Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain

EMBO Journal

Volumn 16, Issue 10, 1997, Pages 2814-2825

  Spengler, Dietmar ^b   Villalba, Martin ^b   Hoffmann, Anke ^a   Pantaloni, Colette ^b   Houssami, Souheir ^b   Bockaert, Joël ^b   Journot, Laurent ^b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b CCIPE   (France)

Author keywords

Apoptosis; Cell cycle; p53; PACAP; Zinc finger

Indexed keywords

PROTEIN P16; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN; CANCER CELL; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL DIVISION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; GROWTH RATE; HOMEOSTASIS; HUMAN; HUMAN CELL; HYPOPHYSIS; MALE; MOLECULAR CLONING; MOUSE; NERVE DEGENERATION; NEWBORN; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BRAIN; CELL CYCLE PROTEINS; CLONING, MOLECULAR; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR SEQUENCE DATA; PITUITARY GLAND; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; TISSUE DISTRIBUTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; ZINC FINGERS;

ANIMALIA; MUS MUSCULUS;

EID: 0030955765     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.10.2814     Document Type: Article

References (56)

1. Baker, S.J., Markowitz, S., Fearon, E.R., Willson, J.K.V. and Vogelstein, B. (1990) Suppression of human colorectal carcinoma cell growth by wild-type p53. Science, 249, 912-915.
2. Bates, S. and Vousden, K.H. (1996) p53 in signaling checkpoint arrest or apoptosis. Curr. Opin. Genet. Dev., 6, 12-19.
3. Chen, P.-L., Chen, Y., Bookstein, R. and Lee, W.-H. (1990) Genetic mechanisms of tumor suppression by the human p53 gene. Science, 250, 1576-1580.
4. Chen, X., Ko, L.J., Jayaraman, L. and Prives, C. (1996) p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev., 10, 2438-2451.
5. Deutsch, P.J. and Sun, Y. (1992) The 38-amino acid form of pituitary adenylate cyclase-activating polypetide stimulates dual signalling cascades in PC12 cells and promotes neunte outgrowth. J. Biol. Chem., 265, 14008-14015.
6. DiCicco-Bloom, E. and Deutsch, P.J. (1992) Pituitary adenylate cyclase activating polypeptide (PACAP) potently stimulates mitosis, neuritogenesis and survival in cultured rat sympathetic neuroblasts. Regulatory Peptides, 37,
7. Diller, L. et al. (1990) p53 functions as a cell cycle control protein in osteosarcomas. Mol. Cell. Biol., 10, 5772-5781.
8. Eizenberg, O., Faber-Elman, A., Gottlieb, E., Oren, M., Rotter, V. and Schwartz, M. (1995) Direct involvement of p53 in programmed cell death of oligodendrocytes. EMBO J., 14, 1136-1144.
9. Eizenberg, O., Faber-Elman, A., Gottlieb, E., Oren, M., Rotter, V. and Schwartz, M. (1996) p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells. Mol. Cell. Biol., 16, 5178-5185.
10. El-Deiry, W.S. et al. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell. 75, 817-825.
11. Englert, C., Hou, X., Maheswaran, S., Bennet, P., Ngwu, C., Re, G.G., Garvin, J., Rosner, M.R. and Haber, D.A. (1995) WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J., 14, 4662-4675.
12. Fisher, D.E. (1994) Apoptosis in cancer therapy: crossing the threshold. Cell, 78, 539-542.
13. Goodrich, D.W., Wang, N.P., Qian, Y.-W., Lee, E.Y.-H.P. and Lee, W.-H. (1991) The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell, 67, 293-302.
14. Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA, 89, 5547-5551.
15. Gossen, M. and Bujard, H. (1993) Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells. Nucleic Acids Res., 21, 4411-4412.
16. Gougeon, M.L. and Montagnier, L. (1993) Apoptosis in AIDS. Science, 260, 1269-1278.
17. Grana, X. and Reddy, E.P. (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin-dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene, 11, 211-219.
18. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. and Elledge, S.J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75, 805-816.
19. Hartwell, L.H. and Kastan, M.B. (1994) Cell cycle control and cancer. Science, 266, 1821-1828.
20. Heintz, N. (1993) Cell death and the cell cycle: a relationship between transformation and neurodegeneration? Trends Biochem. Sci., 18, 157-159.
21. Hockenbery, D., Nunez, G., Milliman, C., Schreiber, D. and Korsmeyer, S.J. (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programed cell death. Nature, 348, 334-336.
22. Hoffmann, A., Villalba, M. Journot, L. and Spengler, D. (1997) A novel tetracycline-dependent expression vector with low basal expression and potent regulatory porperties in various mammalian cell lines. Nucleic Acids Res., 25, 1078-1079.
