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Volumn 25, Issue 9, 2013, Pages 720-732

Ghrelin signaling in the gut, its physiological properties, and therapeutic potential

Author keywords

Ghrelin; Hypomotility disorders; Prokinetic

Indexed keywords

CAPROMORELIN; EX 1314; GASTROINTESTINAL AGENT; GHRELIN; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; IPAMORELIN; PLACEBO; PROKINETIC AGENT; RC 1139; RM 131; TZP 102; ULIMORELIN; UNCLASSIFIED DRUG; GHRELIN RECEPTOR;

EID: 84881306147     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12193     Document Type: Review
Times cited : (57)

References (113)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-60.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • Zhang JV, Ren PG, Avsian-Kretchmer O et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005; 310: 996-9.
    • (2005) Science , vol.310 , pp. 996-999
    • Zhang, J.V.1    Ren, P.G.2    Avsian-Kretchmer, O.3
  • 4
    • 20244366719 scopus 로고    scopus 로고
    • Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin
    • Nishi Y, Hiejima H, Hosoda H et al. Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. Endocrinology 2005; 146: 2255-64.
    • (2005) Endocrinology , vol.146 , pp. 2255-2264
    • Nishi, Y.1    Hiejima, H.2    Hosoda, H.3
  • 5
    • 84863084353 scopus 로고    scopus 로고
    • Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein
    • Janssen S, Laermans J, Iwakura H, Tack J, Depoortere I. Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. PLoS ONE 2012; 7: e40168.
    • (2012) PLoS ONE , vol.7
    • Janssen, S.1    Laermans, J.2    Iwakura, H.3    Tack, J.4    Depoortere, I.5
  • 6
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 2000; 279: 909-13.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 7
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000; 141: 4255-61.
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3
  • 8
    • 79952138344 scopus 로고    scopus 로고
    • Bitter taste receptors and alpha-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying
    • Janssen S, Laermans J, Verhulst PJ, Thijs T, Tack J, Depoortere I. Bitter taste receptors and alpha-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proc Natl Acad Sci U S A 2011; 108: 2094-9.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2094-2099
    • Janssen, S.1    Laermans, J.2    Verhulst, P.J.3    Thijs, T.4    Tack, J.5    Depoortere, I.6
  • 9
    • 9444246501 scopus 로고    scopus 로고
    • A receptor in pituitary and hypothalamus that functions in growth hormone release
    • Howard AD, Feighner SD, Cully DF et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273: 974-7.
    • (1996) Science , vol.273 , pp. 974-977
    • Howard, A.D.1    Feighner, S.D.2    Cully, D.F.3
  • 10
    • 11144225093 scopus 로고    scopus 로고
    • Common structural basis for constitutive activity of the ghrelin receptor family
    • Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW. Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem 2004; 279: 53806-17.
    • (2004) J Biol Chem , vol.279 , pp. 53806-53817
    • Holst, B.1    Holliday, N.D.2    Bach, A.3    Elling, C.E.4    Cox, H.M.5    Schwartz, T.W.6
  • 11
    • 84872064517 scopus 로고    scopus 로고
    • Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signalling
    • Schellekens H, van Oeffelen WE, Dinan TG, Cryan JF. Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signalling. J Biol Chem 2013; 288: 181-91.
    • (2013) J Biol Chem , vol.288 , pp. 181-191
    • Schellekens, H.1    van, O.W.2    Dinan, T.G.3    Cryan, J.F.4
  • 12
    • 3042735648 scopus 로고    scopus 로고
    • The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
    • Gnanapavan S, Kola B, Bustin SA et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002; 87: 2988.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2988
    • Gnanapavan, S.1    Kola, B.2    Bustin, S.A.3
  • 14
    • 38149043415 scopus 로고    scopus 로고
    • The autonomic nervous system regulates gastric ghrelin secretion in rats
    • Hosoda H, Kangawa K. The autonomic nervous system regulates gastric ghrelin secretion in rats. Regul Pept 2008; 146: 12-8.
    • (2008) Regul Pept , vol.146 , pp. 12-18
    • Hosoda, H.1    Kangawa, K.2
  • 15
    • 77957668161 scopus 로고    scopus 로고
    • Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice
    • Zhao TJ, Sakata I, Li RL et al. Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc Natl Acad Sci U S A 2010; 107: 15868-73.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15868-15873
    • Zhao, T.J.1    Sakata, I.2    Li, R.L.3
  • 16
    • 43249120798 scopus 로고    scopus 로고
    • Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates
    • Foster-Schubert KE, Overduin J, Prudom CE et al. Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates. J Clin Endocrinol Metab 2008; 93: 1971-9.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1971-1979
    • Foster-Schubert, K.E.1    Overduin, J.2    Prudom, C.E.3
  • 17
    • 14044262360 scopus 로고    scopus 로고
    • Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects
    • le Roux CW, Patterson M, Vincent RP, Hunt C, Ghatei MA, Bloom SR. Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects. J Clin Endocrinol Metab 2005; 90: 1068-71.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1068-1071
    • le Roux, C.W.1    Patterson, M.2    Vincent, R.P.3    Hunt, C.4    Ghatei, M.A.5    Bloom, S.R.6
  • 18
    • 84873138013 scopus 로고    scopus 로고
    • Nutrient sensing in the gut: new roads to therapeutics?
    • Janssen S, Depoortere I. Nutrient sensing in the gut: new roads to therapeutics? Trends Endocrinol Metab 2013; 24: 92-100.
