고
    • Antiproliferative effect of somatostatin and analogs
    • Bousquet C., Puente E., Buscail L., Vaysse N., Susini C. Antiproliferative effect of somatostatin and analogs. Chemotherapy 2001, 47(Suppl. 2):30-39.
    • (2001) Chemotherapy , vol.47 , Issue.SUPPL. 2 , pp. 30-39
    • Bousquet, C.1    Puente, E.2    Buscail, L.3    Vaysse, N.4    Susini, C.5
  • 47
    • 0015914428 scopus 로고
    • Hypothalamic polypeptide that inhibits secretion of immunoreactive pituitary growth hormone
    • Brazeau P., Vale W., Burgus R., Ling N., Butcher M., Rivier J., Guillemin R. Hypothalamic polypeptide that inhibits secretion of immunoreactive pituitary growth hormone. Science 1973, 179:77-79.
    • (1973) Science , vol.179 , pp. 77-79
    • Brazeau, P.1    Vale, W.2    Burgus, R.3    Ling, N.4    Butcher, M.5    Rivier, J.6    Guillemin, R.7
  • 48
    • 84870356552 scopus 로고    scopus 로고
    • Pasireotide LAR is significantly more effective than octreotide LAR at providing biochemical control in patients with acromegaly: results of a 12-month randomized, double-blind, multicenter, Phase III study
    • (abst OR49-3)
    • Bronstein M.D., Sheppard M., Freda P., Gu F., Shen C., Gadelha M., Fleseriu M., Hermosillo-Resendiz K., Ruffin M., Chen Y., Colao A. Pasireotide LAR is significantly more effective than octreotide LAR at providing biochemical control in patients with acromegaly: results of a 12-month randomized, double-blind, multicenter, Phase III study. Endocr. Rev. 2012, 33. (abst OR49-3).
    • (2012) Endocr. Rev. , vol.33
    • Bronstein, M.D.1    Sheppard, M.2    Freda, P.3    Gu, F.4    Shen, C.5    Gadelha, M.6    Fleseriu, M.7    Hermosillo-Resendiz, K.8    Ruffin, M.9    Chen, Y.10    Colao, A.11
  • 49
    • 0019464004 scopus 로고
    • Somatostatin-28 selective action on the pancreatic beta-cell and brain
    • Brown M., Rivier J., Vale W. Somatostatin-28 selective action on the pancreatic beta-cell and brain. Endocrinology 1981, 108:2391-2393.
    • (1981) Endocrinology , vol.108 , pp. 2391-2393
    • Brown, M.1    Rivier, J.2    Vale, W.3
  • 50
    • 0026453393 scopus 로고
    • Molecular-cloning and functional expression of a brain-specific somatostatin receptor
    • Bruno J.F., Xu Y., Song J.F., Berelowitz M. Molecular-cloning and functional expression of a brain-specific somatostatin receptor. Proc. Nal. Acad. Sci. U.S.A. 1992, 89:11151-11155.
    • (1992) Proc. Nal. Acad. Sci. U.S.A. , vol.89 , pp. 11151-11155
    • Bruno, J.F.1    Xu, Y.2    Song, J.F.3    Berelowitz, M.4
  • 52
    • 0036111856 scopus 로고    scopus 로고
    • SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile
    • Bruns C., Lewis I., Briner U., Meno-Tetang G., Weckbecker G. SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile. Eur. J. Endocrinol. 2002, 146:707-716.
    • (2002) Eur. J. Endocrinol. , vol.146 , pp. 707-716
    • Bruns, C.1    Lewis, I.2    Briner, U.3    Meno-Tetang, G.4    Weckbecker, G.5
  • 53
    • 84881314169 scopus 로고    scopus 로고
    • Clinical presentation and response to somatostatin analogue treatment - importance of immunohistochemical granulation pattern and presence of somatostatin receptor subtype 2A in growth hormone secreting adenomas
    • Brzana J., Yedinak C., Gultekin S., Delashaw J., Fleseriu M. Clinical presentation and response to somatostatin analogue treatment - importance of immunohistochemical granulation pattern and presence of somatostatin receptor subtype 2A in growth hormone secreting adenomas. J. Invest. Med. 2012, 60:178.
    • (2012) J. Invest. Med. , vol.60 , pp. 178
    • Brzana, J.1    Yedinak, C.2    Gultekin, S.3    Delashaw, J.4    Fleseriu, M.5
  • 54
    • 0037047302 scopus 로고    scopus 로고
    • Somatostatin, acting at receptor subtype 1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration
    • Buchan A.M.J., Lin C.Y., Choi J., Barber D.L. Somatostatin, acting at receptor subtype 1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration. J. Biol. Chem. 2002, 277:28431-28438.
    • (2002) J. Biol. Chem. , vol.277 , pp. 28431-28438
    • Buchan, A.M.J.1    Lin, C.Y.2    Choi, J.3    Barber, D.L.4
  • 60
    • 0030592830 scopus 로고    scopus 로고
    • A somatostatin analogue inhibits MAP kinase activation and cell proliferation in human neuroblastoma and in human small cell lung carcinoma cell lines
    • Cattaneo M.G., Amoroso D., Gussoni G., Sanguini A.M., Vicentini L.M. A somatostatin analogue inhibits MAP kinase activation and cell proliferation in human neuroblastoma and in human small cell lung carcinoma cell lines. FEBS Lett. 1996, 397:164-168.
    • (1996) FEBS Lett. , vol.397 , pp. 164-168
    • Cattaneo, M.G.1    Amoroso, D.2    Gussoni, G.3    Sanguini, A.M.4    Vicentini, L.M.5
  • 61
    • 33746878815 scopus 로고    scopus 로고
    • Deregulated human glioma cell motility: inhibitory effect of somatostatin
    • Cattaneo M.G., Gentilini D., Vicentini L.M. Deregulated human glioma cell motility: inhibitory effect of somatostatin. Mol. Cell. Endocrinol. 2006, 256:34-39.
    • (2006) Mol. Cell. Endocrinol. , vol.256 , pp. 34-39
    • Cattaneo, M.G.1    Gentilini, D.2    Vicentini, L.M.3
  • 64
    • 83755161916 scopus 로고    scopus 로고
    • Evaluation of 177Lu-DOTA-sst2 antagonist versus 177Lu-DOTA-sst2 agonist binding in human cancers in vitro
    • Cescato R., Waser B., Fani M., Reubi J.C. Evaluation of 177Lu-DOTA-sst2 antagonist versus 177Lu-DOTA-sst2 agonist binding in human cancers in vitro. J. Nucl. Med. 2011, 52:1886-1890.
    • (2011) J. Nucl. Med. , vol.52 , pp. 1886-1890
    • Cescato, R.1    Waser, B.2    Fani, M.3    Reubi, J.C.4
  • 68
    • 0027376928 scopus 로고
    • Octreotide therapy for thyroid stimulating hormone secreting pituitary adenomas: a follow-up of 52 patients
    • Chanson P., Weintraub B.D., Harris A.G. Octreotide therapy for thyroid stimulating hormone secreting pituitary adenomas: a follow-up of 52 patients. Ann. Intern. Med. 1993, 119:236-240.
    • (1993) Ann. Intern. Med. , vol.119 , pp. 236-240
    • Chanson, P.1    Weintraub, B.D.2    Harris, A.G.3
  • 69
    • 0028982707 scopus 로고
    • Somatostatin-14 and its analog octreotide exert a cytostatic effect on GH3 rat pituitary tumor cell proliferation via a transient G0/G1 cell cycle block
    • Cheung N.W., Boyages S.C. Somatostatin-14 and its analog octreotide exert a cytostatic effect on GH3 rat pituitary tumor cell proliferation via a transient G0/G1 cell cycle block. Endocrinology 1995, 136:4174-4181.
    • (1995) Endocrinology , vol.136 , pp. 4174-4181
    • Cheung, N.W.1    Boyages, S.C.2
  • 74
    • 33644944535 scopus 로고    scopus 로고
    • First-line octreotide-LAR therapy induces tumour shrinkage and controls hormone excess in patients with acromegaly: results from an open, prospective, multicentre trial
    • Colao A., Pivonello R., Rosato F., Tita P., Menis E., Barreca A., Ferrara R., Mainini F., Arosio M., Lombardi G. First-line octreotide-LAR therapy induces tumour shrinkage and controls hormone excess in patients with acromegaly: results from an open, prospective, multicentre trial. Clin. Endocrinol. 2006, 64:342-351.
    • (2006) Clin. Endocrinol. , vol.64 , pp. 342-351
    • Colao, A.1    Pivonello, R.2    Rosato, F.3    Tita, P.4    Menis, E.5    Barreca, A.6    Ferrara, R.7    Mainini, F.8    Arosio, M.9    Lombardi, G.10
  • 75
    • 0035062749 scopus 로고    scopus 로고
    • Somatostatin receptor subtype 2 and 5 in human GH-secreting pituitary adenomas: analysis of gene sequence and mRNA expression
    • Corbetta S., Ballare E., Mantovani G., Lania A., Losa M., Di Blasio A.M., Spada A. Somatostatin receptor subtype 2 and 5 in human GH-secreting pituitary adenomas: analysis of gene sequence and mRNA expression. Eur. J. Clin. Invest. 2001, 31:208-214.
    • (2001) Eur. J. Clin. Invest. , vol.31 , pp. 208-214
    • Corbetta, S.1    Ballare, E.2    Mantovani, G.3    Lania, A.4    Losa, M.5    Di Blasio, A.M.6    Spada, A.7
  • 77
    • 84857376637 scopus 로고    scopus 로고
    • Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP
    • Cordoba-Chacon J., Gahete M.D., Culler M.D., Castano J.P., Kineman R.D., Luque R.M. Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP. J. Neuroendocrinol. 2012, 24:453-463.
    • (2012) J. Neuroendocrinol. , vol.24 , pp. 453-463
    • Cordoba-Chacon, J.1    Gahete, M.D.2    Culler, M.D.3    Castano, J.P.4    Kineman, R.D.5    Luque, R.M.6
  • 78
    • 4143066821 scopus 로고    scopus 로고
    • Cabergoline addition to depot somatostatin analogues in resistant acromegalic patients: efficacy and lack of predictive value of prolactin status
    • Cozzi R., Attanasio R., Lodrini S., Lasio G. Cabergoline addition to depot somatostatin analogues in resistant acromegalic patients: efficacy and lack of predictive value of prolactin status. Clin. Endocrinol. 2004, 61:209-215.
    • (2004) Clin. Endocrinol. , vol.61 , pp. 209-215
    • Cozzi, R.1    Attanasio, R.2    Lodrini, S.3    Lasio, G.4
  • 80
    • 33646022576 scopus 로고    scopus 로고
    • Primary treatment of acromegaly with octreotide LAR: a long-term (up to nine years) prospective study of its efficacy in the control of disease activity and tumor shrinkage
    • Cozzi R., Montini M., Attanasio R., Albizzi M., Lasio G., Lodrini S., Doneda P., Cortesi L., Pagani G. Primary treatment of acromegaly with octreotide LAR: a long-term (up to nine years) prospective study of its efficacy in the control of disease activity and tumor shrinkage. J. Clin. Endocrinol. Metabol. 2006, 91:1397-1403.
    • (2006) J. Clin. Endocrinol. Metabol. , vol.91 , pp. 1397-1403
    • Cozzi, R.1    Montini, M.2    Attanasio, R.3    Albizzi, M.4    Lasio, G.5    Lodrini, S.6    Doneda, P.7    Cortesi, L.8    Pagani, G.9
  • 81
    • 0035920129 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase
    • Cuevas B.D., Lu Y.L., Mao M.L., Zhang J.Y., LaPushin R., Siminovitch K., Mills G.B. Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J. Biol. Chem. 2001, 276:27455-27461.
    • (2001) J. Biol. Chem. , vol.276 , pp. 27455-27461
    • Cuevas, B.D.1    Lu, Y.L.2    Mao, M.L.3    Zhang, J.Y.4    LaPushin, R.5    Siminovitch, K.6    Mills, G.B.7
  • 96
    • 67449168131 scopus 로고    scopus 로고
    • The role(s) of somatostatin, structurally related peptides and somatostatin receptors in the gastrointestinal tract: a review
    • den Bosch J.V., Adriaensen D., Van Nassauw L., Timmermans J.P. The role(s) of somatostatin, structurally related peptides and somatostatin receptors in the gastrointestinal tract: a review. Regul. Pept. 2009, 156:1-8.
    • (2009) Regul. Pept. , vol.156 , pp. 1-8
    • den Bosch, J.V.1    Adriaensen, D.2    Van Nassauw, L.3    Timmermans, J.P.4
  • 99
    • 0016190864 scopus 로고
    • Acute suppression of insulin and glucose levels by synthetic somatostatin in normal human subjects
    • Devane G.W., Siler T.M., Yen S.S.C. Acute suppression of insulin and glucose levels by synthetic somatostatin in normal human subjects. J. Clin. Endocrinol. Metabol. 1974, 38:913-915.
    • (1974) J. Clin. Endocrinol. Metabol. , vol.38 , pp. 913-915
    • Devane, G.W.1    Siler, T.M.2    Yen, S.S.C.3
  • 100
    • 84862091799 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of a single dose of pasireotide long-acting release in healthy volunteers: a single-center Phase I study
    • Dietrich H., Hu K., Ruffin M., Song D., Bouillaud E., Wang Y., Hasskarl J. Safety, tolerability, and pharmacokinetics of a single dose of pasireotide long-acting release in healthy volunteers: a single-center Phase I study. Eur. J. Endocrinol. 2012, 166:821-828.
    • (2012) Eur. J. Endocrinol. , vol.166 , pp. 821-828
    • Dietrich, H.1    Hu, K.2    Ruffin, M.3    Song, D.4    Bouillaud, E.5    Wang, Y.6    Hasskarl, J.7
  • 101
    • 0032934791 scopus 로고    scopus 로고
    • Inhibitory and stimulatory effects of somatostatin on two human pancreatic cancer cell lines: a primary role for tyrosine phosphatase SHP-1
    • Douziech N., Calvo E., Coulombe Z., Muradia G., Bastien J., Aubin R.A., Lajas A., Morisset J. Inhibitory and stimulatory effects of somatostatin on two human pancreatic cancer cell lines: a primary role for tyrosine phosphatase SHP-1. Endocrinology 1999, 140:765-777.
    • (1999) Endocrinology , vol.140 , pp. 765-777
    • Douziech, N.1    Calvo, E.2    Coulombe, Z.3    Muradia, G.4    Bastien, J.5    Aubin, R.A.6    Lajas, A.7    Morisset, J.8
  • 102
    • 0017263797 scopus 로고
    • Characteristics of interaction between thyrotropin releasing hormone and somatostatin for thyrotropin and prolactin release
    • Drouin J., Delean A., Rainville D., Lachance R., Labrie F. Characteristics of interaction between thyrotropin releasing hormone and somatostatin for thyrotropin and prolactin release. Endocrinology 1976, 98:514-521.
    • (1976) Endocrinology , vol.98 , pp. 514-521
    • Drouin, J.1    Delean, A.2    Rainville, D.3    Lachance, R.4    Labrie, F.5
  • 105
    • 0033058738 scopus 로고    scopus 로고
    • Summing up 15 years of somatostatin analog therapy in neuroendocrine tumors: future outlook
    • Eriksson B., Oberg K. Summing up 15 years of somatostatin analog therapy in neuroendocrine tumors: future outlook. Ann. Oncol. 1999, 10:S31-S38.
    • (1999) Ann. Oncol. , vol.10
    • Eriksson, B.1    Oberg, K.2
  • 107
    • 0344132653 scopus 로고    scopus 로고
    • Ultra-high-dose lanreotide treatment in patients with metastatic neuroendocrine gastroenteropancreatic tumors
    • Faiss S., Rath U., Mansmann U., Caird D., Clemens N., Riecken E.O., Wiedenmann B. Ultra-high-dose lanreotide treatment in patients with metastatic neuroendocrine gastroenteropancreatic tumors. Digestion 1999, 60:469-476.
