Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 2, 2003, Pages 660-667

  Depoortere, Inge ^a   Thijs, Theo ^a   Thielemans, Leen ^a   Robberecht, Patrick ^b   Peeters, Theo L ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GM 109; GROWTH HORMONE SECRETAGOGUE RECEPTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; HORMONE ANTAGONIST; MOTILIN; NOLPITANTIUM; PHENYLALANYLCYCLO(LYSYLTYROSYL 3 TERT BUTYL BETA ALANYL)TRIFLUOROACETATE; RECEPTOR SUBTYPE; SAREDUTANT; TACHYKININ; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC NERVE; CONTROLLED STUDY; ELECTRIC FIELD; EVALUATION; FEMALE; HORMONAL REGULATION; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSE; MALE; MUSCLE CONTRACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABBIT; STIMULATION; STOMACH ANTRUM;

ANIMALS; BINDING, COMPETITIVE; ELECTRIC STIMULATION; FEMALE; MALE; MEMBRANES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; OLIGOPEPTIDES; PEPTIDE HORMONES; PYLORIC ANTRUM; RABBITS; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, NEUROPEPTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH;

EID: 0037404479     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.047563     Document Type: Article

References (43)

1. Akera T and Cheng VK (1977) A simple method for the determination of affinity and binding site concentration in receptor binding studies. Biochim Biophys Acta 470:412-423.
2. Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, and Ghigo E (2000) Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 23:493-495.
3. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, et al. (2001) Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120:337-345.
4. Asakawa A, Inui A, Momose K, Ueno N, Fujino MA, and Kasuga M (1998) Motilin increases food intake in mice. Peptides 19:987-990.
5. Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A, Malan D, Baj G, Granata R, Broglio F, et al. (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 159:1029-1037.
6. Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV, Warren VA, Howard AD, Van Der Ploeg LH, and Heck JV (2000) Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem 43:4370-4376.
7. Boivin M, Pinelo LR, St-Pierre S, and Poitras P (1997) Neural mediation of the motilin motor effect on the human antrum. Am J Physiol 272:G71-G76.
8. Cassoni P, Papotti M, Ghe C, Catapano F, Sapino A, Graziani A, Deghenghi R, Reissmann T, Ghigo E, and Muccioli G (2001) Identification, characterization and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J Clin Endocrinol Metab 86:1738-1745.
9. Christofides ND, Bloom SR, Besterman HS, Adrian TE, and Ghatei MA (1979) Release of motilin by oral and intravenous nutrients in man. Gut 20:102-106.
10. Coulie B, Tack J, Peeters T, and Janssens J (1998) Involvement of two different pathways in the motor effects of erythromycin on the gastric antrum in humans. Gut 43:395-400.
11. Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, Kojima M, Kangawa K, Arima T, Matsuo H, et al. (2002) Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion. Diabetes 51:124-129.
12. Garthwaite TL (1985) Peripheral motilin administration stimulates feeding in fasted rats. Peptides 6:41-44.
13. Hansen BS, Raun K, Nielsen KK, Johansen PB, Hansen TK, Peschke B, Lau J, Andersen PH, and Ankersen M (1999) Pharmacological characterisation of a new oral GH secretagogue, NN703. Eur J Endocrinol 141:180-189.
14. 2 receptor-mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro. Neuropharmacology 37:131-138.
15. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, et al. (1996) A receptor in pituitary and hypothalamus that functions in growth hormone release. Science (Wash DC) 273:974-977.
16. Kitazawa T, Ishii A, and Taniyama K (1993) The Leu13-motilin (KW-5139)-evoked release of acetylcholine from enteric neurones in the rabbit duodenum. Br J Pharmacol 109:94-99.
17. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, and Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature (Lond) 402:656-660.
18. 13] porcine motilin fragments. Peptides 13:565-569.
19. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, and Kangawa K (2000) Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276:905-908.
20. Muccioli G, Tschop M, Papotti M, Deghenghi R, Heiman M, and Ghigo E (2002) Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 440:235-254.
21. Nagaya N, Miyatake K, Uematsu M, Oya H, Shimizu W, Hosoda H, Kojima M, Nakanishi N, Mori H, and Kangawa K (2001) Hemodynamic, renal and hormonal effects of ghrelin infusion in patients with chronic heart failure. J Clin Endocrinol Metab 86:5854-5859.
22. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, and Matsukura S (2001) A role for ghrelin in the central regulation of feeding. Nature (Lond) 409:194-198.
23. Papotti M, Ghe C, Cassoni P, Catapano F, Deghenghi R, Ghigo E, and Muccioli G (2000) Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 85:3803-3807.
24. Peeters TL (1993) Erythromycin and other macrolides as prokinetic agents. Gastroenterology 105:1886-1899.
25. Peeters TL and Depoortere I (1994) Motilin receptor: a model for development of prokinetics. Dig Dis Sci 39:76S-78S.
26. Peeters TL, Macielag MJ, Depoortere I, Konteatis ZD, Florance JR, Lessor RA, and Galdes A (1992) D-Amino acid and alanine scans of the bioactive portion of porcine motilin. Peptides 13:1103-1107.
27. Peeters TL, Vantrappen G, and Janssens J (1980) Fasting plasma motilin levels are related to the interdigestive motility complex. Gastroenterology 79:716-719.
28. Rosenfeld DJ and Garthwaite TL (1987) Central administration of motilin stimulates feeding in rats. Physiol Behav 39:753-756.
29. Samson WK, Lumpkin MD, and McCann SM (1982) Motilin stimulates growth hormone release in vitro. Brain Res Bull 8:117-121.
30. Samson WK, Lumpkin MD, Nilaver G, and McCann SM (1984) Motilin: a novel growth hormone releasing agent. Brain Res Bull 12:57-62.
31. Serio R, Mule F, Bonvissuto F, and Postorino A (1998) Tachykinins mediate noncholinergic excitatory neural responses in the circular muscle of rat proximal colon. Can J Physiol Pharmacol 76:684-689.
32. Shiba Y, Mizumoto A, Inatomi N, Haga N, Yamamoto O, and Itoh Z (1995) Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs. Gastroenterology 109:1513-1521.
33. Suzuki H, Mochiki E, Haga N, Satoh M, Mizumoto A, and Itoh Z (1998) Motilin controls cyclic release of insulin through vagal cholinergic muscarinic pathways in fasted dogs. Am J Physiol 274:G87-G95.
34. Takanashi H, Yogo K, Ozaki K, Ikuta M, Akima M, Koga H, and Nabata H (1995) GM-109: a novel, selective motilin receptor antagonist in the smooth muscle of the rabbit small intestine. J Pharmacol Exp Ther 273:624-628.
35. Tolle V, Zizzari P, Tomasetto C, Rio MC, Epelbaum J, and Bluet-Pajot MT (2001) In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat. Neuroendocrinology 73:54-61.
36. Tomasetto C, Karam SM, Ribieras S, Masson R, Lefebvre O, Staub A, Alexander G, Chenard MP, and Rio MC (2000) Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 119:395-405.
37. Trudel L, Tomasetto C, Rio MC, Bouin M, Plourde V, Eberling P, and Poitras P (2002) Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol 282:G948-G952.
38. Tschop M, Smiley DL, and Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature (Lond) 407:908-913.
39. 13 motilin in the isolated rabbit gastric antrum. Eur J Pharmacol 337:267-274.
40. von Euler US and Gaddum JH (1931) An unidentified depressor substance in certain tissue extracts. J Physiol (Lond) 72:74-87.
41. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, and Bloom SR (2001) Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992.
42. 2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the guinea-pig stomach. Neuroscience 80:625-634.
43. Zagorodnyuk V, Santicioli P, Turini D, and Maggi CA (1997) Tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum. Neuropeptides 31:265-271.