    • (2013) Trends Endocrinol Metab , vol.24 , pp. 92-100
    • Janssen, S.1    Depoortere, I.2
  • 19
    • 77949266522 scopus 로고    scopus 로고
    • T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach
    • Hass N, Schwarzenbacher K, Breer H. T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach. Cell Tissue Res 2010; 339: 493-504.
    • (2010) Cell Tissue Res , vol.339 , pp. 493-504
    • Hass, N.1    Schwarzenbacher, K.2    Breer, H.3
  • 21
    • 84863962816 scopus 로고    scopus 로고
    • Ghrelin's second life: from appetite stimulator to glucose regulator
    • Verhulst PJ, Depoortere I. Ghrelin's second life: from appetite stimulator to glucose regulator. World J Gastroenterol 2012; 18: 3183-95.
    • (2012) World J Gastroenterol , vol.18 , pp. 3183-3195
    • Verhulst, P.J.1    Depoortere, I.2
  • 22
    • 67649124250 scopus 로고    scopus 로고
    • Targeting the ghrelin receptor to regulate food intake
    • Depoortere I. Targeting the ghrelin receptor to regulate food intake. Regul Pept 2009; 156: 13-23.
    • (2009) Regul Pept , vol.156 , pp. 13-23
    • Depoortere, I.1
  • 23
    • 0037162116 scopus 로고    scopus 로고
    • Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    • Cummings DE, Weigle DS, Frayo RS et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002; 346: 1623-30.
    • (2002) N Engl J Med , vol.346 , pp. 1623-1630
    • Cummings, D.E.1    Weigle, D.S.2    Frayo, R.S.3
  • 24
    • 84862661746 scopus 로고    scopus 로고
    • Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial
    • Peterli R, Steinert RE, Woelnerhanssen B et al. Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial. Obes Surg 2012; 22: 740-8.
    • (2012) Obes Surg , vol.22 , pp. 740-748
    • Peterli, R.1    Steinert, R.E.2    Woelnerhanssen, B.3
  • 25
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • Nakazato M, Murakami N, Date Y et al. A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-8.
    • (2001) Nature , vol.409 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3
  • 26
    • 42649116436 scopus 로고    scopus 로고
    • Ghrelin modulates brain activity in areas that control appetitive behavior
    • Malik S, McGlone F, Bedrossian D, Dagher A. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 2008; 7: 400-9.
    • (2008) Cell Metab , vol.7 , pp. 400-409
    • Malik, S.1    McGlone, F.2    Bedrossian, D.3    Dagher, A.4
  • 27
    • 33745834734 scopus 로고    scopus 로고
    • Ghrelin action in the brain controls adipocyte metabolism
    • Theander-Carrillo C, Wiedmer P, Cettour-Rose P et al. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 2006; 116: 1983-93.
    • (2006) J Clin Invest , vol.116 , pp. 1983-1993
    • Theander-Carrillo, C.1    Wiedmer, P.2    Cettour-Rose, P.3
  • 28
    • 0035834586 scopus 로고    scopus 로고
    • Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats
    • Furuta M, Funabashi T, Kimura F. Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun 2001; 288: 780-5.
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 780-785
    • Furuta, M.1    Funabashi, T.2    Kimura, F.3
  • 29
    • 0034841199 scopus 로고    scopus 로고
    • GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils
    • Hattori N, Saito T, Yagyu T, Jiang BH, Kitagawa K, Inagaki C. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab 2001; 86: 4284-91.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4284-4291
    • Hattori, N.1    Saito, T.2    Yagyu, T.3    Jiang, B.H.4    Kitagawa, K.5    Inagaki, C.6
  • 30
    • 46049083776 scopus 로고    scopus 로고
    • The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
    • Lutter M, Sakata I, Osborne-Lawrence S et al. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci 2008; 11: 752-3.
    • (2008) Nat Neurosci , vol.11 , pp. 752-753
    • Lutter, M.1    Sakata, I.2    Osborne-Lawrence, S.3
  • 31
    • 0033867587 scopus 로고    scopus 로고
    • Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide
    • Tomasetto C, Karam SM, Ribieras S et al. Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 2000; 119: 395-405.
    • (2000) Gastroenterology , vol.119 , pp. 395-405
    • Tomasetto, C.1    Karam, S.M.2    Ribieras, S.3
  • 32
    • 0141957932 scopus 로고    scopus 로고
    • Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin
    • Dass NB, Munonyara M, Bassil AK et al. Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin. Neuroscience 2003; 120: 443-53.
    • (2003) Neuroscience , vol.120 , pp. 443-453
    • Dass, N.B.1    Munonyara, M.2    Bassil, A.K.3
  • 33
    • 8444226059 scopus 로고    scopus 로고
    • Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus
    • Xu L, Depoortere I, Tomasetto C et al. Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus. Regul Pept 2005; 124: 119-25.
    • (2005) Regul Pept , vol.124 , pp. 119-125
    • Xu, L.1    Depoortere, I.2    Tomasetto, C.3
  • 34
    • 20344388544 scopus 로고    scopus 로고
    • Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro
    • Depoortere I, De Winter B, Thijs T, De Man J, Pelckmans P, Peeters T. Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Eur J Pharmacol 2005; 515: 160-8.
    • (2005) Eur J Pharmacol , vol.515 , pp. 160-168
    • Depoortere, I.1    De Winter, B.2    Thijs, T.3    De Man, J.4    Pelckmans, P.5    Peeters, T.6
  • 35
    • 33746780697 scopus 로고    scopus 로고
    • The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones
    • Bassil AK, Dass NB, Sanger GJ. The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones. Eur J Pharmacol 2006; 544: 146-52.
