The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas

Cancer Research

Volumn 60, Issue 24, 2000, Pages 6794-6799

  Pagotto, Uberto ^a   Arzberger, Thomas ^a   Theodoropoulou, Marily ^a   Grübler, Yvonne ^a   Pantaloni, Colette ^b   Saeger, Wolfgang ^c   Losa, Marco ^d   Journot, Laurent ^b   Stalla, Gɒnter K ^a   Spengler, Dietmar ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b CCIPE   (France)

^c Marienkrankenhaus Hamburg   (Germany)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GONADOTROPIN; HYPOPHYSIS HORMONE; MESSENGER RNA; ZINC FINGER PROTEIN;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CHROMOSOME 6Q; CONTROLLED STUDY; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOMA; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL DIVISION; DNA, COMPLEMENTARY; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MUTATION; OLIGONUCLEOTIDES, ANTISENSE; PITUITARY GLAND; PITUITARY NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; ZINC FINGERS;

EID: 0034671667     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Pathogenesis of pituitary tumors
2. G-proteins and hormonal signalling in human pituitary tumors: Genetic mutations and functional alterations
3. Hypermethylation of the p16/CDKN2A/MTS1 gene and loss of protein expression is associated with nonfunctional pituitary adenomas but not somatotrophinomas
4. Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain
5. hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer
6. Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells
7. Identification of a zinc-finger gene at 6q25: A chromosomal region implicated in development of many solid tumors
8. LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein
9. Inhibition of Zac1, a new gene differentially expressed in the anterior pituitary, increases cell proliferation
10. A defined chromosome 6q fragment (at D6S310) harbors a putative tumor suppressor gene for breast cancer
11. Frequent loss of heterozygosity on chromosome 6 in human ovarian carcinoma
12. Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker
13. Cell-specific expression of estrogen receptor in the human pituitary and its adenomas
14. Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors
15. Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth
16. Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma
17. The cytogenesis and pathogenesis of pituitary adenomas
18. Cancer epigenetics comes of age
19. Zac1 (Lot1), a potential tumor suppressor gene, and the gene for epsilon-sarcoglycan are maternally imprinted genes: Identification by a subtractive screen of novel uniparental fibroblast lines
20. The cell cycle control gene ZAC/PLAGL1 is imprinted - A strong candidate gene for transient neonatal diabetes