Antiproliferative effect of somatostatin and analogs

Chemotherapy

Volumn 47, Issue SUPPL. 2, 2001, Pages 30-39

  Bousquet, Corinne ^a   Puente, Elena ^a   Buscail, Louis ^a   Vaysse, Nicole ^a   Susini, Christiane ^a  

^a CHU RANGUEIL   (France)

Author keywords

Proliferation; Receptor signaling; Somatostatin receptor

Indexed keywords

ADENYLATE CYCLASE; ION CHANNEL; PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SOMATOSTATIN 1 RECEPTOR; SOMATOSTATIN 2 RECEPTOR; SOMATOSTATIN 3 RECEPTOR; SOMATOSTATIN 4 RECEPTOR; SOMATOSTATIN 5 RECEPTOR; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER; CELL PROLIFERATION; CELL TYPE; ENZYME INHIBITION; ENZYME REGULATION; HORMONE ACTION; HUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CELL DIVISION; HUMANS; NEOPLASMS; RECEPTORS, SOMATOSTATIN; SIGNAL TRANSDUCTION; SOMATOSTATIN;

EID: 0035084694     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000049159     Document Type: Review

References (59)

1. The somatostatin receptor in the GI tract
2. The neurobiology of somatostatin
3. Oncological applications of somatostatin analogues
4. Somatostatin analogs for diagnosis and treatment of cancer
5. Scintigraphic imaging of pituitary adenomas: An in vivo evaluation of somatostatin receptors
6. Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumours
7. Molecular properties of somatostatin receptors
8. The elucidation of somatostatin receptor functions: A current view
9. Coupling of rat somatostatin receptor subtypes to a G-protein gated inwardly rectifying potassium channel (GIRK1)
10. 2+ current in the pituitary cell line AtT-20
11. 2+ currents in rat insulinoma 1046-38 cells
12. The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity
13. Somatostatin stimulates Ca(2+)-activated K+ channels through protein dephosphorylation
14. Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin
15. Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase
16. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: Mediation by human somatostatin receptor subtypes SSTR1 and SSTR2
17. Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: Coexpression with catalytically inactive SHP-2 blocks responsiveness
18. The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells
19. 0
20. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms
21. Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype SSTR-5
22. Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2
23. Insulin-like growth factors and cancer
24. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry
25. Octreotide inhibits insulin-like growth factor-I hepatic gene expression in the hypophysectomized rat: Evidence for a direct and indirect mechanism of action
26. Octreotide as primary therapy for acromegaly
27. Somatuline (BIM 23014) and tamoxifen treatment of postmenopausal breast cancer patients: Clinical activity and effect on insulin-like growth factor-I (IGF-I) levels
28. Somatostatin analog induces insulin-like growth factor binding protein-1 (IGFBP-1) expression in human hepatoma cells
29. High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice
30. Immunohistochemical localization of somatostatin receptor SSTR-2A in human pancreatic islets
31. Somatostatin analogs: Angiogenesis inhibitors with novel mechanisms of action
32. High density of somatostatin receptors in veins surrounding human cancer tissue: Role in tumor-host interaction?
33. Somatostatin and the immune and haematopoetic system; a review
34. Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells
35. Inhibitory effect of somatostatin on human T lymphocytes proliferation
36. T lymphocytes isolated from the hepatic granulomas of schistosome-infected mice express somatostatin receptor subtype II (SSTR2) messenger RNA
37. Molecular pharmacology of somatostatin receptor subtypes
38. Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization
39. Expression of somatostatin receptor subtypes in human brain tumors
40. Immunocytochemical detection of somatostatin receptors SSTR-1, SSTR-2A, SSTR-2B, and SSTR-3 in paraffin-embedded breast cancer tissue using subtype-specific antibodies
41. Determination of somatostatin receptor subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies
42. Loss of SSTR-2 somatostatin receptor gene expression in human pancreatic and colorectal cancer
43. Somatostatin receptors in human prostate and prostate cancer
44. Protein tyrosine phosphatases in signal transduction
45. SSTR-2 somatostatin receptor mediates negative regulation of insulin receptor signaling through the tyrosine phosphatase Shp-1
46. Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells
47. The tyrosine phosphatase SHP-1 associates with the SSTR-2 somatostatin receptor and is an essential component of SSTR-2-mediated inhibitory growth signaling
48. Somatostatin inhibits PC Cl3 thyroid cell proliferation through the modulation of phosphotyrosine activity. Impairment of the somatostatinergic effects by stable expression of E1A viral oncogene
49. Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3
50. G protein coupled receptor signaled apoptosis is associated with activation of a cation insensitive acidic endonuclease and intracellular acidification
51. Insulin-like growth factor expression in human cancer cell lines
52. Role of growth factors in pancreatic cancer
53. Coexpression of gastrin and gastrin receptors (CCK-B and delta CCK-B) in gastrointestinal tumour cell lines
54. Inhibition of L-type calcium channels by octreotide in isolated human neuroendocrine tumor cells of the gut
55. Presence and characterization of the somatostatin precursor in ormal human pituitaries and in growth hormone secreting adenomas
56. Somatostatin (SRIH) messenger ribonucleic acid expression in human neuroendocrine and brain tumors using in situ hybridization histochemistry: Comparison with SRIH receptor content
57. Synthesis of somatostatin by breast cancer cells and their inhibition by exogenous somatostatin and sandostatin
58. Preprosomatostatin messenger RNA is expressed by inflammatory cells and induced by inflammatory mediators and cytokines
59. SSTR-2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells