Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis

Molecular Endocrinology

Volumn 17, Issue 1, 2003, Pages 93-106

  Strowski, Mathias Z ^a,c   Kohler, Martin ^a   Chen, Howard Y ^a   Trumbauer, Myrna E ^a   Li, Zhihua ^a   Szalkowski, Deborah ^a   Gopal Truter, Shobhna ^a   Fisher, Jill K ^a   Schaeffer, James M ^a   Blake, Allan D ^b   Zhang, Bei B ^a   Wilkinson, Hilary A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b SETON HALL UNIVERSITY   (United States)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; LEPTIN; SOMATOSTATIN 28; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 5; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET; PRIORITY JOURNAL;

ANIMALS; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; FEMALE; GENE TARGETING; GLUCOSE; HOMEOSTASIS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; ORGAN CULTURE TECHNIQUES; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; SOMATOSTATIN-28; TRANSFECTION;

ANIMALIA;

EID: 12244309064     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2001-0035     Document Type: Article

References (55)

1. Brazeau P, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guillemin R 1973 Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179:77-79
2. Arnold R, Trautmann ME, Creutzfeldt W, Benning R, Benning M, Neuhaus C, Jurgensen R, Stein K, Schafer H, Bruns C, Dennler HJ 1996 Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumors. Gut 38:430-438
3. Fehmann HC, Wulbrand U, Arnold R 2000 Treatment of endocrine gastroenteropancreatic tumors with somatostatin analogues. Recent Results Cancer Res 153:15-22
4. Lamberts SW, Krenning EP, Klijn JG, Reubi JC 1990 The clinical use of somatostatin analogues in the treatment of cancer. Baillieres Clin Endocrinol Metab 4:29-49
5. Stewart PM, James RA 1999 The future of somatostatin analogue therapy. Baillieres Best Pract Res Clin Endocrinol Metab 13:409-418
6. Richardson UI, Schonbrunn A 1981 Inhibition of adrenocorticotropin secretion by somatostatin in pituitary cells in culture. Endocrinology 108:281-290
7. Shimon I, Taylor JE, Dong JZ, Bitonte RA, Kim S, Morgan B, Coy DH, Culler MD, Melmed S 1997 Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation. J Clin Invest 99:789-798
8. Martinez V, Curi AP, Torkian B, Schaeffer JM, Wilkinson HA, Walsh JH, Tache Y 1998 High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice. Gastroenterology 114:1125-1132
9. Epelbaum J, Enjalbert A, Krantic S, Musset F, Bertrand P, Rasolonjanahary R, Shu C, Kordon C 1987 Somatostatin receptors on pituitary somatotrophs, thyrotrophs, and lactotrophs: pharmacological evidence for loose coupling to adenylate cyclase. Endocrinology 121:2177-2185
10. Tallent MK, Siggins GR 1997 Somatostatin depresses excitatory but not inhibitory neurotransmission in rat CA1 hippocampus. J Neurophysiol 78:3008-3018
11. Tallent MK, Siggins GR 1999 Somatostatin acts in CA1 and CA3 to reduce hippocampal epileptiform activity. J Neurophysiol 81:1626-1635
12. Viollet C, Vaillend C, Videau C, Bluet-Pajot MT, Ungerer A, L'Heritier A, Kopp C, Potier B, Billard J, Schaeffer J, Smith RG, Rohrer SP, Wilkinson H, Zheng H, Epelbaum J 2000 Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice. Eur J Neurosci 12:3761-3770
13. von der Ohe M, Layer P, Wollny C, Ensinck JW, Peeters TL, Beglinger C, Goebell H 1992 Somatostatin 28 and coupling of human interdigestive intestinal motility and pancreatic secretion. Gastroenterology 103:974-981
14. Brinkmeier ML, Camper SA 1997 Localization of somatostatin receptor genes on mouse chromosomes 2, 11, 12, 15, and 17: correlation with growth QTLs. Genomics 43:9-14
15. Vanetti M, Kouba M, Wang X, Vogt G, Hollt V 1992 Cloning and expression of a novel mouse somatostatin receptor (SSTR2B). FEBS Lett 311:290-294
16. Vanetti M, Vogt G, Hollt V 1993 The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization. FEBS Lett 331:260-266
17. Raulf F, Perez J, Hoyer D, Bruns C 1994 Differential expression of five somatostatin receptor subtypes, SSTR1-5, in the CNS and peripheral tissue. Digestion 55:46-53
18. Reed DK, Korytko AI, Hipkin RW, Wehrenberg WB, Schonbrunn A, Cuttler L 1999 Pituitary somatostatin receptor (sst)1-5 expression during rat development: age-dependent expression of sst2. Endocrinology 140:4739-4744
19. Bruno JF, Xu Y, Song J, Berelowitz M 1993 Tissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat. Endocrinology 133:2561-2567
20. Burgus R, Ling N, Butcher M, Guillemin R 1973 Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone. Proc Natl Acad Sci USA 70:684-688
21. Praydayrol L, Jornvall H, Mutt V, Ribet A 1980 N-terminally extended somatostatin: the primary structure of somatostatin-28. FEBS Lett 109:55-58
22. Patel YC, Srikant CB 1994 Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology 135:2814-2817
23. Patel YC, Greenwood MT, Panetta R, Demchyshyn L, Niznik H, Srikant CB 1995 The somatostatin receptor family. Life Sci 57:1249-1265
24. Patel YC, Greenwood M, Panetta R, Hukovic N, Grigorakis S, Robertson LA, Srikant CB 1996 Molecular biology of somatostatin receptor subtypes. Metabolism 45:31-38
