Ghrelin does not affect gastrointestinal contractility in rainbow trout and goldfish in vitro

General and Comparative Endocrinology

Volumn 178, Issue 3, 2012, Pages 539-545

  Kitazawa, Takio ^a   Itoh, Kentaro ^a   Yaosaka, Noriko ^a   Maruyama, Keisuke ^b   Matsuda, Kouhei ^b   Teraoka, Hiroki ^a   Kaiya, Hiroyuki ^c  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Gastrointestinal motility; Ghrelin; Goldfish; Growth hormone secretagogue receptor 1a; Neuromedin U; Rainbow trout

Indexed keywords

ATROPINE; CARBACHOL; GHRELIN; GHRELIN RECEPTOR; MESSENGER RNA; NEUROMEDIN U; NEUROTENSIN; SUBSTANCE P; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; ELECTROSTIMULATION; FEMALE; GASTROINTESTINAL MOTILITY; GOLDFISH; IN VITRO STUDY; INTESTINE CONTRACTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAINBOW TROUT;

EID: 84864821852     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2012.06.025     Document Type: Article

References (49)

1. Baudet M.L., Harvey S. Ghrelin-induced GH secretion in domestic fowl in vivo and in vitro. J. Endocrinol. 2003, 179:97-105.
2. Chu C., Jin Q., Kunitake T., Kato K., Nabekura T., Nakazato M., Kangawa K., Kannan H. Cardiovascular actions of central neuromedin U in conscious rats. Regul. Pept. 2002, 105:29-34.
3. Dass N.B., Munonyara M., Bassil A.K., Hervieu G.J., Osbourne S., Corcoran S., Morgan M., Sanger G.J. Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin. Neuroscience 2003, 120:443-453.
4. Depoortere I., De Winter B., Thijs T., De Man J., Pelckmans P., Peeters T. Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Eur. J. Pharmacol. 2005, 515:160-168.
5. Edholm T., Levin F., Hellström P.M., Schmidt P.T. Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul. Pept. 2004, 121:25-30.
6. Fujino K., Inui A., Asakawa A., Kihara N., Fujimura M., Fujimiya M. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J. Physiol. 2003, 550:227-240.
7. Fukuda H., Mizuta Y., Isomoto H., Takeshima F., Ohnita K., Ohba K., Omagari K., Taniyama K., Kohno S. Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats. Scand. J. Gastroenterol. 2004, 39:1209-1214.
8. Furuse M., Tachibana T., Ohgushi A., Ando R., Yoshimatsu T., Denbow D.M. Intracerebroventricular injection of ghrelin and growth hormone releasing factor inhibits food intake in neonatal chicks. Neurosci. Lett. 2001, 301:123-126.
9. Geelissen S.M., Swennen Q., Geyten S.V., Kuhn E.R., Kaiya H., Kangawa K., Decuypere E., Buyse J., Darras V.M. Peripheral ghrelin reduces food intake and respiratory quotient in chicken. Domest. Anim. Endocrinol. 2006, 30:108-116.
10. Hosoda H., Kojima M., Kangawa K. Biological, physiological, and pharmacological aspects of ghrelin. J. Pharmacol. Sci. 2006, 100:398-410.
11. Jönsson E., Forsman A., Einarsdottir I.E., Kaiya H., Ruohonen K., Bjornsson B.T. Plasma ghrelin levels in rainbow trout in response to fasting, feeding and food composition, and effects of ghrelin on voluntary food intake. Comp. Biochem. Physiol. 2007, 147A:1116-1124.
12. Kaiya H., Kojima M., Hosoda H., Moriyama S., Takahashi A., Kawauchi H., Kangawa K. Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout. Endocrinology 2003, 144:5215-5226.
13. Kaiya H., Miura T., Matsuda K., Miyazato M., Kangawa K. Two functional growth hormone secretagogue receptor (ghrelin receptor) type 1a and 2a in goldfish, Carassius auratus. Mol. Cell. Endocrinol. 2010, 327:25-39.
14. Kaiya H., Miyazato M., Kangawa K. Recent advances in the phylogenetic study of ghrelin. Peptides 2011, 32:2155-2174.
