PET imaging of somatostatin receptors: Design, synthesis and preclinical evaluation of a novel 18F-labelled, carbohydrated analogue of octreotide

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 30, Issue 1, 2003, Pages 117-122

  Wester, H J ^a   Schottelius, M ^a   Scheidhauer, K ^a   Meisetschlager G ^a   Herz, M ^a   Rau, F C ^a   Reubi, J C ^b   Schwaiger, M ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Carbohydration; Glycation; Octreotate; Octreotide; PET; Somatostatin

Indexed keywords

CARBOHYDRATE DERIVATIVE; FLUORINE 18; OCTREOTATE[LYSINE 3 TYROSINE][N ALPHA (1 DEOXY DEXTRO FRUCTOSYL) N EPSILON (2 FLUOROPROPIONYL) F 18]; OCTREOTIDE; OCTREOTIDE[3 TYROSINE]; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; GLYCATION; HUMAN; LIPOPHILICITY; LIVER CARCINOMA; LIVER METASTASIS; MOUSE; NONHUMAN; PANCREAS TUMOR; POSITRON EMISSION TOMOGRAPHY; RAT; RECEPTOR AFFINITY; TISSUE DISTRIBUTION; TUMOR SCINTISCANNING; URINARY EXCRETION;

AGED; ANIMALS; CARCINOID TUMOR; CELLS, CULTURED; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FEMALE; FRUCTOSE; HUMANS; ISOTOPE LABELING; LIVER NEOPLASMS; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, UNKNOWN PRIMARY; OCTREOTIDE; ORGAN SPECIFICITY; PANCREATIC NEOPLASMS; PEPTIDES, CYCLIC; RADIOPHARMACEUTICALS; RATS; RATS, INBRED LEW; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; SOMATOSTATIN-28; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0037870080     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-002-1012-1     Document Type: Article

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