    • (1999) Digestion , vol.60 , pp. 469-476
    • Faiss, S.1    Rath, U.2    Mansmann, U.3    Caird, D.4    Clemens, N.5    Riecken, E.O.6    Wiedenmann, B.7
  • 108
    • 0043132282 scopus 로고    scopus 로고
    • International Lanreotide and Interferon Alfa Study Group. Prospective, randomized, multicenter trial on the antiproliferative effect of lanreotide, interferon alfa, and their combination for therapy of metastatic neuroendocrine gastroenteropancreatic tumors - the International Lanreotide and Interferon Alfa Study Group
    • Faiss S., Pape U.F., Böhmig M., Dörffel Y., Mansmann U., Golder W., Riecken E.O., Wiedenmann B. International Lanreotide and Interferon Alfa Study Group. Prospective, randomized, multicenter trial on the antiproliferative effect of lanreotide, interferon alfa, and their combination for therapy of metastatic neuroendocrine gastroenteropancreatic tumors - the International Lanreotide and Interferon Alfa Study Group. J. Clin. Oncol. 2003, 21:2689-2696.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2689-2696
    • Faiss, S.1    Pape, U.F.2    Böhmig, M.3    Dörffel, Y.4    Mansmann, U.5    Golder, W.6    Riecken, E.O.7    Wiedenmann, B.8
  • 110
    • 78649244235 scopus 로고    scopus 로고
    • Long-term treatment of acromegaly with pasireotide (SOM230): results from a phase II extension study
    • Farrall A.J., Ruffin M., Wetli-Hermosillo K., Petersenn S. Long-term treatment of acromegaly with pasireotide (SOM230): results from a phase II extension study. Endocr. Rev. 2010, 31:S856.
    • (2010) Endocr. Rev. , vol.31
    • Farrall, A.J.1    Ruffin, M.2    Wetli-Hermosillo, K.3    Petersenn, S.4
  • 114
    • 42149145552 scopus 로고    scopus 로고
    • Correlation of in vitro and in vivo somatotropic adenoma responsiveness to somatostatin analogs and dopamine agonists with immunohistochemical evaluation of somatostatin and dopamine receptors and electron microscopy
    • Ferone D., de Herder W.W., Pivonello R., Kros J.M., van Koetsveld P.M., de Jong T., Minuto F., Colao A., Lamberts S.W.J., Hofland L.J. Correlation of in vitro and in vivo somatotropic adenoma responsiveness to somatostatin analogs and dopamine agonists with immunohistochemical evaluation of somatostatin and dopamine receptors and electron microscopy. J. Clin. Endocrinol. Metabol. 2008, 93:1412-1417.
    • (2008) J. Clin. Endocrinol. Metabol. , vol.93 , pp. 1412-1417
    • Ferone, D.1    de Herder, W.W.2    Pivonello, R.3    Kros, J.M.4    van Koetsveld, P.M.5    de Jong, T.6    Minuto, F.7    Colao, A.8    Lamberts, S.W.J.9    Hofland, L.J.10
  • 117
    • 0036015230 scopus 로고    scopus 로고
    • Treatment of malignant endocrine pancreatic tumors with a combination of alpha-interferon and somatostatin analogs
    • Fjallskog M.L., Sundin A., Westlin J.E., Oberg K., Janson E.T., Eriksson B. Treatment of malignant endocrine pancreatic tumors with a combination of alpha-interferon and somatostatin analogs. Med. Oncol. 2002, 19:35-42.
    • (2002) Med. Oncol. , vol.19 , pp. 35-42
    • Fjallskog, M.L.1    Sundin, A.2    Westlin, J.E.3    Oberg, K.4    Janson, E.T.5    Eriksson, B.6
  • 120
    • 0037388747 scopus 로고    scopus 로고
    • Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities
    • Florio T., Morini M., Villa V., Arena S., Corsaro A., Thellung S., Culler M.D., Pfeffer U., Noonan D.M., Schettini G., Albini A. Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities. Endocrinology 2003, 144:1574-1584.
    • (2003) Endocrinology , vol.144 , pp. 1574-1584
    • Florio, T.1    Morini, M.2    Villa, V.3    Arena, S.4    Corsaro, A.5    Thellung, S.6    Culler, M.D.7    Pfeffer, U.8    Noonan, D.M.9    Schettini, G.10    Albini, A.11
  • 121
    • 0028134705 scopus 로고
    • The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells
    • Florio T., Rim C., Hershberger R.E., Loda M., Stork P.J.S. The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells. Mol. Endocrinol. 1994, 8:1289-1297.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1289-1297
    • Florio, T.1    Rim, C.2    Hershberger, R.E.3    Loda, M.4    Stork, P.J.S.5
  • 122
    • 0029658454 scopus 로고    scopus 로고
    • Multiple intracellular effectors modulate physiological functions of the cloned somatostatin receptors
    • Florio T., Schettini G. Multiple intracellular effectors modulate physiological functions of the cloned somatostatin receptors. J. Mol. Endocrinol. 1996, 17:89-100.
    • (1996) J. Mol. Endocrinol. , vol.17 , pp. 89-100
    • Florio, T.1    Schettini, G.2
  • 123
    • 0029939159 scopus 로고    scopus 로고
    • Somatostatin inhibits PC C13 thyroid cell proliferation through the modulation of phosphotyrosine phosphatase activity. Impairment of the somatostatinergic effects by stable expression of E1A viral oncogene
    • Florio T., Scorziello A., Fattore M., Dalto V., Salzano S., Rossi G., Berlingieri M.T., Fusco A., Schettini G. Somatostatin inhibits PC C13 thyroid cell proliferation through the modulation of phosphotyrosine phosphatase activity. Impairment of the somatostatinergic effects by stable expression of E1A viral oncogene. J. Biol. Chem. 1996, 271:6129-6136.
    • (1996) J. Biol. Chem. , vol.271 , pp. 6129-6136
    • Florio, T.1    Scorziello, A.2    Fattore, M.3    Dalto, V.4    Salzano, S.5    Rossi, G.6    Berlingieri, M.T.7    Fusco, A.8    Schettini, G.9
  • 124
    • 0033728783 scopus 로고    scopus 로고
    • Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2
    • Florio T., Thellung S., Arena S., Corsaro A., Bajetto A., Schettini G., Stork P.J.S. Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2. J. Physiol. Paris 2000, 94:239-250.
    • (2000) J. Physiol. Paris , vol.94 , pp. 239-250
    • Florio, T.1    Thellung, S.2    Arena, S.3    Corsaro, A.4    Bajetto, A.5    Schettini, G.6    Stork, P.J.S.7
  • 126
    • 0002709117 scopus 로고    scopus 로고
    • Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1)
    • Florio T., Yao H., Carey K.D., Dillon T.J., Stork P.J.S. Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1). Mol. Endocrinol. 1999, 13:24-37.
    • (1999) Mol. Endocrinol. , vol.13 , pp. 24-37
    • Florio, T.1    Yao, H.2    Carey, K.D.3    Dillon, T.J.4    Stork, P.J.S.5
  • 127
    • 42049083552 scopus 로고    scopus 로고
    • Low levels of Raf kinase inhibitory protein in growth hormone-secreting pituitary adenomas correlate with poor response to octreotide treatment
    • Fougner S.L., Bollerslev J., Latif F., Hald J.K., Lund T., Ramm-Pettersen J., Berg J.P. Low levels of Raf kinase inhibitory protein in growth hormone-secreting pituitary adenomas correlate with poor response to octreotide treatment. J. Clin. Endocrinol. Metabol. 2008, 93:1211-1216.
    • (2008) J. Clin. Endocrinol. Metabol. , vol.93 , pp. 1211-1216
    • Fougner, S.L.1    Bollerslev, J.2    Latif, F.3    Hald, J.K.4    Lund, T.5    Ramm-Pettersen, J.6    Berg, J.P.7
  • 128
    • 83455200225 scopus 로고    scopus 로고
    • Adenoma granulation pattern correlates with clinical variables and effect of somatostatin analogue treatment in a large series of patients with acromegaly
    • Fougner S.L., Casar-Borota O., Heck A., Berg J.P., Bollerslev J. Adenoma granulation pattern correlates with clinical variables and effect of somatostatin analogue treatment in a large series of patients with acromegaly. Clin. Endocrinol. 2012, 76:96-102.
    • (2012) Clin. Endocrinol. , vol.76 , pp. 96-102
    • Fougner, S.L.1    Casar-Borota, O.2    Heck, A.3    Berg, J.P.4    Bollerslev, J.5
  • 129
    • 77952785994 scopus 로고    scopus 로고
    • The expression of E-cadherin in somatotroph pituitary adenomas is related to tumor size, invasiveness, and somatostatin analog response
    • Fougner S.L., Lekva T., Borota O.C., Hald J.K., Bollerslev J., Berg J.P. The expression of E-cadherin in somatotroph pituitary adenomas is related to tumor size, invasiveness, and somatostatin analog response. J. Clin. Endocrinol. Metabol. 2010, 95:2334-2342.
    • (2010) J. Clin. Endocrinol. Metabol. , vol.95 , pp. 2334-2342
    • Fougner, S.L.1    Lekva, T.2    Borota, O.C.3    Hald, J.K.4    Bollerslev, J.5    Berg, J.P.6
  • 130
    • 0033135279 scopus 로고    scopus 로고
    • Combination therapy with octreotide and alpha-interferon: effect on tumor growth in metastatic endocrine gastroenteropancreatic tumors
    • Frank M., Klose K.J., Wied M., Ishaque N., Schade-Brittinger C., Arnold R. Combination therapy with octreotide and alpha-interferon: effect on tumor growth in metastatic endocrine gastroenteropancreatic tumors. Am. J. Gastroenterol. 1999, 94:1381-1387.
    • (1999) Am. J. Gastroenterol. , vol.94 , pp. 1381-1387
    • Frank, M.1    Klose, K.J.2    Wied, M.3    Ishaque, N.4    Schade-Brittinger, C.5    Arnold, R.6
  • 132
    • 0027943354 scopus 로고
    • Somatostatin receptor subtype Sstr2 mediates the inhibition of high voltage activated calcium channels by somatostatin and its analog SMS-201-995
    • Fujii Y., Gonoi T., Yamada Y., Chihara K., Inagaki N., Seino S. Somatostatin receptor subtype Sstr2 mediates the inhibition of high voltage activated calcium channels by somatostatin and its analog SMS-201-995. FEBS Lett. 1994, 355:117-120.
    • (1994) FEBS Lett. , vol.355 , pp. 117-120
    • Fujii, Y.1    Gonoi, T.2    Yamada, Y.3    Chihara, K.4    Inagaki, N.5    Seino, S.6
  • 137
    • 26644444556 scopus 로고    scopus 로고
    • Re-evaluation of the efficacy of the association of cabergoline to somatostatin analogues in acromegalic patients
    • Gatta B., Hau D.H., Catargi B., Roger P., Tabarin A. Re-evaluation of the efficacy of the association of cabergoline to somatostatin analogues in acromegalic patients. Clin. Endocrinol. 2005, 63:477-478.
    • (2005) Clin. Endocrinol. , vol.63 , pp. 477-478
    • Gatta, B.1    Hau, D.H.2    Catargi, B.3    Roger, P.4    Tabarin, A.5
  • 140
    • 0037061645 scopus 로고    scopus 로고
    • Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units
    • Gazal S., Gelerman G., Ziv O., Karpov O., Litman P., Bracha M., Afargan M., Gilon C. Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units. J. Med. Chem. 2002, 45:1665-1671.
    • (2002) J. Med. Chem. , vol.45 , pp. 1665-1671
    • Gazal, S.1    Gelerman, G.2    Ziv, O.3    Karpov, O.4    Litman, P.5    Bracha, M.6    Afargan, M.7    Gilon, C.8
  • 147
    • 0035449109 scopus 로고    scopus 로고
    • Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules
    • Gromada J., Hoy M., Buschard K., Salehi A., Rorsman P. Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. J. Physiol. 2001, 535:519-532.
    • (2001) J. Physiol. , vol.535 , pp. 519-532
    • Gromada, J.1    Hoy, M.2    Buschard, K.3    Salehi, A.4    Rorsman, P.5
  • 148
    • 84865303875 scopus 로고    scopus 로고
    • Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro
    • Gruszka A., Culler M.D., Melmed S. Somatostatin analogs and chimeric somatostatin-dopamine molecules differentially regulate human growth hormone and prolactin gene expression and secretion in vitro. Mol. Cell. Endocrinol. 2012, 362:104-109.
    • (2012) Mol. Cell. Endocrinol. , vol.362 , pp. 104-109
    • Gruszka, A.1    Culler, M.D.2    Melmed, S.3
  • 149
    • 0017054813 scopus 로고
    • Somatostatin inhibits release of acetylcholine induced electrically in myenteric plexus
    • Guillemin R. Somatostatin inhibits release of acetylcholine induced electrically in myenteric plexus. Endocrinology 1976, 99:1653-1654.
    • (1976) Endocrinology , vol.99 , pp. 1653-1654
    • Guillemin, R.1
  • 151
    • 0028350896 scopus 로고
    • Rat somatostatin receptor type-1 couples to G-proteins and inhibition of cyclic-AMP accumulation
    • Hadcock J.R., Strnad J., Eppler C.M. Rat somatostatin receptor type-1 couples to G-proteins and inhibition of cyclic-AMP accumulation. Mol. Pharmacol. 1994, 45:410-416.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 410-416
    • Hadcock, J.R.1    Strnad, J.2    Eppler, C.M.3
  • 153
    • 0020411740 scopus 로고
    • Somatostatin inhibits multi-receptor stimulation of cyclic-AMP formation and corticotropin secretion in mouse pituitary tumor cells
    • Heisler S., Reisine T.D., Hook V.Y.H., Axelrod J. Somatostatin inhibits multi-receptor stimulation of cyclic-AMP formation and corticotropin secretion in mouse pituitary tumor cells. Proc. Natl. Acad. Sci. U.S.A. 1982, 79:6502-6506.
    • (1982) Proc. Natl. Acad. Sci. U.S.A. , vol.79 , pp. 6502-6506
    • Heisler, S.1    Reisine, T.D.2    Hook, V.Y.H.3    Axelrod, J.4
  • 154
    • 0035985284 scopus 로고    scopus 로고
    • The clinical role of somatostatin analogues as antineoplastic agents: much ado about nothing?
    • Hejna M., Schmidinger M., Raderer M. The clinical role of somatostatin analogues as antineoplastic agents: much ado about nothing?. Ann. Oncol. 2002, 13:653-668.
    • (2002) Ann. Oncol. , vol.13 , pp. 653-668
    • Hejna, M.1    Schmidinger, M.2    Raderer, M.3
  • 157
    • 0027457177 scopus 로고
    • Pharmacokinetics and efficacy of a long-acting formulation of the new somatostatin analog BIM-23014 in patients with acromegaly
    • Heron I., Thomas F., Dero M., Gancel A., Ruiz J.M., Schatz B., Kuhn J.M. Pharmacokinetics and efficacy of a long-acting formulation of the new somatostatin analog BIM-23014 in patients with acromegaly. J. Clin. Endocrinol. Metabol. 1993, 76:721-727.
    • (1993) J. Clin. Endocrinol. Metabol. , vol.76 , pp. 721-727
    • Heron, I.1    Thomas, F.2    Dero, M.3    Gancel, A.4    Ruiz, J.M.5    Schatz, B.6    Kuhn, J.M.7
  • 158
    • 0028176917 scopus 로고
    • The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in chinese hamster ovary cells via pertussis toxin sensitive pathways
    • Hershberger R.E., Newman B.L., Florio T., Bunzow J., Civelli O., Li X.J., Forte M., Stork P.J.S. The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in chinese hamster ovary cells via pertussis toxin sensitive pathways. Endocrinology 1994, 134:1277-1285.
    • (1994) Endocrinology , vol.134 , pp. 1277-1285
    • Hershberger, R.E.1    Newman, B.L.2    Florio, T.3    Bunzow, J.4    Civelli, O.5    Li, X.J.6    Forte, M.7    Stork, P.J.S.8
  • 159
  • 161
    • 0037323565 scopus 로고    scopus 로고
    • The pathophysiological consequences of somatostatin receptor internalization and resistance
    • Hofland L.J., Lamberts S.W.J. The pathophysiological consequences of somatostatin receptor internalization and resistance. Endocr. Rev. 2003, 24:28-47.