15. Kaiya H., Miyazato M., Kangawa K., Peter R.E., Unniappan S. Ghrelin: a multifunctional hormone in non-mammalian vertebrates. Comp. Biochem. Physiol. A 2008, 149:109-128.
16. Kaiya H., Mori T., Miyazato M., Kangawa K. Ghrelin receptor (GHS-R)-like receptor and its genomic organisation in rainbow trout, Oncorhynchus mykiss. Comp. Biochem. Physiol. A 2009, 153:438-450.
17. Kaiya H., Van Der Geyten S., Kojima M., Hosoda H., Kitajima Y., Matsumoto M., Geelissen S., Darras V.M., Kangawa K. Chicken ghrelin: purification, cDNA cloning, and biological activity. Endocrinology 2002, 143:3454-3463.
18. Kitazawa T., De Smet B., Verbeke K., Depoortere I., Peeters T.L. Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro. Gut 2005, 54:1078-1084.
19. Kitazawa T., Kaiya H., Taneike T. Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro. Peptides 2007, 28:617-624.
20. Kitazawa T., Kudo K., Ishigami M., Furuhashi H., Temma K., Kondo H. Evidence that a substance P-like peptide mediates the non-cholinergic excitatory response of the carp intestinal bulb (Cyprinus carpio). Naunyn-Schimiedeberg's Arch. Pharmacol. 1988, 338:68-73.
21. Kitazawa T., Maeda Y., Kaiya H. Molecular cloning of growth hormone secretagogue-receptor and effect of quail ghrelin on gastrointestinal motility in Japanese quail. Regul. Pept. 2009, 158:132-142.
22. Kitazawa T., Nakamura T., Saeki A., Teraoka H., Hiraga T., Kaiya H. Molecular identification of ghrelin receptor (GHS-R1a) and its functional role in the gastrointestinal tract of the guinea-pig. Peptides 2011, 32:1876-1886.
23. Kojima M., Kangawa K. Ghrelin: structure and function. Physiol. Rev. 2005, 85:495-522.
24. Kojima M., Haruno R., Nakazato M., Date Y., Murakami N., Hanada R., Matsuo H., Kangawa K. Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Biochem. Biophys. Res. Commun. 2000, 276:435-438.
25. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
26. Masuda Y., Tanaka T., Inomata N., Ohnuma N., Tanaka S., Itoh Z., Hosoda H., Kojima M., Kangawa K. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem. Biophys. Res. Commun. 2000, 276:905-908.
27. Matsuda K., Miura T., Kaiya H., Maruyama K., Shimakura S., Uchiyama M., Kangawa K., Shioda S. Regulation of food intake by acyl and des-acyl ghrelins in the goldfish. Peptides 2006, 27:2321-2325.
28. Matsuda K., Miura T., Kaiya H., Maruyama K., Uchiyama M., Kangawa K., Shioda S. Stimulatory effect of n-octanoylated ghrelin on locomotor activity in the goldfish, Carassius auratus. Peptides 2006, 27:1335-1340.
29. Matsumoto M., Hosoda H., Kitajima Y., Morozumi N., Minamitake Y., Tanaka S., Matsuo H., Kojima M., Hayashi Y., Kangawa K. Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides. Biochem. Biophys. Res. Commun. 2001, 287:142-146.
30. Maruyama K., Kaiya H., Miyazato M., Konno N., Wakasugi T., Uchiyama M., Shioda S., Murakami N., Matsuda K. Isolation and characterization of two cDNAs encoding the neuromedin U receptor from goldfish brain. J. Neuroendocrinol. 2011, 23:282-291.
31. Maruyama K., Konno N., Ishiguro K., Wakasugi T., Uchiyama M., Shioda S., Matsuda K. Isolation and characterization of four cDNAs endoding neuromedin U (NMU) from the brain and gut of goldfish, and the inhibitory effect of a deduced NMU on food intake and locomotor activity. J. Neuroendocrinol. 2008, 20:71-78.
32. McKee K.K., Tan C.P., Palyha O.C., Liu J., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D., Van der Ploeg L.H. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. Genomics 1997, 46:426-434.
33. Minamino N., Kangawa K., Matsuo H. Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem. Biophys. Res. Commun. 1985, 130:1078-1085.
34. Miura T., Maruyama K., Kaiya H., Miyazato M., Kangawa K., Uchiyama M., Shioda S., Matsuda K. Purification and properties of ghrelin from the intestine of the goldfish, Carassius auratus. Peptides 2009, 30:758-765.
35. Miura T., Maruyama K., Shimakura S., Kaiya H., Uchiyama M., Kangawa K., Shioda S., Matsuda K. Regulation of food intake in the goldfish by interaction between ghrelin and orexin. Peptides 2007, 28:1207-1213.
36. Murashita K., Kurokawa T., Nilsen T., Ronnestad I. Ghrelin, cholecystokinin, and peptide YY in Atlantic salmon (Salmo salar): molecular cloning and tissue expression. Gen. Comp. Endocrinol. 2009, 160:223-235.
37. Nakahara K., Hanada R., Murakami N., Teranishi H., Ohgusu H., Fukushima N., Moriyama M., Ida T., Kangawa K., Kojima M. The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Biochem. Biophys. Res. Commun. 2004, 318:156-161.
38. Nakamura T., Onaga T., Kitazawa T. Ghrelin stimulates gastric motility of the guinea-pig through activation of a capsaicin-sensitive neural pathway: in vivo and in vitro functional studies. Neurogastroenterol. Motil. 2010, 22:446-452.
39. Nakazato M., Hanada R., Murakami N., Date Y., Mondal M.S., Kojima M., Yoshimatsu H., Kangawa K., Matsukura S. Central effects of neuromedin U in the regulation of energy homeostasis. Biochem. Biophys. Res. Commun. 2000, 277:191-194.
40. Ogawa A., Mochiki E., Yanai M., Morita H., Toyomasu Y., Ogata K., Ohno T., Asano T., Kuwano H. Interdigestive migrating contractions are coregulated by ghrelin and motilin in conscious dogs. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2012, 302:R233-R241.
41. Olsson C., Holbrook J.D., Bompadre G., Jönsson E., Hoyle C.H.V., Sanger G.J., Holmgren S., Andrews P.L.R. Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin. Gen. Comp. Endocrinol. 2008, 155:217-226.
42. Peeters T.L. Ghrelin: a new player in the control of gastrointestinal functions. Gut 2005, 54:1638-1649.
43. Riley L.G., Fox B.K., Kaiya H., Hirano T., Grau E.G. Long-term treatment of ghrelin stimulates feeding, fat deposition and alters the GH/GF-I axis in the tilapia, Oreochromis mossambicus. Gen. Comp. Endocrinol. 2005, 142:234-240.
44. Saito E.S., Kaiya H., Tachibana T., Tmononaga S., Denbow D.M., Kangawa K., Furuse M. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul. Pept. 2005, 125:201-208.
45. Shousha S., Nakahara K., Kojima M., Miyazato M., Hosoda H., Kangawa K., Murakami N. Different effects of peripheral and central ghrelin on regulation of food intake in the Japanese quail. Gen. Comp. Endocrinol. 2005, 141:178-183.
46. Tack J., Depoortere I., Bisschops R., Delporte C, Coulie B., Meulemans A., Janssens J., Peeters T. Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 2006, 55:327-333.
47. Takeshita E., Matsuura B., Dong M., Miller L.J., Matsui H., Onji M. Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract. J. Gastroenterol. 2006, 41:223-230.
48. Unniappan S., Lin X., Cervini L., River J., Kaiya H., Kangawa K., Peter R.E. Goldfish ghrelin: molecular characterization of the complementary deoxyribonucleic acid, partial gene structure and evidence for its stimulatory role in food intake. Endocrinology 2002, 143:4143-4146.
49. Unniappan S., Peter R.E. Structure, distribution and physiological function of ghrelin in fish. Comp. Biochem. Physiol. 2005, 140:396-408.