    • (2006) Eur J Pharmacol , vol.544 , pp. 146-152
    • Bassil, A.K.1    Dass, N.B.2    Sanger, G.J.3
  • 36
    • 22644444107 scopus 로고    scopus 로고
    • Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro
    • Kitazawa T, De Smet B, Verbeke K, Depoortere I, Peeters TL. Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro. Gut 2005; 54: 1078-84.
    • (2005) Gut , vol.54 , pp. 1078-1084
    • Kitazawa, T.1    De Smet, B.2    Verbeke, K.3    Depoortere, I.4    Peeters, T.L.5
  • 37
    • 10644280945 scopus 로고    scopus 로고
    • Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats
    • Fukuda H, Mizuta Y, Isomoto H et al. Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats. Scand J Gastroenterol 2004; 39: 1209-14.
    • (2004) Scand J Gastroenterol , vol.39 , pp. 1209-1214
    • Fukuda, H.1    Mizuta, Y.2    Isomoto, H.3
  • 38
    • 0037404479 scopus 로고    scopus 로고
    • Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum
    • Depoortere I, Thijs T, Thielemans L, Robberecht P, Peeters TL. Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum. J Pharmacol Exp Ther 2003; 305: 660-7.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 660-667
    • Depoortere, I.1    Thijs, T.2    Thielemans, L.3    Robberecht, P.4    Peeters, T.L.5
  • 39
    • 53049083900 scopus 로고    scopus 로고
    • Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice
    • Verhulst PJ, De Smet B, Saels I et al. Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice. Gastroenterology 2008; 135: 1267-76.
    • (2008) Gastroenterology , vol.135 , pp. 1267-1276
    • Verhulst, P.J.1    De Smet, B.2    Saels, I.3
  • 40
    • 33846833890 scopus 로고    scopus 로고
    • Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro
    • Kitazawa T, Kaiya H, Taneike T. Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro. Peptides 2007; 28: 617-24.
    • (2007) Peptides , vol.28 , pp. 617-624
    • Kitazawa, T.1    Kaiya, H.2    Taneike, T.3
  • 41
    • 84862763558 scopus 로고    scopus 로고
    • Peripheral "chicken" obestatin administration does not affect feed intake and gut muscle contractility of meat-type and layer-type chicks (Gallus gallus domesticus)
    • Song Z, Verhulst PJ, Ansari Z et al. Peripheral "chicken" obestatin administration does not affect feed intake and gut muscle contractility of meat-type and layer-type chicks (Gallus gallus domesticus). Regul Pept 2012; 177: 60-7.
    • (2012) Regul Pept , vol.177 , pp. 60-67
    • Song, Z.1    Verhulst, P.J.2    Ansari, Z.3
  • 42
    • 84864821852 scopus 로고    scopus 로고
    • Ghrelin does not affect gastrointestinal contractility in rainbow trout and goldfish in vitro
    • Kitazawa T, Itoh K, Yaosaka N et al. Ghrelin does not affect gastrointestinal contractility in rainbow trout and goldfish in vitro. Gen Comp Endocrinol 2012; 178: 539-45.
    • (2012) Gen Comp Endocrinol , vol.178 , pp. 539-545
    • Kitazawa, T.1    Itoh, K.2    Yaosaka, N.3
  • 43
    • 33646773565 scopus 로고    scopus 로고
    • Role of endogenous ghrelin in the hyperphagia of mice with streptozotocin-induced diabetes
    • Dong J, Peeters TL, De Smet B et al. Role of endogenous ghrelin in the hyperphagia of mice with streptozotocin-induced diabetes. Endocrinology 2006; 147: 2634-42.
    • (2006) Endocrinology , vol.147 , pp. 2634-2642
    • Dong, J.1    Peeters, T.L.2    De Smet, B.3
  • 44
    • 80052703452 scopus 로고    scopus 로고
    • Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig
    • Kitazawa T, Nakamura T, Saeki A, Teraoka H, Hiraga T, Kaiya H. Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig. Peptides 2011; 32: 1876-86.
    • (2011) Peptides , vol.32 , pp. 1876-1886
    • Kitazawa, T.1    Nakamura, T.2    Saeki, A.3    Teraoka, H.4    Hiraga, T.5    Kaiya, H.6
  • 45
    • 27744579950 scopus 로고    scopus 로고
    • Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon
    • Bassil AK, Dass NB, Murray CD, Muir A, Sanger GJ. Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon. Eur J Pharmacol 2005; 524: 138-44.
    • (2005) Eur J Pharmacol , vol.524 , pp. 138-144
    • Bassil, A.K.1    Dass, N.B.2    Murray, C.D.3    Muir, A.4    Sanger, G.J.5
  • 46
    • 58149263331 scopus 로고    scopus 로고
    • Endogenous and exogenous ghrelin enhance the colonic and gastric manifestations of dextran sodium sulphate-induced colitis in mice
    • De Smet B, Thijs T, Moechars D et al. Endogenous and exogenous ghrelin enhance the colonic and gastric manifestations of dextran sodium sulphate-induced colitis in mice. Neurogastroenterol Motil 2009; 21: 59-70.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 59-70
    • De Smet, B.1    Thijs, T.2    Moechars, D.3
  • 47
    • 36248960540 scopus 로고    scopus 로고
    • Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin
    • Olsson C, Holbrook JD, Bompadre G et al. Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin. Gen Comp Endocrinol 2008; 155: 217-26.