    • (2003) Endocr. Rev. , vol.24 , pp. 28-47
    • Hofland, L.J.1    Lamberts, S.W.J.2
  • 164
    • 14844346593 scopus 로고    scopus 로고
    • Induction of apoptosis with hybrids of Arg-Gly-Asp molecules and peptides and antimitotic effects of hybrids of cytostatic drugs and peptides
    • Hofland L.J., Capello A., Krenning E.P., de Jong M., van Hagen M.P. Induction of apoptosis with hybrids of Arg-Gly-Asp molecules and peptides and antimitotic effects of hybrids of cytostatic drugs and peptides. J. Nucl. Med. 2005, 46(Suppl. 1):191S-198S.
    • (2005) J. Nucl. Med. , vol.46 , Issue.SUPPL. 1
    • Hofland, L.J.1    Capello, A.2    Krenning, E.P.3    de Jong, M.4    van Hagen, M.P.5
  • 167
    • 0038757751 scopus 로고    scopus 로고
    • Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform - implication of JAK2
    • Hortala M., Ferjoux G., Estival A., Bertrand C., Schulz S., Pradayrol L., Susini C., Clemente F. Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform - implication of JAK2. J. Biol. Chem. 2003, 278:20574-20581.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20574-20581
    • Hortala, M.1    Ferjoux, G.2    Estival, A.3    Bertrand, C.4    Schulz, S.5    Pradayrol, L.6    Susini, C.7    Clemente, F.8
  • 168
    • 0038228812 scopus 로고    scopus 로고
    • Somatostatin receptors
    • Watson, S.P., Girdlestone, D. (Eds.), The IUPHAR Compendium of Receptor Characterization and Classification, second ed.
    • Hoyer, D., Epelbaum, J., Feniuk, W., Humphrey, P.P., Meyerhof, W., O'Carroll, A.M., et al., 2000. Somatostatin receptors. In: Watson, S.P., Girdlestone, D. (Eds.), The IUPHAR Compendium of Receptor Characterization and Classification, second ed.
    • (2000)
    • Hoyer, D.1    Epelbaum, J.2    Feniuk, W.3    Humphrey, P.P.4    Meyerhof, W.5    O'Carroll, A.M.6
  • 169
    • 0028246882 scopus 로고
    • Subtype specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2
    • Hou C.F., Gilbert R.L., Barber D.L. Subtype specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2. J. Biol. Chem. 1994, 269:10357-10362.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10357-10362
    • Hou, C.F.1    Gilbert, R.L.2    Barber, D.L.3
  • 170
    • 79959208861 scopus 로고    scopus 로고
    • Response, survival, and long-term toxicity after therapy with the radiolabeled somatostatin analogue [90Y-DOTA]-TOC in metastasized neuroendocrine cancers
    • Imhof A., Brunner P., Marincek N., Briel M., Schindler C., Rasch H., Mäcke H.R., Rochlitz C., Müller-Brand J., Walter M.A. Response, survival, and long-term toxicity after therapy with the radiolabeled somatostatin analogue [90Y-DOTA]-TOC in metastasized neuroendocrine cancers. J. Clin. Oncol. 2011, 29:2416-2423.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2416-2423
    • Imhof, A.1    Brunner, P.2    Marincek, N.3    Briel, M.4    Schindler, C.5    Rasch, H.6    Mäcke, H.R.7    Rochlitz, C.8    Müller-Brand, J.9    Walter, M.A.10
  • 172
    • 0020527915 scopus 로고
    • A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells
    • Jakobs K.H., Aktories K., Schultz G. A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells. Nature 1983, 303:177-178.
    • (1983) Nature , vol.303 , pp. 177-178
    • Jakobs, K.H.1    Aktories, K.2    Schultz, G.3
  • 173
    • 0032100585 scopus 로고    scopus 로고
    • Determination of somatostatin receptor subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies
    • Janson E.T., Stridsberg M., Gobl A., Westlin J.E., Oberg K. Determination of somatostatin receptor subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies. Cancer Res. 1998, 58:2375-2378.
    • (1998) Cancer Res. , vol.58 , pp. 2375-2378
    • Janson, E.T.1    Stridsberg, M.2    Gobl, A.3    Westlin, J.E.4    Oberg, K.5
  • 174
    • 22744440925 scopus 로고    scopus 로고
    • Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy
    • Jaquet P., Gunz G., Saveanu A., Dufour H., Taylor J., Dong J., Kim S., Moreau J.P., Enjalbert A., Culler M.D. Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy. Eur. J. Endocrinol. 2005, 153:135-141.
    • (2005) Eur. J. Endocrinol. , vol.153 , pp. 135-141
    • Jaquet, P.1    Gunz, G.2    Saveanu, A.3    Dufour, H.4    Taylor, J.5    Dong, J.6    Kim, S.7    Moreau, J.P.8    Enjalbert, A.9    Culler, M.D.10
  • 176
    • 0028296575 scopus 로고
    • Pharmacokinetics and efficacy of the long-acting somatostatin analog somatuline in acromegaly
    • Johnson M.R., Chowdrey H.S., Thomas F., Grint C., Lightman S.L. Pharmacokinetics and efficacy of the long-acting somatostatin analog somatuline in acromegaly. Eur. J. Endocrinol. 1994, 130:229-234.
    • (1994) Eur. J. Endocrinol. , vol.130 , pp. 229-234
    • Johnson, M.R.1    Chowdrey, H.S.2    Thomas, F.3    Grint, C.4    Lightman, S.L.5
  • 179
    • 29144441277 scopus 로고    scopus 로고
    • Treatment of advanced neuroendocrine tumours with radiolabelled somatostatin analogues
    • Kaltsas G.A., Papadogias D., Makras P., Grossman A.B. Treatment of advanced neuroendocrine tumours with radiolabelled somatostatin analogues. Endocr. Relat. Cancer 2005, 12:683-699.
    • (2005) Endocr. Relat. Cancer , vol.12 , pp. 683-699
    • Kaltsas, G.A.1    Papadogias, D.2    Makras, P.3    Grossman, A.B.4
  • 181
    • 0029789246 scopus 로고    scopus 로고
    • The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells
    • Keane M.M., Lowrey G.A., Ettenberg S.A., Dayton M.A., Lipkowitz S. The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells. Cancer Res. 1996, 56:4236-4243.
    • (1996) Cancer Res. , vol.56 , pp. 4236-4243
    • Keane, M.M.1    Lowrey, G.A.2    Ettenberg, S.A.3    Dayton, M.A.4    Lipkowitz, S.5
  • 182
    • 80052612606 scopus 로고    scopus 로고
    • Quality of life in 265 patients with gastroenteropancreatic or bronchial neuroendocrine tumors treated with [Lu-177-DOTA(0), Tyr(3)]Octreotate
    • Khan S., Krenning E.P., van Essen M., Kam B.L., Teunissen J.J., Kwekkeboom D.J. Quality of life in 265 patients with gastroenteropancreatic or bronchial neuroendocrine tumors treated with [Lu-177-DOTA(0), Tyr(3)]Octreotate. J. Nucl. Med. 2011, 52:1361-1368.
    • (2011) J. Nucl. Med. , vol.52 , pp. 1361-1368
    • Khan, S.1    Krenning, E.P.2    van Essen, M.3    Kam, B.L.4    Teunissen, J.J.5    Kwekkeboom, D.J.6
  • 183
    • 0032758263 scopus 로고    scopus 로고
    • Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine tumors
    • Kimura N., Pilichowska M., Date F., Kimura I., Schindler M. Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine tumors. Clin. Cancer Res. 1999, 5:3483-3487.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 3483-3487
    • Kimura, N.1    Pilichowska, M.2    Date, F.3    Kimura, I.4    Schindler, M.5
  • 184
    • 0025880464 scopus 로고
    • Assignment of G protein subtypes to specific receptors inducing inhibition of calcium currents
    • Kleuss C., Hescheler J., Ewel C., Rosenthal W., Schultz G., Wittig B. Assignment of G protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 1991, 353:43-48.
    • (1991) Nature , vol.353 , pp. 43-48
    • Kleuss, C.1    Hescheler, J.2    Ewel, C.3    Rosenthal, W.4    Schultz, G.5    Wittig, B.6
  • 185
    • 0025887564 scopus 로고
    • Somatostatin regulation of glycoprotein hormone and free subunit secretion in clinically non-functioning and somatotroph adenomas in vitro
    • Klibanski A., Alexander J.M., Bikkal H.A., Hsu D.W., Swearingen B., Zervas N.T. Somatostatin regulation of glycoprotein hormone and free subunit secretion in clinically non-functioning and somatotroph adenomas in vitro. J. Clin. Endocrinol. Metabol. 1991, 73:1248-1255.
    • (1991) J. Clin. Endocrinol. Metabol. , vol.73 , pp. 1248-1255
    • Klibanski, A.1    Alexander, J.M.2    Bikkal, H.A.3    Hsu, D.W.4    Swearingen, B.5    Zervas, N.T.6
  • 186
    • 0026551305 scopus 로고
    • Expression cloning of a rat brain somatostatin receptor cDNA
    • Kluxen F.W., Bruns C., Lubbert H. Expression cloning of a rat brain somatostatin receptor cDNA. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:4618-4622.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 4618-4622
    • Kluxen, F.W.1    Bruns, C.2    Lubbert, H.3
  • 187
    • 0023818534 scopus 로고
    • Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. I. An increase in potassium conductance is responsible for both the hyperpolarization and the decrease in intracellular free calcium produced by somatostatin
    • Koch B.D., Blalock J.B., Schonbrunn A. Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. I. An increase in potassium conductance is responsible for both the hyperpolarization and the decrease in intracellular free calcium produced by somatostatin. J. Biol. Chem. 1988, 263:216-225.
    • (1988) J. Biol. Chem. , vol.263 , pp. 216-225
    • Koch, B.D.1    Blalock, J.B.2    Schonbrunn, A.3
  • 188
    • 0021341542 scopus 로고
    • The somatostatin receptor is directly coupled to adenylate cyclase in GH4C1 pituitary cell membranes
    • Koch B.D., Schonbrunn A. The somatostatin receptor is directly coupled to adenylate cyclase in GH4C1 pituitary cell membranes. Endocrinology 1984, 114:1784-1790.
    • (1984) Endocrinology , vol.114 , pp. 1784-1790
    • Koch, B.D.1    Schonbrunn, A.2
  • 189
    • 0023086304 scopus 로고
    • Escape of the response to a long-acting somatostatin analog (SMS 201-995) in patients with vipoma
    • Koelz A., Kraenzlin M., Gyr K., Meier V., Bloom S.R., Heitz P., Stalder H. Escape of the response to a long-acting somatostatin analog (SMS 201-995) in patients with vipoma. Gastroenterology 1987, 92:527-531.
    • (1987) Gastroenterology , vol.92 , pp. 527-531
    • Koelz, A.1    Kraenzlin, M.2    Gyr, K.3    Meier, V.4    Bloom, S.R.5    Heitz, P.6    Stalder, H.7
  • 191
    • 84857715394 scopus 로고    scopus 로고
    • Somatostatin receptor subtype 2A immunohistochemistry using a new monoclonal antibody selects tumors suitable for in vivo somatostatin receptor targeting
    • Koerner M., Waser B., Schonbrunn A., Perren A., Reubi J.C. Somatostatin receptor subtype 2A immunohistochemistry using a new monoclonal antibody selects tumors suitable for in vivo somatostatin receptor targeting. Am. J. Surg. Pathol. 2012, 36:242-252.
    • (2012) Am. J. Surg. Pathol. , vol.36 , pp. 242-252
    • Koerner, M.1    Waser, B.2    Schonbrunn, A.3    Perren, A.4    Reubi, J.C.5
  • 193
    • 0017133348 scopus 로고
    • Effect of growth hormone release inhibiting hormone on hormones stimulating exocrine pancreatic secretion
    • Konturek S.J., Tasler J., Obtulowicz W., Coy D.H., Schally A.V. Effect of growth hormone release inhibiting hormone on hormones stimulating exocrine pancreatic secretion. J. Clin. Invest. 1976, 58:1-6.
    • (1976) J. Clin. Invest. , vol.58 , pp. 1-6
    • Konturek, S.J.1    Tasler, J.2    Obtulowicz, W.3    Coy, D.H.4    Schally, A.V.5
  • 194
    • 0028285739 scopus 로고
    • Effect of octreotide on glucose tolerance in acromegaly
    • Koop B.L., Harris A.G., Ezzat S. Effect of octreotide on glucose tolerance in acromegaly. Eur. J. Endocrinol. 1994, 130:581-586.
    • (1994) Eur. J. Endocrinol. , vol.130 , pp. 581-586
    • Koop, B.L.1    Harris, A.G.2    Ezzat, S.3
  • 196
    • 0032748271 scopus 로고    scopus 로고
    • Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs
    • Kreienkamp H.J., Akgun E., Baumeister H., Meyerhof W., Richter D. Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs. FEBS Lett. 1999, 462:464-466.
    • (1999) FEBS Lett. , vol.462 , pp. 464-466
    • Kreienkamp, H.J.1    Akgun, E.2    Baumeister, H.3    Meyerhof, W.4    Richter, D.5
  • 197
    • 0031793402 scopus 로고    scopus 로고
    • Rat somatostatin receptor subtype 4 can be made sensitive to agonist-induced internalization by mutation of a single threonine (residue 331)
    • Kreienkamp H.J., Roth A., Richter D. Rat somatostatin receptor subtype 4 can be made sensitive to agonist-induced internalization by mutation of a single threonine (residue 331). DNA Cell Biol. 1998, 17:869-878.
    • (1998) DNA Cell Biol. , vol.17 , pp. 869-878
    • Kreienkamp, H.J.1    Roth, A.2    Richter, D.3
  • 200
    • 0029808327 scopus 로고    scopus 로고
    • Effector coupling of somatostatin receptor subtypes on human endocrine tumors
    • Kubota A., Yamada Y., Kagimoto S., Seino S., Seino Y. Effector coupling of somatostatin receptor subtypes on human endocrine tumors. Metabolism 1996, 45:42-45.
    • (1996) Metabolism , vol.45 , pp. 42-45
    • Kubota, A.1    Yamada, Y.2    Kagimoto, S.3    Seino, S.4    Seino, Y.5
  • 202
    • 0022510433 scopus 로고
    • Treatment of the malignant carcinoid syndrome. Evaluation of a long-acting somatostatin analog
    • Kvols L.K., Moertel C.G., Oconnell M.J., Schutt A.J., Rubin J., Hahn R.G. Treatment of the malignant carcinoid syndrome. Evaluation of a long-acting somatostatin analog. N. Eng. J. Med. 1986, 315:663-666.
    • (1986) N. Eng. J. Med. , vol.315 , pp. 663-666
    • Kvols, L.K.1    Moertel, C.G.2    Oconnell, M.J.3    Schutt, A.J.4    Rubin, J.5    Hahn, R.G.6
  • 203
    • 0027457465 scopus 로고
    • Evaluation of a radiolabeled somatostatin analog (I-123 octreotide) in the detection and localization of carcinoid and islet cell tumors
    • Kvols L.K., Brown M.L., O'Connor M.K., Hung J.C., Hayostek R.J., Reubi J.C., Lamberts S.W. Evaluation of a radiolabeled somatostatin analog (I-123 octreotide) in the detection and localization of carcinoid and islet cell tumors. Radiology 1993, 187:129-133.
    • (1993) Radiology , vol.187 , pp. 129-133
    • Kvols, L.K.1    Brown, M.L.2    O'Connor, M.K.3    Hung, J.C.4    Hayostek, R.J.5    Reubi, J.C.6    Lamberts, S.W.7
  • 204
    • 84867411913 scopus 로고    scopus 로고
    • Pasireotide (SOM230) shows efficacy and tolerability in the treatment of patients with advanced neuroendocrine tumors refractory or resistant to octreotide LAR: results from a phase II study
    • Kvols L.K., Oberg K.E., O'Dorisio T.M., Mohideen P., de Herder W.W., Arnold R., Hu K., Zhang Y.L., Hughes G., Anthony L., Wiedenmann B. Pasireotide (SOM230) shows efficacy and tolerability in the treatment of patients with advanced neuroendocrine tumors refractory or resistant to octreotide LAR: results from a phase II study. Endocr. Rel. Cancer 2012, 19:657-666.
    • (2012) Endocr. Rel. Cancer , vol.19 , pp. 657-666
    • Kvols, L.K.1    Oberg, K.E.2    O'Dorisio, T.M.3    Mohideen, P.4    de Herder, W.W.5    Arnold, R.6    Hu, K.7    Zhang, Y.L.8    Hughes, G.9    Anthony, L.10    Wiedenmann, B.11
  • 209
    • 0141925804 scopus 로고    scopus 로고
    • Sst2 somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation
    • Lahlou H., Saint-Laurent N., Esteve J.P., Eychene A., Pradayrol L., Pyronnet S., Susini C. Sst2 somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation. J. Biol. Chem. 2003, 278:39356-39371.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39356-39371
    • Lahlou, H.1    Saint-Laurent, N.2    Esteve, J.P.3    Eychene, A.4    Pradayrol, L.5    Pyronnet, S.6    Susini, C.7
  • 210
    • 0024117485 scopus 로고
    • The role of somatostatin in the regulation of anterior-pituitary hormone secretion and the use of its analogs in the treatment of human pituitary tumors
    • Lamberts S.W. The role of somatostatin in the regulation of anterior-pituitary hormone secretion and the use of its analogs in the treatment of human pituitary tumors. Endocr. Rev. 1988, 9:417-436.
    • (1988) Endocr. Rev. , vol.9 , pp. 417-436
    • Lamberts, S.W.1
  • 211
    • 0024214960 scopus 로고
    • Development of resistance to a long-acting somatostatin analog during treatment of 2 patients with metastatic endocrine pancreatic tumors
    • Lamberts S.W., Pieters G.F.F.M., Metselaar H.J., Ong G.L., Tan H.S., Reubi J.C. Development of resistance to a long-acting somatostatin analog during treatment of 2 patients with metastatic endocrine pancreatic tumors. Acta Endocrinol. 1988, 119:561-566.
    • (1988) Acta Endocrinol. , vol.119 , pp. 561-566
    • Lamberts, S.W.1    Pieters, G.F.F.M.2    Metselaar, H.J.3    Ong, G.L.4    Tan, H.S.5    Reubi, J.C.6
  • 212
    • 0023792354 scopus 로고
    • Successful treatment with SMS-201-995 of Cushing syndrome caused by ectopic adrenocorticotropin secretion from a metastatic gastrin-secreting pancreatic islet cell carcinoma
    • Lamberts S.W., Tilanus H.W., Klooswijk A.I.J., Bruining H.A., van der Lely A.J., de Jong F.H. Successful treatment with SMS-201-995 of Cushing syndrome caused by ectopic adrenocorticotropin secretion from a metastatic gastrin-secreting pancreatic islet cell carcinoma. J. Clin. Endocrinol. Metabol. 1988, 67:1080-1083.
    • (1988) J. Clin. Endocrinol. Metabol. , vol.67 , pp. 1080-1083
    • Lamberts, S.W.1    Tilanus, H.W.2    Klooswijk, A.I.J.3    Bruining, H.A.4    van der Lely, A.J.5    de Jong, F.H.6
  • 213
    • 0024320037 scopus 로고
    • The effect of the long-acting somatostatin analog SMS-201-995 on ACTH secretion in Nelson's syndrome and Cushings disease
    • Lamberts S.W., Uitterlinden P., Klijn J.M. The effect of the long-acting somatostatin analog SMS-201-995 on ACTH secretion in Nelson's syndrome and Cushings disease. Acta Endocrinol. 1989, 120:760-766.
    • (1989) Acta Endocrinol. , vol.120 , pp. 760-766
    • Lamberts, S.W.1    Uitterlinden, P.2    Klijn, J.M.3
  • 215
    • 0026041670 scopus 로고
    • The role of somatostatin and its analogs in the diagnosis and treatment of tumors
    • Lamberts S.W., Krenning E.P., Reubi J.C. The role of somatostatin and its analogs in the diagnosis and treatment of tumors. Endocr. Rev. 1991, 12:450-482.
    • (1991) Endocr. Rev. , vol.12 , pp. 450-482
    • Lamberts, S.W.1    Krenning, E.P.2    Reubi, J.C.3
  • 216
    • 0027393291 scopus 로고
    • Octreotide and related somatostatin analogs in the diagnosis and treatment of pituitary disease and somatostatin receptor scintigraphy
    • Lamberts S.W., Hofland L.J., de Herder W.W., Kwekkeboom D.J., Reubi J.C., Krenning E.P. Octreotide and related somatostatin analogs in the diagnosis and treatment of pituitary disease and somatostatin receptor scintigraphy. Front. Neuroendocrinol. 1993, 14:27-55.
    • (1993) Front. Neuroendocrinol. , vol.14 , pp. 27-55
    • Lamberts, S.W.1    Hofland, L.J.2    de Herder, W.W.3    Kwekkeboom, D.J.4    Reubi, J.C.5    Krenning, E.P.6
  • 218
    • 0022590470 scopus 로고
    • A comparison among the growth hormone-lowering effects in acromegaly of the somatostatin analog SMS 201-995, bromocriptine, and the combination of both drugs
    • Lamberts S.W., Zweens M., Verschoor L., del Pozo E. A comparison among the growth hormone-lowering effects in acromegaly of the somatostatin analog SMS 201-995, bromocriptine, and the combination of both drugs. J. Clin. Endocrinol. Metabol. 1986, 63:16-19.
    • (1986) J. Clin. Endocrinol. Metabol. , vol.63 , pp. 16-19
    • Lamberts, S.W.1    Zweens, M.2    Verschoor, L.3    del Pozo, E.4
  • 219
    • 0023628230 scopus 로고
    • Clinical and pathophysiological aspects of somatostatin and the gastrointestinal tract
    • Lamers C.B. Clinical and pathophysiological aspects of somatostatin and the gastrointestinal tract. Acta. Endocrinol. Suppl. (Copenh) 1987, 286:19-25.
    • (1987) Acta. Endocrinol. Suppl. (Copenh) , vol.286 , pp. 19-25
    • Lamers, C.B.1
  • 220
    • 0027336786 scopus 로고
    • Gi alpha-3 and G(o) alpha selectively associate with the cloned somatostatin receptor subtype SSTR2
    • Law S.F., Yasuda K., Bell G.I., Reisine T. Gi alpha-3 and G(o) alpha selectively associate with the cloned somatostatin receptor subtype SSTR2. J. Biol. Chem. 1993, 268:10721-10727.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10721-10727
    • Law, S.F.1    Yasuda, K.2    Bell, G.I.3    Reisine, T.4
  • 221
    • 0026071869 scopus 로고
    • Effects of epidermal growth-factor and analogs of luteinizing-hormone-releasing hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors
    • Lee M.T., Liebow C., Kamer A.R., Schally A.V. Effects of epidermal growth-factor and analogs of luteinizing-hormone-releasing hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors. Proc. Natl. Acad. Sci. U.S.A. 1991, 88:1656-1660.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 1656-1660
    • Lee, M.T.1    Liebow, C.2    Kamer, A.R.3    Schally, A.V.4
  • 223
    • 59749083610 scopus 로고    scopus 로고
    • Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro
    • Lesche S., Lehmann D., Nagel F., Schmid H.A., Schulz S. Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro. J. Clin. Endocrinol. Metabol. 2009, 94:654-661.
    • (2009) J. Clin. Endocrinol. Metabol. , vol.94 , pp. 654-661
    • Lesche, S.1    Lehmann, D.2    Nagel, F.3    Schmid, H.A.4    Schulz, S.5
  • 225
    • 0024267374 scopus 로고
    • Quantitative in-situ hybridization histochemistry studies on growth hormone (GH) gene expression in acromegalic somatotrophs: effects of somatostatin, GH-releasing factor and cortisol
    • Levy A., Lightman S.L. Quantitative in-situ hybridization histochemistry studies on growth hormone (GH) gene expression in acromegalic somatotrophs: effects of somatostatin, GH-releasing factor and cortisol. J. Mol. Endocrinol. 1988, 1:19-26.
    • (1988) J. Mol. Endocrinol. , vol.1 , pp. 19-26
    • Levy, A.1    Lightman, S.L.2
  • 226
    • 2342618936 scopus 로고    scopus 로고
    • Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
    • Liang J., Slingerland J.M. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003, 2:339-345.
    • (2003) Cell Cycle , vol.2 , pp. 339-345
    • Liang, J.1    Slingerland, J.M.2
  • 227
    • 0037674938 scopus 로고    scopus 로고
    • Conserved motifs in somatostatin, D-2-dopamine, and alpha(2B)-adrenergic receptors for inhibiting the Na-H exchanger, NHE1
    • Lin C.Y., Varma M.G., Joubel A., Madabushi S., Lichtarge O., Barber D.L. Conserved motifs in somatostatin, D-2-dopamine, and alpha(2B)-adrenergic receptors for inhibiting the Na-H exchanger, NHE1. J. Biol. Chem. 2003, 278:15128-15135.
    • (2003) J. Biol. Chem. , vol.278 , pp. 15128-15135
    • Lin, C.Y.1    Varma, M.G.2    Joubel, A.3    Madabushi, S.4    Lichtarge, O.5    Barber, D.L.6
  • 229
    • 0034737646 scopus 로고    scopus 로고
    • Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis
    • Liu D., Martino G., Thangaraju M., Sharma M., Halwani F., Shen S.H., Patel Y.C., Srikant C.B. Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis. J. Biol. Chem. 2000, 275:9244-9250.
    • (2000) J. Biol. Chem. , vol.275 , pp. 9244-9250
    • Liu, D.1    Martino, G.2    Thangaraju, M.3    Sharma, M.4    Halwani, F.5    Shen, S.H.6    Patel, Y.C.7    Srikant, C.B.8
  • 231
    • 0030813044 scopus 로고    scopus 로고
    • The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling
    • Lopez F., Esteve J.P., Buscail L., Delesque N., Saint Laurent N., Theveniau M., Nahmias C., Vaysse N., Susini C. The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling. J. Biol. Chem. 1997, 272:24448-24454.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24448-24454
    • Lopez, F.1    Esteve, J.P.2    Buscail, L.3    Delesque, N.4    Saint Laurent, N.5    Theveniau, M.6    Nahmias, C.7    Vaysse, N.8    Susini, C.9
  • 232
    • 0029786519 scopus 로고    scopus 로고
    • Molecular mechanisms of antiproliferative effect of somatostatin: involvement of a tyrosine phosphatase
    • Lopez F., Esteve J.P., Buscail L., Delesque N., SaintLaurent N., Vaysse N., Susini C. Molecular mechanisms of antiproliferative effect of somatostatin: involvement of a tyrosine phosphatase. Metabolism 1996, 45:14-16.
    • (1996) Metabolism , vol.45 , pp. 14-16
    • Lopez, F.1    Esteve, J.P.2    Buscail, L.3    Delesque, N.4    SaintLaurent, N.5    Vaysse, N.6    Susini, C.7
  • 233
    • 0035487006 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase is a SHP-1 substrate involved in sst2 somatostatin receptor growth inhibitory signaling
    • Lopez F., Ferjoux G., Cordelier P., Saint-Laurent N., Esteve J.P., Vaysse N., Buscail L., Susini C. Neuronal nitric oxide synthase is a SHP-1 substrate involved in sst2 somatostatin receptor growth inhibitory signaling. FASEB J. 2001, 15:2300-2302.
    • (2001) FASEB J. , vol.15 , pp. 2300-2302
    • Lopez, F.1    Ferjoux, G.2    Cordelier, P.3    Saint-Laurent, N.4    Esteve, J.P.5    Vaysse, N.6    Buscail, L.7    Susini, C.8
  • 234
    • 33646793998 scopus 로고    scopus 로고
    • Identification of the somatostatin receptor subtypes (sst) mediating the divergent, stimulatory/inhibitory actions of somatostatin on growth hormone secretion
    • Luque R.M., Duran-Prado M., Garcia-Navarro S., Gracia-Navarro F., Kineman R.D., Malagon M.M., Castano J.P. Identification of the somatostatin receptor subtypes (sst) mediating the divergent, stimulatory/inhibitory actions of somatostatin on growth hormone secretion. Endocrinology 2006, 147:2902-2908.
    • (2006) Endocrinology , vol.147 , pp. 2902-2908
    • Luque, R.M.1    Duran-Prado, M.2    Garcia-Navarro, S.3    Gracia-Navarro, F.4    Kineman, R.D.5    Malagon, M.M.6    Castano, J.P.7
  • 236
    • 0036473397 scopus 로고    scopus 로고
    • The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals
    • Luttrell L.M., Lefkowitz R.J. The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell Sci. 2002, 115:455-465.
    • (2002) J. Cell Sci. , vol.115 , pp. 455-465
    • Luttrell, L.M.1    Lefkowitz, R.J.2
  • 237
    • 21844451422 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic comparison of a novel multiligand somatostatin analog, SOM230, with octreotide in patients with acromegaly
    • Ma P., Wang Y., van der Hoek J., Nedelman J., Schran H., Tran L.L., Lamberts S.W. Pharmacokinetic-pharmacodynamic comparison of a novel multiligand somatostatin analog, SOM230, with octreotide in patients with acromegaly. Clin. Pharmacol. Ther. 2005, 78:69-80.
    • (2005) Clin. Pharmacol. Ther. , vol.78 , pp. 69-80
    • Ma, P.1    Wang, Y.2    van der Hoek, J.3    Nedelman, J.4    Schran, H.5    Tran, L.L.6    Lamberts, S.W.7
  • 240
    • 78649524272 scopus 로고    scopus 로고
    • Short- and long-term efficacy of combined cabergoline and octreotide treatment in controlling IGF-I levels in acromegaly
    • Mattar P., Martins M.R.A., Abucham J. Short- and long-term efficacy of combined cabergoline and octreotide treatment in controlling IGF-I levels in acromegaly. Neuroendocrinology 2010, 92:120-127.
    • (2010) Neuroendocrinology , vol.92 , pp. 120-127
    • Mattar, P.1    Martins, M.R.A.2    Abucham, J.3
  • 241
    • 77949273975 scopus 로고    scopus 로고
    • Effects of lanreotide SR and Autogel on tumor mass in patients with acromegaly: a systematic review
    • Mazziotti G., Giustina A. Effects of lanreotide SR and Autogel on tumor mass in patients with acromegaly: a systematic review. Pituitary 2010, 13:60-67.
    • (2010) Pituitary , vol.13 , pp. 60-67
    • Mazziotti, G.1    Giustina, A.2
  • 242
    • 33745066200 scopus 로고    scopus 로고
    • Gluc-Lys([18F]FP)-TOCA PET in patients with SSTR-positive tumors: biodistribution and diagnostic evaluation compared with [111In]DTPA-octreotide
    • Meisetschläger G., Poethko T., Stahl A., Wolf I., Scheidhauer K., Schottelius M., Herz M., Wester H.J., Schwaiger M. Gluc-Lys([18F]FP)-TOCA PET in patients with SSTR-positive tumors: biodistribution and diagnostic evaluation compared with [111In]DTPA-octreotide. J. Nucl. Med. 2006, 47:566-573.
    • (2006) J. Nucl. Med. , vol.47 , pp. 566-573
    • Meisetschläger, G.1    Poethko, T.2    Stahl, A.3    Wolf, I.4    Scheidhauer, K.5    Schottelius, M.6    Herz, M.7    Wester, H.J.8    Schwaiger, M.9
  • 243
    • 33845491265 scopus 로고    scopus 로고
    • Medical progress: acromegaly
    • Melmed S. Medical progress: acromegaly. N. Eng. J. Med. 2006, 355:2558-2573.
    • (2006) N. Eng. J. Med. , vol.355 , pp. 2558-2573
    • Melmed, S.1
  • 246
    • 34347380169 scopus 로고    scopus 로고
    • A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR (long acting repeatable octreotide) in the primary therapy of patients with acromegaly
    • Mercado M., Borges F., Bouterfa H., Chang T.C., Chervin A., Farrall A.J., Patocs A., Petersenn S., Podoba J., Safari M., Wardlaw J. A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR (long acting repeatable octreotide) in the primary therapy of patients with acromegaly. Clin. Endocrinol. 2007, 66:859-868.
