Characterization of intracellular signaling mediated by human somatostatin receptor 5: Role of the DRY motif and the third intracellular loop

Endocrinology

Volumn 150, Issue 7, 2009, Pages 3169-3176

  Peverelli, Erika ^a   Lania, Andrea G ^a   Mantovani, Giovanna ^a   Beck Peccoz, Paolo ^a   Spada, Anna ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SOMATOSTATIN RECEPTOR 5;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE MUTATION; GROWTH HORMONE RELEASE; HORMONE RELEASE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; RAT; SIGNAL TRANSDUCTION; WILD TYPE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GROWTH HORMONE; HUMANS; RATS; RECEPTORS, SOMATOSTATIN; SIGNAL TRANSDUCTION; SOMATOSTATIN;

EID: 67649672452     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1785     Document Type: Article

References (48)

1. Patel YC 1999 Somatostatin and its receptors family. Front Neuroendocrinol 20:157-198
2. Møller LN, Stidsen CE, Hartmann B, Holst JJ 2003 Somatostatin receptors. Biochim Biophys Acta 1616:1-84 (Pubitemid 37272115)
3. Reisine T, Bell G 1995 Molecular biology of somatostatin receptor. Endocr Rev 16:427-442
4. Csaba Z, Dournaud P 2001 Cellular biology of somatostatin receptors. Neuropeptides 35:1-23 (Pubitemid 32382313)
5. Weckbecker G, Liu R, Tolcsvai L, Bruns C 1992 Antiproliferative effects of the somatostatin analogue octreotide (SMS 201-995) on ZR-75-1 human breast cancer cells in vivo and in vitro. Cancer Res 52:4973-4978
6. Law SF, Manning D, Reisine T 1991 Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors. J Biol Chem 266:17885-17897 (Pubitemid 21908025)
7. Law SF, Reisine T 1992 Agonist binding to rat brain somatostatin receptors alters the interaction of the receptor with guanine nucleotide-binding regulatory proteins. Mol Pharmacol 42:398-402 (Pubitemid 23024656)
8. Chen C, Vincent JD, Clarke IJ 1994 Ion channels and signal transduction pathways in the regulation of growth hormone secretion. Trends Endocrinol Metab 5:227-233 (Pubitemid 24329540)
9. Yang SK, Chen C 2007 Involvement of somatostatin receptor subtypes in membrane ion channel modification by somatostatin in pituitary somatotropes. Clin Exp Pharmacol Physiol 34:1221-1227 (Pubitemid 350013249)
10. Lopez F, Estève JP, Buscail L, Delesque N, Saint-Laurent N, Théveniau M, Nahmias C, Vaysse N, Susini C 1997 The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling. J Biol Chem 272:24448-24454 (Pubitemid 27418653)
11. Buscail L, Estève JP, Saint-Laurent N, Bertrand V, Reisine T, O'Carroll AM, Bell GI, Schally AV, Vaysse N, Susini C 1995 Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms. Proc Natl Acad Sci USA 92:1580-1584
12. Sharma K, Patel YC, Srikant CB 1999 C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest. Mol Endocrinol 13:82-90 (Pubitemid 29022281)
13. Cordelier P, Estève JP, Bousquet C, Delesque N, O'Carroll AM, Schally AV, Vaysse N, Susini C, Buscail L 1997 Characterization of the antiproliferative signal mediated by somatostatin receptor subtype 5. Proc Natl Acad Sci USA 94:9343-9348 (Pubitemid 27357831)
14. Patel YC, Srikant CB 1997 Somatostatin receptor. Trends Endocrinol Metab 10:398-405
15. Wess J 1998 Molecular basis of receptor/G-protein-coupling selectivity. Pharmacol Ther 80:231-264 (Pubitemid 28537822)
16. Peverelli E, Mantovani G, Calebiro D, Doni A, Bondioni S, Lania A, Beck-Peccoz P, Spada A 2008 The third intracellular loop of the human somatostatin receptor 5 is crucial for arrestin binding and receptor internalization after somatostatin stimulation. Mol Endocrinol 22:676-688
17. Okamoto T, Nishimoto I 1992 Detection of G protein-activator regions in Mq subtype muscarinic, cholinergic, and a2-adrenergic receptors based upon characteristics in primary structure. J Biol Chem 267:8342-8346
18. Pauwels PJ, Gouble A, Wurch T 1999 Activation of constitutive 5-hydroxytryptamine(1B) receptor by a series of mutations in the BBXXB motif: positioning of the third intracellular loop distal junction and its G(o)alpha protein interactions. Biochem J 343:435-442 (Pubitemid 29511779)
19. Ulloa-Aguirre A, Uribe A, Zariñán T, Bustos-Jaimes I, Pérez-Solis MA, Dias JA 2007 Role of the intracellular domains of the human FSH receptor in G(αS) protein coupling and receptor expression. Mol Cell Endocrinol 260-262:153-162 (Pubitemid 44792348)
20. Wu D, Jiang H, Simon MI 1995 Different α1-adrenergic receptor sequences required for activating different Gα subunits of Gq class of G proteins. J Biol Chem 270:9828-9832
21. Timossi C, Ortiz-Elizondo C, Pineda DB, Dias JA, Conn PM, Ulloa-Aguirre A 2004 Functional significance of the BBXXB motif reversed present in the cytoplasmic domains of the human follicle-stimulating hormone receptor. Mol Cell Endocrinol 223:17-26 (Pubitemid 38992906)
22. Acharya S, Karnik SS 1996 Modulation of GDP release from transducin by the conserved Glu134-Arg135 sequence in rhodopsin. J Biol Chem 271:25406-25411 (Pubitemid 26337912)
