Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: Role of the phosphotyrosine phosphatase SHP-2

Journal of Physiology Paris

Volumn 94, Issue 3-4, 2000, Pages 239-250

  Florio, Tullio ^a,b   Thellung, Stefano ^a,c   Arena, Sara ^a,c   Corsaro, Alessandro ^a,c   Bajetto, Adriana ^a,c   Schettini, Gennaro ^a,c   Stork, Philip J S ^d  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cell proliferation; Map kinase; p21(cip1 WAF1); Somatostatin; Tyrosine phosphatase

Indexed keywords

GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN P21; PROTEIN TYROSINE PHOSPHATASE; RAS PROTEIN; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CHO CELL; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVATION; NONHUMAN; ONCOGENE SRC; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

EID: 0033728783     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(00)00214-X     Document Type: Article

References (87)

1. Somatostatin controls Kaposi sarcoma growth through inhibition of angiogenesis
2. Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase
3. Molecular biology of somatostatin receptors
4. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor β to Ras
5. Sst2 somatostatin receptor mediates negative regulation of insulin receptor signaling through the tyrosine phosphatase SHP-1
6. Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase
7. Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat
8. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: Mediation by human somatostatin receptor subtypes SSTR1 and SSTR2
9. A somatostatin analogue inhibits MAP kinase activation and cell proliferation in human neuroblastoma and in human small cell lung carcinoma cell lines
10. Somatostatin-14 and its analog octreotide exert a cytostatic effect on GH3 rat pituitary tumor cell proliferation via a transient G0/G1 cell cycle block
11. Identification of the functional components of the ras signaling pathway regulating pituitary cell-specific gene expression
12. Inhibition by cAMP ras-dependent activation of raf
13. Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5
14. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells
15. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
16. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors
17. Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases
18. G protein-coupled receptor systems involved in cell growth and oncogenesis
19. Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling
20. Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin
21. SMS 201-995 inhibits in vitro and in vivo growth of human colon cancer
22. The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells
23. Multiple intracellular effectors modulate physiological functions of the cloned somatostatin receptors
24. Somatostatin inhibits PC C13 thyroid cell proliferation through the modulation of phosphotyrosine activity
25. Oncogene transformation of PC C13 clonal thyroid cell line that induces an autonomous pattern of proliferation that correlates with loss of basal and stimulated phoshotyrosine phosphatase activity
26. Somatostatin activation of MAP kinase via somatostatin receptor 1 (SSTR1)
27. Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells
28. Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway
29. Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells
30. Phosphatidyl inositol 3-kinase is an early intermediated in the Gβγ-mediated mitogen-activated protein kinase signaling pathway
31. Regulation of mitogen-activated protein kinase in the pars tuberalis of the ovine pituitary: Interactions between melatonin, insulin-like growth factor-1, and forskolin
32. The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in CHO cells via pertussis toxin sensitive pathways
33. Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cells line
34. Classification and nomenclature of somatostatin receptors
35. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice
36. βγ Interactions with PH domains and Ras-MAPK signaling pathways
37. Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation
38. Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain
39. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by Gβγ activation of p21ras
40. Coupling of rat somatostatin receptor subtypes to a G-protein gated inwardly rectifying potassium channel (GIRK1)
41. The role of somatostatin and its analogs in the diagnosis and treatment of tumors
42. Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by the p38/HOG MAPK pathway
43. Effects of epidermal growth factor and analogues of luteinizing hormone-releasing hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors
44. The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling
45. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ
46. Lack of SHPT1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness
47. Ras recruits Raf-1 to the plasmamembrane for activation by tyrosine phosphorylation
48. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
49. Reduced tyrosine kinase specific activity is associated with hypophosphorylation of pp60c-src in cells infected with avian erythroblastosis virus
50. Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin
51. The complexity of Raf-1 regulation
52. Structure and function of SH2-domain containing tyrosine phosphatase
53. Widespread distribution of somatostatin receptor messenger ribonucleic acids in rat pituitary
54. Sst2 somatostatin receptor mediates cell cycle arrest and induction of p27(Kip1). Evidence for the role of SHP-1
55. G protein activation of a hormone-stimulated protein-tyrosine phosphatase in human tumor cells
56. Regulation of Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association
57. Growth of human breast cancer cell lines is inhibited by the somatostatin analog BIM23014
58. Somatostatin analogues RC-160 inhibits the growth of transplanted colon cancer in rats
59. Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin
60. Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from ras-transformed NIH3T3 cells: Co-expression with catalytically inactive SHP-2 blocks responsiveness
61. Biochemical and functional properties of somatostatin receptors
62. Multiple actions of somatostatin in neoplastic disease
63. Somatostatin receptors in human endocrine tumors
64. The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors
65. A role for mitogen activated protein kinase in mediating the ability of gonadotropin-releasing hormone to activate the glycoprotein hormone α-subunit promoter
66. On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: Wortmannin-sensitive pathway to activate mitogen-activated protein kinase
67. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2
68. Growth factor signaling by receptor tyrosine kinases
69. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
70. Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase
71. Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells
72. Dominant inhibitory ras mutants selectively inhibit the activity of either cellular or oncogenic ras
73. Octapeptide analogues of somatostatin inhibit the clonal growth and vasoactive intestinal peptide-stimulated cyclic AMP formation in human small cell lung cancer cells
74. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene
75. Somatostatin inhibits deoxyribonucleic acid synthesis induced by both thyrotropin and insulin-like growth factor-I in FRTL5 cells
76. B-Raf dependent regulation of the MEK-1/MAP kinase pathway in PC12 cells and regulation by cAMP
77. Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a signalling pathway
78. Parathyroid hormone activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of Ras
79. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap 1-dependent pathway
80. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
81. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3', 5'-monophosphate
82. Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction
83. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
84. Nerve growth factor induce transcription of the p21(WAF/CIP1) and Cyclin D1 genes ir PC12 cells by activating the SpI transcription factor
85. Co-purification of a protein tyrosine phosphatase with activated somatostatin receptors from rat pancreatic acinar membranes
86. Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase
87. Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase