Effector coupling of somatostatin receptor subtypes on human endocrine tumors

Metabolism: Clinical and Experimental

Volumn 45, Issue SUPPL.1, 1996, Pages 42-45

  Kubota, Akira ^a   Yamada, Yuichiro ^a   Kagimoto, Shinji ^a   Seino, Susumu ^a   Seino, Yutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; FORSKOLIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; OCTREOTIDE; PERTUSSIS TOXIN; RECEPTOR SUBTYPE; SOMATOSTATIN 14; SOMATOSTATIN 28; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; VAPREOTIDE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; ENDOCRINE TUMOR; ENZYME ACTIVITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

EID: 0029808327     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90078-5     Document Type: Article

References (11)

1. Reichlin S: Somatostatin. N Engl J Med 309:1495-1501, 1556-1563, 1983
2. Lamberts SWJ, Krenning EP, Reubi JC: The role of somatostatin and its analogues in the diagnosis and treatment of tumours. Endocr Rev 12:450-482, 1991
3. Evers BM, Parekh D, Townsend CM Jr, et al: Somatostatin and analogues in the treatment of cancer. Ann Surg 213:190-198, 1991
4. Bauer W, Briner U, Doepfner W, et al: SMS-201-995: A very potent and selective octapeptide analogue of Somatostatin with prolonged action. Life Sci 31:1133-1140, 1982
5. Cai RZ, Szoke B, Lu R, et al: Synthesis and biological activity of highly potent octapeptide analogues of somatostatin. Proc Natl Acad Sci USA 83:1896-1900, 1986
6. Yamada Y, Post SR, Wang K, et al: Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract and kidney. Proc Natl Acad Sci USA 89:251-255, 1992
7. Yamada Y, Reisine T, Law SF, et al: Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR-3, a protein coupled to adenylyl cyclase. Mol Endocrinol 6:2136-2142, 1992
8. Yamada Y, Kagimoto S, Kubota A, et al: Cloning, functional expression and pharmacological characterization of a fourth (hSSTR-4) and a fifth (hSSTR-5) human somatostatin receptor subtype. Biochem Biophys Res Commun 195:844-852, 1993
9. Kubota A, Yamada Y, Kagimoto S, et al: Identification of somatostatin receptor subtypes and an implication for the effecacy of SMS-201-995 in treatment of human endocrine tumours. J Clin Invest 93:1321-1325, 1994
10. Kubota A, Yamada Y, Kagimoto S, et al: Multiple effector coupling of somatostatin receptor subtype SSTR-1. Biochem Biophys Res Commun 204:176-186, 1994
11. iα1 protein. Biochem Biophys Res Commun 202:1188-1195, 1994