23. Shibata T, Suzuki C, Ohnishi J, Murakami K, Miyazaki H 1996 Identification of regions in the human angiotensin II receptor type 1 responsible for Gi and Gq coupling by mutagenesis study. Biochem Biophys Res Commun 218:383-389 (Pubitemid 26034543)
24. Zhu SZ, Wang SZ, Hu J, el-Fakahany EE 1994 An arginine residue conserved in most G protein-coupled receptors is essential for the function of the M1 muscarinic receptor. Mol Pharmacol 45:517-523 (Pubitemid 24094942)
25. Scheer A, Costa T, Fanelli F, De Benedetti PG, Mhaouty-Kodja S, Abuin L, Nenniger-Tosato M, Cotecchia S 2000 Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the α1b-adrenergic receptor: effects on receptor isomerization and activation. Mol Pharmacol 57:219-231 (Pubitemid 30084498)
26. Alewijnse AE, Timmerman H, Jacobs EH, Smit MJ, Roovers E, Cotecchia S, Leurs R 2000 The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H2 receptor. Mol Pharmacol 57:890-898 (Pubitemid 30253371)
27. Chung DA, Wade SM, Fowler CB, Woods DD, Abada PB, Mosberg HI, Neubig RR 2002 Mutagenesis and peptide analysis of the DRY motif in the α2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors. Biochem Biophys Res Commun 293:1233-1241 (Pubitemid 34681074)
28. Capra V, Veltri A, Foglia C, Crimaldi L, Habib A, Parenti M, Rovati GE 2004 Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling. Mol Pharmacol 66:880-889 (Pubitemid 39319460)
29. Timossi C, Maldonado D, Vizcaíno A, Lindau-Shepard B, Conn PM, Ulloa-Aguirre A 2002 Structural determinants in the second intracellular loop of the human follicle-stimulating hormone receptor are involved in G(s) protein activation. Mol Cell Endocrinol 189:157-168 (Pubitemid 34229173)
30. Rovati GE, Capra V, Neubig RR 2007 The highly conserved DRY motif of class A GPCRs: beyond the ground state. Mol Pharmacol 71:959-964
31. Ren SG, Taylor J, Dong J, Yu R, Culler MD, Melmed S 2003 Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion. J Clin Endocrinol Metab 88:4239-4245 (Pubitemid 37153726)
32. 2+ in rat somatotrophs. Endocrinology 122:1419-1425
33. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450
34. Lania AG, Mantovani G, Ferrero S, Pellegrini C, Bondioni S, Peverelli E, Braidotti P, Locatelli M, Zavanone ML, Ferrante E, Bosari S, Beck-Peccoz P, Spada A 2004 Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase A regulatory subunit 1A protein. Cancer Res 64:9193-9198 (Pubitemid 40003794)
35. Spada A, Vallar L, Giannattasio G 1984 Presence of an adenylate cyclase dually regulated by somatostatin and human pancreatic growth hormone (GH)-releasing factor in human GH-secreting cells. Endocrinology 115:1203-1209 (Pubitemid 14074496)
36. Chazenbalk GD, Nagayama Y, Russo D, Wadsworth HL, Rapoport B 1990 Functional analysis of the cytoplasmic domains of the human thyrotropin receptor by site-directed mutagenesis. J Biol Chem 265:20970-20975 (Pubitemid 120014106)
37. Franke RR, Sakmar TP, Graham RM, Khorana HG 1992 Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin. J Biol Chem 267:14767-14774
38. Rosenthal W, Antaramian A, Gilbert S, Birnbaumer M 1993 Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase. J Biol Chem 268:13033-13303 (Pubitemid 23307714)
39. Jones PG, Curtis CA, Hulme EC 1995 The function of a highly conserved arginine residue in activation of the muscarinic M1 receptor. Eur J Pharmacol 288:251-257
40. Schulz A, Schöneberg, T, Paschke R, Shultz G, Gudermann T 1999 Role of the third intracellular loop for the activation of gonadotropin receptors. Mol Endocrinol 13:181-190 (Pubitemid 29067994)
41. Fanelli F, Barbier P, Zanchetta D, De Benedetti PD, Chini B 1999 Activation mechanism of human oxytocin receptor: a combined study of experimental and computer-simulated mutagenesis. Mol Endocrinol 56:214-225 (Pubitemid 29309831)
42. Kim JH, Cho EY, Min C, Park JH, Kim KM 2008 Characterization of functional roles of DRY motif in the 2nd intracellular loop of dopamine D2 and D3 receptors. Arch Pharm Res 31:474-481
43. Liapakis G, Tallent M, Reisine T 1996 Molecular and functional properties of somatostatin receptor subtypes. Metabolism 45:12-13 (Pubitemid 26281930)
44. Shimon I, Yan X, Taylor JE, Weiss MH, Culler MD, Melmed S 1997 Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest 100:2386-2392
45. Ballarè E, Persani L, Lania AG, Filopanti M, Giammona E, Corbetta S, Mantovani S, Arosio M, Beck-Peccoz P, Faglia G, Spada A 2001 Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment. J Clin Endocrinol Metab 86:3809-3814 (Pubitemid 32755981)
46. Ferguson SS 2001 Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signalling. Pharmacol Rev 53:1-24 (Pubitemid 32173106)
47. Lefkowitz RJ, Shenoy SK 2005 Transduction of receptor signals by β-arrestins. Science 308:512-517 (Pubitemid 40570575)
48. Filopanti M, Ronchi C, Ballarè E, Bondioni S, Lania AG, Losa M, Gelmini S, Peri A, Orlando C, Beck-Peccoz P, Spada A 2005 Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly. J Clin Endocrinol Metab 90:4824-4828 (Pubitemid 41159378)