Somatostatin receptor subtype 2A immunohistochemistry using a new monoclonal antibody selects tumors suitable for in vivo somatostatin receptor targeting

American Journal of Surgical Pathology

Volumn 36, Issue 2, 2012, Pages 242-252

  Körner, Meike ^a   Waser, Beatrice ^a   Schonbrunn, Agnes ^b   Perren, Aurel ^a   Reubi, Jean Claude ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Immunohistochemistry; Monoclonal anti sst2A antibody; Neuroendocrine tumors; Somatostatin receptor autoradiography; Somatostatin receptors

Indexed keywords

MONOCLONAL ANTIBODY; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 2;

ARTICLE; AUTORADIOGRAPHY; CHEMISTRY; COMPARATIVE STUDY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; NEOPLASM; PATHOLOGY; RETROSPECTIVE STUDY;

ANTIBODIES, MONOCLONAL; AUTORADIOGRAPHY; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASMS; RECEPTORS, SOMATOSTATIN; RETROSPECTIVE STUDIES;

EID: 84857715394     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31823d07f3     Document Type: Article

References (28)

1. Asnacios A, Courbon F, Rochaix P, et al. Indium-11-pentreotide scintigraphy and somatostatin receptor subtype 2 expression: new prognostic factors for malignant well-differentiated endocrine tumors. J Clin Oncol. 2008;26:963-970. (Pubitemid 351398091)
2. Baskin DG, Wimpy TH. Calibration of [14C]plastic standards for quantitative autoradiography of [125I]labeled ligands with Amersham Hyperfilm beta-max. Neurosci Lett. 1989;104:171-177. (Pubitemid 19225609)
3. Dournaud P, Gu YZ, Schonbrunn A, et al. Localization of the somatostatin receptor SST2A in rat brain using a specific antipeptide antibody. J Neurosci. 1996;16:4468-4478. (Pubitemid 26243042)
4. Fischer T, Doll C, Jacobs S, et al. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab. 2009;93:4519-4524. (Pubitemid 352789555)
5. Gabriel M, Decristoforo C, Kendler D, et al. 68Ga-DOTA-Tyr3- octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med. 2007; 48:508-518. (Pubitemid 47571404)
6. Garden OA, Reubi JC, Dykes NL, et al. Somatostatin receptor imaging in vivo by planar scintigraphy facilitates the diagnosis of canine insulinomas. J Vet Intern Med. 2005;19:168-176. (Pubitemid 40463331)
7. Gu YZ, Schonbrunn A. Coupling specificity between somatostatin receptor sst2A and G proteins: isolation of the receptor-G protein complex with a receptor antibody. Mol Endocrinol. 1997; 11:527-537. (Pubitemid 27193789)
8. Gugger M, Waser B, Kappeler A, et al. Cellular detection of sst2A receptors in human gastrointestinal tissue. Gut. 2004;53:1431-1436. (Pubitemid 39265261)
9. Körner M, Eltschinger V, Waser B, et al. Value of immunohistochemistry for somatostatin receptor subtype sst2A in cancer tissues: lessons from the comparison of anti-sst2A antibodies with somatostatin receptor autoradiography. Am J Surg Pathol. 2005;29: 1642-1651.
10. Krenning EP, Kwekkeboom DJ, Pauwels S, et al. Somatostatin receptor scintigraphy. In: Freeman LM, ed. Nuclear Medicine Annual 1995. New York: Raven Press; 1995:1-50.
11. Kwekkeboom DJ, de Herder WW, Kam BL, et al. Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3] octreotate: toxicity, efficacy, and survival. J Clin Oncol. 2008;26: 2124-2130.
12. Maecke HR, Reubi JC. Somatostatin receptors as targets for nuclear medicine imaging and radionuclide treatment. J Nucl Med. 2011;52:841-844.
13. Miederer M, Seidl S, Buck A, et al. Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68Ga-DOTATOC PET/CT. Eur J Nucl Med Mol Imaging. 2009;36:48-52.
14. Miller JA, Zahniser NR. The use of 14C-labeled tissue paste standards for the calibration of 125I-labeled ligands in quantitative autoradiography. Neurosci Lett. 1987;81:345-350. (Pubitemid 17159522)
15. Moelans CB, Kibbelaar RE, van den Heuvel MC, et al. Validation of a fully automated HER2 staining kit in breast cancer. Cell Oncol. 2010;32:149-155.
16. Müssig K, Öksüz MÖ, Dudziak K, et al. Association of somatostatin receptor 2 immunohistochemical expression with [111In]-DTPA octreotide scintigraphy and [68Ga]-DOTATOC PET/CT in neuroendocrine tumors. Horm Metab Res. 2010;42: 599-606.
17. Reubi JC. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr Rev. 2003;24:389-427. (Pubitemid 37056239)
18. Reubi JC, Kappeler A, Waser B, et al. Immunohistochemical localization of somatostatin receptors sst2A in human tumors. Am J Pathol. 1998;153:233-245. (Pubitemid 28317526)
19. Reubi JC, Kappeler A, Waser B, et al. Immunohistochemical localization of somatostatin receptor sst2A in human pancreatic islets. J Clin Endocrinol Metab. 1998;83:3746-3749. (Pubitemid 28500920)
20. Reubi JC, Kvols LK, Waser B, et al. Detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas. Cancer Res. 1990;50: 5969-5977. (Pubitemid 20331408)
21. Reubi JC, Laissue JA, Waser B, et al. Immunohistochemical detection of somatostatin sst2a receptors in the lymphatic, smooth muscular, and peripheral nervous systems of the human gastrointestinal tract: facts and artifacts. J Clin Endocrinol Metab. 1999; 84:2942-2950. (Pubitemid 30642033)
22. Reubi JC, Schar JC, Waser B, et al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000;27:273-282. (Pubitemid 30167697)
23. Reubi JC, Waser B. Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting. Eur J Nucl Med Mol Imaging. 2003; 30:781-793. (Pubitemid 36612963)
24. Reubi JC, Waser B, Lamberts SWJ, et al. Somatostatin (SRIH) messenger ribonucleic acid expression in human neuroendocrine and brain tumors using in situ hybridization histochemistry: Comparison with SRIH receptor content. J Clin Endocrinol Metab. 1993;76: 642-647. (Pubitemid 23086480)
25. Reubi JC, Waser B, Liu Q, et al. Subcellular distribution of somatostatin sst2A receptors in human tumors of the nervous and neuroendocrine systems: membranous versus intracellular location. J Clin Endocrinol Metab. 2000;85:3882-3891.
26. Reubi JC, Waser B, Schaer JC, et al. Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands. Eur J Nucl Med. 2001;28:836-846. (Pubitemid 32662546)
27. Schulz S, Schulz S, Schmitt J, et al. Immunocytochemical detection of somatostatin receptors sst1, sst2A, sst2B, and sst3 in paraffinembedded breast cancer tissue using subtype-specific antibodies. Clin Cancer Res. 1998;4:2047-2052. (Pubitemid 28415646)
28. Volante M, Brizzi MP, Faggiano A, et al. Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: A proposal of scoring system correlated with somatostatin receptor scintigraphy. Mod Pathol. 2007;20:1172-1182. (Pubitemid 47609066)