    • (2008) Gen Comp Endocrinol , vol.155 , pp. 217-226
    • Olsson, C.1    Holbrook, J.D.2    Bompadre, G.3
  • 48
    • 0037592273 scopus 로고    scopus 로고
    • Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    • Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimiya M. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol 2003; 550: 227-40.
    • (2003) J Physiol , vol.550 , pp. 227-240
    • Fujino, K.1    Inui, A.2    Asakawa, A.3    Kihara, N.4    Fujimura, M.5    Fujimiya, M.6
  • 49
    • 0034609952 scopus 로고    scopus 로고
    • Ghrelin stimulates gastric acid secretion and motility in rats
    • Masuda Y, Tanaka T, Inomata N et al. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 2000; 276: 905-8.
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 905-908
    • Masuda, Y.1    Tanaka, T.2    Inomata, N.3
  • 50
    • 0035133586 scopus 로고    scopus 로고
    • Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
    • Asakawa A, Inui A, Kaga T et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001; 120: 337-45.
    • (2001) Gastroenterology , vol.120 , pp. 337-345
    • Asakawa, A.1    Inui, A.2    Kaga, T.3
  • 51
    • 2642565900 scopus 로고    scopus 로고
    • Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells
    • Dornonville de la Cour C, Lindstrom E, Norlen P, Hakanson R. Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells. Regul Pept 2004; 120: 23-32.
    • (2004) Regul Pept , vol.120 , pp. 23-32
    • Dornonville de la Cour, C.1    Lindstrom, E.2    Norlen, P.3    Hakanson, R.4
  • 52
    • 38149107496 scopus 로고    scopus 로고
    • Effect of ghrelin on gastric myoelectric activity and gastric emptying in rats
    • Tumer C, Oflazoglu HD, Obay BD, Kelle M, Tasdemir E. Effect of ghrelin on gastric myoelectric activity and gastric emptying in rats. Regul Pept 2008; 146: 26-32.
    • (2008) Regul Pept , vol.146 , pp. 26-32
    • Tumer, C.1    Oflazoglu, H.D.2    Obay, B.D.3    Kelle, M.4    Tasdemir, E.5
  • 53
    • 77949310042 scopus 로고    scopus 로고
    • Ghrelin stimulates gastric motility of the guinea pig through activation of a capsaicin-sensitive neural pathway: in vivo and in vitro functional studies
    • Nakamura T, Onaga T, Kitazawa T. Ghrelin stimulates gastric motility of the guinea pig through activation of a capsaicin-sensitive neural pathway: in vivo and in vitro functional studies. Neurogastroenterol Motil 2010; 22(446-52): e107.
    • (2010) Neurogastroenterol Motil , vol.22 , Issue.52-446
    • Nakamura, T.1    Onaga, T.2    Kitazawa, T.3
  • 54
    • 0036083505 scopus 로고    scopus 로고
    • Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat
    • Trudel L, Tomasetto C, Rio MC et al. Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol 2002; 282: G948-52.
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282
    • Trudel, L.1    Tomasetto, C.2    Rio, M.C.3
  • 55
    • 38149073220 scopus 로고    scopus 로고
    • Ghrelin accelerates gastric emptying via early manifestation of antro-pyloric coordination in conscious rats
    • Ariga H, Nakade Y, Tsukamoto K et al. Ghrelin accelerates gastric emptying via early manifestation of antro-pyloric coordination in conscious rats. Regul Pept 2008; 146: 112-6.
    • (2008) Regul Pept , vol.146 , pp. 112-116
    • Ariga, H.1    Nakade, Y.2    Tsukamoto, K.3
  • 56
    • 29244469386 scopus 로고    scopus 로고
    • Energy homeostasis and gastric emptying in ghrelin knockout mice
    • De Smet B, Depoortere I, Moechars D et al. Energy homeostasis and gastric emptying in ghrelin knockout mice. J Pharmacol Exp Ther 2006; 316: 431-9.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 431-439
    • De Smet, B.1    Depoortere, I.2    Moechars, D.3
  • 57
    • 33645080691 scopus 로고    scopus 로고
    • Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs
    • Ohno T, Kamiyama Y, Aihara R et al. Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs. Neurogastroenterol Motil 2006; 18: 129-35.
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 129-135
    • Ohno, T.1    Kamiyama, Y.2    Aihara, R.3
  • 58
    • 0036787457 scopus 로고    scopus 로고
    • The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    • Date Y, Murakami N, Toshinai K et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002; 123: 1120-8.
    • (2002) Gastroenterology , vol.123 , pp. 1120-1128
    • Date, Y.1    Murakami, N.2    Toshinai, K.3
  • 60
    • 66749111412 scopus 로고    scopus 로고
    • Enhanced gastrointestinal motility with orally active ghrelin receptor agonists
    • Charoenthongtrakul S, Giuliana D, Longo KA et al. Enhanced gastrointestinal motility with orally active ghrelin receptor agonists. J Pharmacol Exp Ther 2009; 329: 1178-86.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 1178-1186
    • Charoenthongtrakul, S.1    Giuliana, D.2    Longo, K.A.3
  • 61
    • 58949088281 scopus 로고    scopus 로고
    • Greenwood-Van Meerveld B. Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus
    • Fraser GL, Venkova K, Hoveyda HR, Thomas H. Greenwood-Van Meerveld B. Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus. Eur J Pharmacol 2009; 604: 132-7.