    • (2007) Clin. Endocrinol. , vol.66 , pp. 859-868
    • Mercado, M.1    Borges, F.2    Bouterfa, H.3    Chang, T.C.4    Chervin, A.5    Farrall, A.J.6    Patocs, A.7    Petersenn, S.8    Podoba, J.9    Safari, M.10    Wardlaw, J.11
  • 247
    • 0028365950 scopus 로고
    • 2+ current modulated by cGMP-dependent protein kinase
    • 2+ current modulated by cGMP-dependent protein kinase. Nature 1994, 369:336-339.
    • (1994) Nature , vol.369 , pp. 336-339
    • Meriney, S.D.1    Gray, D.B.2    Pilar, G.R.3
  • 249
    • 0026489450 scopus 로고
    • Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain
    • Meyerhof W., Wulfsen I., Schonrock C., Fehr S., Richter D. Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:10267-10271.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 10267-10271
    • Meyerhof, W.1    Wulfsen, I.2    Schonrock, C.3    Fehr, S.4    Richter, D.5
  • 253
    • 84867581999 scopus 로고    scopus 로고
    • Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents
    • Moss C.E., Marsh W.J., Parker H.E., Ogunnowo-Bada E., Riches C.H., Habib A.M., Evans M.L., Gribble F.M., Reimann F. Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents. Diabetologia 2012, 55:3094-3103.
    • (2012) Diabetologia , vol.55 , pp. 3094-3103
    • Moss, C.E.1    Marsh, W.J.2    Parker, H.E.3    Ogunnowo-Bada, E.4    Riches, C.H.5    Habib, A.M.6    Evans, M.L.7    Gribble, F.M.8    Reimann, F.9
  • 254
    • 4043058143 scopus 로고    scopus 로고
    • Central and peripheral actions of somatostatin on the growth hormone - IGF-I axis
    • Murray R.D., Kim K., Ren S.G., Chelly M., Umehara Y., Melmed S. Central and peripheral actions of somatostatin on the growth hormone - IGF-I axis. J. Clin. Invest. 2004, 114:349-356.
    • (2004) J. Clin. Invest. , vol.114 , pp. 349-356
    • Murray, R.D.1    Kim, K.2    Ren, S.G.3    Chelly, M.4    Umehara, Y.5    Melmed, S.6
  • 256
    • 49249113074 scopus 로고    scopus 로고
    • A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly
    • Murray R.D., Melmed S. A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly. J. Clin. Endocrinol. Metabol. 2008, 93:2957-2968.
    • (2008) J. Clin. Endocrinol. Metabol. , vol.93 , pp. 2957-2968
    • Murray, R.D.1    Melmed, S.2
  • 258
    • 0024533648 scopus 로고
    • Insulin-like growth factor-I action on growth hormone secretion and messenger ribonucleic-acid levels: interaction with somatostatin
    • Namba H., Morita S., Melmed S. Insulin-like growth factor-I action on growth hormone secretion and messenger ribonucleic-acid levels: interaction with somatostatin. Endocrinology 1989, 124:1794-1799.
    • (1989) Endocrinology , vol.124 , pp. 1794-1799
    • Namba, H.1    Morita, S.2    Melmed, S.3
  • 259
    • 64549105745 scopus 로고    scopus 로고
    • Combined treatment for acromegaly with long-acting somatostatin analogs and pegvisomant: long-term safety for up to 4.5 years (median 2.2 years) of follow-up in 86 patients
    • Neggers S.J., de Herder W.W., Janssen J.A., Feelders R.A., van der Lely A.J. Combined treatment for acromegaly with long-acting somatostatin analogs and pegvisomant: long-term safety for up to 4.5 years (median 2.2 years) of follow-up in 86 patients. Eur. J. Endocrinol. 2009, 160:529-533.
    • (2009) Eur. J. Endocrinol. , vol.160 , pp. 529-533
    • Neggers, S.J.1    de Herder, W.W.2    Janssen, J.A.3    Feelders, R.A.4    van der Lely, A.J.5
  • 262
    • 0021775780 scopus 로고
    • The hormonal regulation of food intake, digestion, and absorption
    • Nicholl C.G., Polak J.M., Bloom S.R. The hormonal regulation of food intake, digestion, and absorption. Ann. Rev. Nutr. 1985, 5:213-239.
    • (1985) Ann. Rev. Nutr. , vol.5 , pp. 213-239
    • Nicholl, C.G.1    Polak, J.M.2    Bloom, S.R.3
  • 264
    • 55249120008 scopus 로고    scopus 로고
    • Clinicopathological features of growth hormone-producing pituitary adenomas: difference among various types defined by cytokeratin distribution pattern including a transitional form
    • Obari A., Sano T., Ohyama K., Kudo E., Qian Z.R., Yoneda A., Rayhan N., Rahman M.M., Yamada S. Clinicopathological features of growth hormone-producing pituitary adenomas: difference among various types defined by cytokeratin distribution pattern including a transitional form. Endocr. Pathol. 2008, 19:82-91.
    • (2008) Endocr. Pathol. , vol.19 , pp. 82-91
    • Obari, A.1    Sano, T.2    Ohyama, K.3    Kudo, E.4    Qian, Z.R.5    Yoneda, A.6    Rayhan, N.7    Rahman, M.M.8    Yamada, S.9
  • 265
    • 68149168844 scopus 로고    scopus 로고
    • Somatostatin analog octreotide LAR in gastro-entero-pancreatic tumors
    • Oberg K. Somatostatin analog octreotide LAR in gastro-entero-pancreatic tumors. Expert Rev. Anticancer Ther. 2009, 9:557-566.
    • (2009) Expert Rev. Anticancer Ther. , vol.9 , pp. 557-566
    • Oberg, K.1
  • 266
    • 84864979948 scopus 로고    scopus 로고
    • Gallium-68 somatostatin receptor PET/CT: is it time to replace (111)Indium DTPA octreotide for patients with neuroendocrine tumors?
    • Oberg K. Gallium-68 somatostatin receptor PET/CT: is it time to replace (111)Indium DTPA octreotide for patients with neuroendocrine tumors?. Endocrine 2012, 42:3-4.
    • (2012) Endocrine , vol.42 , pp. 3-4
    • Oberg, K.1
  • 267
    • 84925581799 scopus 로고    scopus 로고
    • Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy
    • Oberg K.E., Reubi J.C., Kwekkeboom D.J., Krenning E.P. Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy. Gastroenterology 2010, 139:742-753.
    • (2010) Gastroenterology , vol.139 , pp. 742-753
    • Oberg, K.E.1    Reubi, J.C.2    Kwekkeboom, D.J.3    Krenning, E.P.4
  • 268
    • 0027086821 scopus 로고
    • Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28
    • O'Carroll A.M., Lolait S.J., Konig M., Mahan L.C. Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28. Mol. Pharmacol. 1992, 42:939-946.
    • (1992) Mol. Pharmacol. , vol.42 , pp. 939-946
    • O'Carroll, A.M.1    Lolait, S.J.2    Konig, M.3    Mahan, L.C.4
  • 269
  • 270
    • 34547756475 scopus 로고    scopus 로고
    • Somatostatin receptor subtypes in human non-functioning neuroendocrine tumors and effects of somatostatin analogue SOM230 on cell proliferation in cell line NCI-H727
    • Ono K., Suzuki T., Miki Y., Taniyama Y., Nakamura Y., Noda Y., Watanabe M., Sasano H. Somatostatin receptor subtypes in human non-functioning neuroendocrine tumors and effects of somatostatin analogue SOM230 on cell proliferation in cell line NCI-H727. Anticancer Res. 2007, 27:2231-2239.
    • (2007) Anticancer Res. , vol.27 , pp. 2231-2239
    • Ono, K.1    Suzuki, T.2    Miki, Y.3    Taniyama, Y.4    Nakamura, Y.5    Noda, Y.6    Watanabe, M.7    Sasano, H.8
  • 271
    • 33751036065 scopus 로고    scopus 로고
    • Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a non-endothelial function of VEGF in pituitary tumours
    • Onofri C., Theodoropoulou M., Losa M., Uhl E., Lange M., Arzt E., Stalla G.K., Renner U. Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a non-endothelial function of VEGF in pituitary tumours. J. Endocrinol. 2006, 191:249-261.
    • (2006) J. Endocrinol. , vol.191 , pp. 249-261
    • Onofri, C.1    Theodoropoulou, M.2    Losa, M.3    Uhl, E.4    Lange, M.5    Arzt, E.6    Stalla, G.K.7    Renner, U.8
  • 274
    • 0019441949 scopus 로고
    • Somatostatin: mechanism of action in pancreatic-islet beta-cells
    • Pace C.S., Tarvin J.T. Somatostatin: mechanism of action in pancreatic-islet beta-cells. Diabetes 1981, 30:836-842.
    • (1981) Diabetes , vol.30 , pp. 836-842
    • Pace, C.S.1    Tarvin, J.T.2
  • 278
    • 0026682699 scopus 로고
    • G-protein activation of a hormone-stimulated phosphatase in human tumor-cells
    • Pan M.G., Florio T., Stork P.J.S. G-protein activation of a hormone-stimulated phosphatase in human tumor-cells. Science 1992, 256:1215-1217.
    • (1992) Science , vol.256 , pp. 1215-1217
    • Pan, M.G.1    Florio, T.2    Stork, P.J.S.3
  • 279
    • 0035726431 scopus 로고    scopus 로고
    • Immunohistochemical detection of somatostatin receptor types 1-5 in medullary carcinoma of the thyroid
    • Papotti M., Kumar U., Volante M., Pecchioni C., Patel Y.C. Immunohistochemical detection of somatostatin receptor types 1-5 in medullary carcinoma of the thyroid. Clin. Endocrinol. 2001, 54:641-649.
    • (2001) Clin. Endocrinol. , vol.54 , pp. 641-649
    • Papotti, M.1    Kumar, U.2    Volante, M.3    Pecchioni, C.4    Patel, Y.C.5
  • 280
    • 20844461864 scopus 로고    scopus 로고
    • Somatostatin (SRIF) receptor subtype 2 and 5 gene expression in growth hormone-secreting pituitary adenomas: the relationship with endogenous SRIF activity and response to octreotide
    • Park C.Y., Yang I.Y., Woo J.T., Kim S.W., Kim J.W., Kim Y.S., Sohn S.J., Kim E.H., Lee M., Park H.S., Jung J.C., Park S.J. Somatostatin (SRIF) receptor subtype 2 and 5 gene expression in growth hormone-secreting pituitary adenomas: the relationship with endogenous SRIF activity and response to octreotide. Endocr. J. 2004, 51:227-236.
    • (2004) Endocr. J. , vol.51 , pp. 227-236
    • Park, C.Y.1    Yang, I.Y.2    Woo, J.T.3    Kim, S.W.4    Kim, J.W.5    Kim, Y.S.6    Sohn, S.J.7    Kim, E.H.8    Lee, M.9    Park, H.S.10    Jung, J.C.11    Park, S.J.12
  • 283
    • 0032780823 scopus 로고    scopus 로고
    • Somatostatin and its receptor family
    • Patel Y.C. Somatostatin and its receptor family. Front. Neuroendocrinol. 1999, 20:157-198.
    • (1999) Front. Neuroendocrinol. , vol.20 , pp. 157-198
    • Patel, Y.C.1
  • 284
    • 0027302917 scopus 로고
    • Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation
    • Patel Y.C., Greenwood M., Kent G., Panetta R., Srikant C.B. Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. Biochem. Biophys. Res. Commun. 1993, 192:288-294.
    • (1993) Biochem. Biophys. Res. Commun. , vol.192 , pp. 288-294
    • Patel, Y.C.1    Greenwood, M.2    Kent, G.3    Panetta, R.4    Srikant, C.B.5
  • 286
    • 0020669339 scopus 로고
    • In vivo and in vitro plasma disappearance and metabolism of somatostatin-28 and somatostatin-14 in the rat
    • Patel Y.C., Wheatley T. In vivo and in vitro plasma disappearance and metabolism of somatostatin-28 and somatostatin-14 in the rat. Endocrinology 1983, 112:220-225.
    • (1983) Endocrinology , vol.112 , pp. 220-225
    • Patel, Y.C.1    Wheatley, T.2
  • 287
    • 83255167036 scopus 로고    scopus 로고
    • Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study
    • Pavel M.E., Hainsworth J.D., Baudin E., Peeters M., Horsch D., Klimovsky J., Lebwohl D., Jehl V., Wolin E.M., Oberg K., Van Cutsem E., Yao J.C. Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study. Lancet 2011, 378:2005-2012.
    • (2011) Lancet , vol.378 , pp. 2005-2012
    • Pavel, M.E.1    Hainsworth, J.D.2    Baudin, E.3    Peeters, M.4    Horsch, D.5    Klimovsky, J.6    Lebwohl, D.7    Jehl, V.8    Wolin, E.M.9    Oberg, K.10    Van Cutsem, E.11    Yao, J.C.12
  • 288
    • 0033955375 scopus 로고    scopus 로고
    • Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas
    • Petersenn S., Heyens M., Ludecke D.K., Beil F.U., Schulte H.M. Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas. Clin. Endocrinol. 2000, 52:35-42.
    • (2000) Clin. Endocrinol. , vol.52 , pp. 35-42
    • Petersenn, S.1    Heyens, M.2    Ludecke, D.K.3    Beil, F.U.4    Schulte, H.M.5
  • 290
    • 67649672452 scopus 로고    scopus 로고
    • Characterization of intracellular signaling mediated by human somatostatin receptor 5: role of the DRY motif and the third intracellular loop
    • Peverelli E., Lania A.G., Mantovani G., Beck-Peccoz P., Spada A. Characterization of intracellular signaling mediated by human somatostatin receptor 5: role of the DRY motif and the third intracellular loop. Endocrinology 2009, 150:3169-3176.
    • (2009) Endocrinology , vol.150 , pp. 3169-3176
    • Peverelli, E.1    Lania, A.G.2    Mantovani, G.3    Beck-Peccoz, P.4    Spada, A.5
  • 291
    • 74849085773 scopus 로고    scopus 로고
    • The dopamine-somatostatin chimeric compound BIM-23A760 exerts antiproliferative and cytotoxic effects in human non-functioning pituitary tumors by activating ERK1/2 and p38 pathways
    • Peverelli E., Olgiati L., Locatelli M., Magni P., Fustini M.F., Frank G., Mantovani G., Beck-Peccoz P., Spada A., Lania A. The dopamine-somatostatin chimeric compound BIM-23A760 exerts antiproliferative and cytotoxic effects in human non-functioning pituitary tumors by activating ERK1/2 and p38 pathways. Cancer Lett. 2010, 288:170-176.
    • (2010) Cancer Lett. , vol.288 , pp. 170-176
    • Peverelli, E.1    Olgiati, L.2    Locatelli, M.3    Magni, P.4    Fustini, M.F.5    Frank, G.6    Mantovani, G.7    Beck-Peccoz, P.8    Spada, A.9    Lania, A.10
  • 294
    • 0021159151 scopus 로고
    • Long-acting and selective suppression of growth hormone secretion by somatostatin analog SMS-201-995 in acromegaly
    • Plewe G., Krause U., Beyer J., Neufeld M., Delpozo E. Long-acting and selective suppression of growth hormone secretion by somatostatin analog SMS-201-995 in acromegaly. Lancet 1984, 2:782-784.
    • (1984) Lancet , vol.2 , pp. 782-784
    • Plewe, G.1    Krause, U.2    Beyer, J.3    Neufeld, M.4    Delpozo, E.5
  • 296
    • 0025641087 scopus 로고
    • Gastrointestinal side-effects of octreotide during long-term treatment of acromegaly
    • Plockinger U., Dienemann D., Quabbe H.J. Gastrointestinal side-effects of octreotide during long-term treatment of acromegaly. J. Clin. Endocrinol. Metabol. 1990, 71:1658-1662.
    • (1990) J. Clin. Endocrinol. Metabol. , vol.71 , pp. 1658-1662
    • Plockinger, U.1    Dienemann, D.2    Quabbe, H.J.3
  • 297
    • 84856094615 scopus 로고    scopus 로고
    • DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4-and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in octreotide non-responsive tumours
    • Plockinger U., Hoffmann U., Geese M., Lupp A., Buchfelder M., Flitsch J., Vajkoczy P., Jakob W., Saeger W., Schulz S., Dohrmann C. DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4-and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in octreotide non-responsive tumours. Eur. J. Endocrinol. 2012, 166:223-234.
    • (2012) Eur. J. Endocrinol. , vol.166 , pp. 223-234
    • Plockinger, U.1    Hoffmann, U.2    Geese, M.3    Lupp, A.4    Buchfelder, M.5    Flitsch, J.6    Vajkoczy, P.7    Jakob, W.8    Saeger, W.9    Schulz, S.10    Dohrmann, C.11
  • 298
    • 0028135581 scopus 로고
    • Preoperative octreotide treatment of growth hormone secreting and clinically non-functioning pituitary macroadenomas: effect on tumor volume and lack of correlation with immunohistochemistry and somatostatin receptor scintigraphy
    • Plockinger U., Reichel M., Fett U., Saeger W., Quabbe H.J. Preoperative octreotide treatment of growth hormone secreting and clinically non-functioning pituitary macroadenomas: effect on tumor volume and lack of correlation with immunohistochemistry and somatostatin receptor scintigraphy. J. Clin. Endocrinol. Metabol. 1994, 79:1416-1423.
    • (1994) J. Clin. Endocrinol. Metabol. , vol.79 , pp. 1416-1423
    • Plockinger, U.1    Reichel, M.2    Fett, U.3    Saeger, W.4    Quabbe, H.J.5
  • 299
    • 0142103488 scopus 로고    scopus 로고
    • Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells - involvement of Rac and MAP kinase activity
    • Pola S., Cattaneo M.G., Vicentini L.M. Anti-migratory and anti-invasive effect of somatostatin in human neuroblastoma cells - involvement of Rac and MAP kinase activity. J. Biol. Chem. 2003, 278:40601-40606.
    • (2003) J. Biol. Chem. , vol.278 , pp. 40601-40606
    • Pola, S.1    Cattaneo, M.G.2    Vicentini, L.M.3
  • 301
    • 0029894515 scopus 로고    scopus 로고
    • Transforming growth factor-beta and p27 expression in pituitary cells
    • Qian X., Jin L., Grande J.P., Lloyd R.V. Transforming growth factor-beta and p27 expression in pituitary cells. Endocrinology 1996, 137:3051-3060.
    • (1996) Endocrinology , vol.137 , pp. 3051-3060
    • Qian, X.1    Jin, L.2    Grande, J.P.3    Lloyd, R.V.4
  • 303
    • 84869496395 scopus 로고    scopus 로고
    • Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model
    • Quinn T.J., Yuan Z.Q., Adem A., Geha R., Vrikshajanani C., Koba W., Fine E., Hughes D.T., Schmid H.A., Libutti S.K. Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. Surgery 2012, 152:1068-1076.
    • (2012) Surgery , vol.152 , pp. 1068-1076
    • Quinn, T.J.1    Yuan, Z.Q.2    Adem, A.3    Geha, R.4    Vrikshajanani, C.5    Koba, W.6    Fine, E.7    Hughes, D.T.8    Schmid, H.A.9    Libutti, S.K.10
  • 305
    • 0030949012 scopus 로고    scopus 로고
    • Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness
    • Reardon D.B., Dent P., Wood S.L., Kong T., Sturgill T.W. Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness. Mol. Endocrinol. 1997, 11:1062-1069.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1062-1069
    • Reardon, D.B.1    Dent, P.2    Wood, S.L.3    Kong, T.4    Sturgill, T.W.5
  • 306
    • 0029918489 scopus 로고    scopus 로고
    • Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin
    • Reardon D.B., Wood S.L., Brautigan D.L., Bell G.I., Dent P., Sturgill T.W. Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin. Biochem. J. 1996, 314:401-404.
    • (1996) Biochem. J. , vol.314 , pp. 401-404
    • Reardon, D.B.1    Wood, S.L.2    Brautigan, D.L.3    Bell, G.I.4    Dent, P.5    Sturgill, T.W.6
  • 307
    • 0029014727 scopus 로고
    • Octreotide-associated biliary tract dysfunction and gallstone formation: pathophysiology and management
    • Redfern J.S., Fortuner W.J. Octreotide-associated biliary tract dysfunction and gallstone formation: pathophysiology and management. Am. J. Gastroenterol. 1995, 90:1042-1052.
    • (1995) Am. J. Gastroenterol. , vol.90 , pp. 1042-1052
    • Redfern, J.S.1    Fortuner, W.J.2
  • 308
    • 0020573238 scopus 로고
    • Prolonged somatostatin pretreatment desensitizes somatostatins inhibition of receptor mediated release of adrenocorticotropin hormone and sensitizes adenylate cyclase
    • Reisine T., Axelrod J. Prolonged somatostatin pretreatment desensitizes somatostatins inhibition of receptor mediated release of adrenocorticotropin hormone and sensitizes adenylate cyclase. Endocrinology 1983, 113:811-813.
    • (1983) Endocrinology , vol.113 , pp. 811-813
    • Reisine, T.1    Axelrod, J.2
  • 309
    • 0344874253 scopus 로고    scopus 로고
    • Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand
    • Ren S.G., Kim S., Taylor J., Dong J.S., Moreau J.P., Culler M.D., Melmed S. Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand. J. Clin. Endocrinol. Metabol. 2003, 88:5414-5421.
    • (2003) J. Clin. Endocrinol. Metabol. , vol.88 , pp. 5414-5421
    • Ren, S.G.1    Kim, S.2    Taylor, J.3    Dong, J.S.4    Moreau, J.P.5    Culler, M.D.6    Melmed, S.7
  • 311
    • 0030245732 scopus 로고    scopus 로고
    • Neurotransmitter induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin
    • Renstrom E., Ding W.G., Bokvist K., Rorsman P. Neurotransmitter induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin. Neuron 1996, 17:513-522.
    • (1996) Neuron , vol.17 , pp. 513-522
    • Renstrom, E.1    Ding, W.G.2    Bokvist, K.3    Rorsman, P.4
  • 313
    • 0026725933 scopus 로고
    • In vitro detection of somatostatin receptors in human tumors
    • Reubi J.C., Krenning E., Lamberts S.W.J., Kvols L. In vitro detection of somatostatin receptors in human tumors. Metabolism 1992, 41:104-110.
    • (1992) Metabolism , vol.41 , pp. 104-110
    • Reubi, J.C.1    Krenning, E.2    Lamberts, S.W.J.3    Kvols, L.4
  • 314
    • 0025028868 scopus 로고
    • Detection of somatostatin receptors in surgical and percutaneous needle-biopsy samples of carcinoids and islet cell carcinomas
    • Reubi J.C., Kvols L.K., Waser B., Nagorney D.M., Heitz P.U., Charboneau J.W., Reading C.C., Moertel C. Detection of somatostatin receptors in surgical and percutaneous needle-biopsy samples of carcinoids and islet cell carcinomas. Cancer Res. 1990, 50:5969-5977.
    • (1990) Cancer Res. , vol.50 , pp. 5969-5977
    • Reubi, J.C.1    Kvols, L.K.2    Waser, B.3    Nagorney, D.M.4    Heitz, P.U.5    Charboneau, J.W.6    Reading, C.C.7    Moertel, C.8
  • 315
    • 0026726498 scopus 로고
    • Somatostatin receptors in human cancer: incidence, characteristics, functional correlates and clinical implications
    • Reubi J.C., Laissue J., Krenning E., Lamberts S.W. Somatostatin receptors in human cancer: incidence, characteristics, functional correlates and clinical implications. J. Steroid Biochem. Mol. Biol. 1992, 43:27-35.
    • (1992) J. Steroid Biochem. Mol. Biol. , vol.43 , pp. 27-35
    • Reubi, J.C.1    Laissue, J.2    Krenning, E.3    Lamberts, S.W.4
  • 316
    • 0034924612 scopus 로고    scopus 로고
    • Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands
    • Reubi J.C., Waser B., Schaer J.C., Laissue J.A. Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands. Eur. J. Nucl. Med. 2001, 28:836-846.
    • (2001) Eur. J. Nucl. Med. , vol.28 , pp. 836-846
    • Reubi, J.C.1    Waser, B.2    Schaer, J.C.3    Laissue, J.A.4
  • 318
    • 0019451703 scopus 로고
    • Cholestatic action of somatostatin in the rat - effect on the different fractions of bile secretion
    • Ricci G.L., Fevery J. Cholestatic action of somatostatin in the rat - effect on the different fractions of bile secretion. Gastroenterology 1981, 81:552-562.
    • (1981) Gastroenterology , vol.81 , pp. 552-562
    • Ricci, G.L.1    Fevery, J.2
  • 319
    • 0019367724 scopus 로고
    • Inhibition of adrenocorticotropin secretion by somatostatin in pituitary-cells in culture
    • Richardson U.I., Schonbrunn A. Inhibition of adrenocorticotropin secretion by somatostatin in pituitary-cells in culture. Endocrinology 1981, 108:281-290.
    • (1981) Endocrinology , vol.108 , pp. 281-290
    • Richardson, U.I.1    Schonbrunn, A.2
  • 320
    • 70350442637 scopus 로고    scopus 로고
    • Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group
    • Rinke A., Muller H.H., Schade-Brittinger C., Klose K.J., Barth P., Wied M., Mayer C., Aminossadati B., Pape U.F., Blaker M., Harder J., Arnold C., Gress T., Arnold R. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J. Clin. Oncol. 2009, 27:4656-4663.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4656-4663
    • Rinke, A.1    Muller, H.H.2    Schade-Brittinger, C.3    Klose, K.J.4    Barth, P.5    Wied, M.6    Mayer, C.7    Aminossadati, B.8    Pape, U.F.9    Blaker, M.10    Harder, J.11    Arnold, C.12    Gress, T.13    Arnold, R.14
  • 321
    • 0034616021 scopus 로고    scopus 로고
    • Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity
    • Rocheville M., Lange D.C., Kumar U., Patel S.C., Patel R.C., Patel Y.C. Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 2000, 288:154-157.
    • (2000) Science , vol.288 , pp. 154-157
    • Rocheville, M.1    Lange, D.C.2    Kumar, U.3    Patel, S.C.4    Patel, R.C.5    Patel, Y.C.6
  • 322
    • 0034677745 scopus 로고    scopus 로고
    • Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers
    • Rocheville M., Lange D.C., Kumar U., Sasi R., Patel R.C., Patel Y.C. Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. J. Biol. Chem. 2000, 275:7862-7869.
    • (2000) J. Biol. Chem. , vol.275 , pp. 7862-7869
    • Rocheville, M.1    Lange, D.C.2    Kumar, U.3    Sasi, R.4    Patel, R.C.5    Patel, Y.C.6
  • 325
    • 0017640397 scopus 로고
    • Prevention by somatostatin of rise in blood pressure and plasma renin mediated by beta-receptor stimulation
    • Rosenthal J., Escobarjimenez F., Raptis S. Prevention by somatostatin of rise in blood pressure and plasma renin mediated by beta-receptor stimulation. Clin. Endocrinol. 1977, 6:455-462.
    • (1977) Clin. Endocrinol. , vol.6 , pp. 455-462
    • Rosenthal, J.1    Escobarjimenez, F.2    Raptis, S.3
  • 326
    • 0027994721 scopus 로고
    • Characterization of somatostatin receptor subtypes controlling rat gastric-acid and pancreatic amylase release
    • Rossowski W.J., Gu Z.F., Akarca U.S., Jensen R.T., Coy D.H. Characterization of somatostatin receptor subtypes controlling rat gastric-acid and pancreatic amylase release. Peptides 1994, 15:1421-1424.
    • (1994) Peptides , vol.15 , pp. 1421-1424
    • Rossowski, W.J.1    Gu, Z.F.2    Akarca, U.S.3    Jensen, R.T.4    Coy, D.H.5
  • 327
    • 31444447551 scopus 로고    scopus 로고
    • SOM230 inhibits insulin-like growth factor-I action in mammary gland development by pituitary independent mechanism: mediated through somatostatin subtype receptor 3?
    • Ruan W.F., Fahlbusch F., Clemmons D.R., Monaco M.E., Walden P.D., Silva A.P., Schmid H.A., Kleinberg D.L. SOM230 inhibits insulin-like growth factor-I action in mammary gland development by pituitary independent mechanism: mediated through somatostatin subtype receptor 3?. Mol. Endocrinol. 2006, 20:426-436.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 426-436
    • Ruan, W.F.1    Fahlbusch, F.2    Clemmons, D.R.3    Monaco, M.E.4    Walden, P.D.5    Silva, A.P.6    Schmid, H.A.7    Kleinberg, D.L.8
  • 329
    • 0027947499 scopus 로고
    • On the mechanism of cytosolic phospholipase A2 Activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase
    • Sakanaka C., Ferby I., Waga I., Bito H., Shimizu T. On the mechanism of cytosolic phospholipase A2 Activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase. Biochem. Biophys. Res. Commun. 1994, 205:18-23.
    • (1994) Biochem. Biophys. Res. Commun. , vol.205 , pp. 18-23
    • Sakanaka, C.1    Ferby, I.2    Waga, I.3    Bito, H.4    Shimizu, T.5
  • 330
    • 33750090081 scopus 로고    scopus 로고
    • Somatostatin and dopamine-somatostatin multiple ligands directed towards somatostatin and dopamine receptors in pituitary adenomas
    • Saveanu A., Gunz G., Guillen S., Dufour H., Culler M.D., Jaquet P. Somatostatin and dopamine-somatostatin multiple ligands directed towards somatostatin and dopamine receptors in pituitary adenomas. Neuroendocrinology 2006, 83:258-263.
    • (2006) Neuroendocrinology , vol.83 , pp. 258-263
    • Saveanu, A.1    Gunz, G.2    Guillen, S.3    Dufour, H.4    Culler, M.D.5    Jaquet, P.6
  • 331
    • 0036929913 scopus 로고    scopus 로고
    • Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells
    • Saveanu A., Lavaque E., Gunz G., Barlier A., Kim S., Taylor J.E., Culler M.D., Enjalbert A., Jaquet P. Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells. J. Clin. Endocrinol. Metabol. 2002, 87:5545-5552.
    • (2002) J. Clin. Endocrinol. Metabol. , vol.87 , pp. 5545-5552
    • Saveanu, A.1    Lavaque, E.2    Gunz, G.3    Barlier, A.4    Kim, S.5    Taylor, J.E.6    Culler, M.D.7    Enjalbert, A.8    Jaquet, P.9
  • 332
    • 0024213731 scopus 로고
    • Oncological applications of somatostatin analogs
    • Schally A.V. Oncological applications of somatostatin analogs. Cancer Res. 1988, 48:6977-6985.
    • (1988) Cancer Res. , vol.48 , pp. 6977-6985
    • Schally, A.V.1
  • 334
    • 0025863086 scopus 로고
    • Brain Somatostatin: receptor-coupled transducing mechanisms and role in cognitive functions
    • Schettini G. Brain Somatostatin: receptor-coupled transducing mechanisms and role in cognitive functions. Pharmacol. Res. 1991, 23:203-215.
    • (1991) Pharmacol. Res. , vol.23 , pp. 203-215
    • Schettini, G.1
  • 335
    • 0021924681 scopus 로고
    • Pertussis toxin selectively abolishes hormone induced lowering of cytosolic calcium in Gh3 cells
    • Schlegel W., Wuarin F., Zbaren C., Wollheim C.B., Zahnd G.R. Pertussis toxin selectively abolishes hormone induced lowering of cytosolic calcium in Gh3 cells. FEBS Lett. 1985, 189:27-32.
    • (1985) FEBS Lett. , vol.189 , pp. 27-32
    • Schlegel, W.1    Wuarin, F.2    Zbaren, C.3    Wollheim, C.B.4    Zahnd, G.R.5
  • 336
    • 6044221565 scopus 로고    scopus 로고
    • Functional activity of the multiligand analog SOM230 at human recombinant somatostatin receptor subtypes supports its usefulness in neuroendocrine tumors
    • Schmid H.A., Schoeffter P. Functional activity of the multiligand analog SOM230 at human recombinant somatostatin receptor subtypes supports its usefulness in neuroendocrine tumors. Neuroendocrinology 2004, 80:47-50.
