Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway

EMBO Journal

Volumn 25, Issue 17, 2006, Pages 3943-3954

  Bousquet, Corinne ^a   Guillermet Guibert, Julie ^a   Saint Laurent, Nathalie ^a   Archer Lahlou, Elodie ^a   Lopez, Frédéric ^a   Fanjul, Marjorie ^a   Ferrand, Audrey ^a   Fourmy, Daniel ^a   Pichereaux, Carole ^b   Monsarrat, Bernard ^b   Pradayrol, Lucien ^a   Estève, Jean Pierre ^a   Susini, Christiane ^a  

^a CHU RANGUEIL   (France)

^b INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Cell survival; G protein coupled sst2 somatostatin receptor; PI3K pathway; Protein interaction; Tumor growth

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; PROTEIN SH2; SOMATOSTATIN; SOMATOSTATIN RECEPTOR 2;

ARTICLE; CANCER GROWTH; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SURFACE PLASMON RESONANCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; FEMALE; HUMANS; MICE; MICE, NUDE; MUTATION; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, SOMATOSTATIN; SIGNAL TRANSDUCTION; SOMATOSTATIN; SRC HOMOLOGY DOMAINS; SURFACE PLASMON RESONANCE; TRANSPLANTATION, HETEROLOGOUS; TYROSINE;

EID: 33748365850     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601279     Document Type: Article

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