    • (2009) Eur J Pharmacol , vol.604 , pp. 132-137
    • Fraser, G.L.1    Venkova, K.2    Hoveyda, H.R.3    Thomas, H.4
  • 62
    • 41149124312 scopus 로고    scopus 로고
    • Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats
    • Ochi M, Tominaga K, Tanaka F et al. Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats. Life Sci 2008; 82: 862-8.
    • (2008) Life Sci , vol.82 , pp. 862-868
    • Ochi, M.1    Tominaga, K.2    Tanaka, F.3
  • 63
    • 84863509381 scopus 로고    scopus 로고
    • Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease
    • Nahata M, Muto S, Oridate N et al. Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease. Am J Physiol Gastrointest Liver Physiol 2012; 303: G42-53.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303
    • Nahata, M.1    Muto, S.2    Oridate, N.3
  • 65
    • 28744458773 scopus 로고    scopus 로고
    • Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin
    • Rudd JA, Ngan MP, Wai MK et al. Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin. Neurosci Lett 2006; 392: 79-83.
    • (2006) Neurosci Lett , vol.392 , pp. 79-83
    • Rudd, J.A.1    Ngan, M.P.2    Wai, M.K.3
  • 66
    • 55449107159 scopus 로고    scopus 로고
    • Prokinetic effects of a ghrelin receptor agonist GHRP-6 in diabetic mice
    • Zheng Q, Qiu WC, Yan J et al. Prokinetic effects of a ghrelin receptor agonist GHRP-6 in diabetic mice. World J Gastroenterol 2008; 14: 4795-9.
    • (2008) World J Gastroenterol , vol.14 , pp. 4795-4799
    • Zheng, Q.1    Qiu, W.C.2    Yan, J.3
  • 67
    • 47849127573 scopus 로고    scopus 로고
    • Ghrelin improves delayed gastrointestinal transit in alloxan-induced diabetic mice
    • Qiu WC, Wang ZG, Lv R et al. Ghrelin improves delayed gastrointestinal transit in alloxan-induced diabetic mice. World J Gastroenterol 2008; 14: 2572-7.
    • (2008) World J Gastroenterol , vol.14 , pp. 2572-2577
    • Qiu, W.C.1    Wang, Z.G.2    Lv, R.3
  • 68
    • 0038644013 scopus 로고    scopus 로고
    • Two new peptides to improve post-operative gastric ileus in dog
    • Trudel L, Bouin M, Tomasetto C et al. Two new peptides to improve post-operative gastric ileus in dog. Peptides 2003; 24: 531-4.
    • (2003) Peptides , vol.24 , pp. 531-534
    • Trudel, L.1    Bouin, M.2    Tomasetto, C.3
  • 69
    • 23844433696 scopus 로고    scopus 로고
    • Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on post-operative and on morphine induced ileus
    • Poitras P, Polvino WJ, Rocheleau B. Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on post-operative and on morphine induced ileus. Peptides 2005; 26: 1598-601.
    • (2005) Peptides , vol.26 , pp. 1598-1601
    • Poitras, P.1    Polvino, W.J.2    Rocheleau, B.3
  • 70
    • 34547851716 scopus 로고    scopus 로고
    • Greenwood-Van Meerveld B. Prokinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative ileus
    • Venkova K, Fraser G, Hoveyda HR. Greenwood-Van Meerveld B. Prokinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative ileus. Dig Dis Sci 2007; 52: 2241-8.
    • (2007) Dig Dis Sci , vol.52 , pp. 2241-2248
    • Venkova, K.1    Fraser, G.2    Hoveyda, H.R.3
  • 72
    • 4344584000 scopus 로고    scopus 로고
    • Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice
    • De Winter BY, De Man JG, Seerden TC et al. Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice. Neurogastroenterol Motil 2004; 16: 439-46.
    • (2004) Neurogastroenterol Motil , vol.16 , pp. 439-446
    • De Winter, B.Y.1    De Man, J.G.2    Seerden, T.C.3
  • 73
    • 34447550829 scopus 로고    scopus 로고
    • Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach
    • Ariga H, Tsukamoto K, Chen C, Mantyh C, Pappas TN, Takahashi T. Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach. Neurogastroenterol Motil 2007; 19: 675-80.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 675-680
    • Ariga, H.1    Tsukamoto, K.2    Chen, C.3    Mantyh, C.4    Pappas, T.N.5    Takahashi, T.6
  • 74
    • 58149218357 scopus 로고    scopus 로고
    • Ghrelin regulates gastric phase III-like contractions in freely moving conscious mice
    • Zheng J, Ariga H, Taniguchi H, Ludwig K, Takahashi T. Ghrelin regulates gastric phase III-like contractions in freely moving conscious mice. Neurogastroenterol Motil 2009; 21: 78-84.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 78-84
    • Zheng, J.1    Ariga, H.2    Taniguchi, H.3    Ludwig, K.4    Takahashi, T.5
  • 75
    • 3142534319 scopus 로고    scopus 로고
    • Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons
    • Edholm T, Levin F, Hellstrom PM, Schmidt PT. Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept 2004; 121: 25-30.
    • (2004) Regul Pept , vol.121 , pp. 25-30
    • Edholm, T.1    Levin, F.2    Hellstrom, P.M.3    Schmidt, P.T.4
  • 76
    • 34147144639 scopus 로고    scopus 로고
    • Effects of ghrelin on feeding regulation and interdigestive migrating complex in rats
    • Wang Y, Dong L, Cheng Y, Zhao P. Effects of ghrelin on feeding regulation and interdigestive migrating complex in rats. Scand J Gastroenterol 2007; 42: 447-53.