25. Mandarino L, Stenner D, Blanchard W, Nissen S, Gerich J, Ling N, Brazeau P, Bohlen P, Esch F, Guillemin R 1981 Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion. Nature 291:76-77
26. Amherdt M, Patel YC, Orci L 1989 Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells. J Clin Invest 84:412-417
27. Mitra SW, Mezey E, Hunyady B, Chamberlain L, Hayes E, Foor F, Wang Y, Schonbrunn A, Schaeffer JM 1999 Colocalization of somatostatin receptor sst5 and insulin in rat pancreatic β-cells. Endocrinology 140:3790-3796
28. Hunyady B, Hipkin RW, Schonbrunn A, Mezey E 1997 Immunohistochemical localization of somatostatin receptor SST2A in the rat pancreas. Endocrinology 138:2632-2635
29. Grigorakis S, Panetta R, Patel YC 1995 Somatostatin receptor (sstr) subtypes 1-5 in islets and differential downregulation of sstr2 mRNA by SST agonists. Diabetes 44:132A
30. Kumar U, Sasi R, Suresh S, Patel A, Thangaraju M, Metrakos P, Patel SC, Patel YC 1999 Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. Diabetes 48:77-85
31. Portela-Gomes GM, Stridsberg M, Grimelius L, Oberg K, Janson ET 2000 Expression of the five different somatostatin receptor subtypes in endocrine cells of the pancreas. Appl Immunohistochem Mol Morphol 8:126-132
32. Murphy WA, Heiman ML, Lance VA, Mezo I, Coy DH 1985 Octapeptide analogs of somatostatin exhibiting greatly enhanced in vivo and in vitro inhibition of growth hormone secretion in the rat. Biochem Biophys Res Commun 132:922-928
33. Coy DH, Rossowski WJ 1995 Somatostatin analogues and multiple receptors: possible physiological roles. Ciba Found Symp 190:240-252
34. Fagan SP, Azizzadeh A, Moldovan S, Ray MK, Adrian TE, Ding X, Coy DH, Brunicardi FC 1998 Insulin secretion is inhibited by subtype five somatostatin receptor in the mouse. Surgery 124:254-258; discussion 258-259
35. Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM 1998 Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282:737-740
36. Kreienkamp HJ, Akgun E, Baumeister H, Meyerhof W, Richter D 1999 Somatostatin receptor subtype I modulates basal inhibition of growth hormone release in somatotrophs. FEBS Lett 462:464-466
37. Zheng H, Bailey A, Jiang MH, Honda K, Chen HY, Trumbauer ME, Van der Ploeg LH, Schaeffer JM, Leng G, Smith RG 1997 Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol 11:1709-1717
38. Strowski MZ, Parmar RM, Blake AD, Schaeffer JM 2000 Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology 141:111-117
39. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
40. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS 1995 Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1:1311-1314
41. Rossowski WJ, Coy DH 1993 Potent inhibitory effects of a type four receptor-selective somatostatin analog on rat insulin release. Biochem Biophys Res Commun 197:366-371
42. Rossowski WJ, Coy DH 1994 Specific inhibition of rat pancreatic insulin or glucagon release by receptor-selective somatostatin analogs. Biochem Biophys Res Commun 205:341-346
43. Moldovan S, Atiya A, Adrian TE, Kleinman RM, Lloyd K, Olthoff K, Imagawa D, Shevlin L, Coy D, Walsh J, Brunicardi, FC 1995 Somatostatin inhibits B-cell secretion via a subtype-2 somatostatin receptor in the isolated perfused human pancreas. J Surg Res 59:85-90
44. Vicennati V, Pasquali R 2000 Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: evidence for a central and a peripheral alteration. J Clin Endocrinol Metab 85:4093-4098
45. Pasquali R, Cantobelli S, Casimirri F, Capelli M, Bortoluzzi L, Flamia R, Labate AM, Barbara L 1993 The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 77:341-346
46. Cherrington AD, Caldwell MD, Dietz MR, Exton JH, Crofford OB 1977 The effect of somatostatin on glucose uptake and production by rat tissues in vitro. Diabetes 26:740-748
47. Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB 2000 In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141:2328-2339
48. Sivitz WI, Walsh SA, Morgan DA, Thomas MJ, Haynes WG 1997 Effects of leptin on insulin sensitivity in normal rats. Endocrinology 138:3395-3401
49. Simon MA, Romero B, Calle C 1988 Characterization of somatostatin binding sites in isolated rat adipocytes. Regul Pept 23:261-270
50. Donahoo WT, Jensen DR, Yost TJ, Eckel RH 1997 Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion. J Clin Endocrinol Metab 82:4139-4143
51. Nakamura T, Nagasaka S, Ishikawa S, Nonaka M, Fujibayashi K, Saito T, Kusaka I, Higashiyama M 2000 Crucial role of insulin in leptin maintenance: profound decrease in serum leptin by octreotide acetate in insulinoma subjects. Endocr J 47:359-364
52. Ludvik B, Nolan JJ, Baloga J, Sacks D, Olefsky J 1995 Effect of obesity on insulin resistance in normal subjects and patients with NIDDM. Diabetes 44:1121-1125
53. Bradley A, Evans M, Kaufman MH, Robertson E 1984 Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309:255-256
54. Gotoh M, Maki T, Kiyoizumi T, Satomi S, Monaco AP 1985 An improved method for isolation of mouse pancreatic islets. Transplantation 40:437-438
55. Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van der Ploeg LH 2000 Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26:97-102