Prokinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative ileus

Digestive Diseases and Sciences

Volumn 52, Issue 9, 2007, Pages 2241-2248

  Venkova, Kalina ^a   Fraser, Graeme ^b   Hoveyda, Hamid R ^b   Greenwood Van Meerveld, Beverley ^a,c  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b Tranzyme Pharma Inc   (Canada)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Gastrointestinal transit; Ghrelin receptor agonist; Postoperative ileus

Indexed keywords

GHRELIN; MORPHINE; OPIATE AGONIST; TZP 101; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; GASTROINTESTINAL TRANSIT; ILEUS; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SMALL INTESTINE; STOMACH;

ANALGESICS, OPIOID; ANIMALS; BINDING SITES; DRUG THERAPY, COMBINATION; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; ILEUS; MALE; MORPHINE; PEPTIDE HORMONES; POSTOPERATIVE COMPLICATIONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, OPIOID, MU; TREATMENT OUTCOME;

EID: 34547851716     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9783-7     Document Type: Article

References (50)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
2. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K (2000) Ghrelin strongly stimulates growth hormone (GH) release in humans. J Clin Endocinol Metab 85:4909-4911
3. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatli MA, Bloom SR (2001) Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992
4. Peeters TL (2006) Ghrelin: a new player in the control of gastrointestinal functions. Gut 54:1638-1649
5. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141:4255-4261
6. Kojima M, Kangawa K (2005) Ghrelin: structure and function. Physiol Rev 85:495-522
7. Dass NB, Munonyara M, Bassil AK, Hervieu GJ, Osbourne S, Corcoran S, Morgan M, Sanger GJ (2003) Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin. Neuroscience 120:443-453
8. Xu L, Depoortere I, Tomasetto C, Zandecki M, Tang M, Timmermans JP, Peeters TL (2005) Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus. Regul Pept 124:119-125
9. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M (2001) Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterol 120:337-345
10. Fukuda H, Mizuta Y, Isomoto H, Takeshima F, Ohnita K, Ohba K, Omagari K, Taniyama K, Kohno S (2004) Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats. Scand J Gastroenterol 39:1209-1214
11. Tebbe JJ, Tebbe CG, Mronga S, Ritter M, Schafer MK (2005) Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced alteration of colonic transit time in conscious fed rats. BMC Gastroenterol 5:5
12. Shimizu Y, Chang EC, Shafton AD, Ferens DM, Sanger GJ, Witherington J, Furness JB (2006) Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat. J Physiol 576:329-338
13. Trudel L, Tomasetto C, Rio MC, Bouin M, Plourde V, Eberling P, Poitras P (2002) Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol 282:G948-G952
14. De Winter BY, De Man JG, Seerden TC, Depoortere I, Herman AG, Peeters TL, Pelckmans PA (2004) Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice. Neurogastroenterol Motil 16:439-446
15. Liu YL, Malik NM, Sanger GJ, Andrews PLR (2006) Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents. Cancer Chemother Pharmacol 58:326-333
16. Levin F, Edholm T, Schmidt PT, Grybäck P, Jacobsson H, Degerblad M, Höybye C, Holst JJ, Rehfeld JF, Hellström PM, Näslund E (2006) Ghrelin stimulates gastric emptying and hunger in normal weight humans. J Clin Endocrin Metab 91:3296-3302
17. Tack J, Depoortere I, Bisschops R, Verbeke K, Janssens J, Peeters T (2005) Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis. Aliment Pharmacol Ther 22:847-853
18. Murray CD, Martin NM, Patterson M, Taylor SA, Ghatei MA, Kamm MA, Johnston C, Bloom SR, Emmanuel AV (2005) Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. Gut 54:1693-1698
19. Binn M, Albert C, Gougeon A, Maerki H, Coulie B, Lemoyne M, Rabasa Lhoret R, Tomasetto C, Poitras P (2006) Ghrelin gastrokinetic action in patients with neurogenic gastroparesis. Peptides 27:1603-1606
20. Kehlet H, Williamson R, Buchler MW, Beart RW (2005) A survey of perceptions and attitudes among European surgeons towards the clinical impact and management of postoperative ileus. Colorectal Dis 7:245-250
21. Fotiadis RJ, Badvie S, Westen MD, Allen-Mersh TG (2004) Epidural analgesia in gastrointestinal surgery. Br J Surg 91:828-841
22. Greenwood-Van Meerveld B, Gardner CJ, Little PJ, Hicks GA, Dehaven-Hudkins DL (2004) Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil 16:46-53
23. Wittbrodt E (2006) The impact of postoperative ileus and emerging therapies. P&T 31:39-59
24. Fraser GL, Hoveyda HR, Venkova K, Johnson A, Samia M, Greenwood-Van Meerveld B, Tannenbaum GS (2005) Pharmacological separation of gastrointestinal and endocrine effects of ghrelin using a novel ghrelin agonist, TZP-101. Neurogastroenterol Motil 17:85
25. Kälff JC, Schraut WH, Simmons RL, Bauer AJ (1998) Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus. Ann Surg 228:652-663
26. Miller MS, Galligan JJ, Burks TF (1981) Accurate measurement of intestinal transit in the rat. J Pharmacol Methods 6:211-217
27. Crooks PA, Kottayil SG, Al-Ghananeem AM, Byrn SR, Butterfield DA (2006) Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett 16:4291-4295
28. Poitras P, Polvino WJ, Rocheleau B (2005) Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on post-operative and on morphine induced ileus. Peptides 26:1598-1601
29. De Winter BY, Boeckxstaens GE, De Man JG, Moreels TG, Herman AG, Pelckmans PA (1997) Effect of adrenergic and nitrergic blockade on experimental ileus in rats. Br J Pharmacol 120:464-468
30. Espat NJ, Cheng G, Kelley MC, Vogel SB, Sninsky CA Hocking MP (1995) Vasoactive intestinal peptide and substance P receptor antagonists improve postoperative ileus. J Surg Res 58:719-723
31. Kälff JC, Türler A, Schwarz NT, Schraut WH, Lee KK, Tweardy DJ, Billiar TR, Simmons RL, Bauer AJ (2003) Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg 237:301-315
32. Schwarz NT, Beer-Stolz D, Simmons RL, Bauer AJ (2002) Pathogenesis of paralytic ileus: intestinal manipulation opens a transient pathway between the intestinal lumen and the leukocytic infiltrate of the jejunal muscularis. Ann Surg 235:31-40
33. De Jonge WJ, The FO, Van Der Zanden EP, Van Den Wijngaard RM, Boeckxstaens GE (2005) Inflammation and gut motility; neural control of intestinal immune cell activation. J Pediatr Gastroenterol Nutr 41:S10-S11
34. Konturek PC, Brzozowski T, Pajdo R, Nikiforuk A, Kwiecien S, Harsch I, Drozdowicz D, Hahn EG, Konturek SJ (2004) Ghrelin-a new gastroprotective factor in gastric mucosa. J Physiol Pharmacol 55:325-336
35. Bassil AK, Dass NB, Murray CD, Muir A, Sanger GJ (2005) Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon. Eur J Pharmacol 524:138-144
36. Kitazawa T, De Smet B, Verbeke K, Depoortere I, Peeters TL (2005) Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro. Gut 54:1078-1084
37. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M (2001) Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterol 120:337-345
38. Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimiya M (2003) Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol 550:227-240
39. Bassil AK, Dass NB, Sanger GJ (2006) The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykinergic motor neurones. Eur J Pharmacol 544:146-152
40. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K, Nakazato M (2002) The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123:1120-1128
41. Sakata I, Yamazaki M, Inoue K, Hayashi Y, Kangawa K, Sakai T (2003) Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion. Neurosci Lett 342:183-186
42. Edholm T, Levin F, Hellstrom PM, Schmidt PT (2004) Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept 121:25-30
43. Artinyan A, Nunoo-Mensah JW, Essani R, Balasubramaniam S, Gauderman J, Gonzalez-Ruiz C, Vukasin P, Kaiser AM, Beart RW (2005) Prolonged postoperative ileus: definition, risk factors and predictors in patients undergoing open colorectal surgery. Gastroenterology 128:A-979
44. Senagore AJ (2006) Overview of POI and its impact on surgical outcomes. Supplement Contemp Surg (March 2006) 4-7
45. Galligan JJ, Burks TF (1983) Centrally mediated inhibition of small intestinal transit and motility by morphine in the rat. J Pharmacol Exp Ther 226:356-361
46. Gmerek DE, Cowan A, Woods JH (1986) Independent central and peripheral mediation of morphine-induced inhibition of gastrointestinal transit in rats. J Pharmacol Exp Ther 236:8-13
47. Thorn SE, Wickbom G, Philipson L, Leissner P, Wattwil M (1996) Myoelectric activity in the stomach and duodenum after epidural administration of morphine or bupivacaine. Acta Anaesthesiol Scand 40:773-778
48. Schmidt WK (2001) Alvimopan (ADL 8-2698) is a novel peripheral opioid antagonist. Am J Surg 182:27S-38S
49. Murphy DB, Sutton JA, Prescott LF, Murphy MB (1997) Opioid-induced delay in gastric emptying: a peripheral mechanism in humans. Anesthesiology 87:765-770
50. Fukuda H, Suenaga K, Uemura K, Tsuchida D, Mantyh CR, Papas TN, Hicks GA, Takahashi T (2004) The selective mu opioid receptor antagonist, alvimopan, accelerates gastrointestinal transit in a rodent model of postoperative ileus. Gastroenterol 126:A-641