    • (2007) Scand J Gastroenterol , vol.42 , pp. 447-453
    • Wang, Y.1    Dong, L.2    Cheng, Y.3    Zhao, P.4
  • 77
    • 79959823331 scopus 로고    scopus 로고
    • Food intake and interdigestive gastrointestinal motility in ghrelin receptor mutant rats
    • Bulbul M, Babygirija R, Zheng J et al. Food intake and interdigestive gastrointestinal motility in ghrelin receptor mutant rats. J Gastroenterol 2011; 46: 469-78.
    • (2011) J Gastroenterol , vol.46 , pp. 469-478
    • Bulbul, M.1    Babygirija, R.2    Zheng, J.3
  • 78
    • 65049086757 scopus 로고    scopus 로고
    • The effect of growth hormone releasing peptide-2 on upper gastrointestinal contractile activity and food intake in conscious dogs
    • Kudoh K, Shibata C, Funayama Y et al. The effect of growth hormone releasing peptide-2 on upper gastrointestinal contractile activity and food intake in conscious dogs. J Gastroenterol 2009; 44: 297-304.
    • (2009) J Gastroenterol , vol.44 , pp. 297-304
    • Kudoh, K.1    Shibata, C.2    Funayama, Y.3
  • 79
    • 33745698827 scopus 로고    scopus 로고
    • Inhibitory effects of gastric electrical stimulation on ghrelin-induced excitatory effects on gastric motility and food intake in dogs
    • Yin J, Chen J. Inhibitory effects of gastric electrical stimulation on ghrelin-induced excitatory effects on gastric motility and food intake in dogs. Scand J Gastroenterol 2006; 41: 903-9.
    • (2006) Scand J Gastroenterol , vol.41 , pp. 903-909
    • Yin, J.1    Chen, J.2
  • 80
    • 84855323193 scopus 로고    scopus 로고
    • Interdigestive migrating contractions are coregulated by ghrelin and motilin in conscious dogs
    • Ogawa A, Mochiki E, Yanai M et al. Interdigestive migrating contractions are coregulated by ghrelin and motilin in conscious dogs. Am J Physiol Regul Integr Comp Physiol 2012; 302: R233-41.
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.302
    • Ogawa, A.1    Mochiki, E.2    Yanai, M.3
  • 81
    • 77955841124 scopus 로고    scopus 로고
    • Association between plasma ghrelin and motilin levels during MMC cycle in conscious dogs
    • Zietlow A, Nakajima H, Taniguchi H, Ludwig K, Takahashi T. Association between plasma ghrelin and motilin levels during MMC cycle in conscious dogs. Regul Pept 2010; 164: 78-82.
    • (2010) Regul Pept , vol.164 , pp. 78-82
    • Zietlow, A.1    Nakajima, H.2    Taniguchi, H.3    Ludwig, K.4    Takahashi, T.5
  • 82
    • 84861117958 scopus 로고    scopus 로고
    • Coordination of motilin and ghrelin regulates the migrating motor complex of gastrointestinal motility in Suncus murinus
    • Mondal A, Xie Z, Miyano Y et al. Coordination of motilin and ghrelin regulates the migrating motor complex of gastrointestinal motility in Suncus murinus. Am J Physiol Gastrointest Liver Physiol 2012; 302: G1207-15.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302
    • Mondal, A.1    Xie, Z.2    Miyano, Y.3
  • 83
    • 84878384716 scopus 로고    scopus 로고
    • The role of the vagus nerve in the migrating motor complex and ghrelin- and motilin-induced gastric contraction in suncus
    • Miyano Y, Sakata I, Kuroda K et al. The role of the vagus nerve in the migrating motor complex and ghrelin- and motilin-induced gastric contraction in suncus. PLoS ONE 2013; 8: e64777.
    • (2013) PLoS ONE , vol.8
    • Miyano, Y.1    Sakata, I.2    Kuroda, K.3
  • 84
    • 23944509038 scopus 로고    scopus 로고
    • Ghrelin-induced stimulation of colonic propulsion is dependent on hypothalamic neuropeptide Y1- and corticotrophin-releasing factor 1 receptor activation
    • Tebbe JJ, Mronga S, Tebbe CG, Ortmann E, Arnold R, Schafer MK. Ghrelin-induced stimulation of colonic propulsion is dependent on hypothalamic neuropeptide Y1- and corticotrophin-releasing factor 1 receptor activation. J Neuroendocrinol 2005; 17: 570-6.
    • (2005) J Neuroendocrinol , vol.17 , pp. 570-576
    • Tebbe, J.J.1    Mronga, S.2    Tebbe, C.G.3    Ortmann, E.4    Arnold, R.5    Schafer, M.K.6
  • 85
    • 25444433117 scopus 로고    scopus 로고
    • Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced alteration of colonic transit time in conscious fed rats
    • Tebbe JJ, Tebbe CG, Mronga S, Ritter M, Schafer MK. Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced alteration of colonic transit time in conscious fed rats. BMC Gastroenterol 2005; 5: 5.
    • (2005) BMC Gastroenterol , vol.5 , pp. 5
    • Tebbe, J.J.1    Tebbe, C.G.2    Mronga, S.3    Ritter, M.4    Schafer, M.K.5
  • 86
    • 33748916666 scopus 로고    scopus 로고
    • Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat
    • Shimizu Y, Chang EC, Shafton AD et al. Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat. J Physiol 2006; 576: 329-38.
