SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 303, Issue 9, 2012, Pages

  Kailey, Balrik ^a   van de Bunt, Martijn ^a   Cheley, Stephen ^b   Johnson, Paul R ^a,c,d   MacDonald, Patrick E ^b   Gloyn, Anna L ^a,c   Rorsman, Patrik ^a,c   Braun, Matthias ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Oxford Biomedical Research Centre ^*  (United Kingdom)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Electrophysiology; Exocytosis; Glucagon; Insulin; Somatostatin receptor 2

Indexed keywords

CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CALCIUM ION; HORMONE RECEPTOR STIMULATING AGENT; POTASSIUM CHANNEL BLOCKING AGENT; SOMATOSTATIN; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 3; SOMATOSTATIN RECEPTOR 4; SOMATOSTATIN RECEPTOR 5; TERTIAPIN Q; TOLBUTAMIDE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ARTICLE; BINDING AFFINITY; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL MEMBRANE STEADY POTENTIAL; CELL POLARITY; CELL TYPE; CELLULAR SECRETION; DEPOLARIZATION; DRUG RECEPTOR BINDING; EXOCYTOSIS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPERPOLARIZATION; IMMUNOHISTOCHEMISTRY; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CALCIUM SIGNALING; CELLS, CULTURED; EXOCYTOSIS; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GENE EXPRESSION REGULATION; GLUCAGON-SECRETING CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; KINETICS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PROTEIN ISOFORMS; PROTEIN SUBUNITS; RECEPTORS, SOMATOSTATIN; RECOMBINANT PROTEINS; RNA, MESSENGER; SOMATOSTATIN;

EID: 84868312359     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00207.2012     Document Type: Article

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