23. Hoffman, B. and Liebermann, D.A. (1995) Molecular controls of apoptosis: differentiation/growth arrest primary response genes, protooncogenes, and tumor suppressor genes as positive and negative regulators. Oncogene. 9, 1807-1812.
24. Hollstein, M., Sidransky, D., Vogelstein, B. and Harris, C.C. (1991) p53 mutations in human cancer. Science, 253, 49-53.
25. Hunter, T. and Pines, J. (1994) Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell, 79, 573-582.
26. Jazwinski, S.M. (1996) Longevity, genes and aging. Science, 273, 54-59.
27. Karp, J.E. and Broder, S. (1995) Molecular foundations of cancer: new targets for intervention. Nature Med., 1, 309-320.
28. Klug, A. and Schwabe, J.W.R. (1995) Zinc fingers. FASEB J., 9, 597-604.
29. Ko, L.J. and Prives, C. (1996) p53: puzzle and paradigm. Genes Dev. 10, 1054-1072.
30. Korsmeyer, S.J. (1995) Regulators of cell death. Trends Genet., 11, 101-105.
31. Kovacs, K. and Horvath, E. (1987) Pathology of pituitary tumors. Endocrinol. Metab. Clin. N. Am., 16, 529-551.
32. Levine, A. (1993) The tumor suppressor genes. Annu. Rev. Biochem., 62, 623-651.
33. Lowe, S.W., Ruley, H.E., Jacks, T. and Housman, D.E. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 957-967.
34. Lowe, S.W., Bodis, S., Mc Clatchey, A., Remington, L., Ruley, H.E., Fisher, D.E., Housman, D.E. and Jacks, T. (1994) p53 status and the efficacy of cancer therapy in vivo. Science, 266, 807-810.
35. Melmed, S. (1993) In Levine, A.J. and Schmidek, H.H. (eds), Molecular Genetics of Nervous System Tumors. Wiley-Liss Inc., New York, pp. 255-263.
36. Miyata, A., Arimura, A., Dahl, R.R., Minamino, N., Uehara, A., Jiang, L., Culler, M.D. and Coy, D.H. (1989) Isolation of a novel 38 residue hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem. Biophys. Res. Commun., 164, 567-574.
37. Morrison, R.S., Wenzel, H.J., Kinoshita, Y., Robbins, C.A., Donehower, L.A. and Schwartzkroin, P.A. (1996) Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death. J. Neurosci., 16, 1337-1345.
38. Pincus, D.W., DiCicco-Bloom, E.M. and Black, I.B. (1990) Vasoactive intestinal peptide regulates mitotsis, differentiation and survival of cultured sympathetic neuroblasts. Nature, 343, 564-567.
39. Raff, M.C., Barres, B.A., Burne, J.F., Coles, H.S., Ishizaki, Y. and Jacobson, M.D. (1993) Programed cell death and the control of cell survival: lessons from the nervous system. Science, 262, 695-700.
40. Roemer, K. and Friedmann, T. (1993) Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein. Proc. Natl Acad. Sci. USA, 90, 9252-9256.
41. Ross, M.E. (1996) Cell division and the nervous system: regulating the cycle from neural differentiation to death. Trends Neurosci., 19, 62-68.
42. Roth, J.A. et al. (1996) Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nature Med., 2, 985-991.
43. II250: a TBP-associated factor implicated in cell-cycle regulation. Nature, 362, 175-179.
44. Saeger, W. (1995) Latent hyperplasias and adenomas in post-mortem pituitaries. Presented at the 6th Meeting of the International Pituitary Pathologists' Club, The Buchanan Arms Hotel, Drymen, UK.
45. Sakhi, S., Bruce, A., Sun, N., Tocco, G., Baudry, M. and Schreiber, S.S. (1994) p53 induction is associated with neuronal damage in the central nervous system. Proc. Natl. Acad. Sci. USA, 91, 7525-7529.
46. Schuh, R. et al. (1986) A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segemntation gene. Cell, 47, 1025-1032.
47. Spengler, D., Waeber, C., Pantaloni, C., Holsboer, F., Bockaert, J., Seeburg, P.H. and Journot, L. (1993) Differential signal transduction by five splice variants of the PACAP receptor. Nature, 365, 170-175.
48. Steller, H. (1995) Mechanisms and genes of cellular suicide. Science, 267, 1445-1449.
49. Thompson, C.B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science, 267, 1456-1462.
50. Villalba, M., Bockaert, J. and Journot, L. (1997) Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway. J. Neurosci., 17, 83-90.
51. Weinberg, R. (1993) Tumor suppressor genes. Neuron, 11, 191-196.
52. Werner, H., Shen-Orr, Z., Rauscher, F.J., Morris, J.F., Roberts, C.T and LeRoith, D. (1995) Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression. Mol Cell. Biol., 15, 3516-3522.
53. Williamson, M.P. (1994) The structure and function of proline-rich regions in proteins. Biochem. J., 297, 249-260.
54. Wood, K.A. and Youle, R.J. (1995) The role of free radicals and p53 in neuron apoptosis in vivo. J. Neurosci., 15, 5851-5857.
55. Val-138: Modulation of the cell cycle, viability and expression of p53-responsive genes. Oncogene, 11, 1-6.
56. Yonish-Rouach, E., Deguin, V., Zaitchouk, T., Breugnot, C., Mishal, Z., Jenkins, J.R. and May, E. (1996) Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53. Oncogene, 12, 2197-2205.