    • (2006) J Physiol , vol.576 , pp. 329-338
    • Shimizu, Y.1    Chang, E.C.2    Shafton, A.D.3
  • 87
    • 58149216616 scopus 로고    scopus 로고
    • Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation
    • Shafton AD, Sanger GJ, Witherington J et al. Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation. Neurogastroenterol Motil 2009; 21: 71-7.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 71-77
    • Shafton, A.D.1    Sanger, G.J.2    Witherington, J.3
  • 88
    • 66749133611 scopus 로고    scopus 로고
    • Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus
    • Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B. Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus. J Pharmacol Exp Ther 2009; 329: 1110-6.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 1110-1116
    • Venkova, K.1    Mann, W.2    Nelson, R.3    Greenwood-Van Meerveld, B.4
  • 89
    • 65349101149 scopus 로고    scopus 로고
    • Influence of ghrelin on the gastric accommodation reflex and on meal-induced satiety in man
    • e8-9.
    • Ang D, Nicolai H, Vos R et al. Influence of ghrelin on the gastric accommodation reflex and on meal-induced satiety in man. Neurogastroenterol Motil 2009; 21: 528-33, e8-9.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 528-533
    • Ang, D.1    Nicolai, H.2    Vos, R.3
  • 90
    • 33144482883 scopus 로고    scopus 로고
    • Influence of ghrelin on interdigestive gastrointestinal motility in humans
    • Tack J, Depoortere I, Bisschops R et al. Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 2006; 55: 327-33.
    • (2006) Gut , vol.55 , pp. 327-333
    • Tack, J.1    Depoortere, I.2    Bisschops, R.3
  • 91
    • 33748752142 scopus 로고    scopus 로고
    • Ghrelin stimulates gastric emptying and hunger in normal-weight humans
    • Levin F, Edholm T, Schmidt PT et al. Ghrelin stimulates gastric emptying and hunger in normal-weight humans. J Clin Endocrinol Metab 2006; 91: 3296-302.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3296-3302
    • Levin, F.1    Edholm, T.2    Schmidt, P.T.3
  • 92
    • 77951948495 scopus 로고    scopus 로고
    • Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans
    • Falken Y, Hellstrom PM, Sanger GJ et al. Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans. Neurogastroenterol Motil 2010; 22: e192-200.
    • (2010) Neurogastroenterol Motil , vol.22
    • Falken, Y.1    Hellstrom, P.M.2    Sanger, G.J.3
  • 93
    • 60749116316 scopus 로고    scopus 로고
    • Comparison of gastric emptying and plasma ghrelin levels in patients with functional dyspepsia and non-erosive reflux disease
    • Shindo T, Futagami S, Hiratsuka T et al. Comparison of gastric emptying and plasma ghrelin levels in patients with functional dyspepsia and non-erosive reflux disease. Digestion 2009; 79: 65-72.
    • (2009) Digestion , vol.79 , pp. 65-72
    • Shindo, T.1    Futagami, S.2    Hiratsuka, T.3
  • 94
    • 20444433958 scopus 로고    scopus 로고
    • Plasma acylated ghrelin levels correlate with subjective symptoms of functional dyspepsia in female patients
    • Shinomiya T, Fukunaga M, Akamizu T et al. Plasma acylated ghrelin levels correlate with subjective symptoms of functional dyspepsia in female patients. Scand J Gastroenterol 2005; 40: 648-53.
    • (2005) Scand J Gastroenterol , vol.40 , pp. 648-653
    • Shinomiya, T.1    Fukunaga, M.2    Akamizu, T.3
  • 95
    • 41749120794 scopus 로고    scopus 로고
    • Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite
    • Akamizu T, Iwakura H, Ariyasu H et al. Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite. Eur J Endocrinol 2008; 158: 491-8.
    • (2008) Eur J Endocrinol , vol.158 , pp. 491-498
    • Akamizu, T.1    Iwakura, H.2    Ariyasu, H.3
  • 96
    • 34247401370 scopus 로고    scopus 로고
    • Relation among plasma ghrelin level, gastric emptying, and psychologic condition in patients with functional dyspepsia
    • Takamori K, Mizuta Y, Takeshima F et al. Relation among plasma ghrelin level, gastric emptying, and psychologic condition in patients with functional dyspepsia. J Clin Gastroenterol 2007; 41: 477-83.
    • (2007) J Clin Gastroenterol , vol.41 , pp. 477-483
    • Takamori, K.1    Mizuta, Y.2    Takeshima, F.3
  • 97
    • 66149148307 scopus 로고    scopus 로고
    • Plasma ghrelin levels and their relationship with gastric emptying in patients with dysmotility-like functional dyspepsia
    • Lee KJ, Cha DY, Cheon SJ, Yeo M, Cho SW. Plasma ghrelin levels and their relationship with gastric emptying in patients with dysmotility-like functional dyspepsia. Digestion 2009; 80: 58-63.
    • (2009) Digestion , vol.80 , pp. 58-63
    • Lee, K.J.1    Cha, D.Y.2    Cheon, S.J.3    Yeo, M.4    Cho, S.W.5
  • 98
    • 84863230209 scopus 로고    scopus 로고
    • Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelin
    • Arai M, Matsumura T, Tsuchiya N et al. Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelin. Hepatogastroenterology 2012; 59: 62-6.
    • (2012) Hepatogastroenterology , vol.59 , pp. 62-66
    • Arai, M.1    Matsumura, T.2    Tsuchiya, N.3
  • 100
    • 27744441026 scopus 로고    scopus 로고
    • Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study
    • Murray CD, Martin NM, Patterson M et al. Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. Gut 2005; 54: 1693-8.