    • (2004) Neuroendocrinology , vol.80 , pp. 47-50
    • Schmid, H.A.1    Schoeffter, P.2
  • 337
    • 43549111835 scopus 로고    scopus 로고
    • Pasireotide (SOM230): development, mechanism of action and potential applications
    • Schmid H.A. Pasireotide (SOM230): development, mechanism of action and potential applications. Mol. Cell. Endocrinol. 2008, 286:69-74.
    • (2008) Mol. Cell. Endocrinol. , vol.286 , pp. 69-74
    • Schmid, H.A.1
  • 338
    • 83455211387 scopus 로고    scopus 로고
    • Effects of somatostatin analogs on glucose homeostasis in rats
    • Schmid H.A., Brueggen J. Effects of somatostatin analogs on glucose homeostasis in rats. J. Endocrinol. 2012, 212:49-60.
    • (2012) J. Endocrinol. , vol.212 , pp. 49-60
    • Schmid, H.A.1    Brueggen, J.2
  • 339
    • 2542544479 scopus 로고    scopus 로고
    • First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography
    • Schottelius M., Poethko T., Herz M., Reubi J.C., Kessler H., Schwaiger M., Wester H.J. First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography. Clin. Cancer Res. 2004, 10:3593-3606.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3593-3606
    • Schottelius, M.1    Poethko, T.2    Herz, M.3    Reubi, J.C.4    Kessler, H.5    Schwaiger, M.6    Wester, H.J.7
  • 340
    • 17444441370 scopus 로고    scopus 로고
    • Immunocytochemical detection of somatostatin receptors sst(1), sst(2A), sst(2B), and sst(3) in paraffin-embedded breast cancer tissue using subtype-specific antibodies
    • Schulz S., Schulz S., Schmitt J., Wiborny D., Schmidt H., Olbricht S., Weise W., Roessner A., Gramsch C., Hollt V. Immunocytochemical detection of somatostatin receptors sst(1), sst(2A), sst(2B), and sst(3) in paraffin-embedded breast cancer tissue using subtype-specific antibodies. Clin. Cancer Res. 1998, 4:2047-2052.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2047-2052
    • Schulz, S.1    Schulz, S.2    Schmitt, J.3    Wiborny, D.4    Schmidt, H.5    Olbricht, S.6    Weise, W.7    Roessner, A.8    Gramsch, C.9    Hollt, V.10
  • 341
    • 0027537043 scopus 로고
    • Interactions of the P107 and Rb proteins with E2F during the cell proliferation response
    • Schwarz J.K., Devoto S.H., Smith E.J., Chellappan S.P., Jakoi L., Nevins J.R. Interactions of the P107 and Rb proteins with E2F during the cell proliferation response. EMBO J. 1993, 12:1013-1020.
    • (1993) EMBO J. , vol.12 , pp. 1013-1020
    • Schwarz, J.K.1    Devoto, S.H.2    Smith, E.J.3    Chellappan, S.P.4    Jakoi, L.5    Nevins, J.R.6
  • 342
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R., Krebs E.G. The MAPK signaling cascade. FASEB J. 1995, 9:726-735.
    • (1995) FASEB J. , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 343
    • 0033588252 scopus 로고    scopus 로고
    • Prolonged activation of extracellular signal-regulated kinase by a protein kinase C-dependent and N17Ras-insensitive mechanism mediates the proliferative response of G(i/o)-coupled somatostatin sst(4) receptors
    • Sellers L.A. Prolonged activation of extracellular signal-regulated kinase by a protein kinase C-dependent and N17Ras-insensitive mechanism mediates the proliferative response of G(i/o)-coupled somatostatin sst(4) receptors. J. Biol. Chem. 1999, 274:24280-24288.
    • (1999) J. Biol. Chem. , vol.274 , pp. 24280-24288
    • Sellers, L.A.1
  • 344
    • 0033852193 scopus 로고    scopus 로고
    • Receptor isoforms mediate opposing proliferative effects through gbetagamma-activated p38 or Akt pathways
    • Sellers L.A., Alderton F., Carruthers A.M., Schindler M., Humphrey P.P. Receptor isoforms mediate opposing proliferative effects through gbetagamma-activated p38 or Akt pathways. Mol. Cell. Biol. 2000, 20:5974-5985.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5974-5985
    • Sellers, L.A.1    Alderton, F.2    Carruthers, A.M.3    Schindler, M.4    Humphrey, P.P.5
  • 345
    • 0033522985 scopus 로고    scopus 로고
    • Activated g protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Resultant effects on cell proliferation
    • Sellers L.A., Feniuk W., Humphrey P.P., Lauder H. Activated g protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Resultant effects on cell proliferation. J. Biol. Chem. 1999, 274:16423-16430.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16423-16430
    • Sellers, L.A.1    Feniuk, W.2    Humphrey, P.P.3    Lauder, H.4
  • 346
    • 17744392005 scopus 로고    scopus 로고
    • Effectiveness of adding dopamine agonist therapy to long-acting somatostatin analogues in the management of acromegaly
    • Selvarajah D., Webster J., Ross R., Newell-Price J. Effectiveness of adding dopamine agonist therapy to long-acting somatostatin analogues in the management of acromegaly. Eur. J. Endocrinol. 2005, 152:569-574.
    • (2005) Eur. J. Endocrinol. , vol.152 , pp. 569-574
    • Selvarajah, D.1    Webster, J.2    Ross, R.3    Newell-Price, J.4
  • 347
    • 0029959644 scopus 로고    scopus 로고
    • Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3
    • Sharma K., Patel Y.C., Srikant C.B. Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3. Mol. Endocrinol. 1996, 10:1688-1696.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 1688-1696
    • Sharma, K.1    Patel, Y.C.2    Srikant, C.B.3
  • 348
    • 0032513507 scopus 로고    scopus 로고
    • Induction of wild-type p53, Bax, and acidic endonuclease during somatostatin-signaled apoptosis in MCF-7 human breast cancer cells
    • Sharma K., Srikant C.B. Induction of wild-type p53, Bax, and acidic endonuclease during somatostatin-signaled apoptosis in MCF-7 human breast cancer cells. Int. J. Cancer 1998, 76:259-266.
    • (1998) Int. J. Cancer , vol.76 , pp. 259-266
    • Sharma, K.1    Srikant, C.B.2
  • 349
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw R.J., Cantley L.C. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006, 441:424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 350
    • 84900811735 scopus 로고    scopus 로고
    • An open-label, dose-escalation study of once- and twice-daily pasireotide in healthy volunteers: safety, tolerability and effects on glucose, insulin and glucagon levels
    • June 16 (Epub ahead of print).
    • Shenouda, M., Maldonado, M., Wang, Y., Bouillaud, E., Hudson, M., Nesheiwat, D., Hu, K., 2012. An open-label, dose-escalation study of once- and twice-daily pasireotide in healthy volunteers: safety, tolerability and effects on glucose, insulin and glucagon levels. Am. J. Ther. June 16 (Epub ahead of print).
    • (2012) Am. J. Ther.
    • Shenouda, M.1    Maldonado, M.2    Wang, Y.3    Bouillaud, E.4    Hudson, M.5    Nesheiwat, D.6    Hu, K.7
  • 351
    • 0034660892 scopus 로고    scopus 로고
    • The Pezcoller lecture: cancer cell cycles revisited
    • Sherr C.J. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. 2000, 60:3689-3695.
    • (2000) Cancer Res. , vol.60 , pp. 3689-3695
    • Sherr, C.J.1
  • 352
    • 10244235366 scopus 로고    scopus 로고
    • PTR-3173 (Somatoprim (TM)), a novel somatostatin analog with affinity for somatostatin receptors 2, 4 and 5 is a potent inhibitor of human GH secretion
    • Shimon I., Rubinek T., Hadani M., Alhadef N. PTR-3173 (Somatoprim (TM)), a novel somatostatin analog with affinity for somatostatin receptors 2, 4 and 5 is a potent inhibitor of human GH secretion. J. Endocrinol. Invest. 2004, 27:721-727.
    • (2004) J. Endocrinol. Invest. , vol.27 , pp. 721-727
    • Shimon, I.1    Rubinek, T.2    Hadani, M.3    Alhadef, N.4
  • 353
    • 0031028364 scopus 로고    scopus 로고
    • Somatostatin receptor subtype specificity in human fetal pituitary cultures - differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation
    • Shimon I., Taylor J.E., Dong J.Z., Bitonte R.A., Kim S., Morgan B., Coy D.H., Culler M.D., Melmed S. Somatostatin receptor subtype specificity in human fetal pituitary cultures - differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation. J Clin. Invest. 1997, 99:789-798.
    • (1997) J Clin. Invest. , vol.99 , pp. 789-798
    • Shimon, I.1    Taylor, J.E.2    Dong, J.Z.3    Bitonte, R.A.4    Kim, S.5    Morgan, B.6    Coy, D.H.7    Culler, M.D.8    Melmed, S.9
  • 354
    • 0030690974 scopus 로고    scopus 로고
    • Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas - novel potential therapy for functional pituitary tumors
    • Shimon I., Yan X.M., Taylor J.E., Weiss M.H., Culler M.D., Melmed S. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas - novel potential therapy for functional pituitary tumors. J Clin. Invest. 1997, 100:2386-2392.
    • (1997) J Clin. Invest. , vol.100 , pp. 2386-2392
    • Shimon, I.1    Yan, X.M.2    Taylor, J.E.3    Weiss, M.H.4    Culler, M.D.5    Melmed, S.6
  • 355
    • 0016243374 scopus 로고
    • Inhibition by somatostatin on release of TSH induced in man by thyrotropin-releasing factor
    • Siler T.M., Yen S.C., Vale W., Guillemin R. Inhibition by somatostatin on release of TSH induced in man by thyrotropin-releasing factor. J. Clin. Endocrinol. Metabol. 1974, 38:742-745.
    • (1974) J. Clin. Endocrinol. Metabol. , vol.38 , pp. 742-745
    • Siler, T.M.1    Yen, S.C.2    Vale, W.3    Guillemin, R.4
  • 356
    • 0022514033 scopus 로고
    • Regulation of growth hormone mRNA and pro-opiomelanocortin mRNA levels by cyclic AMP in rat anterior pituitary cells in culture
    • Simard J., Labrie F., Gossard F. Regulation of growth hormone mRNA and pro-opiomelanocortin mRNA levels by cyclic AMP in rat anterior pituitary cells in culture. DNA 1986, 5:263-270.
    • (1986) DNA , vol.5 , pp. 263-270
    • Simard, J.1    Labrie, F.2    Gossard, F.3
  • 357
  • 359
    • 0033575927 scopus 로고    scopus 로고
    • The pivotal role of phosphoinositide-3 kinase in the human somatostatin sst(4) receptor-mediated stimulation of p44/p42 mitogen-activated protein kinase and extracellular acidification
    • Smalley K.S.M., Feniuk W., Sellers L.A., Humphrey P.P.A. The pivotal role of phosphoinositide-3 kinase in the human somatostatin sst(4) receptor-mediated stimulation of p44/p42 mitogen-activated protein kinase and extracellular acidification. Biochem. Biophys. Res. Commun. 1999, 263:239-243.
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 239-243
    • Smalley, K.S.M.1    Feniuk, W.2    Sellers, L.A.3    Humphrey, P.P.A.4
  • 360
    • 59649100349 scopus 로고    scopus 로고
    • 2+-channels in murine pancreatic beta-cells are inhibited by an exclusive coupling with somatostatin receptor subtype 1
    • 2+-channels in murine pancreatic beta-cells are inhibited by an exclusive coupling with somatostatin receptor subtype 1. Endocrinology 2009, 150:741-748.
    • (2009) Endocrinology , vol.150 , pp. 741-748
    • Smith, P.A.1
  • 361
    • 0025695763 scopus 로고
    • Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary-tumors with or without constitutively active adenylyl cyclase
    • Spada A., Arosio M., Bochicchio D., Bazzoni N., Vallar L., Bassetti M., Faglia G. Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary-tumors with or without constitutively active adenylyl cyclase. J. Clin. Endocrinol. Metabol. 1990, 71:1421-1426.
    • (1990) J. Clin. Endocrinol. Metabol. , vol.71 , pp. 1421-1426
    • Spada, A.1    Arosio, M.2    Bochicchio, D.3    Bazzoni, N.4    Vallar, L.5    Bassetti, M.6    Faglia, G.7
  • 362
    • 0030955765 scopus 로고    scopus 로고
    • Regulation of apopotosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain
    • Spengler D., Villalba M., Hoffmann A., Pantaloni C., Houssami S., Bockaert J., Journot L. Regulation of apopotosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997, 16:2814-2825.
    • (1997) EMBO J. , vol.16 , pp. 2814-2825
    • Spengler, D.1    Villalba, M.2    Hoffmann, A.3    Pantaloni, C.4    Houssami, S.5    Bockaert, J.6    Journot, L.7
  • 363
    • 0028933059 scopus 로고
    • Cell cycle dependent induction of apoptosis by somatostatin analog SMS-201-995 in AtT-20 mouse pituitary cells
    • Srikant C.B. Cell cycle dependent induction of apoptosis by somatostatin analog SMS-201-995 in AtT-20 mouse pituitary cells. Biochem. Biophys. Res. Commun. 1995, 209:400-406.
    • (1995) Biochem. Biophys. Res. Commun. , vol.209 , pp. 400-406
    • Srikant, C.B.1
  • 364
    • 0029937024 scopus 로고    scopus 로고
    • Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells
    • Srikant C.B., Shen S.H. Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells. Endocrinology 1996, 137:3461-3468.
    • (1996) Endocrinology , vol.137 , pp. 3461-3468
    • Srikant, C.B.1    Shen, S.H.2
  • 366
    • 33746273283 scopus 로고    scopus 로고
    • Effects of the long-acting somatostatin analogue Lanreotide Autogel on glucose tolerance and insulin resistance in acromegaly
    • Steffin B., Gutt B., Bidlingmaier M., Dieterle C., Oltmann F., Schopohl J. Effects of the long-acting somatostatin analogue Lanreotide Autogel on glucose tolerance and insulin resistance in acromegaly. Eur. J. Endocrinol. 2006, 155:73-78.
    • (2006) Eur. J. Endocrinol. , vol.155 , pp. 73-78
    • Steffin, B.1    Gutt, B.2    Bidlingmaier, M.3    Dieterle, C.4    Oltmann, F.5    Schopohl, J.6
  • 367
    • 0035798223 scopus 로고    scopus 로고
    • Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKC delta
    • Stetak A., Csermely P., Ullrich A., Keri G. Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKC delta. Biochem. Biophys. Res. Commun. 2001, 288:564-572.
    • (2001) Biochem. Biophys. Res. Commun. , vol.288 , pp. 564-572
    • Stetak, A.1    Csermely, P.2    Ullrich, A.3    Keri, G.4
  • 368
    • 0036282611 scopus 로고    scopus 로고
    • Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells
    • Strowski M.Z., Dashkevicz M.P., Parmar R.M., Wilkinson H., Kohler M., Schaeffer J.M., Blake A.D. Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells. Neuroendocrinology 2002, 75:339-346.
    • (2002) Neuroendocrinology , vol.75 , pp. 339-346
    • Strowski, M.Z.1    Dashkevicz, M.P.2    Parmar, R.M.3    Wilkinson, H.4    Kohler, M.5    Schaeffer, J.M.6    Blake, A.D.7
  • 370
    • 0034465470 scopus 로고    scopus 로고
    • Somatostatin inhibits insulin and glucagon secretion via two receptor subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice
    • Strowski M.Z., Parmar R.M., Blake A.D., Schaeffer J.M. Somatostatin inhibits insulin and glucagon secretion via two receptor subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology 2000, 141:111-117.
    • (2000) Endocrinology , vol.141 , pp. 111-117
    • Strowski, M.Z.1    Parmar, R.M.2    Blake, A.D.3    Schaeffer, J.M.4
  • 375
    • 0025266882 scopus 로고
    • Modulation of growth-hormone (GH) secretion and GH mRNA levels by GH-releasing factor, somatostatin and secretagogues in cultured bovine adenohypophyseal cells
    • Tanner J.W., Davis S.K., Mcarthur N.H., French J.T., Welsh T.H. Modulation of growth-hormone (GH) secretion and GH mRNA levels by GH-releasing factor, somatostatin and secretagogues in cultured bovine adenohypophyseal cells. J. Endocrinol. 1990, 125:109-115.
    • (1990) J. Endocrinol. , vol.125 , pp. 109-115
    • Tanner, J.W.1    Davis, S.K.2    Mcarthur, N.H.3    French, J.T.4    Welsh, T.H.5
  • 376
    • 0023893674 scopus 로고
    • In vitro and in vivo inhibition of human small cell lung-carcinoma (NCI-H69) growth by a somatostatin analog
    • Taylor J.E., Bogden A.E., Moreau J.P., Coy D.H. In vitro and in vivo inhibition of human small cell lung-carcinoma (NCI-H69) growth by a somatostatin analog. Biochem. Biophys. Res. Commun. 1988, 153:81-86.
    • (1988) Biochem. Biophys. Res. Commun. , vol.153 , pp. 81-86
    • Taylor, J.E.1    Bogden, A.E.2    Moreau, J.P.3    Coy, D.H.4
  • 378
    • 0036201631 scopus 로고    scopus 로고
    • Activation of human somatostatin receptor 2 promotes apoptosis through a mechanism that is independent from induction of p53
    • Teijeiro R., Rios R., Costoya J.A., Castro R., Bello J.L., Devesa J., Arce V.M. Activation of human somatostatin receptor 2 promotes apoptosis through a mechanism that is independent from induction of p53. Cell. Physiol. Biochem. 2002, 12:31-38.
    • (2002) Cell. Physiol. Biochem. , vol.12 , pp. 31-38
    • Teijeiro, R.1    Rios, R.2    Costoya, J.A.3    Castro, R.4    Bello, J.L.5    Devesa, J.6    Arce, V.M.7
  • 379
    • 0031005019 scopus 로고    scopus 로고
    • Somatostatin acts by inhibiting the cyclic 3',5'-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency
    • Tentler J.J., Hadcock J.R., Gutierrez-Hartmann A. Somatostatin acts by inhibiting the cyclic 3',5'-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency. Mol. Endocrinol. 1997, 11:859-866.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 859-866
    • Tentler, J.J.1    Hadcock, J.R.2    Gutierrez-Hartmann, A.3
  • 380
    • 4344624707 scopus 로고    scopus 로고
    • Quality of life in patients with gastroenteropancreatic tumors treated with [177Lu-DOTA0, Tyr3]octreotate
    • Teunissen J.J., Kwekkeboom D.J., Krenning E.P. Quality of life in patients with gastroenteropancreatic tumors treated with [177Lu-DOTA0, Tyr3]octreotate. J. Clin. Oncol. 2004, 22:2724-2729.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2724-2729
    • Teunissen, J.J.1    Kwekkeboom, D.J.2    Krenning, E.P.3
  • 384
    • 32944477371 scopus 로고    scopus 로고
    • Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression
    • Theodoropoulou M., Zhang J., Laupheimer S., Paez-Pereda M., Erneux C., Florio T., Pagotto U., Stalla G.K. Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression. Cancer Res. 2006, 66:1576-1582.
    • (2006) Cancer Res. , vol.66 , pp. 1576-1582
    • Theodoropoulou, M.1    Zhang, J.2    Laupheimer, S.3    Paez-Pereda, M.4    Erneux, C.5    Florio, T.6    Pagotto, U.7    Stalla, G.K.8
  • 389
    • 0028129624 scopus 로고
    • Octreotide treatment results in the inhibition of GH gene-expression in the adenoma of the patients with acromegaly
    • Tsukamoto N., Nagaya T., Kuwayama A., Takano K., Shizume K., Sugita K., Seo H. Octreotide treatment results in the inhibition of GH gene-expression in the adenoma of the patients with acromegaly. Endocrine J. 1994, 41:437-444.
    • (1994) Endocrine J. , vol.41 , pp. 437-444
    • Tsukamoto, N.1    Nagaya, T.2    Kuwayama, A.3    Takano, K.4    Shizume, K.5    Sugita, K.6    Seo, H.7
  • 390
    • 0025322867 scopus 로고
    • Somatostatin inhibits deoxyribonucleic-acid synthesis induced by both thyrotropin and insulin-like growth factor-i in FRTL5 cells
    • Tsuzaki S., Moses A.C. Somatostatin inhibits deoxyribonucleic-acid synthesis induced by both thyrotropin and insulin-like growth factor-i in FRTL5 cells. Endocrinology 1990, 126:3131-3138.
    • (1990) Endocrinology , vol.126 , pp. 3131-3138
    • Tsuzaki, S.1    Moses, A.C.2
  • 391
    • 2442705543 scopus 로고    scopus 로고
    • Differential beta-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes
    • Tulipano G., Stumm R., Pfeiffer M., Kreienkamp H.J., Hollt V., Schulz S. Differential beta-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes. J. Biol. Chem. 2004, 279:21374-21382.
    • (2004) J. Biol. Chem. , vol.279 , pp. 21374-21382
    • Tulipano, G.1    Stumm, R.2    Pfeiffer, M.3    Kreienkamp, H.J.4    Hollt, V.5    Schulz, S.6
  • 393
    • 0016270926 scopus 로고
    • Effects of somatostatin on secretion of thyrotropin and prolactin
    • Vale W., Rivier C., Brazeau P., Guillemin R. Effects of somatostatin on secretion of thyrotropin and prolactin. Endocrinology 1974, 95:968-977.
    • (1974) Endocrinology , vol.95 , pp. 968-977
    • Vale, W.1    Rivier, C.2    Brazeau, P.3    Guillemin, R.4
  • 394
    • 33644616790 scopus 로고    scopus 로고
    • Survival and response after peptide receptor radionuclide therapy with [90Y-DOTA0, Tyr3]octreotide in patients with advanced gastroenteropancreatic neuroendocrine tumors
    • Valkema R., Pauwels S., Kvols L.K., Barone R., Jamar F., Bakker W.H., Kwekkeboom D.J., Bouterfa H., Krenning E.P. Survival and response after peptide receptor radionuclide therapy with [90Y-DOTA0, Tyr3]octreotide in patients with advanced gastroenteropancreatic neuroendocrine tumors. Semin. Nucl. Med. 2006, 36:147-156.
    • (2006) Semin. Nucl. Med. , vol.36 , pp. 147-156
    • Valkema, R.1    Pauwels, S.2    Kvols, L.K.3    Barone, R.4    Jamar, F.5    Bakker, W.H.6    Kwekkeboom, D.J.7    Bouterfa, H.8    Krenning, E.P.9
  • 399
    • 0026673028 scopus 로고
    • Cloning and expression of a novel mouse somatostatin receptor (Sstr2B)
    • Vanetti M., Kouba M., Wang X.M., Vogt G., Hollt V. Cloning and expression of a novel mouse somatostatin receptor (Sstr2B). FEBS Lett. 1992, 311:290-294.
    • (1992) FEBS Lett. , vol.311 , pp. 290-294
    • Vanetti, M.1    Kouba, M.2    Wang, X.M.3    Vogt, G.4    Hollt, V.5
  • 402
    • 19744366733 scopus 로고    scopus 로고
    • Octreotide in insulinoma patients: efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sstS antibodies
    • Vezzosi D., Bennet A., Rochaix P., Courbon F., Selves J., Pradere B., Buscail L., Susini C., Caron P. Octreotide in insulinoma patients: efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sstS antibodies. Eur. J. Endocrinol. 2005, 152:757-767.
    • (2005) Eur. J. Endocrinol. , vol.152 , pp. 757-767
    • Vezzosi, D.1    Bennet, A.2    Rochaix, P.3    Courbon, F.4    Selves, J.5    Pradere, B.6    Buscail, L.7    Susini, C.8    Caron, P.9
  • 403
  • 408
    • 0035173408 scopus 로고    scopus 로고
    • Comparative somatostatin receptor scintigraphy using in-111-DOTA-lanreotide and in-111-DOTA-Tyr3-octreotide versus F-18-FDG-PET for evaluation of somatostatin receptor-mediated radionuclide therapy
    • Virgolini I., Patri P., Novotny C., Traub T., Leimer M., Füger B., Li S.R., Angelberger P., Raderer M., Wogritsch S., Kurtaran A., Kletter K., Dudczak R. Comparative somatostatin receptor scintigraphy using in-111-DOTA-lanreotide and in-111-DOTA-Tyr3-octreotide versus F-18-FDG-PET for evaluation of somatostatin receptor-mediated radionuclide therapy. Ann. Oncol. 2001, 12(Suppl. 2):S41-S45.
    • (2001) Ann. Oncol. , vol.12 , Issue.SUPPL. 2
    • Virgolini, I.1    Patri, P.2    Novotny, C.3    Traub, T.4    Leimer, M.5    Füger, B.6    Li, S.R.7    Angelberger, P.8    Raderer, M.9    Wogritsch, S.10    Kurtaran, A.11    Kletter, K.12    Dudczak, R.13
  • 409
    • 0034742565 scopus 로고    scopus 로고
    • The clinical value of [90Y-DOTA]-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study
    • Waldherr C., Pless M., Maecke H.R., Haldemann A., Mueller-Brand J. The clinical value of [90Y-DOTA]-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study. Ann. Oncol. 2001, 12:941-945.
    • (2001) Ann. Oncol. , vol.12 , pp. 941-945
    • Waldherr, C.1    Pless, M.2    Maecke, H.R.3    Haldemann, A.4    Mueller-Brand, J.5
  • 411
    • 0036773070 scopus 로고    scopus 로고
    • SOM230: a new somatostatin peptidomimetic with potent inhibitory effects on the growth hormone/insulin-like growth factor-I axis in rats, primates, and dogs
    • Weckbecker G., Briner U., Lewis I., Bruns C. SOM230: a new somatostatin peptidomimetic with potent inhibitory effects on the growth hormone/insulin-like growth factor-I axis in rats, primates, and dogs. Endocrinology 2002, 143:4123-4130.
    • (2002) Endocrinology , vol.143 , pp. 4123-4130
    • Weckbecker, G.1    Briner, U.2    Lewis, I.3    Bruns, C.4
  • 413
    • 0028670841 scopus 로고
    • Somatostatin analog octreotide enhances the antineoplastic effects of tamoxifen and ovariectomy on 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas
    • Weckbecker G., Tolcsvai L., Stolz B., Pollak M. Somatostatin analog octreotide enhances the antineoplastic effects of tamoxifen and ovariectomy on 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas. Cancer Res. 1994, 54:6334-6337.
    • (1994) Cancer Res. , vol.54 , pp. 6334-6337
    • Weckbecker, G.1    Tolcsvai, L.2    Stolz, B.3    Pollak, M.4
  • 418
    • 0030968052 scopus 로고    scopus 로고
    • Characterization of human recombinant somatostatin sst5 receptors mediating activation of phosphoinositide metabolism
    • Wilkinson G.F., Feniuk W., Humphrey P.P.A. Characterization of human recombinant somatostatin sst5 receptors mediating activation of phosphoinositide metabolism. Brit. J. Pharmacol. 1997, 121:91-96.
    • (1997) Brit. J. Pharmacol. , vol.121 , pp. 91-96
    • Wilkinson, G.F.1    Feniuk, W.2    Humphrey, P.P.A.3
  • 419
    • 0031565112 scopus 로고    scopus 로고
    • 2+ and inositol 1,4,5-trisphosphate in CHO-K1 cells expressing human recombinant somatostatin sst5 receptors
    • 2+ and inositol 1,4,5-trisphosphate in CHO-K1 cells expressing human recombinant somatostatin sst5 receptors. Eur. J. Pharmacol. 1997, 340:277-285.
    • (1997) Eur. J. Pharmacol. , vol.340 , pp. 277-285
    • Wilkinson, G.F.1    Feniuk, W.2    Humphrey, P.P.A.3
  • 420
    • 0023218289 scopus 로고
    • A comparison of the effects of bromocriptine and somatostatin on growth hormone gene expression in the rat anterior pituitary gland in vitro
    • Wood D.F., Docherty K., Ramsden D.B., Sheppard M.C. A comparison of the effects of bromocriptine and somatostatin on growth hormone gene expression in the rat anterior pituitary gland in vitro. Mol. Cell. Endocrinol. 1987, 52:257-261.
    • (1987) Mol. Cell. Endocrinol. , vol.52 , pp. 257-261
    • Wood, D.F.1    Docherty, K.2    Ramsden, D.B.3    Sheppard, M.C.4
  • 422
    • 0026544424 scopus 로고
    • Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney
    • Yamada Y., Post S.R., Wang K., Tager H.S., Bell G.I., Seino S. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:251-255.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 251-255
    • Yamada, Y.1    Post, S.R.2    Wang, K.3    Tager, H.S.4    Bell, G.I.5    Seino, S.6
  • 423
    • 0027055232 scopus 로고
    • Somatostatin receptors, an expanding gene family: cloning and functional characterization of human Sstr3, A Protein Coupled to Adenylyl Cyclase
    • Yamada Y., Reisine T., Law S.F., Ihara Y., Kubota A., Kagimoto S., Seino M., Seino Y., Bell G.I., Seino S. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human Sstr3, A Protein Coupled to Adenylyl Cyclase. Mol. Endocrinol. 1992, 6:2136-2142.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 2136-2142
    • Yamada, Y.1    Reisine, T.2    Law, S.F.3    Ihara, Y.4    Kubota, A.5    Kagimoto, S.6    Seino, M.7    Seino, Y.8    Bell, G.I.9    Seino, S.10
  • 424
    • 0344659810 scopus 로고
    • Hyperpolarization of the membrane-potential caused by somatostatin in dissociated human pituitary-adenoma cells that secrete growth hormone
    • Yamashita N., Shibuya N., Ogata E. Hyperpolarization of the membrane-potential caused by somatostatin in dissociated human pituitary-adenoma cells that secrete growth hormone. Proc. Natl. Acad. Sci. U.S.A. 1986, 83:6198-6202.
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 6198-6202
    • Yamashita, N.1    Shibuya, N.2    Ogata, E.3
  • 430
    • 0016401654 scopus 로고
    • Effect of somatostatin in patients with acromegaly: suppression of growth-hormone, prolactin, insulin and glucose levels
    • Yen S.C., Siler T.M., Devane G.W. Effect of somatostatin in patients with acromegaly: suppression of growth-hormone, prolactin, insulin and glucose levels. N. Eng. J. Med. 1974, 290:935-938.
    • (1974) N. Eng. J. Med. , vol.290 , pp. 935-938
    • Yen, S.C.1    Siler, T.M.2    Devane, G.W.3
  • 431
    • 0031887249 scopus 로고    scopus 로고
    • Regulation of the p85/p110 phosphatidylinositol 3 '-kinase: stabilization and inhibition of the p110 alpha catalytic subunit by the p85 regulatory subunit
    • Yu J.H., Zhang Y.T., McIlroy J., Rordorf-Nikolic T., Orr G.A., Backer J.M. Regulation of the p85/p110 phosphatidylinositol 3 '-kinase: stabilization and inhibition of the p110 alpha catalytic subunit by the p85 regulatory subunit. Mol. Cell. Biol. 1998, 18:1379-1387.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1379-1387
    • Yu, J.H.1    Zhang, Y.T.2    McIlroy, J.3    Rordorf-Nikolic, T.4    Orr, G.A.5    Backer, J.M.6
  • 435
    • 0038578269 scopus 로고    scopus 로고
    • Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas: effects on cell viability, GH, and PRL secretion
    • Zatelli M.C., Piccin D., Tagliati F., Ambrosio M.R., Margutti A., Padovani R., Scanarini M., Culler M.D., degli Uberti E. Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas: effects on cell viability, GH, and PRL secretion. J. Clin. Endocrinol. Metabol. 2003, 88:2797-2802.
    • (2003) J. Clin. Endocrinol. Metabol. , vol.88 , pp. 2797-2802
    • Zatelli, M.C.1    Piccin, D.2    Tagliati, F.3    Ambrosio, M.R.4    Margutti, A.5    Padovani, R.6    Scanarini, M.7    Culler, M.D.8    degli Uberti, E.9


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