    • (2005) Gut , vol.54 , pp. 1693-1698
    • Murray, C.D.1    Martin, N.M.2    Patterson, M.3
  • 101
    • 33744970471 scopus 로고    scopus 로고
    • Ghrelin gastrokinetic action in patients with neurogenic gastroparesis
    • Binn M, Albert C, Gougeon A et al. Ghrelin gastrokinetic action in patients with neurogenic gastroparesis. Peptides 2006; 27: 1603-6.
    • (2006) Peptides , vol.27 , pp. 1603-1606
    • Binn, M.1    Albert, C.2    Gougeon, A.3
  • 103
    • 77956316577 scopus 로고    scopus 로고
    • Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study
    • Ejskjaer N, Dimcevski G, Wo J et al. Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study. Neurogastroenterol Motil 2010; 22: 1069-e281.
    • (2010) Neurogastroenterol Motil , vol.22
    • Ejskjaer, N.1    Dimcevski, G.2    Wo, J.3
  • 104
    • 66149083914 scopus 로고    scopus 로고
    • Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis
    • Ejskjaer N, Vestergaard ET, Hellstrom PM et al. Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis. Aliment Pharmacol Ther 2009; 29: 1179-87.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 1179-1187
    • Ejskjaer, N.1    Vestergaard, E.T.2    Hellstrom, P.M.3
  • 105
    • 79951664458 scopus 로고    scopus 로고
    • Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting-randomised clinical study subset data
    • Wo JM, Ejskjaer N, Hellstrom PM et al. Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting-randomised clinical study subset data. Aliment Pharmacol Ther 2011; 33: 679-88.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 679-688
    • Wo, J.M.1    Ejskjaer, N.2    Hellstrom, P.M.3
  • 106
    • 38349084347 scopus 로고    scopus 로고
    • Ghrelin agonist (TZP-101): safety, pharmacokinetics and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study
    • Lasseter KC, Shaughnessy L, Cummings D et al. Ghrelin agonist (TZP-101): safety, pharmacokinetics and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study. J Clin Pharmacol 2008; 48: 193-202.
    • (2008) J Clin Pharmacol , vol.48 , pp. 193-202
    • Lasseter, K.C.1    Shaughnessy, L.2    Cummings, D.3
  • 107
    • 84872676054 scopus 로고    scopus 로고
    • A phase 2a, randomized, double-blind 28-day study of TZP-102 a ghrelin receptor agonist for diabetic gastroparesis
    • Ejskjaer N, Wo JM, Esfandyari T et al. A phase 2a, randomized, double-blind 28-day study of TZP-102 a ghrelin receptor agonist for diabetic gastroparesis. Neurogastroenterol Motil 2013; 25: e140-50.
    • (2013) Neurogastroenterol Motil , vol.25
    • Ejskjaer, N.1    Wo, J.M.2    Esfandyari, T.3
  • 108
    • 84872040988 scopus 로고    scopus 로고
    • Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics
    • Shin A, Camilleri M, Busciglio I et al. Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics. Diabetes Care 2013; 36: 41-8.
    • (2013) Diabetes Care , vol.36 , pp. 41-48
    • Shin, A.1    Camilleri, M.2    Busciglio, I.3
  • 109
    • 84885834009 scopus 로고    scopus 로고
    • The ghrelin agonist RM-131 accelerates gastric emptying of solids and reduces symptoms in patients with type 1 diabetes mellitus
    • S1542-3565(13)00578-8
    • Shin A, Camilleri M, Busciglio I et al. The ghrelin agonist RM-131 accelerates gastric emptying of solids and reduces symptoms in patients with type 1 diabetes mellitus. Clin Gastroenterol Hepatol 2013; pii: S1542-3565(13)00578-8.
    • (2013) Clin Gastroenterol Hepatol
    • Shin, A.1    Camilleri, M.2    Busciglio, I.3
  • 111
    • 77449137453 scopus 로고    scopus 로고
    • The Ghrelin agonist TZP-101 for management of postoperative ileus after partial colectomy: a randomized, dose-ranging, placebo-controlled clinical trial
    • Popescu I, Fleshner PR, Pezzullo JC, Charlton PA, Kosutic G, Senagore AJ. The Ghrelin agonist TZP-101 for management of postoperative ileus after partial colectomy: a randomized, dose-ranging, placebo-controlled clinical trial. Dis Colon Rectum 2010; 53: 126-34.
    • (2010) Dis Colon Rectum , vol.53 , pp. 126-134
    • Popescu, I.1    Fleshner, P.R.2    Pezzullo, J.C.3    Charlton, P.A.4    Kosutic, G.5    Senagore, A.J.6
  • 112
    • 84866005648 scopus 로고    scopus 로고
    • Ghrelin agonist TZP-101/ulimorelin accelerates gastrointestinal recovery independently of opioid use and surgery type: covariate analysis of phase 2 data
    • Bochicchio G, Charlton P, Pezzullo JC, Kosutic G, Senagore A. Ghrelin agonist TZP-101/ulimorelin accelerates gastrointestinal recovery independently of opioid use and surgery type: covariate analysis of phase 2 data. World J Surg 2012; 36: 39-45.
    • (2012) World J Surg , vol.36 , pp. 39-45
    • Bochicchio, G.1    Charlton, P.2    Pezzullo, J.C.3    Kosutic, G.4    Senagore, A.5


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